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The map label for this gene is thiD [H]

Identifier: 222094487

GI number: 222094487

Start: 812601

End: 813413

Strand: Direct

Name: thiD [H]

Synonym: BCQ_0825

Alternate gene names: 222094487

Gene position: 812601-813413 (Clockwise)

Preceding gene: 222094486

Following gene: 222094488

Centisome position: 15.58

GC content: 38.13

Gene sequence:

>813_bases
ATGAAAGTAAATAAAGCTTTAACAATTGCAGGATCTGATAGTGGCGGCGGTGCCGGCATTCAAGCAGATTTAAAAACATT
CCAAGAGCTTGGTGTGTATGGGATGACGGCTATTACGGCAATTACTGCTCAAAACACGCTTGGCGTTCAAGGGGTATATC
CAGTTTCGTTAGAAGGTATTACGGAACAGTTGAATTCAATTGGTACGGATTTAACACCAGATGCTGTGAAATTAGGAATG
TTATTTAGCAGCGAAATTATTCAAATTGTAGCAGAACATATTAATAAATTTGGCTGGAATAATATTGTACTAGATCCTGT
TATGATTGCTAAGGGCGGTGCATCATTATTACAGCAAGAAGCAGTACAAGCGTTAAAAGAATATTTATTGCCAGTAGCAA
CAGTTGTAACGCCGAATGTTCCTGAGGCAGAAGTGTTAACGGGGCTAGAAATTCATAACGTTGAAGATAGTAAAGAGGCT
GCAAAAGTATTGCATGAATTAGGGGCGAAATATGTACTTATGAAGGGCGGACATGCAGAATATCAAGGTAATGAAGTAAT
TGATTTACTTTTTGATGGAGAAAAGTTTATTGAATTTAGAAGTGAACGAATTCCTTCAAAGCAAACGCATGGAAGCGGGT
GTACATTTGCTTCAGCGGTTACAGCTGGACTTGCGAAAGGATACTCAATTGAAGAGGCAGTTCAAGAAGCAAAACAATTT
ATTAGTATAGCAATTGAAGAGCCGCTACATATTGGAAGTGGTCATGGACCGACGAATCATTTTGCATATAAATTGAATAA
AGCACATGTATAA

Upstream 100 bases:

>100_bases
TGCTTTTAAAGATGGTCGTGTACTTGTACATGGAACGAAAGATATAAGTGAAGCAAAAACAGTTTATCATCGTTATTTTG
GATAGAAAAGGATGAGTGGG

Downstream 100 bases:

>100_bases
GTAGACAAAAGTCAGTTGTATAACTGGCTTTTTTTTCTGTTTACTTTTTCTAGATACAAGAGTAATATATCAGCCAGAAT
ATATTTTTTGTAATACGCTG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKVNKALTIAGSDSGGGAGIQADLKTFQELGVYGMTAITAITAQNTLGVQGVYPVSLEGITEQLNSIGTDLTPDAVKLGM
LFSSEIIQIVAEHINKFGWNNIVLDPVMIAKGGASLLQQEAVQALKEYLLPVATVVTPNVPEAEVLTGLEIHNVEDSKEA
AKVLHELGAKYVLMKGGHAEYQGNEVIDLLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSIEEAVQEAKQF
ISIAIEEPLHIGSGHGPTNHFAYKLNKAHV

Sequences:

>Translated_270_residues
MKVNKALTIAGSDSGGGAGIQADLKTFQELGVYGMTAITAITAQNTLGVQGVYPVSLEGITEQLNSIGTDLTPDAVKLGM
LFSSEIIQIVAEHINKFGWNNIVLDPVMIAKGGASLLQQEAVQALKEYLLPVATVVTPNVPEAEVLTGLEIHNVEDSKEA
AKVLHELGAKYVLMKGGHAEYQGNEVIDLLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSIEEAVQEAKQF
ISIAIEEPLHIGSGHGPTNHFAYKLNKAHV
>Mature_270_residues
MKVNKALTIAGSDSGGGAGIQADLKTFQELGVYGMTAITAITAQNTLGVQGVYPVSLEGITEQLNSIGTDLTPDAVKLGM
LFSSEIIQIVAEHINKFGWNNIVLDPVMIAKGGASLLQQEAVQALKEYLLPVATVVTPNVPEAEVLTGLEIHNVEDSKEA
AKVLHELGAKYVLMKGGHAEYQGNEVIDLLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSIEEAVQEAKQF
ISIAIEEPLHIGSGHGPTNHFAYKLNKAHV

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=264, Percent_Identity=43.1818181818182, Blast_Score=208, Evalue=3e-55,
Organism=Escherichia coli, GI1788758, Length=249, Percent_Identity=27.3092369477912, Blast_Score=64, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6325378, Length=272, Percent_Identity=33.0882352941176, Blast_Score=146, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6324997, Length=273, Percent_Identity=33.6996336996337, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324517, Length=273, Percent_Identity=34.0659340659341, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28739; Mature: 28739

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVNKALTIAGSDSGGGAGIQADLKTFQELGVYGMTAITAITAQNTLGVQGVYPVSLEGI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHH
TEQLNSIGTDLTPDAVKLGMLFSSEIIQIVAEHINKFGWNNIVLDPVMIAKGGASLLQQE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHH
AVQALKEYLLPVATVVTPNVPEAEVLTGLEIHNVEDSKEAAKVLHELGAKYVLMKGGHAE
HHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEECCCCHHHHHHHHHHCCCCEEEEECCCCC
YQGNEVIDLLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSIEEAVQEAKQF
CCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ISIAIEEPLHIGSGHGPTNHFAYKLNKAHV
HHHHHHCCEECCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MKVNKALTIAGSDSGGGAGIQADLKTFQELGVYGMTAITAITAQNTLGVQGVYPVSLEGI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHH
TEQLNSIGTDLTPDAVKLGMLFSSEIIQIVAEHINKFGWNNIVLDPVMIAKGGASLLQQE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHH
AVQALKEYLLPVATVVTPNVPEAEVLTGLEIHNVEDSKEAAKVLHELGAKYVLMKGGHAE
HHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEECCCCHHHHHHHHHHCCCCEEEEECCCCC
YQGNEVIDLLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSIEEAVQEAKQF
CCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ISIAIEEPLHIGSGHGPTNHFAYKLNKAHV
HHHHHHCCEECCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]