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The map label for this gene is mvaS [H]

Identifier: 221232461

GI number: 221232461

Start: 1670757

End: 1671929

Strand: Reverse

Name: mvaS [H]

Synonym: SPN23F_17280

Alternate gene names: 221232461

Gene position: 1671929-1670757 (Counterclockwise)

Preceding gene: 221232462

Following gene: 221232460

Centisome position: 75.27

GC content: 42.46

Gene sequence:

>1173_bases
ATGACAATCGGTATTGATAAGATTGGTTTTGCGACCAGTCAATATGTCTTGAAATTACAAGACTTAGCAGAAGCGAGGGG
AATTGACCCTGAAAAATTAAGTAAAGGACTCTTACTCAAGGAATTGAGTATTGCGCCCCTAACTGAGGACATCGTGACCT
TGGCGGCCAGTGCTAGTGACTCTATTTTAACTGAGCAAGAAAGACAAGAAGTTGACATGGTCATTGTGGCTACCGAGTCA
GGAATTGACCAGAGTAAGGCTGCGGCCGTCTTTGTGCATGGCTTGCTGGGCATCCAGCCCTTTGCTCGTAGTTTCGAGAT
TAAAGAAGCCTGCTACGGAGCGACTGCTGCCCTCCATTATGCCAAATTGCATGTGGAAAATTCTCCGGAGTCCAAGGTCT
TGGTCATTGCCAGTGATATTGCCAAATACGGTATTGAAACTCCAGGAGAACCAACTCAAGGTGCTGGAAGTGTAGCTATG
TTGATTACACAAAATCCACGCATGATGGCCTTTAATAATGACAATGTAGCTCAGACCCGTGACATCATGGATTTCTGGCG
ACCAAATTACTCGACAACTCCTTATGTAAATGGTGTCTATTCTACCCAACAATACTTGGATAGTTTGAAAACGACTTGGC
TTGAATATCAAAAACGCTACCAGCTTACTTTGGATGATTTTGCGGCTGTTTGTTTCCACTTGCCTTATCCTAAATTAGCG
CTAAAAGGCTTGAAAAAAATCATGGATAAGAACTTGCCTCAAGAGAAAAAAGACCTCTTGCAAAAGCATTTTGACCAGTC
TATTCTCTACAGTCAAAAGGTGGGGAATATCTACACAGGTTCACTTTTCCTTGGACTTTTGTCTCTCTTGGAAAATACAG
ATAGCTTGAAAGCTGGGGATAAAATCGCCCTTTATAGTTACGGAAGTGGAGCTGTGGCTGAGTTCTTCAGTGGTGAATTG
GTTGAAGGATATGAAGCTTATTTGGATAAAGACCGCTTGAACAAGCTCAACCAACGAACTGCCCTATCCGTTGCAGACTA
TGAAAAGGTCTTTTTTGAGGAAGTAAACTTGGATGAAACAAACTCTGCCCAGTTTGCTGGCTATGAAAATCAAGATTTTG
CCTTGGTTGAAATTCTTGACCACCAACGCCGTTATAGCAAGGTTGAAAAATAA

Upstream 100 bases:

>100_bases
CTTGATTTGGTGAATCAAGTCTTTTTTCTCTCTTTTACTGCCATTTGTGATAAAATAGTATAGAACGATTTTTTACATGA
ATGATAAAACAGAGGTAAAT

Downstream 100 bases:

>100_bases
TGAAGATAAGTTGGAATGGATTTTCTAAAAAATCATACCAAGAGCGCCTCGAGCTGCTAAAAGCTCAGGCGCTCCTTAGT
CCTGAGAGACAAGCTAGTCT

Product: 3-hydroxy-3-methylglutaryl coenzyme A synthase

Products: (S)-3-hydroxy-3-methylglutaryl-CoA; CoA

Alternate protein names: HMG synthase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSIAPLTEDIVTLAASASDSILTEQERQEVDMVIVATES
GIDQSKAAAVFVHGLLGIQPFARSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAM
LITQNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQKRYQLTLDDFAAVCFHLPYPKLA
LKGLKKIMDKNLPQEKKDLLQKHFDQSILYSQKVGNIYTGSLFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGEL
VEGYEAYLDKDRLNKLNQRTALSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK

Sequences:

>Translated_390_residues
MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSIAPLTEDIVTLAASASDSILTEQERQEVDMVIVATES
GIDQSKAAAVFVHGLLGIQPFARSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAM
LITQNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQKRYQLTLDDFAAVCFHLPYPKLA
LKGLKKIMDKNLPQEKKDLLQKHFDQSILYSQKVGNIYTGSLFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGEL
VEGYEAYLDKDRLNKLNQRTALSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK
>Mature_389_residues
TIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSIAPLTEDIVTLAASASDSILTEQERQEVDMVIVATESG
IDQSKAAAVFVHGLLGIQPFARSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAML
ITQNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQKRYQLTLDDFAAVCFHLPYPKLAL
KGLKKIMDKNLPQEKKDLLQKHFDQSILYSQKVGNIYTGSLFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELV
EGYEAYLDKDRLNKLNQRTALSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK

Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac- AcpK) and

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA synthase family [H]

Homologues:

Organism=Homo sapiens, GI5031751, Length=449, Percent_Identity=27.1714922048998, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI148298764, Length=416, Percent_Identity=27.6442307692308, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI148298677, Length=416, Percent_Identity=27.6442307692308, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17560126, Length=371, Percent_Identity=25.3369272237197, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323509, Length=400, Percent_Identity=24.75, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24654139, Length=374, Percent_Identity=28.6096256684492, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24654137, Length=374, Percent_Identity=28.6096256684492, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24654133, Length=374, Percent_Identity=28.6096256684492, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24654135, Length=374, Percent_Identity=28.6096256684492, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17933694, Length=374, Percent_Identity=28.6096256684492, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013746
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08540 HMG_CoA_synt_C; PF01154 HMG_CoA_synt_N [H]

EC number: 2.3.3.10

Molecular weight: Translated: 43531; Mature: 43400

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSIAPLTEDIVTLAASASD
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHCCCCCCHHHHHHHHHCCCC
SILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFARSFEIKEACYGATAALHY
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
AKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAMLITQNPRMMAFNNDNVAQTR
EEEEECCCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHH
DIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQKRYQLTLDDFAAVCFHLPYPKLA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHH
LKGLKKIMDKNLPQEKKDLLQKHFDQSILYSQKVGNIYTGSLFLGLLSLLENTDSLKAGD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCCCCCC
KIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLNKLNQRTALSVADYEKVFFEEVNLDET
EEEEEECCCCHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NSAQFAGYENQDFALVEILDHQRRYSKVEK
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSIAPLTEDIVTLAASASD
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHCCCCCCHHHHHHHHHCCCC
SILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFARSFEIKEACYGATAALHY
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
AKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAMLITQNPRMMAFNNDNVAQTR
EEEEECCCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHH
DIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQKRYQLTLDDFAAVCFHLPYPKLA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHH
LKGLKKIMDKNLPQEKKDLLQKHFDQSILYSQKVGNIYTGSLFLGLLSLLENTDSLKAGD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCCCCCC
KIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLNKLNQRTALSVADYEKVFFEEVNLDET
EEEEEECCCCHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NSAQFAGYENQDFALVEILDHQRRYSKVEK
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acetyl-CoA; H2O; acetoacetyl-CoA

Specific reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704258; 9384377 [H]