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The map label for this gene is ppnK

Identifier: 221230183

GI number: 221230183

Start: 1618848

End: 1619783

Strand: Direct

Name: ppnK

Synonym: MLBr_01359

Alternate gene names: 221230183

Gene position: 1618848-1619783 (Clockwise)

Preceding gene: 221230182

Following gene: 221230184

Centisome position: 49.54

GC content: 61.11

Gene sequence:

>936_bases
GTGACTCCTCGCAAGGCGGCGCAACGGACTGTGTTGCTGGTCGTCCACACCGGACGTGACGAAGCAACCGAGACGGCTCG
TCGTGTAAAGAAAATTGTGGGCGACAATGGAATTGCACTTCGGGTGTTATCTGCTGAGGCGGTCGATAGGGGATCGCTGC
ATCTTGCTCTCGACAATATGCGTGCAATGGGTGTTGATATCGAGGTGGTTGACGCTGACCCGCACGTTGCCCAGGGTTGC
GAACTGGTGCTGGTGCTAGGTGGTGATGGCACCTTCTTACGTGCCGCTGAGCTGGCTCGCACCGCCCGCATCCCAGTGTT
GGGTGTCAACCTGGGACGGATCGGCTTTTTAGCGGAGGCCGAAGCGGAGGCTATTGACGTTGTGCTGGAGCACGTCATCG
CGCGGAGCTACCGCGTGGAGGAGCGCTTAACACTCGACATCGTGGTACGCCAAGGCGGGAACATCATCGATCAGGGGTGG
GCACTTAACGAAGCCAGCTTGGAAAAGGGTCCGCGGCTGGGTGTGCTCGGGGTGGTCGTCGAAATCGAAGGGCGGCCAGT
GTCCACGTTCGGTTGCGACGGGGTGTTGGTATCGACCCCCACGGGATCCACCGCCTATGCGTTCTCGGCAGGTGGTCCGG
TGCTATGGCCGGATCTCGAAGCTATCCTGGTGGTCCCCAACAACGCTCATGCTCTGTTCGGCCGGCCGATGGTCACCAGC
CCCGATGCTACCGTGGCAATTGAGCTAGAGGCCAACGGCAACGACGCACTGGTGTTCTGCGACGGTCGCCGCGAAATGAT
TATACCGGCCGGCGGACGGCTCGAGGTGACTCGCTGTGCCACACCAGTGAAATGGGCGCGCCTAGATAGCGCGCCGTTCA
CTGACCGCTTGGTGAGCAAATTCCGGTTGCCGGTGACCGGTTGGCGCGGGAAGTGA

Upstream 100 bases:

>100_bases
ACGTCGAATACTTCCTGTGGCTACGCGCTCAGACCGATCTGGAGCTCTCGACCGATGGGCTGGAGGCAGCCGTGCAACGT
GCCATCGCAGAAGGCCCGCA

Downstream 100 bases:

>100_bases
TGGCGTTGCCTGGTGCGCACTGAATGTTGACGGAAATACGAATCGAGTCGTTGGGCGCTATCAGCGTTGCGACAGCTGAG
TTCGATCGGGGCCTGACTGT

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTPRKAAQRTVLLVVHTGRDEATETARRVKKIVGDNGIALRVLSAEAVDRGSLHLALDNMRAMGVDIEVVDADPHVAQGC
ELVLVLGGDGTFLRAAELARTARIPVLGVNLGRIGFLAEAEAEAIDVVLEHVIARSYRVEERLTLDIVVRQGGNIIDQGW
ALNEASLEKGPRLGVLGVVVEIEGRPVSTFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTS
PDATVAIELEANGNDALVFCDGRREMIIPAGGRLEVTRCATPVKWARLDSAPFTDRLVSKFRLPVTGWRGK

Sequences:

