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The map label for this gene is spH [H]

Identifier: 222094431

GI number: 222094431

Start: 746781

End: 747797

Strand: Direct

Name: spH [H]

Synonym: BCQ_0745

Alternate gene names: 222094431

Gene position: 746781-747797 (Clockwise)

Preceding gene: 222094430

Following gene: 222094432

Centisome position: 14.32

GC content: 36.87

Gene sequence:

>1017_bases
ATGGAGGTATGGAACGTGAAAGGTAAATTGCTAAAAGGTGTACTTAGCCTTGGGATTGGTTTAGGAGTTTTATACGGAGG
ATCTTCAGCTCAAGCAGATACGTCTACAGATCAAAACAACATTTTGAAAGTGATGACGCATAACGTGTACATGCTATCAA
CTAACTTATATCCGAATTGGGGACAAAGTCAGCGTGCTGATTTAATTGGGGCGGCAGATTATATTAAAAATCAAGACGTT
GTTATATTAAATGAAGTGTTTGATAATAGTGCTTCAGATCGCCTTTTAGGAAATTTGAAGAAAGAATACCCAAATCAAAC
AGCTGTATTAGGTCGTAGTAACGGAAATGAATGGGATAAAACGTTAGGTAGTTATTCATCTTCAACGCCTGAAGATGGAG
GCGTTGCAATCGTGAGCAAATGGCCGATCGTTGAAAAGGTTCAATATGTATTTGCAAATGGATGCGGGCCGGATAATTTA
TCGAATAAAGGATTTGTATACACGAAGATTAAGAAAAATGATCGTTTCGTTCATGTAATTGGGACGCATTTGCAGGCAGA
AGATAGTATGTGCGGAAAAACTTCACCTGCATCTGTACGTACAAACCAGTTAAAAGAAATTCAAGATTTTATTAAAAATA
AAAATATACCAAATGACGAGTACGTCCTATTTGGTGGTGATATGAATGTGAATAAAATAAATGCTGAGAACAATAGTGAC
TCAGAATACGCATCAATGTTCAAAACATTGCACGCTTCTATTCCATCTTATACGGGACATACAGCAACTTGGGATGCGAC
GACAAACAGTATTGCAAAATATAATTTCCCTGATAGCCCTGCCGAGTATTTAGATTATATTATTGCAAGTAAAGACCATG
CGAACCCGTCATTTGTAGAGAATAAAGTGTTACAACCGAAATCTCCACAGTGGACTGTTACATCATGGCTCAAAAAATAT
ACGTATGATGATTATTCTGATCATTATCCAGTAGCAGCAACTATTTCTATGAAGTAG

Upstream 100 bases:

>100_bases
GCCTAATGAATTAGAAGCCATTAGGCTTCTGTACTTAGGAATCTCCCACTTCAAACAGTCCGTAAGGACGTTAAGTGGTG
AGTAGTTCAATACTATACAC

Downstream 100 bases:

>100_bases
TCCTAAAAAAGTTTCTTCTTAAATAGGAAGAAACTTTTTTATTTTGTAGAGGAGATTCCAACTTTCTTTCCAATATGTAT
AAGACATATAGAGAAGAGGA

Product: sphingomyelinase c

Products: NA

Alternate protein names: SMase; Cereolysin B; SMPLC; Sphingomyelin phosphodiesterase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MEVWNVKGKLLKGVLSLGIGLGVLYGGSSAQADTSTDQNNILKVMTHNVYMLSTNLYPNWGQSQRADLIGAADYIKNQDV
VILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDKTLGSYSSSTPEDGGVAIVSKWPIVEKVQYVFANGCGPDNL
SNKGFVYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSD
SEYASMFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFVENKVLQPKSPQWTVTSWLKKY
TYDDYSDHYPVAATISMK

Sequences:

>Translated_338_residues
MEVWNVKGKLLKGVLSLGIGLGVLYGGSSAQADTSTDQNNILKVMTHNVYMLSTNLYPNWGQSQRADLIGAADYIKNQDV
VILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDKTLGSYSSSTPEDGGVAIVSKWPIVEKVQYVFANGCGPDNL
SNKGFVYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSD
SEYASMFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFVENKVLQPKSPQWTVTSWLKKY
TYDDYSDHYPVAATISMK
>Mature_338_residues
MEVWNVKGKLLKGVLSLGIGLGVLYGGSSAQADTSTDQNNILKVMTHNVYMLSTNLYPNWGQSQRADLIGAADYIKNQDV
VILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDKTLGSYSSSTPEDGGVAIVSKWPIVEKVQYVFANGCGPDNL
SNKGFVYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSD
SEYASMFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFVENKVLQPKSPQWTVTSWLKKY
TYDDYSDHYPVAATISMK

Specific function: Required, with sphingomyelinase, to effect target cell lysis (hemolysis) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the neutral sphingomyelinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.12 [H]

Molecular weight: Translated: 37485; Mature: 37485

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVWNVKGKLLKGVLSLGIGLGVLYGGSSAQADTSTDQNNILKVMTHNVYMLSTNLYPNW
CCEECCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEEEECCEEEEEECCCCCC
GQSQRADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDK
CCCCHHHHHHHHHHHCCCCEEEEHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHH
TLGSYSSSTPEDGGVAIVSKWPIVEKVQYVFANGCGPDNLSNKGFVYTKIKKNDRFVHVI
HHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEE
GTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSD
ECCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCCCCC
SEYASMFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFVE
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHH
NKVLQPKSPQWTVTSWLKKYTYDDYSDHYPVAATISMK
HCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MEVWNVKGKLLKGVLSLGIGLGVLYGGSSAQADTSTDQNNILKVMTHNVYMLSTNLYPNW
CCEECCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEEEECCEEEEEECCCCCC
GQSQRADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDK
CCCCHHHHHHHHHHHCCCCEEEEHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHH
TLGSYSSSTPEDGGVAIVSKWPIVEKVQYVFANGCGPDNLSNKGFVYTKIKKNDRFVHVI
HHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEE
GTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSD
ECCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCCCCC
SEYASMFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFVE
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHH
NKVLQPKSPQWTVTSWLKKYTYDDYSDHYPVAATISMK
HCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2848222; 8387306; 3137122 [H]