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The map label for this gene is ilvC

Identifier: 220931926

GI number: 220931926

Start: 1178749

End: 1179741

Strand: Direct

Name: ilvC

Synonym: Hore_10850

Alternate gene names: 220931926

Gene position: 1178749-1179741 (Clockwise)

Preceding gene: 220931925

Following gene: 220931927

Centisome position: 45.72

GC content: 40.68

Gene sequence:

>993_bases
ATGATTCATGTCTATTATGATAAAGACGCCAACCTGGGATTACTTGAGGAAAAGATGATTGCTGTACTGGGTTATGGGAG
CCAGGGTCATGCCCAGGCCCAGAACTTAAAGGATAGTGGTCTAAATGTTATAGTTGGATTAAGGAAAGGTTCCAGTAGCT
GGAAAAAAGCAGAAAGTGATGGGTTTAGGGTATTTAAGACCAGTGAGGCAGTTAAAAGGGCCGATATCATTCAGGTATTG
ATACCTGATGAAGTTCAGAGTAGAGTCTATAAAGAGGATATTGAACCATACTTAGAAGAAGGTAATGCCCTGGTATTTTC
ACATGGATTTAATATTCATTTTGGACAGATAGTTCCTCCCGATAATGTTGATATTTTCATGGTTGCCCCAAAAAGCCCGG
GACACCTTGTCAGGAGAATGTATCTTGAAGGAAAAGGCGTTCCAGGGTTACTGGCAGTAGAGCAGGATTATTCAGGTAAG
GCTAAAGAACTGGGATTGGCCTATGCTAAAGGAATTGGTTGTACAAAAGCTGGTGTAATTGAGACTACCTTTAAAGAAGA
GACCGAAACTGATCTTTTTGGGGAACAGGCAGTTCTCTGTGGTGGTGTTACTTCACTGGTTAAGGCAGGTTTTGAGGTCC
TGGTTGAAGCAGGTTATCAGCCAGAAATAGCATATTTCGAATGTCTCAATGAATTAAAGTTAATAGTTGATCTTATGTTT
GAAGGTGGGTTAACAAAGATGAGGCATTCTATAAGTGATACGGCCCAGTATGGAGACCTTATGGTGGGGCCGAGGATTGT
AAATGATAATGTAAAGGATGAAATGAGAAGCGTATTGAAGGAAATTCAGTCAGGGGAATTTGCCAAAAAGTGGATTCTGG
AAAACAAGGCTAACCGGCCGGTATTTAATGCCTTAACCAGTAAGGATGAAAATCACCTGATTGAAAAGGTGGGTAAAAAA
TTAAGGGATATGATGCCCTGGATTAATGAATAG

Upstream 100 bases:

>100_bases
GGAATAATTGAGGTAGTCAGAACCGGTTTAGTTGCTTTAAGCCGGGGGCTTGACCTCCAGGGTAAAAATCAGAAAATAAG
TTAAAGGAGTGGTTATTGTT

Downstream 100 bases:

>100_bases
AAGGTGTGTTTAAAATGGGTGAGGTTAAAATATTTGATACAACGTTAAGGGATGGCGAGCAGTCTCCCGGCGTCAGTCTT
ATTCCTGAAGAAAAACTTGC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MIHVYYDKDANLGLLEEKMIAVLGYGSQGHAQAQNLKDSGLNVIVGLRKGSSSWKKAESDGFRVFKTSEAVKRADIIQVL
IPDEVQSRVYKEDIEPYLEEGNALVFSHGFNIHFGQIVPPDNVDIFMVAPKSPGHLVRRMYLEGKGVPGLLAVEQDYSGK
AKELGLAYAKGIGCTKAGVIETTFKEETETDLFGEQAVLCGGVTSLVKAGFEVLVEAGYQPEIAYFECLNELKLIVDLMF
EGGLTKMRHSISDTAQYGDLMVGPRIVNDNVKDEMRSVLKEIQSGEFAKKWILENKANRPVFNALTSKDENHLIEKVGKK
LRDMMPWINE

Sequences:

>Translated_330_residues
MIHVYYDKDANLGLLEEKMIAVLGYGSQGHAQAQNLKDSGLNVIVGLRKGSSSWKKAESDGFRVFKTSEAVKRADIIQVL
IPDEVQSRVYKEDIEPYLEEGNALVFSHGFNIHFGQIVPPDNVDIFMVAPKSPGHLVRRMYLEGKGVPGLLAVEQDYSGK
AKELGLAYAKGIGCTKAGVIETTFKEETETDLFGEQAVLCGGVTSLVKAGFEVLVEAGYQPEIAYFECLNELKLIVDLMF
EGGLTKMRHSISDTAQYGDLMVGPRIVNDNVKDEMRSVLKEIQSGEFAKKWILENKANRPVFNALTSKDENHLIEKVGKK
LRDMMPWINE
>Mature_330_residues
MIHVYYDKDANLGLLEEKMIAVLGYGSQGHAQAQNLKDSGLNVIVGLRKGSSSWKKAESDGFRVFKTSEAVKRADIIQVL
IPDEVQSRVYKEDIEPYLEEGNALVFSHGFNIHFGQIVPPDNVDIFMVAPKSPGHLVRRMYLEGKGVPGLLAVEQDYSGK
AKELGLAYAKGIGCTKAGVIETTFKEETETDLFGEQAVLCGGVTSLVKAGFEVLVEAGYQPEIAYFECLNELKLIVDLMF
EGGLTKMRHSISDTAQYGDLMVGPRIVNDNVKDEMRSVLKEIQSGEFAKKWILENKANRPVFNALTSKDENHLIEKVGKK
LRDMMPWINE

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=288, Percent_Identity=35.7638888888889, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=304, Percent_Identity=34.5394736842105, Blast_Score=160, Evalue=3e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_HALOH (B8CX20)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508834.1
- ProteinModelPortal:   B8CX20
- SMR:   B8CX20
- GeneID:   7312827
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_10850
- HOGENOM:   HBG286525
- OMA:   AMKQCLK
- ProtClustDB:   CLSK2476425
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36664; Mature: 36664

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHVYYDKDANLGLLEEKMIAVLGYGSQGHAQAQNLKDSGLNVIVGLRKGSSSWKKAESD
CEEEEECCCCCCCHHHHHHHHEEECCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHCCCC
GFRVFKTSEAVKRADIIQVLIPDEVQSRVYKEDIEPYLEEGNALVFSHGFNIHFGQIVPP
CEEEEECHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCC
DNVDIFMVAPKSPGHLVRRMYLEGKGVPGLLAVEQDYSGKAKELGLAYAKGIGCTKAGVI
CCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
ETTFKEETETDLFGEQAVLCGGVTSLVKAGFEVLVEAGYQPEIAYFECLNELKLIVDLMF
EHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLTKMRHSISDTAQYGDLMVGPRIVNDNVKDEMRSVLKEIQSGEFAKKWILENKANRP
CCCHHHHHHHHHHHHHHCCEEECCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
VFNALTSKDENHLIEKVGKKLRDMMPWINE
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIHVYYDKDANLGLLEEKMIAVLGYGSQGHAQAQNLKDSGLNVIVGLRKGSSSWKKAESD
CEEEEECCCCCCCHHHHHHHHEEECCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHCCCC
GFRVFKTSEAVKRADIIQVLIPDEVQSRVYKEDIEPYLEEGNALVFSHGFNIHFGQIVPP
CEEEEECHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCC
DNVDIFMVAPKSPGHLVRRMYLEGKGVPGLLAVEQDYSGKAKELGLAYAKGIGCTKAGVI
CCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
ETTFKEETETDLFGEQAVLCGGVTSLVKAGFEVLVEAGYQPEIAYFECLNELKLIVDLMF
EHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLTKMRHSISDTAQYGDLMVGPRIVNDNVKDEMRSVLKEIQSGEFAKKWILENKANRP
CCCHHHHHHHHHHHHHHCCEEECCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
VFNALTSKDENHLIEKVGKKLRDMMPWINE
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA