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The map label for this gene is adhB [H]

Identifier: 222094427

GI number: 222094427

Start: 742678

End: 743730

Strand: Direct

Name: adhB [H]

Synonym: BCQ_0741

Alternate gene names: 222094427

Gene position: 742678-743730 (Clockwise)

Preceding gene: 222094425

Following gene: 222094428

Centisome position: 14.24

GC content: 38.08

Gene sequence:

>1053_bases
ATGAAAGCATTACTTTGGCATAATCAACGTGATGTAAGAGTAGAAGAAGTACCAGAACCAACTGTAAAACCAGGAGCAGT
TAAGATTAAAGTGAAATGGTGTGGTATCTGCGGGACAGACTTGCATGAATATTTAGCAGGACCTATTTTTATTCCGACAG
AAGAGCATCCATTAACACATGTAAAAGCACCGGTTATTTTAGGTCATGAGTTTAGCGGTGAGGTAGTTGAAATCGGTGAA
GGCGTTACATCTCATAAAGTGGGAGACCGCGTCGTTGTAGAACCAATTTATTCTTGTGGTAAATGTGAAGCTTGTAAACA
TGGACATTACAATGTTTGTGAACAACTTGTTTTCCACGGTCTTGGCGGAGAAGGCGGCGGTTTCTCTGAATATACAGTAG
TACCAGAAGATATGGTTCACCATATTCCAGATGAAATGACGTATGAACAAGGTGCTCTTGTAGAACCAGCAGCAGTAGCG
GTTCATGCAGTACGTCAAAGTAAATTAAAAGAAGGGGAAGCAGTAGCAGTCTTTGGTTGTGGTCCAATTGGACTTCTTGT
TATCCAAGCAGCTAAAGCAGCAGGAGCAACTCCTGTTATTGCAGTTGAACTTTCTAAAGAACGTCAAGAATTAGCAAAAT
TAGCAGGTGCGGATTACGTATTGAATCCAGCGACTCAAGATGTATTAGCTGAAATTCGCAACTTAACAAATGGTTTAGGT
GTAAATGTAAGCTTTGAAGTAACTGGTGTTGAAGTAGTACTTCGTCAAGCAATTGAAAGTACAAGTTTCGAAGGACAAAC
TGTAATTGTTAGTGTATGGGAAAAAGACGCAACAATTACTCCAAACAATCTTGTACTAAAAGAAAAAGAAGTGGTTGGTA
TTTTAGGATACCGTCATATCTTCCCAGCTGTTATTAAATTAATTAGCTCTGGTCAAATTCAAGCAGAGAAATTAATTACG
AAAAAAATCACAGTAGATCAAGTTGTTGAAGAAGGATTTGAAGCACTTGTAAAAGATAAAACACAAGTGAAAATTCTTGT
TTCACCTAAATAA

Upstream 100 bases:

>100_bases
TGGAAATGAGATTGTTTTTTTGAAATATATGGATAGAAGTATTATAATAGATTTGTAAACTTCACCAGGTTAAGTATATA
CATAGAGAGGGATGTATAAA

Downstream 100 bases:

>100_bases
TATAGAATAGTAAAAAGTAGCTCTTTTCTAGAAATAGAAGAGGGCTACTTTTTTTCTGTACAGAAAGGTGATAGACTTTC
CTGTAACTACAGGTATTTTG

Product: zinc-containing alcohol dehydrogenase, long-chain

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKALLWHNQRDVRVEEVPEPTVKPGAVKIKVKWCGICGTDLHEYLAGPIFIPTEEHPLTHVKAPVILGHEFSGEVVEIGE
GVTSHKVGDRVVVEPIYSCGKCEACKHGHYNVCEQLVFHGLGGEGGGFSEYTVVPEDMVHHIPDEMTYEQGALVEPAAVA
VHAVRQSKLKEGEAVAVFGCGPIGLLVIQAAKAAGATPVIAVELSKERQELAKLAGADYVLNPATQDVLAEIRNLTNGLG
VNVSFEVTGVEVVLRQAIESTSFEGQTVIVSVWEKDATITPNNLVLKEKEVVGILGYRHIFPAVIKLISSGQIQAEKLIT
KKITVDQVVEEGFEALVKDKTQVKILVSPK

Sequences:

>Translated_350_residues
MKALLWHNQRDVRVEEVPEPTVKPGAVKIKVKWCGICGTDLHEYLAGPIFIPTEEHPLTHVKAPVILGHEFSGEVVEIGE
GVTSHKVGDRVVVEPIYSCGKCEACKHGHYNVCEQLVFHGLGGEGGGFSEYTVVPEDMVHHIPDEMTYEQGALVEPAAVA
VHAVRQSKLKEGEAVAVFGCGPIGLLVIQAAKAAGATPVIAVELSKERQELAKLAGADYVLNPATQDVLAEIRNLTNGLG
VNVSFEVTGVEVVLRQAIESTSFEGQTVIVSVWEKDATITPNNLVLKEKEVVGILGYRHIFPAVIKLISSGQIQAEKLIT
KKITVDQVVEEGFEALVKDKTQVKILVSPK
>Mature_350_residues
MKALLWHNQRDVRVEEVPEPTVKPGAVKIKVKWCGICGTDLHEYLAGPIFIPTEEHPLTHVKAPVILGHEFSGEVVEIGE
GVTSHKVGDRVVVEPIYSCGKCEACKHGHYNVCEQLVFHGLGGEGGGFSEYTVVPEDMVHHIPDEMTYEQGALVEPAAVA
VHAVRQSKLKEGEAVAVFGCGPIGLLVIQAAKAAGATPVIAVELSKERQELAKLAGADYVLNPATQDVLAEIRNLTNGLG
VNVSFEVTGVEVVLRQAIESTSFEGQTVIVSVWEKDATITPNNLVLKEKEVVGILGYRHIFPAVIKLISSGQIQAEKLIT
KKITVDQVVEEGFEALVKDKTQVKILVSPK

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=32.0588235294118, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI4501929, Length=380, Percent_Identity=31.3157894736842, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI4501933, Length=382, Percent_Identity=30.3664921465969, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI71743840, Length=362, Percent_Identity=30.1104972375691, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI262073058, Length=362, Percent_Identity=30.1104972375691, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI34577061, Length=381, Percent_Identity=30.4461942257218, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI156523966, Length=359, Percent_Identity=29.2479108635098, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=29.2479108635098, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI71565154, Length=374, Percent_Identity=29.6791443850267, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI71565152, Length=387, Percent_Identity=26.6149870801034, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1788073, Length=331, Percent_Identity=34.7432024169184, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1788075, Length=348, Percent_Identity=32.4712643678161, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1787863, Length=331, Percent_Identity=32.6283987915408, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=30.791788856305, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1788407, Length=350, Percent_Identity=31.4285714285714, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI226510992, Length=352, Percent_Identity=29.5454545454545, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1790718, Length=320, Percent_Identity=29.375, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786552, Length=359, Percent_Identity=33.4261838440111, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI87082125, Length=288, Percent_Identity=30.2083333333333, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1786825, Length=237, Percent_Identity=32.4894514767932, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87081918, Length=316, Percent_Identity=29.746835443038, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1787572, Length=205, Percent_Identity=29.2682926829268, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=222, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=327, Percent_Identity=36.085626911315, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17562878, Length=325, Percent_Identity=34.7692307692308, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI25146526, Length=386, Percent_Identity=26.9430051813472, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71997431, Length=388, Percent_Identity=27.0618556701031, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17565904, Length=229, Percent_Identity=32.7510917030568, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=309, Percent_Identity=29.4498381877023, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=309, Percent_Identity=25.2427184466019, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=281, Percent_Identity=29.5373665480427, Blast_Score=81, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=378, Percent_Identity=35.1851851851852, Blast_Score=228, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6319258, Length=377, Percent_Identity=36.3395225464191, Blast_Score=219, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=33.4319526627219, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6319955, Length=338, Percent_Identity=33.4319526627219, Blast_Score=185, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6323099, Length=312, Percent_Identity=33.974358974359, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=28.3018867924528, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323729, Length=239, Percent_Identity=29.7071129707113, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=259, Percent_Identity=28.957528957529, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=273, Percent_Identity=27.4725274725275, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=246, Percent_Identity=30.4878048780488, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323980, Length=369, Percent_Identity=23.8482384823848, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=335, Percent_Identity=32.2388059701493, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17737897, Length=335, Percent_Identity=31.3432835820896, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI17737895, Length=378, Percent_Identity=26.984126984127, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI221457811, Length=336, Percent_Identity=24.4047619047619, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45551930, Length=336, Percent_Identity=24.4047619047619, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45550770, Length=336, Percent_Identity=24.4047619047619, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 37807; Mature: 37807

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALLWHNQRDVRVEEVPEPTVKPGAVKIKVKWCGICGTDLHEYLAGPIFIPTEEHPLTH
CCCEEECCCCCCCHHCCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCEEECCCCCCCCE
VKAPVILGHEFSGEVVEIGEGVTSHKVGDRVVVEPIYSCGKCEACKHGHYNVCEQLVFHG
ECCCEEECCCCCCCEEEECCCCCCCCCCCEEEEHHHHCCCCCCHHCCCCHHHHHHHHHHC
LGGEGGGFSEYTVVPEDMVHHIPDEMTYEQGALVEPAAVAVHAVRQSKLKEGEAVAVFGC
CCCCCCCCCCEEECHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEC
GPIGLLVIQAAKAAGATPVIAVELSKERQELAKLAGADYVLNPATQDVLAEIRNLTNGLG
CHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCC
VNVSFEVTGVEVVLRQAIESTSFEGQTVIVSVWEKDATITPNNLVLKEKEVVGILGYRHI
CEEEEEECHHHHHHHHHHHHCCCCCCEEEEEEECCCCEECCCCEEEECHHHHHHHHHHHH
FPAVIKLISSGQIQAEKLITKKITVDQVVEEGFEALVKDKTQVKILVSPK
HHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MKALLWHNQRDVRVEEVPEPTVKPGAVKIKVKWCGICGTDLHEYLAGPIFIPTEEHPLTH
CCCEEECCCCCCCHHCCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCEEECCCCCCCCE
VKAPVILGHEFSGEVVEIGEGVTSHKVGDRVVVEPIYSCGKCEACKHGHYNVCEQLVFHG
ECCCEEECCCCCCCEEEECCCCCCCCCCCEEEEHHHHCCCCCCHHCCCCHHHHHHHHHHC
LGGEGGGFSEYTVVPEDMVHHIPDEMTYEQGALVEPAAVAVHAVRQSKLKEGEAVAVFGC
CCCCCCCCCCEEECHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEC
GPIGLLVIQAAKAAGATPVIAVELSKERQELAKLAGADYVLNPATQDVLAEIRNLTNGLG
CHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCC
VNVSFEVTGVEVVLRQAIESTSFEGQTVIVSVWEKDATITPNNLVLKEKEVVGILGYRHI
CEEEEEECHHHHHHHHHHHHCCCCCCEEEEEEECCCCEECCCCEEEECHHHHHHHHHHHH
FPAVIKLISSGQIQAEKLITKKITVDQVVEEGFEALVKDKTQVKILVSPK
HHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]