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The map label for this gene is cysK [H]

Identifier: 220933138

GI number: 220933138

Start: 2518649

End: 2519566

Strand: Direct

Name: cysK [H]

Synonym: Hore_23060

Alternate gene names: 220933138

Gene position: 2518649-2519566 (Clockwise)

Preceding gene: 220933137

Following gene: 220933144

Centisome position: 97.69

GC content: 46.3

Gene sequence:

>918_bases
ATGGCTATTTACAAAAATGTCTCGGAGTTAATAGGTAAAACACCTATCGTAAAACTTAACAGATTAAACCCTGAAAATTC
ACCTGAAATTCTGGTCAAACTGGAAATGTTCAATCCCGGAAGCAGTATTAAAGACAGAATCTGCTATAACATGATCAGGG
ATGCTGAAGAAAAAGGTAAATTAAAACCTGGAGGCACCATTGTAGAACCGACCAGTGGTAACACCGGAATCGGCCTCTCC
CTTATCGGGGCAGCCAGGGGTTATAATGTTATCCTGACAATGCCTGAGACCATGAGTATTGAAAGGCGAAAGCTTTTAAA
GGCCTTTGGGGCTCAGGTAGTCTTAACCCCCGGGGATAAAGGAATGCAGGGGGCAATCGACAGGGCCCGGGAACTTGTCA
AAAATAACGATAACTACTTTATGCCCCAGCAGTTCCAGAACCCGGCCAACCCGGAAATCCATCGTAAAACCACAGCAAAA
GAAATCCTCGAAGATACTGATGGTAAGATAGACTATTTTGTAGCCGGGGTCGGTACCGGCGGTACCCTGACCGGAACCGG
AGAGGTTTTAAAAGAACACAATCCCAACATTAAAGTAGTGGCGGTGGAACCTGAAGATTCCCCGGTTCTCTCAGGAGGTG
AGCCCGGCCCCCATCAAATACAGGGTATTGGAGCCGGTTTTATCCCCGATGTTCTGGATACAGATTTAATTGACAGGGTT
ATTAAAGTCGGTAATGAAGAGGCTATGGAGACAGCCAGAAATCTGGCCAGACAGGAGGGCCTCCTGGTCGGTATATCTTC
CGGGGCAGCCGTTAAAGCTGCTCTAAAACTGGCCAAAGGAGTAGACCCTGATAAAACTATCCTGGTTATCGCCCCCGATA
CCGGAGAAAGATATTTAAGTACTGATCTATTCAAATAA

Upstream 100 bases:

>100_bases
GACAAAGTGCTCCTTACATATTATCATTATATTAACCCTGAAAACATATCAATTTACTTGGTTTTATATTATTAAAATAA
AAAAGGAGTTGATAGCTGAC

Downstream 100 bases:

>100_bases
GTTTCGTAAATATAGCCATTATAAATTCCCCATATTTATATATAAATATTAAGGTTGTTAATTCCTCCTTTAGTTTTCTT
CTATAGGGTATTATTTCTTC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MAIYKNVSELIGKTPIVKLNRLNPENSPEILVKLEMFNPGSSIKDRICYNMIRDAEEKGKLKPGGTIVEPTSGNTGIGLS
LIGAARGYNVILTMPETMSIERRKLLKAFGAQVVLTPGDKGMQGAIDRARELVKNNDNYFMPQQFQNPANPEIHRKTTAK
EILEDTDGKIDYFVAGVGTGGTLTGTGEVLKEHNPNIKVVAVEPEDSPVLSGGEPGPHQIQGIGAGFIPDVLDTDLIDRV
IKVGNEEAMETARNLARQEGLLVGISSGAAVKAALKLAKGVDPDKTILVIAPDTGERYLSTDLFK

Sequences:

>Translated_305_residues
MAIYKNVSELIGKTPIVKLNRLNPENSPEILVKLEMFNPGSSIKDRICYNMIRDAEEKGKLKPGGTIVEPTSGNTGIGLS
LIGAARGYNVILTMPETMSIERRKLLKAFGAQVVLTPGDKGMQGAIDRARELVKNNDNYFMPQQFQNPANPEIHRKTTAK
EILEDTDGKIDYFVAGVGTGGTLTGTGEVLKEHNPNIKVVAVEPEDSPVLSGGEPGPHQIQGIGAGFIPDVLDTDLIDRV
IKVGNEEAMETARNLARQEGLLVGISSGAAVKAALKLAKGVDPDKTILVIAPDTGERYLSTDLFK
>Mature_304_residues
AIYKNVSELIGKTPIVKLNRLNPENSPEILVKLEMFNPGSSIKDRICYNMIRDAEEKGKLKPGGTIVEPTSGNTGIGLSL
IGAARGYNVILTMPETMSIERRKLLKAFGAQVVLTPGDKGMQGAIDRARELVKNNDNYFMPQQFQNPANPEIHRKTTAKE
ILEDTDGKIDYFVAGVGTGGTLTGTGEVLKEHNPNIKVVAVEPEDSPVLSGGEPGPHQIQGIGAGFIPDVLDTDLIDRVI
KVGNEEAMETARNLARQEGLLVGISSGAAVKAALKLAKGVDPDKTILVIAPDTGERYLSTDLFK

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=43.0868167202572, Blast_Score=241, Evalue=4e-64,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=43.0868167202572, Blast_Score=241, Evalue=4e-64,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=43.0868167202572, Blast_Score=241, Evalue=4e-64,
Organism=Homo sapiens, GI11345492, Length=287, Percent_Identity=26.1324041811847, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788754, Length=312, Percent_Identity=59.2948717948718, Blast_Score=317, Evalue=7e-88,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=40.2684563758389, Blast_Score=244, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=50.3355704697987, Blast_Score=286, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI115535073, Length=305, Percent_Identity=50.4918032786885, Blast_Score=266, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17562970, Length=296, Percent_Identity=46.6216216216216, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=45.819397993311, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=46.6442953020134, Blast_Score=227, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=45.5399061032864, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=41.0094637223975, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=39.3650793650794, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=46.6101694915254, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996324, Length=342, Percent_Identity=27.1929824561404, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=40.3174603174603, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321449, Length=325, Percent_Identity=35.6923076923077, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=40.2597402597403, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=40.2597402597403, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32784; Mature: 32653

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIYKNVSELIGKTPIVKLNRLNPENSPEILVKLEMFNPGSSIKDRICYNMIRDAEEKGK
CCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
LKPGGTIVEPTSGNTGIGLSLIGAARGYNVILTMPETMSIERRKLLKAFGAQVVLTPGDK
CCCCCEEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECCCCC
GMQGAIDRARELVKNNDNYFMPQQFQNPANPEIHRKTTAKEILEDTDGKIDYFVAGVGTG
CHHHHHHHHHHHHHCCCCEECCHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCC
GTLTGTGEVLKEHNPNIKVVAVEPEDSPVLSGGEPGPHQIQGIGAGFIPDVLDTDLIDRV
CEECCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHH
IKVGNEEAMETARNLARQEGLLVGISSGAAVKAALKLAKGVDPDKTILVIAPDTGERYLS
HHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH
TDLFK
HCCCC
>Mature Secondary Structure 
AIYKNVSELIGKTPIVKLNRLNPENSPEILVKLEMFNPGSSIKDRICYNMIRDAEEKGK
CCHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
LKPGGTIVEPTSGNTGIGLSLIGAARGYNVILTMPETMSIERRKLLKAFGAQVVLTPGDK
CCCCCEEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECCCCC
GMQGAIDRARELVKNNDNYFMPQQFQNPANPEIHRKTTAKEILEDTDGKIDYFVAGVGTG
CHHHHHHHHHHHHHCCCCEECCHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCC
GTLTGTGEVLKEHNPNIKVVAVEPEDSPVLSGGEPGPHQIQGIGAGFIPDVLDTDLIDRV
CEECCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHH
IKVGNEEAMETARNLARQEGLLVGISSGAAVKAALKLAKGVDPDKTILVIAPDTGERYLS
HHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH
TDLFK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA