Click here to switch to the map view.

The map label for this gene is nrdZ [H]

Identifier: 220933052

GI number: 220933052

Start: 2418558

End: 2420858

Strand: Direct

Name: nrdZ [H]

Synonym: Hore_22200

Alternate gene names: 220933052

Gene position: 2418558-2420858 (Clockwise)

Preceding gene: 220933051

Following gene: 220933053

Centisome position: 93.81

GC content: 43.24

Gene sequence:

>2301_bases
ATGGCTGATATTAAGCTTACCAGAAATGCCATTAAGGTCCTTAAAGCACGGTATCTTAAAAGAGATGCCAGTGGGGAACT
TATTGAAACCCCGGAAGAAATGTTTAAAAGAGTAGCAAACAATATTGCCAGTGCCAATGAAAAATATGGTGAAGATCCCG
AAAGAGATAAAGAGGCCTTTTTCAACCTTATGGCCAGCCTTGATTTTTTACCCAACTCTCCAACCCTGATGAATGCCGAT
AACGACCTCCAGCAGCTGAGTGCCTGTTTTGTCCTCCCTATCGAGGATAGTATGGATGGTATTTTCGATGCCCTCAAATA
TACCGCCCTTATTCAAAAAAGCGGAGGCGGAACGGGTTTTAGTTTCTCCAGGCTCCGCCCTAAAAGTGATATTGTAAAAA
CAACCGGTGGGGTTGCCAGTGGTCCTATCTCCTTTATGGAGATTTTTGACGCAGCAACCAATACTGTTAAACAGGGTGGT
AAACGGCGGGGAGCTAATATGGGTATATTAAGGGTTGACCACCCGGATATTATGGAGTTTATAACCGCCAAAGCGGACGA
AAACCGGCTTAATAACTTTAATATCTCTGTGGCTGTAACTGATGAATTTATGGAAGCAGTTAAAAAAGATGAAGAGTATG
ACCTGGTCAATCCCCGGAGTGGACAGGTTGTTGGTCAGCTGCGGGCCCGGGAAGTGTTTAATAAAATTGTTGAAATGGCC
CACAAAAACGGTGAACCGGGAATAATCTTTATAGATGAAATAAACAGACATAACCCCACCCCCCATCTGGGTGAAATTGA
AAGCACCAACCCCTGTGGTGAACAACCTCTCCTGCCCTATGAGGCCTGTAACCTGGGGTCTATCAATCTCTCCCACATGG
TTAAAAATGAGGGTGATAAGCCTGAGGTAGATTTTGAGAAATTAGAAAATACGGTGAGAACAGCTACCCGCTTTTTAGAT
AATGTTATTGATATGAATCGTTATCCCCTTGAACAAATAAAGGAAATGGTTTATTCAAATCGAAAAATCGGGCTTGGAGT
CATGGGCTGGAGTGACCTCCTAATAAGACTGGGTATCCCCTATAACAGTGATAGGGCTGTAAACCTGGCTGAAAAAGTAA
TGAAGTTTATTAATGAAATCTCTCATGATGAATCCCATAAAATTGCCAGGAAAAGAGGTTCCTTCCCCAATATTGAAGGA
AGTATCTATGATAAGTCCATGAGAAATGCTACCACGACTACCATTGCCCCGACCGGATCTATAAGCATTATTGCCGGGTG
TAGTAGTGGTATTGAACCTCTCTTTGCCATTAACTACGAACGTCATGTCCTTGATGATACTTTAATCGAAGTCCACCCCT
ATTTTGAGAAAATAGCCAGAGAAAGGGGCTTTTACAGTGAAGAGTTAATGGCTAAAGTCGCTGAGAGGGGTTCAATTCAG
GGAATGTCCGAAATACCGGAAGATGTCCAGAAGATATTCGTTACCGCCCATGATATTGAACCAGAATGGCATATCAAAAT
GCAGGCCGCCTTCCAGAAATGGGTTGATAATGCTGTCAGTAAAACAGTCAATTTCCGCCATGAAGCCACTAAAGAAGATG
TAGCCAGGGTATATACCCTGGCCTATGACCTGAAGTGCAAGGGAGTTACTATCTACCGTGATGGGAGCCGTTCTGAACAG
GTTCTGGCCACAGGTCGAAGTAAAACTTACGGTAATAACGGTTTTAAAAAACGTCCCCGTCCCAAAATAACCTATGGGAC
CACTGAAAAAACAAAAATAGGCTGTGGCAAACTCTATATTACCATTAATGCCGATGACAAAGGAATATGTGAGGTCTTCA
CCACTACCGGTAAAGGTGGAGGCTGTCATGCCCAGTCAGAAGCGATAAGCCGGCTGGCCTCCCTGGCTATTAGAAGCGGT
ATCTCTATCAAAGAAATAACAGACCAGTTAAAGGGAATAAGGTGTGAAGCAGCCCTTATCCGAAAAGGGGTTAATAATAC
TTCCTGTCCTGACGCTATCGGACGAGCTATTGAAAAATTTGTCAGGGCCACCGATAATGGCAGGCTATTTCAACAAAACC
TGAGCCTGGCTACTGATGAAAATAATTCGGCTTCCAACAATAGTAGTAAACCCGGTAAATCATCAAAAAATAATAAAACC
GGGGGAATATCTCTATCTAAAGAAGATGATGGAAGCAGCAAAACCACTACAGGTAGTACCTGCCCTGAATGTGGTTATAA
ACTGGAACATGAAGGTGGCTGTACCGTCTGCCGTAACTGTGGTTTTTCCAAATGTGGATAA

Upstream 100 bases:

>100_bases
TTTAATAAAACAGGTATAAAGCAACATACATATCTTATTTTTCATGTATAGCTTTTAATGGATACTTTTTTAATTATTTT
ACTAAAAATGAGGTGATAAT

Downstream 100 bases:

>100_bases
AGCCCGGTCCTTCCGGGCAATCCCCCTTTAGGATTATGGGTATCTTTCTGGTAATCCCCTTTTATAGGGGGATTTATTTC
TTTAAGCAAAATTAACTAAA

Product: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 766; Mature: 765

Protein sequence:

>766_residues
MADIKLTRNAIKVLKARYLKRDASGELIETPEEMFKRVANNIASANEKYGEDPERDKEAFFNLMASLDFLPNSPTLMNAD
NDLQQLSACFVLPIEDSMDGIFDALKYTALIQKSGGGTGFSFSRLRPKSDIVKTTGGVASGPISFMEIFDAATNTVKQGG
KRRGANMGILRVDHPDIMEFITAKADENRLNNFNISVAVTDEFMEAVKKDEEYDLVNPRSGQVVGQLRAREVFNKIVEMA
HKNGEPGIIFIDEINRHNPTPHLGEIESTNPCGEQPLLPYEACNLGSINLSHMVKNEGDKPEVDFEKLENTVRTATRFLD
NVIDMNRYPLEQIKEMVYSNRKIGLGVMGWSDLLIRLGIPYNSDRAVNLAEKVMKFINEISHDESHKIARKRGSFPNIEG
SIYDKSMRNATTTTIAPTGSISIIAGCSSGIEPLFAINYERHVLDDTLIEVHPYFEKIARERGFYSEELMAKVAERGSIQ
GMSEIPEDVQKIFVTAHDIEPEWHIKMQAAFQKWVDNAVSKTVNFRHEATKEDVARVYTLAYDLKCKGVTIYRDGSRSEQ
VLATGRSKTYGNNGFKKRPRPKITYGTTEKTKIGCGKLYITINADDKGICEVFTTTGKGGGCHAQSEAISRLASLAIRSG
ISIKEITDQLKGIRCEAALIRKGVNNTSCPDAIGRAIEKFVRATDNGRLFQQNLSLATDENNSASNNSSKPGKSSKNNKT
GGISLSKEDDGSSKTTTGSTCPECGYKLEHEGGCTVCRNCGFSKCG

Sequences:

>Translated_766_residues
MADIKLTRNAIKVLKARYLKRDASGELIETPEEMFKRVANNIASANEKYGEDPERDKEAFFNLMASLDFLPNSPTLMNAD
NDLQQLSACFVLPIEDSMDGIFDALKYTALIQKSGGGTGFSFSRLRPKSDIVKTTGGVASGPISFMEIFDAATNTVKQGG
KRRGANMGILRVDHPDIMEFITAKADENRLNNFNISVAVTDEFMEAVKKDEEYDLVNPRSGQVVGQLRAREVFNKIVEMA
HKNGEPGIIFIDEINRHNPTPHLGEIESTNPCGEQPLLPYEACNLGSINLSHMVKNEGDKPEVDFEKLENTVRTATRFLD
NVIDMNRYPLEQIKEMVYSNRKIGLGVMGWSDLLIRLGIPYNSDRAVNLAEKVMKFINEISHDESHKIARKRGSFPNIEG
SIYDKSMRNATTTTIAPTGSISIIAGCSSGIEPLFAINYERHVLDDTLIEVHPYFEKIARERGFYSEELMAKVAERGSIQ
GMSEIPEDVQKIFVTAHDIEPEWHIKMQAAFQKWVDNAVSKTVNFRHEATKEDVARVYTLAYDLKCKGVTIYRDGSRSEQ
VLATGRSKTYGNNGFKKRPRPKITYGTTEKTKIGCGKLYITINADDKGICEVFTTTGKGGGCHAQSEAISRLASLAIRSG
ISIKEITDQLKGIRCEAALIRKGVNNTSCPDAIGRAIEKFVRATDNGRLFQQNLSLATDENNSASNNSSKPGKSSKNNKT
GGISLSKEDDGSSKTTTGSTCPECGYKLEHEGGCTVCRNCGFSKCG
>Mature_765_residues
ADIKLTRNAIKVLKARYLKRDASGELIETPEEMFKRVANNIASANEKYGEDPERDKEAFFNLMASLDFLPNSPTLMNADN
DLQQLSACFVLPIEDSMDGIFDALKYTALIQKSGGGTGFSFSRLRPKSDIVKTTGGVASGPISFMEIFDAATNTVKQGGK
RRGANMGILRVDHPDIMEFITAKADENRLNNFNISVAVTDEFMEAVKKDEEYDLVNPRSGQVVGQLRAREVFNKIVEMAH
KNGEPGIIFIDEINRHNPTPHLGEIESTNPCGEQPLLPYEACNLGSINLSHMVKNEGDKPEVDFEKLENTVRTATRFLDN
VIDMNRYPLEQIKEMVYSNRKIGLGVMGWSDLLIRLGIPYNSDRAVNLAEKVMKFINEISHDESHKIARKRGSFPNIEGS
IYDKSMRNATTTTIAPTGSISIIAGCSSGIEPLFAINYERHVLDDTLIEVHPYFEKIARERGFYSEELMAKVAERGSIQG
MSEIPEDVQKIFVTAHDIEPEWHIKMQAAFQKWVDNAVSKTVNFRHEATKEDVARVYTLAYDLKCKGVTIYRDGSRSEQV
LATGRSKTYGNNGFKKRPRPKITYGTTEKTKIGCGKLYITINADDKGICEVFTTTGKGGGCHAQSEAISRLASLAIRSGI
SIKEITDQLKGIRCEAALIRKGVNNTSCPDAIGRAIEKFVRATDNGRLFQQNLSLATDENNSASNNSSKPGKSSKNNKTG
GISLSKEDDGSSKTTTGSTCPECGYKLEHEGGCTVCRNCGFSKCG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=586, Percent_Identity=28.6689419795222, Blast_Score=222, Evalue=1e-57,
Organism=Escherichia coli, GI1789030, Length=467, Percent_Identity=28.051391862955, Blast_Score=135, Evalue=9e-33,
Organism=Escherichia coli, GI2367133, Length=514, Percent_Identity=20.6225680933852, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17555242, Length=586, Percent_Identity=29.3515358361775, Blast_Score=234, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6320914, Length=588, Percent_Identity=28.2312925170068, Blast_Score=223, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6322123, Length=582, Percent_Identity=28.0068728522337, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI17352481, Length=577, Percent_Identity=27.7296360485269, Blast_Score=210, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 84663; Mature: 84532

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIKLTRNAIKVLKARYLKRDASGELIETPEEMFKRVANNIASANEKYGEDPERDKEAF
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
FNLMASLDFLPNSPTLMNADNDLQQLSACFVLPIEDSMDGIFDALKYTALIQKSGGGTGF
HHHHHHHHCCCCCCCEECCCCHHHHHHHEEEEECCCCHHHHHHHHHHHHHHEECCCCCCC
SFSRLRPKSDIVKTTGGVASGPISFMEIFDAATNTVKQGGKRRGANMGILRVDHPDIMEF
CHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCEEECCCHHHHHH
ITAKADENRLNNFNISVAVTDEFMEAVKKDEEYDLVNPRSGQVVGQLRAREVFNKIVEMA
HHHCCCCCCCCCEEEEEEECHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HKNGEPGIIFIDEINRHNPTPHLGEIESTNPCGEQPLLPYEACNLGSINLSHMVKNEGDK
HCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHCCCCC
PEVDFEKLENTVRTATRFLDNVIDMNRYPLEQIKEMVYSNRKIGLGVMGWSDLLIRLGIP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECHHHHHEEECCC
YNSDRAVNLAEKVMKFINEISHDESHKIARKRGSFPNIEGSIYDKSMRNATTTTIAPTGS
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEECCCCC
ISIIAGCSSGIEPLFAINYERHVLDDTLIEVHPYFEKIARERGFYSEELMAKVAERGSIQ
EEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
GMSEIPEDVQKIFVTAHDIEPEWHIKMQAAFQKWVDNAVSKTVNFRHEATKEDVARVYTL
CHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AYDLKCKGVTIYRDGSRSEQVLATGRSKTYGNNGFKKRPRPKITYGTTEKTKIGCGKLYI
HEEEEECCEEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEECCEEEEE
TINADDKGICEVFTTTGKGGGCHAQSEAISRLASLAIRSGISIKEITDQLKGIRCEAALI
EEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
RKGVNNTSCPDAIGRAIEKFVRATDNGRLFQQNLSLATDENNSASNNSSKPGKSSKNNKT
HCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCEEECCCCCCCCCCCCCCCCCCCCCC
GGISLSKEDDGSSKTTTGSTCPECGYKLEHEGGCTVCRNCGFSKCG
CCEEECCCCCCCCCCCCCCCCHHCCCEEECCCCCHHHHCCCCCCCC
>Mature Secondary Structure 
ADIKLTRNAIKVLKARYLKRDASGELIETPEEMFKRVANNIASANEKYGEDPERDKEAF
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
FNLMASLDFLPNSPTLMNADNDLQQLSACFVLPIEDSMDGIFDALKYTALIQKSGGGTGF
HHHHHHHHCCCCCCCEECCCCHHHHHHHEEEEECCCCHHHHHHHHHHHHHHEECCCCCCC
SFSRLRPKSDIVKTTGGVASGPISFMEIFDAATNTVKQGGKRRGANMGILRVDHPDIMEF
CHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCEEECCCHHHHHH
ITAKADENRLNNFNISVAVTDEFMEAVKKDEEYDLVNPRSGQVVGQLRAREVFNKIVEMA
HHHCCCCCCCCCEEEEEEECHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HKNGEPGIIFIDEINRHNPTPHLGEIESTNPCGEQPLLPYEACNLGSINLSHMVKNEGDK
HCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHCCCCC
PEVDFEKLENTVRTATRFLDNVIDMNRYPLEQIKEMVYSNRKIGLGVMGWSDLLIRLGIP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECHHHHHEEECCC
YNSDRAVNLAEKVMKFINEISHDESHKIARKRGSFPNIEGSIYDKSMRNATTTTIAPTGS
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEECCCCC
ISIIAGCSSGIEPLFAINYERHVLDDTLIEVHPYFEKIARERGFYSEELMAKVAERGSIQ
EEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
GMSEIPEDVQKIFVTAHDIEPEWHIKMQAAFQKWVDNAVSKTVNFRHEATKEDVARVYTL
CHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AYDLKCKGVTIYRDGSRSEQVLATGRSKTYGNNGFKKRPRPKITYGTTEKTKIGCGKLYI
HEEEEECCEEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEECCEEEEE
TINADDKGICEVFTTTGKGGGCHAQSEAISRLASLAIRSGISIKEITDQLKGIRCEAALI
EEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
RKGVNNTSCPDAIGRAIEKFVRATDNGRLFQQNLSLATDENNSASNNSSKPGKSSKNNKT
HCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCEEECCCCCCCCCCCCCCCCCCCCCC
GGISLSKEDDGSSKTTTGSTCPECGYKLEHEGGCTVCRNCGFSKCG
CCEEECCCCCCCCCCCCCCCCHHCCCEEECCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]