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The map label for this gene is menB [H]

Identifier: 222523398

GI number: 222523398

Start: 122876

End: 123703

Strand: Direct

Name: menB [H]

Synonym: Chy400_0100

Alternate gene names: 222523398

Gene position: 122876-123703 (Clockwise)

Preceding gene: 222523397

Following gene: 222523399

Centisome position: 2.33

GC content: 59.66

Gene sequence:

>828_bases
ATGCCAATCGAGTGGGTCAAAGTTCACGATTATACCGACATCATCTACGAACACGATGCTGCCGGTGAAGGCATTGCCAA
AATTACCATCAACCGTCCCGAAAAGCGCAACGCATTTCGTCCGGAAACCGTCAACGAGCTGATTGACGCCTTCTCGCGTG
CACGCGACGACGAACGGATCGGTGTGATCCTCTTCACCGGTGCCGGCGACAAAGCGTTCTGCTCCGGCGGTGATCAGAGC
GTGCGCGGCATTGGCGGGTACGTCGGCAAAGACCAGATTCCACGCCTGAACGTGCTCGACCTCCAGCGCCTGATTCGCAT
CATTCCCAAACCGGTCATCGCCCTGGTCGCCGGCTACGCCATCGGCGGCGGACACGTCTTGCACGTCGTCTGCGACCTGA
CCATCGCTGCCGACAATGCCATCTTTGGTCAGACCGGGCCAAAAGTGGGAAGCTTTGACGGCGGTTACGGTTCAAACCTG
CTGGCCCGCATGGTCGGCGACAAAAAAGCGCGTGAAATCTGGTACCTCTGCCGCCAATACAACGCACAGCAGGCACTCGA
AATGGGGCTGGTCAACGCCGTGGTCCCCCTCGAACGCCTCGAAGACGAGGGCGTGCAATGGGCACGCGAAATCCTCGAAA
AGAGTCCACTGGCCATCCGCATGCTCAAAGCCAGCATCAACGCTGCCGCCGACGGCTATGCCGGACTCCAGCAACTGGCC
GGTGACGCAACCCTGCTCTACTACCTGACCGAAGAGGCGCAGGAGGGCAAACAAGCCTTCCTCGAAAAGCGCAAGCCCAA
CTTCCGCCGCTTCCGTCGCTACCCGTAA

Upstream 100 bases:

>100_bases
TGAAATACGTCAGGCCATTCCGCACATCGCCAAACCACCGACACCAATGATTGTGGTACATTATTAATAGGGAACGATAA
GCACAAGTGCGAGGAAACCT

Downstream 100 bases:

>100_bases
ACGCGACACACCGGTAGGCAAGGGCACACCCCCACCCCCTCCCCCAACTCCTCCCCCCAGCGGGGGAGGCCGAAAAAATT
GACAACTCCTCCCCCCAACG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPIEWVKVHDYTDIIYEHDAAGEGIAKITINRPEKRNAFRPETVNELIDAFSRARDDERIGVILFTGAGDKAFCSGGDQS
VRGIGGYVGKDQIPRLNVLDLQRLIRIIPKPVIALVAGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDGGYGSNL
LARMVGDKKAREIWYLCRQYNAQQALEMGLVNAVVPLERLEDEGVQWAREILEKSPLAIRMLKASINAAADGYAGLQQLA
GDATLLYYLTEEAQEGKQAFLEKRKPNFRRFRRYP

Sequences:

>Translated_275_residues
MPIEWVKVHDYTDIIYEHDAAGEGIAKITINRPEKRNAFRPETVNELIDAFSRARDDERIGVILFTGAGDKAFCSGGDQS
VRGIGGYVGKDQIPRLNVLDLQRLIRIIPKPVIALVAGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDGGYGSNL
LARMVGDKKAREIWYLCRQYNAQQALEMGLVNAVVPLERLEDEGVQWAREILEKSPLAIRMLKASINAAADGYAGLQQLA
GDATLLYYLTEEAQEGKQAFLEKRKPNFRRFRRYP
>Mature_274_residues
PIEWVKVHDYTDIIYEHDAAGEGIAKITINRPEKRNAFRPETVNELIDAFSRARDDERIGVILFTGAGDKAFCSGGDQSV
RGIGGYVGKDQIPRLNVLDLQRLIRIIPKPVIALVAGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDGGYGSNLL
ARMVGDKKAREIWYLCRQYNAQQALEMGLVNAVVPLERLEDEGVQWAREILEKSPLAIRMLKASINAAADGYAGLQQLAG
DATLLYYLTEEAQEGKQAFLEKRKPNFRRFRRYP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=263, Percent_Identity=33.4600760456274, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI31542718, Length=256, Percent_Identity=32.03125, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI70995211, Length=228, Percent_Identity=30.2631578947368, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI45643119, Length=207, Percent_Identity=28.9855072463768, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI260275230, Length=207, Percent_Identity=28.9855072463768, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI260274832, Length=207, Percent_Identity=29.4685990338164, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=28.6821705426357, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4757966, Length=225, Percent_Identity=27.5555555555556, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI51538581, Length=225, Percent_Identity=27.5555555555556, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI25453481, Length=225, Percent_Identity=27.5555555555556, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI51538573, Length=225, Percent_Identity=27.5555555555556, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788597, Length=276, Percent_Identity=65.5797101449275, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI87082183, Length=249, Percent_Identity=32.9317269076305, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787659, Length=246, Percent_Identity=33.739837398374, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI221142681, Length=262, Percent_Identity=32.4427480916031, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787660, Length=256, Percent_Identity=32.8125, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788682, Length=226, Percent_Identity=28.3185840707965, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=257, Percent_Identity=34.6303501945525, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17554946, Length=251, Percent_Identity=31.8725099601594, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=215, Percent_Identity=30.6976744186047, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17549921, Length=196, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17536985, Length=220, Percent_Identity=28.6363636363636, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=240, Percent_Identity=27.9166666666667, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=244, Percent_Identity=28.6885245901639, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=26.1904761904762, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI20129971, Length=257, Percent_Identity=34.6303501945525, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653477, Length=257, Percent_Identity=34.6303501945525, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653139, Length=271, Percent_Identity=29.520295202952, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21357171, Length=191, Percent_Identity=31.413612565445, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922422, Length=268, Percent_Identity=24.6268656716418, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24654903, Length=185, Percent_Identity=28.6486486486486, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24650670, Length=214, Percent_Identity=28.5046728971963, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30432; Mature: 30301

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIEWVKVHDYTDIIYEHDAAGEGIAKITINRPEKRNAFRPETVNELIDAFSRARDDERI
CCCCEEEECCHHHHHEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCE
GVILFTGAGDKAFCSGGDQSVRGIGGYVGKDQIPRLNVLDLQRLIRIIPKPVIALVAGYA
EEEEEECCCCCCEECCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHC
IGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDGGYGSNLLARMVGDKKAREIWYLCRQY
CCCCCEEEHEEHHEEECCCCEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
NAQQALEMGLVNAVVPLERLEDEGVQWAREILEKSPLAIRMLKASINAAADGYAGLQQLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHC
GDATLLYYLTEEAQEGKQAFLEKRKPNFRRFRRYP
CCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure 
PIEWVKVHDYTDIIYEHDAAGEGIAKITINRPEKRNAFRPETVNELIDAFSRARDDERI
CCCEEEECCHHHHHEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCE
GVILFTGAGDKAFCSGGDQSVRGIGGYVGKDQIPRLNVLDLQRLIRIIPKPVIALVAGYA
EEEEEECCCCCCEECCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHC
IGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDGGYGSNLLARMVGDKKAREIWYLCRQY
CCCCCEEEHEEHHEEECCCCEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
NAQQALEMGLVNAVVPLERLEDEGVQWAREILEKSPLAIRMLKASINAAADGYAGLQQLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHC
GDATLLYYLTEEAQEGKQAFLEKRKPNFRRFRRYP
CCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]