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The map label for this gene is guaB [H]

Identifier: 221232926

GI number: 221232926

Start: 2206434

End: 2207912

Strand: Reverse

Name: guaB [H]

Synonym: SPN23F_22610

Alternate gene names: 221232926

Gene position: 2207912-2206434 (Counterclockwise)

Preceding gene: 221232927

Following gene: 221232923

Centisome position: 99.4

GC content: 41.24

Gene sequence:

>1479_bases
ATGTCTAATTGGGACACTAAATTTTTGAAAAAAGGTTTTACCTTTGATGATGTATTGCTTATTCCAGCTGAAAGTCATGT
GTTGCCTAACGATGCAGATTTAACAACTAAATTGGCAGATAATTTGACTTTAAATATCCCAATTATTACCGCTGCCATGG
ACACAGTTACAGAGAGTCAAATGGCCATTGCTATTGCTCGTGCAGGCGGTCTCGGAGTTATCCATAAAAACATGTCAATT
GCTCAACAAGCAGACGAGGTTCGTAAGGTAAAACGTTCTGAAAATGGAGTTATTATTGATCCGTTCTTCTTGACGCCTGA
ACATACAATTGCTGAAGCAGATGAGCTTATGGGTCGTTACCGCATCAGTGGTGTTCCAGTTGTTGAAACACTTGAAAATC
GTAAATTGGTTGGTATTTTGACAAACCGAGATCTTCGTTTTATTTCAGATTATAATCAACCAATTTCAAACCATATGACT
AGTGAAAATCTTGTTACTGCTCCTGTGGGTACGGATCTTGCAACGGCTGAGAGTATTCTTCAAGAGCATCGTATTGAAAA
ACTTCCGTTGGTCGATGAAGAAGGCAGTCTTTCTGGTTTGATCACTATCAAAGATATTGAAAAAGTTATTGAGTTTCCAA
ATGCGGCTAAAGATGAGTTTGGTCGTCTTCTAGTTGCAGGTGCAGTAGGTGTTACTTCAGATACATTTGAACGTGCAGAG
GCTCTTTTTGAGGCAGGAGCGGATGCGATTGTTATTGATACTGCACATGGTCATTCTGCAGGTGTCTTGCGTAAAATTGC
CGAGATTCGTGCTCATTTCCCAGATCGGACTTTGATTGCTGGAAATATTGCTACTGCTGAAGGTGCACGTGCCCTTTATG
AAGCGGGTGTAGACGTTGTTAAGGTTGGTATTGGACCAGGTTCTATCTGTACTACTCGTGTGATTGCTGGTGTTGGTGTT
CCGCAAGTAACAGCTATCTACGATGCTGCAGCTGTTGCGCGCGAATATGGTAAAACGATTATTGCTGACGGTGGGATCAA
GTATTCTGGAGATATTGTAAAAGCACTTGCTGCAGGTGGAAATGCTGTTATGCTTGGATCTATGTTTGCTGGAACTGATG
AAGCTCCAGGCGAAACTGAAATCTTCCAAGGACGTAAATTCAAGACTTACCGTGGTATGGGATCAATTGCTGCTATGAAG
AAAGGTTCAAGCGACCGTTATTTCCAAGGTTCTGTCAATGAAGCAAACAAGCTTGTTCCAGAAGGAATTGAAGGTCGTGT
TGCTTATAAAGGAGCGGCAGCTGATATTGTTTTCCAAATGATTGGTGGTATTCGCTCTGGTATGGGTTACTGTGGTGCAG
CTAACCTTAAAGAACTACACGATAATGCTCAATTTATTGAAATGTCTGGTGCTGGTTTGAAAGAAAGCCATCCTCATGAT
GTGCAAATTACTAATGAGGCACCAAATTATTCTATGTAA

Upstream 100 bases:

>100_bases
TATTTACCCCTGTAACATTTGACAAATTTTTATAGAATGGTATGATAGATACAATATAAAAAGAGTCAAGCTCAAAAAGA
AAGAAAAGAGGAAACTTCGA

Downstream 100 bases:

>100_bases
AAAACATTGTAAAAGAACTCCAGTGAAAACAGGAGTTCTTTTACAATGTTGTCAATTTCCATTTACAGAAGCTTTACCAT
CCTGAATAGTGAAGATACTT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTLNIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSI
AQQADEVRKVKRSENGVIIDPFFLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMT
SENLVTAPVGTDLATAESILQEHRIEKLPLVDEEGSLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTFERAE
ALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDRTLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVIAGVGV
PQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMK
KGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAAADIVFQMIGGIRSGMGYCGAANLKELHDNAQFIEMSGAGLKESHPHD
VQITNEAPNYSM