>Translated_311_residues
MTPRKAAQRTVLLVVHTGRDEATETARRVKKIVGDNGIALRVLSAEAVDRGSLHLALDNMRAMGVDIEVVDADPHVAQGC
ELVLVLGGDGTFLRAAELARTARIPVLGVNLGRIGFLAEAEAEAIDVVLEHVIARSYRVEERLTLDIVVRQGGNIIDQGW
ALNEASLEKGPRLGVLGVVVEIEGRPVSTFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTS
PDATVAIELEANGNDALVFCDGRREMIIPAGGRLEVTRCATPVKWARLDSAPFTDRLVSKFRLPVTGWRGK
>Mature_310_residues
TPRKAAQRTVLLVVHTGRDEATETARRVKKIVGDNGIALRVLSAEAVDRGSLHLALDNMRAMGVDIEVVDADPHVAQGCE
LVLVLGGDGTFLRAAELARTARIPVLGVNLGRIGFLAEAEAEAIDVVLEHVIARSYRVEERLTLDIVVRQGGNIIDQGWA
LNEASLEKGPRLGVLGVVVEIEGRPVSTFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSP
DATVAIELEANGNDALVFCDGRREMIIPAGGRLEVTRCATPVKWARLDSAPFTDRLVSKFRLPVTGWRGK

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=235, Percent_Identity=31.063829787234, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788968, Length=236, Percent_Identity=31.7796610169492, Blast_Score=118, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320794, Length=237, Percent_Identity=27.4261603375527, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322509, Length=229, Percent_Identity=27.5109170305677, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325068, Length=187, Percent_Identity=28.8770053475936, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573828, Length=225, Percent_Identity=31.5555555555556, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573830, Length=225, Percent_Identity=31.5555555555556, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24653422, Length=290, Percent_Identity=27.2413793103448, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281363321, Length=290, Percent_Identity=27.2413793103448, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281363323, Length=290, Percent_Identity=27.9310344827586, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI161077047, Length=225, Percent_Identity=31.5555555555556, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28573832, Length=225, Percent_Identity=31.5555555555556, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28573826, Length=225, Percent_Identity=31.5555555555556, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI20129957, Length=290, Percent_Identity=27.2413793103448, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24653424, Length=290, Percent_Identity=27.9310344827586, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_MYCLB (B8ZRH2)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503599.1
- ProteinModelPortal:   B8ZRH2
- SMR:   B8ZRH2
- EnsemblBacteria:   EBMYCT00000087285
- GeneID:   7326027
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016530
- HOGENOM:   HBG713904
- OMA:   CVPEGFD
- ProtClustDB:   PRK03372
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 33219; Mature: 33087

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRKAAQRTVLLVVHTGRDEATETARRVKKIVGDNGIALRVLSAEAVDRGSLHLALDNM
CCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEECC
RAMGVDIEVVDADPHVAQGCELVLVLGGDGTFLRAAELARTARIPVLGVNLGRIGFLAEA
EEECCEEEEEECCCCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCEEEECCCCEEEEECC
EAEAIDVVLEHVIARSYRVEERLTLDIVVRQGGNIIDQGWALNEASLEKGPRLGVLGVVV
CHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCEEECCEECCHHHHCCCCCEEEEEEEE
EIEGRPVSTFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTS
EECCEEEEEECCCEEEEECCCCCEEEEEECCCCEECCCCEEEEEECCCCCEEECCCEECC
PDATVAIELEANGNDALVFCDGRREMIIPAGGRLEVTRCATPVKWARLDSAPFTDRLVSK
CCCEEEEEEEECCCEEEEEECCCCEEEEECCCEEEEEECCCCCEEEECCCCCCHHHHHHH
FRLPVTGWRGK
HCCCCCCCCCC
>Mature Secondary Structure 
TPRKAAQRTVLLVVHTGRDEATETARRVKKIVGDNGIALRVLSAEAVDRGSLHLALDNM
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEECC
RAMGVDIEVVDADPHVAQGCELVLVLGGDGTFLRAAELARTARIPVLGVNLGRIGFLAEA
EEECCEEEEEECCCCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCEEEECCCCEEEEECC
EAEAIDVVLEHVIARSYRVEERLTLDIVVRQGGNIIDQGWALNEASLEKGPRLGVLGVVV
CHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCEEECCEECCHHHHCCCCCEEEEEEEE
EIEGRPVSTFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTS
EECCEEEEEECCCEEEEECCCCCEEEEEECCCCEECCCCEEEEEECCCCCEEECCCEECC
PDATVAIELEANGNDALVFCDGRREMIIPAGGRLEVTRCATPVKWARLDSAPFTDRLVSK
CCCEEEEEEEECCCEEEEEECCCCEEEEECCCEEEEEECCCCCEEEECCCCCCHHHHHHH
FRLPVTGWRGK
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA