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The map label for this gene is argD

Identifier: 221230216

GI number: 221230216

Start: 1690822

End: 1692036

Strand: Direct

Name: argD

Synonym: MLBr_01409

Alternate gene names: 221230216

Gene position: 1690822-1692036 (Clockwise)

Preceding gene: 221230215

Following gene: 221230217

Centisome position: 51.74

GC content: 61.56

Gene sequence:

>1215_bases
ATGACCCCGACACAAACCAACACTGCGACTATGCAGCAGCGCTGGGAAACCGTGATGATGAACAATTATGGCACCCCACC
GATCGTGCTAGCCAGCGGTAACGGCGCCGTAGTCACCGACGTAGACAGCAATACCTATCTGGATTTGCTCGGCGGCATCG
CGGTCAACGTTCTTGGCCACCGCCATCCCGCGGTTATCGAAGCCGTCACACATCAGATAACCACCCTGGGCCACACATCC
AACCTATATGCCACTGAACCAAGTATCACACTCGCCGAAGAATTGGTCGCCCTACTGGGTGCTGACACACAGACACGGGT
GTTCTTCTGCAACTCTGGTACTGAAGCCAACGAGCTGGCGTTCAAACTGTCTCGGCTCACGGGCCGTACGAAACTGGTTG
CTGCGCAAGCAGCTTTCCACGGCCGGACGATGGGTTCGCTGGCATTGACTGGTCAGCCCGCCAAGCAGGCGGCGTTTGAG
CCATTGCCCGGCCACGTCACGCATGTGCCCTACGGTCAAGTCGATGCCCTAGCCGCCGCGGTCGACAACGACACCGCCGC
GGTGTTCCTGGAGCCGATCATGGGGGAAAGTGGTGTCATCGTCCCGCCTGAGGGCTACCTTGCTGCTGCCCGGGATATAA
CGACACGGCACGGCGCCTTGCTGGTAATCGACGAAGTGCAGACCGGAATAGGCCGTACCGGTGCCTTTTTCGCTCACCAA
CACGACAGCATCACCCCGGACGTGGTGACCCTGGCCAAGGGCCTCGGCGGCGGACTGCCGATCGGGGCGTTCCTGGCCAC
CGGGCCAGCGGCGGAGTTGTTGACGCTGGGGCTGCACGGCAGCACCTTCGGCGGCAACCCGGTCTGCACCGCGGCGGCAC
TTGCGGTGCTGCGAGTATTGGCGACCCAGGGCCTGGTCCGGCGTGCCGAGGTGTTGGGCGATTCGATGCGCATCGGCATC
GAATCTCTCAGTCACCCGCTGATCGACCAGGTGCGCGGCCGCGGCTTGCTATTGGGCATCGTGTTGACCGCGCCTCGAGC
CAAAGATATCGAGAAGGCCGCGCGTGACGCTGGGTTTTTGGTTAACGCCACAGCACCGGAGGTCATCCGGTTGGCCCCGC
CGTTGATCATCACCGAATCCCAGATCGACAGCTTCATCACTGCCTTGCCAGGCATTCTGGATGCCTCCATAGCTGAGCTG
GGAAAAAAGGCATGA

Upstream 100 bases:

>100_bases
GGAGTTGTTAACCAACGAGGGCACCGGCACCAAGGTGGTGAGCGCATGACGCGCGCCGGTGATGATGCAGTAGAGAAGCG
ATAGGGATAAGCGGGCACCC

Downstream 100 bases:

>100_bases
CAGCGCCGGTGACGATGCAGAGAGAAACGATGTGGGGGGCGCTTCCCGCTTGCGGGGAAGAGGAGCGGCGCAGTTGACTA
GGCATTTTTTGCGTGATGAC

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTPTQTNTATMQQRWETVMMNNYGTPPIVLASGNGAVVTDVDSNTYLDLLGGIAVNVLGHRHPAVIEAVTHQITTLGHTS
NLYATEPSITLAEELVALLGADTQTRVFFCNSGTEANELAFKLSRLTGRTKLVAAQAAFHGRTMGSLALTGQPAKQAAFE
PLPGHVTHVPYGQVDALAAAVDNDTAAVFLEPIMGESGVIVPPEGYLAAARDITTRHGALLVIDEVQTGIGRTGAFFAHQ
HDSITPDVVTLAKGLGGGLPIGAFLATGPAAELLTLGLHGSTFGGNPVCTAAALAVLRVLATQGLVRRAEVLGDSMRIGI
ESLSHPLIDQVRGRGLLLGIVLTAPRAKDIEKAARDAGFLVNATAPEVIRLAPPLIITESQIDSFITALPGILDASIAEL
GKKA

Sequences:

>Translated_404_residues
MTPTQTNTATMQQRWETVMMNNYGTPPIVLASGNGAVVTDVDSNTYLDLLGGIAVNVLGHRHPAVIEAVTHQITTLGHTS
NLYATEPSITLAEELVALLGADTQTRVFFCNSGTEANELAFKLSRLTGRTKLVAAQAAFHGRTMGSLALTGQPAKQAAFE
PLPGHVTHVPYGQVDALAAAVDNDTAAVFLEPIMGESGVIVPPEGYLAAARDITTRHGALLVIDEVQTGIGRTGAFFAHQ
HDSITPDVVTLAKGLGGGLPIGAFLATGPAAELLTLGLHGSTFGGNPVCTAAALAVLRVLATQGLVRRAEVLGDSMRIGI
ESLSHPLIDQVRGRGLLLGIVLTAPRAKDIEKAARDAGFLVNATAPEVIRLAPPLIITESQIDSFITALPGILDASIAEL
GKKA
>Mature_403_residues
TPTQTNTATMQQRWETVMMNNYGTPPIVLASGNGAVVTDVDSNTYLDLLGGIAVNVLGHRHPAVIEAVTHQITTLGHTSN
LYATEPSITLAEELVALLGADTQTRVFFCNSGTEANELAFKLSRLTGRTKLVAAQAAFHGRTMGSLALTGQPAKQAAFEP
LPGHVTHVPYGQVDALAAAVDNDTAAVFLEPIMGESGVIVPPEGYLAAARDITTRHGALLVIDEVQTGIGRTGAFFAHQH
DSITPDVVTLAKGLGGGLPIGAFLATGPAAELLTLGLHGSTFGGNPVCTAAALAVLRVLATQGLVRRAEVLGDSMRIGIE
SLSHPLIDQVRGRGLLLGIVLTAPRAKDIEKAARDAGFLVNATAPEVIRLAPPLIITESQIDSFITALPGILDASIAELG
KKA

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=380, Percent_Identity=35.2631578947368, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI284507298, Length=290, Percent_Identity=38.2758620689655, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI13994255, Length=419, Percent_Identity=30.0715990453461, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI24119277, Length=417, Percent_Identity=29.4964028776978, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=27.0783847980998, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=27.720207253886, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=26.1282660332542, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI188536080, Length=427, Percent_Identity=23.4192037470726, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38679950, Length=427, Percent_Identity=23.4192037470726, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38679946, Length=427, Percent_Identity=23.4192037470726, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788044, Length=383, Percent_Identity=40.4699738903394, Blast_Score=294, Evalue=6e-81,
Organism=Escherichia coli, GI1789759, Length=392, Percent_Identity=38.5204081632653, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI145693181, Length=404, Percent_Identity=37.1287128712871, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=32.7790973871734, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1787560, Length=388, Percent_Identity=35.0515463917526, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1786349, Length=384, Percent_Identity=29.9479166666667, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786991, Length=394, Percent_Identity=27.6649746192893, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=399, Percent_Identity=33.8345864661654, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI32564660, Length=414, Percent_Identity=28.743961352657, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=258, Percent_Identity=36.8217054263566, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI71992977, Length=425, Percent_Identity=30.5882352941176, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17541228, Length=414, Percent_Identity=25.8454106280193, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=186, Percent_Identity=29.5698924731183, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=413, Percent_Identity=34.3825665859564, Blast_Score=222, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6324432, Length=385, Percent_Identity=32.7272727272727, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321456, Length=424, Percent_Identity=26.1792452830189, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=33.4158415841584, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI28574759, Length=411, Percent_Identity=33.0900243309002, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI161085790, Length=416, Percent_Identity=32.2115384615385, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=30.8788598574822, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI281366494, Length=427, Percent_Identity=25.9953161592506, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24667139, Length=427, Percent_Identity=25.9953161592506, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24667143, Length=427, Percent_Identity=25.9953161592506, Blast_Score=101, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_MYCLE (Q9CC12)

Other databases:

- EMBL:   AL583922
- PIR:   C87085
- RefSeq:   NP_302002.1
- ProteinModelPortal:   Q9CC12
- SMR:   Q9CC12
- EnsemblBacteria:   EBMYCT00000028386
- GeneID:   910549
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1409
- NMPDR:   fig|272631.1.peg.874
- Leproma:   ML1409
- GeneTree:   EBGT00050000015339
- HOGENOM:   HBG725944
- OMA:   MDNYGTP
- ProtClustDB:   PRK03244
- BioCyc:   MLEP272631:ML1409-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 42008; Mature: 41877

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 139-139 BINDING 142-142 BINDING 281-281 BINDING 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTQTNTATMQQRWETVMMNNYGTPPIVLASGNGAVVTDVDSNTYLDLLGGIAVNVLGH
CCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCC
RHPAVIEAVTHQITTLGHTSNLYATEPSITLAEELVALLGADTQTRVFFCNSGTEANELA
CCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
FKLSRLTGRTKLVAAQAAFHGRTMGSLALTGQPAKQAAFEPLPGHVTHVPYGQVDALAAA
HHHHHHCCCHHEEEHHHHHCCCCCCCEEECCCCHHHHCCCCCCCCEEECCCCCHHHHHHH
VDNDTAAVFLEPIMGESGVIVPPEGYLAAARDITTRHGALLVIDEVQTGIGRTGAFFAHQ
HCCCCEEEEEEECCCCCCEEECCCCCEEHHHHHHCCCCEEEEEECHHCCCCCCCEEEEEC
HDSITPDVVTLAKGLGGGLPIGAFLATGPAAELLTLGLHGSTFGGNPVCTAAALAVLRVL
CCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHEEEECCCCCCCCCHHHHHHHHHHHHHH
ATQGLVRRAEVLGDSMRIGIESLSHPLIDQVRGRGLLLGIVLTAPRAKDIEKAARDAGFL
HHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCCEE
VNATAPEVIRLAPPLIITESQIDSFITALPGILDASIAELGKKA
EECCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TPTQTNTATMQQRWETVMMNNYGTPPIVLASGNGAVVTDVDSNTYLDLLGGIAVNVLGH
CCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCC
RHPAVIEAVTHQITTLGHTSNLYATEPSITLAEELVALLGADTQTRVFFCNSGTEANELA
CCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
FKLSRLTGRTKLVAAQAAFHGRTMGSLALTGQPAKQAAFEPLPGHVTHVPYGQVDALAAA
HHHHHHCCCHHEEEHHHHHCCCCCCCEEECCCCHHHHCCCCCCCCEEECCCCCHHHHHHH
VDNDTAAVFLEPIMGESGVIVPPEGYLAAARDITTRHGALLVIDEVQTGIGRTGAFFAHQ
HCCCCEEEEEEECCCCCCEEECCCCCEEHHHHHHCCCCEEEEEECHHCCCCCCCEEEEEC
HDSITPDVVTLAKGLGGGLPIGAFLATGPAAELLTLGLHGSTFGGNPVCTAAALAVLRVL
CCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHEEEECCCCCCCCCHHHHHHHHHHHHHH
ATQGLVRRAEVLGDSMRIGIESLSHPLIDQVRGRGLLLGIVLTAPRAKDIEKAARDAGFL
HHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCCEE
VNATAPEVIRLAPPLIITESQIDSFITALPGILDASIAELGKKA
EECCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002