Sequences:

>Translated_492_residues
MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTLNIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSI
AQQADEVRKVKRSENGVIIDPFFLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMT
SENLVTAPVGTDLATAESILQEHRIEKLPLVDEEGSLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTFERAE
ALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDRTLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVIAGVGV
PQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMK
KGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAAADIVFQMIGGIRSGMGYCGAANLKELHDNAQFIEMSGAGLKESHPHD
VQITNEAPNYSM
>Mature_491_residues
SNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTLNIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSIA
QQADEVRKVKRSENGVIIDPFFLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMTS
ENLVTAPVGTDLATAESILQEHRIEKLPLVDEEGSLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTFERAEA
LFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDRTLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVIAGVGVP
QVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMKK
GSSDRYFQGSVNEANKLVPEGIEGRVAYKGAAADIVFQMIGGIRSGMGYCGAANLKELHDNAQFIEMSGAGLKESHPHDV
QITNEAPNYSM

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=42.1052631578947, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=42.1978021978022, Blast_Score=335, Evalue=8e-92,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=42.1978021978022, Blast_Score=335, Evalue=8e-92,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=42.1978021978022, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=42.2222222222222, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI66933016, Length=456, Percent_Identity=39.9122807017544, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI217035148, Length=455, Percent_Identity=41.0989010989011, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=39.0350877192982, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=40.080971659919, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=40.080971659919, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=40.080971659919, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=40.080971659919, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI156104880, Length=247, Percent_Identity=39.6761133603239, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=56.4681724845996, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1786293, Length=257, Percent_Identity=35.7976653696498, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=34.3096234309623, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71994389, Length=430, Percent_Identity=35.8139534883721, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17560440, Length=220, Percent_Identity=41.3636363636364, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=468, Percent_Identity=37.8205128205128, Blast_Score=312, Evalue=8e-86,
Organism=Saccharomyces cerevisiae, GI6323464, Length=463, Percent_Identity=39.3088552915767, Blast_Score=308, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6323585, Length=461, Percent_Identity=38.3947939262473, Blast_Score=306, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6319352, Length=345, Percent_Identity=37.6811594202899, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=39.4957983193277, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641071, Length=461, Percent_Identity=39.2624728850325, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24641073, Length=461, Percent_Identity=39.2624728850325, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI28571163, Length=419, Percent_Identity=40.3341288782816, Blast_Score=296, Evalue=3e-80,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52445; Mature: 52314

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTLNIPIITAAMDTVTESQ
CCCCCHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHCCEEEEEEEEEHHHHHHHHHH
MAIAIARAGGLGVIHKNMSIAQQADEVRKVKRSENGVIIDPFFLTPEHTIAEADELMGRY
EEEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHH
RISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMTSENLVTAPVGTDLATAESIL
CCCCCCHHHHHCCCEEEEEEECCCEEEHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHH
QEHRIEKLPLVDEEGSLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTFERAE
HHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCCCCHHHHCCEEEECCCCCCHHHHHHHH
ALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDRTLIAGNIATAEGARALYEAGVDVV
HHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCEEE
KVGIGPGSICTTRVIAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGG
EECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCEEECCHHHHHHHCCC
NAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVP
CEEEEEEEECCCCCCCCCHHHHCCCCEEHHCCCCCHHHHCCCCCCCEEECCCCHHHHCCC
EGIEGRVAYKGAAADIVFQMIGGIRSGMGYCGAANLKELHDNAQFIEMSGAGLKESHPHD
CCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCC
VQITNEAPNYSM
EEECCCCCCCCC
>Mature Secondary Structure 
SNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTLNIPIITAAMDTVTESQ
CCCCHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHCCEEEEEEEEEHHHHHHHHHH
MAIAIARAGGLGVIHKNMSIAQQADEVRKVKRSENGVIIDPFFLTPEHTIAEADELMGRY
EEEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHH
RISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMTSENLVTAPVGTDLATAESIL
CCCCCCHHHHHCCCEEEEEEECCCEEEHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHH
QEHRIEKLPLVDEEGSLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTFERAE
HHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCCCCHHHHCCEEEECCCCCCHHHHHHHH
ALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDRTLIAGNIATAEGARALYEAGVDVV
HHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCEEE
KVGIGPGSICTTRVIAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGG
EECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCEEECCHHHHHHHCCC
NAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVP
CEEEEEEEECCCCCCCCCHHHHCCCCEEHHCCCCCHHHHCCCCCCCEEECCCCHHHHCCC
EGIEGRVAYKGAAADIVFQMIGGIRSGMGYCGAANLKELHDNAQFIEMSGAGLKESHPHD
CCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCC
VQITNEAPNYSM
EEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]