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The map label for this gene is fabF [H]

Identifier: 220931874

GI number: 220931874

Start: 1119786

End: 1121033

Strand: Direct

Name: fabF [H]

Synonym: Hore_10310

Alternate gene names: 220931874

Gene position: 1119786-1121033 (Clockwise)

Preceding gene: 220931873

Following gene: 220931875

Centisome position: 43.43

GC content: 43.91

Gene sequence:

>1248_bases
ATGGATAAGCGCGTTGTTATAACTGGTCTGGGTGTTGTTTCCTCCTTGGGAATGAACCTGAATGAATTCTGGGAAAACAT
AAAAAATGGTAAATCCGGTATAAGTAAAATTACCAGATTTGATACCAGTGAATTCCCCAGTAAAATAGGGGCTGAAATAA
AAGACTTTAATCCCGGGGAATATATAGACCGTAAAGACGCCAGAAGAATGGCCATATTTACTCAGTATGCTGTTGTTGCG
GCCATGAAAGCTCTTGCGGATTCAAATTTAGAGATAGATGAAGGTAATGCCCATGAGGTCGGGGTCCTGATAGGTTCAGG
TATTGGAGGTATTGAGGTTTTAGAGGACCAGATTGAGAGGTTAATAAAAAAAGGTCCCCGCAGGGTAAGCCCGTTTTTTG
TTCCTATGATGATCTCCAACATGGCCTCTGGACAGGTTTCAATATATACCGGAGCCAAGGGACCCAACAGTAATGCGGTA
ACCGCCTGTGCTTCTGGAACTACTGCTATTGGGGAAGCAACCGAAATTATAAGACGTGGTGATGCCAGAGTAATGATTGC
AGGAGGTTCTGAAGCAGGTATTGCTCCATCAGCCCTGGCCGGATTCGCTTCAATGAAGGCTCTGTCGACCCGTAATGAAG
AACCTACTAAAGCCAGTCGTCCCTTTGATGCCGAACGGGATGGTTTTGTAATTGGTGAAGGTAGTGGTATTGTAGTTCTT
GAAGAAATGGAACATGCTAAAGCCAGAGGGGCAAATATTTATGCTGAAGTAATTGGTTATGGAGCCAGTGGTGATGCCTA
TCATATTACTCAGCCTGCTCCAGAAGGAGAAGGGGCAGCCCGGGCGATGAAAATGGCAGTTGAAAAATCCGGTCTGAAGC
CTGAAGAGTTGGATTACATTAACGCCCATGGCACTTCAACAGGTTTAAATGATAAATTTGAAACAATTGCTATCAAGAAG
GTGTTCGGAGACCATGCCCGTAACGGGTTAATGGTAAGTTCTACTAAATCTATGACCGGACATTTACTGGGGGCTGCCGG
GGGAGTAGAAACGGTAATTTCCTGTTTAACCCTTAGAGATGGAGTTGTTCCCCCGACAGTTAATTATGAAAATCCGGATC
CGGATTGTGACCTCGATTATGTACCTAATGAATCTAGGGAAGTACCTGAATTAAAAACAGTTATGACCAATTCTTTTGGA
TTTGGGGGTCAGAATGCCTGTCTGGTACTTCGGAAAATTGATGAATAA

Upstream 100 bases:

>100_bases
GTTTATGTTTATATAAACATAAACGGGGTTTCAACCTATTAAGTAATATCTTTTTCAGGAATAAATATATAATTTATAAA
GTGTTGAAAGGAGGAAGATA

Downstream 100 bases:

>100_bases
GGAACCAGGGGAGTAATTTTAATGATAAGAATTTATAATAAAAAGCTTTTAAAAAAACTGGAAGAAAAATTAAATATCAG
ATTTAATGATATATCCCTGT

Product: Beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MDKRVVITGLGVVSSLGMNLNEFWENIKNGKSGISKITRFDTSEFPSKIGAEIKDFNPGEYIDRKDARRMAIFTQYAVVA
AMKALADSNLEIDEGNAHEVGVLIGSGIGGIEVLEDQIERLIKKGPRRVSPFFVPMMISNMASGQVSIYTGAKGPNSNAV
TACASGTTAIGEATEIIRRGDARVMIAGGSEAGIAPSALAGFASMKALSTRNEEPTKASRPFDAERDGFVIGEGSGIVVL
EEMEHAKARGANIYAEVIGYGASGDAYHITQPAPEGEGAARAMKMAVEKSGLKPEELDYINAHGTSTGLNDKFETIAIKK
VFGDHARNGLMVSSTKSMTGHLLGAAGGVETVISCLTLRDGVVPPTVNYENPDPDCDLDYVPNESREVPELKTVMTNSFG
FGGQNACLVLRKIDE

Sequences:

>Translated_415_residues
MDKRVVITGLGVVSSLGMNLNEFWENIKNGKSGISKITRFDTSEFPSKIGAEIKDFNPGEYIDRKDARRMAIFTQYAVVA
AMKALADSNLEIDEGNAHEVGVLIGSGIGGIEVLEDQIERLIKKGPRRVSPFFVPMMISNMASGQVSIYTGAKGPNSNAV
TACASGTTAIGEATEIIRRGDARVMIAGGSEAGIAPSALAGFASMKALSTRNEEPTKASRPFDAERDGFVIGEGSGIVVL
EEMEHAKARGANIYAEVIGYGASGDAYHITQPAPEGEGAARAMKMAVEKSGLKPEELDYINAHGTSTGLNDKFETIAIKK
VFGDHARNGLMVSSTKSMTGHLLGAAGGVETVISCLTLRDGVVPPTVNYENPDPDCDLDYVPNESREVPELKTVMTNSFG
FGGQNACLVLRKIDE
>Mature_415_residues
MDKRVVITGLGVVSSLGMNLNEFWENIKNGKSGISKITRFDTSEFPSKIGAEIKDFNPGEYIDRKDARRMAIFTQYAVVA
AMKALADSNLEIDEGNAHEVGVLIGSGIGGIEVLEDQIERLIKKGPRRVSPFFVPMMISNMASGQVSIYTGAKGPNSNAV
TACASGTTAIGEATEIIRRGDARVMIAGGSEAGIAPSALAGFASMKALSTRNEEPTKASRPFDAERDGFVIGEGSGIVVL
EEMEHAKARGANIYAEVIGYGASGDAYHITQPAPEGEGAARAMKMAVEKSGLKPEELDYINAHGTSTGLNDKFETIAIKK
VFGDHARNGLMVSSTKSMTGHLLGAAGGVETVISCLTLRDGVVPPTVNYENPDPDCDLDYVPNESREVPELKTVMTNSFG
FGGQNACLVLRKIDE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=46.0620525059666, Blast_Score=351, Evalue=7e-97,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=49.7005988023952, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI41872631, Length=423, Percent_Identity=24.822695035461, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=51.8248175182482, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788663, Length=417, Percent_Identity=41.2470023980815, Blast_Score=261, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=418, Percent_Identity=36.6028708133971, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=42.6356589147287, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI212642053, Length=376, Percent_Identity=24.468085106383, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=415, Percent_Identity=24.3373493975904, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=38.0313199105145, Blast_Score=285, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6325025, Length=182, Percent_Identity=29.1208791208791, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=42.654028436019, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI19920632, Length=429, Percent_Identity=24.009324009324, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI221330659, Length=429, Percent_Identity=24.009324009324, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24581345, Length=430, Percent_Identity=23.7209302325581, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44058; Mature: 44058

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRVVITGLGVVSSLGMNLNEFWENIKNGKSGISKITRFDTSEFPSKIGAEIKDFNPGE
CCCEEEEEECHHHHHHCCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCC
YIDRKDARRMAIFTQYAVVAAMKALADSNLEIDEGNAHEVGVLIGSGIGGIEVLEDQIER
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEEEECCCCHHHHHHHHHHH
LIKKGPRRVSPFFVPMMISNMASGQVSIYTGAKGPNSNAVTACASGTTAIGEATEIIRRG
HHHCCCCCCCCEEHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCC
DARVMIAGGSEAGIAPSALAGFASMKALSTRNEEPTKASRPFDAERDGFVIGEGSGIVVL
CCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEE
EEMEHAKARGANIYAEVIGYGASGDAYHITQPAPEGEGAARAMKMAVEKSGLKPEELDYI
ECHHHHHHCCCEEEEEHEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHCCEE
NAHGTSTGLNDKFETIAIKKVFGDHARNGLMVSSTKSMTGHLLGAAGGVETVISCLTLRD
ECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCCCHHHHHHHHHHHC
GVVPPTVNYENPDPDCDLDYVPNESREVPELKTVMTNSFGFGGQNACLVLRKIDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MDKRVVITGLGVVSSLGMNLNEFWENIKNGKSGISKITRFDTSEFPSKIGAEIKDFNPGE
CCCEEEEEECHHHHHHCCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCC
YIDRKDARRMAIFTQYAVVAAMKALADSNLEIDEGNAHEVGVLIGSGIGGIEVLEDQIER
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEEEECCCCHHHHHHHHHHH
LIKKGPRRVSPFFVPMMISNMASGQVSIYTGAKGPNSNAVTACASGTTAIGEATEIIRRG
HHHCCCCCCCCEEHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCC
DARVMIAGGSEAGIAPSALAGFASMKALSTRNEEPTKASRPFDAERDGFVIGEGSGIVVL
CCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEE
EEMEHAKARGANIYAEVIGYGASGDAYHITQPAPEGEGAARAMKMAVEKSGLKPEELDYI
ECHHHHHHCCCEEEEEHEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHCCEE
NAHGTSTGLNDKFETIAIKKVFGDHARNGLMVSSTKSMTGHLLGAAGGVETVISCLTLRD
ECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCCCHHHHHHHHHHHC
GVVPPTVNYENPDPDCDLDYVPNESREVPELKTVMTNSFGFGGQNACLVLRKIDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]