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The map label for this gene is mvaA [H]

Identifier: 221232460

GI number: 221232460

Start: 1669483

End: 1670757

Strand: Reverse

Name: mvaA [H]

Synonym: SPN23F_17270

Alternate gene names: 221232460

Gene position: 1670757-1669483 (Counterclockwise)

Preceding gene: 221232461

Following gene: 221232457

Centisome position: 75.21

GC content: 49.33

Gene sequence:

>1275_bases
ATGAAGATAAGTTGGAATGGATTTTCTAAAAAATCATACCAAGAGCGCCTCGAGCTGCTAAAAGCTCAGGCGCTCCTTAG
TCCTGAGAGACAAGCTAGTCTGGAGAAGGATGAACAGATGAGTGTGACTGTGGCAGACCAGCTGAGTGAGAATGTGGTGG
GAACTTTTTCTCTGCCTTATTCGCTGGTTCCGGAGGTACTTGTCAACGGTCAGGAATACACCGTTCCCTATGTGACAGAA
GAACCCTCTGTGGTTGCGGCGGCCAGCTATGCCAGCAAAATCATCAAGCGTGCAGGTGGTTTTACTGCACAAGTCCATCA
GCGCCAGATGATTGGGCAGGTAGCCCTTTATCAAGTTGCTAATCCTAAACTAGCGCAAGAGAAGATTGCCAGCAAGAAAG
CGGAGCTCTTGGAGCTTGCCAATCAAGCCTATCCTTCTATCGTTAAACGTGGGGGTGGGGCGCGTGATCTGCATGTCGAG
CAGATAAAAGGCGAACCAGACTTTCTCGTTGTTTATATTCATGTCGATACCCAGGAAGCCATGGGTGCCAATATGCTCAA
CACCATGCTGGAAGCCTTGAAACCAGTCTTAGAAGAACTCAGTCAGGGACAGAGTCTCATGGGAATCCTGTCCAACTACG
CGACTGATTCTCTGGTGACTGCAAGCTGTCGCATCGCCTTTCGCTACTTGAGCCGCCAAAAGGATCAAGGACGAGAGATT
GCGGAGAAAATTGCGTTGGCTAGTCAGTTTGCGCAGGCTGATCCTTACCGAGCTGCTACTCATAATAAAGGAATTTTTAA
TGGTATTGATGCGATTTTGATTGCCACTGGTAATGACTGGCGTGCCATCGAAGCTGGGGCCCATGCCTTTGCCAGTCGAG
ATGGACGCTATCAAGGTCTTAGCTGCTGGACGCTGGACCTTGAAAGAGAAGAATTGGTCGGTGAGATGACCCTGCCCATG
CCTGTAGCGACTAAGGGTGGCTCTATCGGCCTCAACCCACGTGTAGCTCTCAGTCATGATCTACTAGGAAATCCTTCTGC
CAGAGAATTAGCCCAGATTATCGTGTCTATCGGGCTTGCTCAAAATTTTGCAGCCCTCAAAGCCTTGGTAAGTACGGGCA
TCCAGCAAGGCCACATGAAACTACAGGCCAAATCCCTAGCTCTCCTAGCTGGGGCTAGTGAATCTGAAGTTGCTCCCCTA
GTAGAGCGCCTCATCTCAGATAAAACCTTTAACCTAGAGACAGCCCAGCGCTATCTCGAAAATTTAAGATCATAA

Upstream 100 bases:

>100_bases
ATGAAACAAACTCTGCCCAGTTTGCTGGCTATGAAAATCAAGATTTTGCCTTGGTTGAAATTCTTGACCACCAACGCCGT
TATAGCAAGGTTGAAAAATA

Downstream 100 bases:

>100_bases
AAACTCAGACGAATCGGTCTGAGTTTTCTTGTGTTTAAATACTTTTTCCTGGTAATAGCGTAACTGGTAAGAAGTAACCA
GTTGTGGCGACTTCCTTGCC

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTVADQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTE
EPSVVAAASYASKIIKRAGGFTAQVHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVE
QIKGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSLVTASCRIAFRYLSRQKDQGREI
AEKIALASQFAQADPYRAATHNKGIFNGIDAILIATGNDWRAIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPM
PVATKGGSIGLNPRVALSHDLLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGASESEVAPL
VERLISDKTFNLETAQRYLENLRS

Sequences:

>Translated_424_residues
MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTVADQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTE
EPSVVAAASYASKIIKRAGGFTAQVHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVE
QIKGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSLVTASCRIAFRYLSRQKDQGREI
AEKIALASQFAQADPYRAATHNKGIFNGIDAILIATGNDWRAIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPM
PVATKGGSIGLNPRVALSHDLLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGASESEVAPL
VERLISDKTFNLETAQRYLENLRS
>Mature_424_residues
MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTVADQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTE
EPSVVAAASYASKIIKRAGGFTAQVHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVE
QIKGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSLVTASCRIAFRYLSRQKDQGREI
AEKIALASQFAQADPYRAATHNKGIFNGIDAILIATGNDWRAIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPM
PVATKGGSIGLNPRVALSHDLLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGASESEVAPL
VERLISDKTFNLETAQRYLENLRS

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 46184; Mature: 46184

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTVADQLSENVVGTFSLPY
CEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEHHHHHHCCCEEEECCCH
SLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGGFTAQVHQRQMIGQVALYQVA
HHHHHHHHCCCEEECCEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
NPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVEQIKGEPDFLVVYIHVDTQEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEEEECCHHH
MGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSLVTASCRIAFRYLSRQKDQGREI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AEKIALASQFAQADPYRAATHNKGIFNGIDAILIATGNDWRAIEAGAHAFASRDGRYQGL
HHHHHHHHHHHHCCCCCHHCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHCCCCCCCCC
SCWTLDLEREELVGEMTLPMPVATKGGSIGLNPRVALSHDLLGNPSARELAQIIVSIGLA
EEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHH
QNFAALKALVSTGIQQGHMKLQAKSLALLAGASESEVAPLVERLISDKTFNLETAQRYLE
HHHHHHHHHHHHCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
NLRS
HHCC
>Mature Secondary Structure
MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTVADQLSENVVGTFSLPY
CEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEHHHHHHCCCEEEECCCH
SLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGGFTAQVHQRQMIGQVALYQVA
HHHHHHHHCCCEEECCEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
NPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVEQIKGEPDFLVVYIHVDTQEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEEEECCHHH
MGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSLVTASCRIAFRYLSRQKDQGREI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AEKIALASQFAQADPYRAATHNKGIFNGIDAILIATGNDWRAIEAGAHAFASRDGRYQGL
HHHHHHHHHHHHCCCCCHHCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHCCCCCCCCC
SCWTLDLEREELVGEMTLPMPVATKGGSIGLNPRVALSHDLLGNPSARELAQIIVSIGLA
EEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHH
QNFAALKALVSTGIQQGHMKLQAKSLALLAGASESEVAPLVERLISDKTFNLETAQRYLE
HHHHHHHHHHHHCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
NLRS
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]