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The map label for this gene is hisG [H]

Identifier: 221230156

GI number: 221230156

Start: 1562267

End: 1563136

Strand: Direct

Name: hisG [H]

Synonym: MLBr_01310

Alternate gene names: 221230156

Gene position: 1562267-1563136 (Clockwise)

Preceding gene: 221230155

Following gene: 221230158

Centisome position: 47.8

GC content: 57.82

Gene sequence:

>870_bases
GTGAGCATGCTGCGGGTTGCCGTTCCTAACAAAGGTGCGCTAAGCGAGCCGGCTACCGAGATCCTTGCTGAGGCTGGCTA
TCGACGACGCACTGATCCCAAAGACCTTACTGTTGTCGACCCCGTTAACCGCGTTGAGTTTTTCTTTCTGCGGCCCAAAG
ACATTGCCATCTATGTCGGTTCCGGAGATCTGGACTTCGGCATTACCGGACGAGACCTGGTGCACGATTCTGATGCGTCG
GTGTGTGAACGCCTGGCGCTGGGTTTCGGATCGTCCAGCTTCCGTTATGCCGGGCCTGCCGGACGCGACTGGACGACGTC
GGATCTGGCCGGAAAAAGGATCGCCACCGCTTACTCGAATTTGGTACGAAAGGACCTGGTTGCCAAGGGTATTGAAGCAA
CAGTTATAAGACTTGACGGCGCTGTAGAGATCTCGGTGCAACTTGGGGTGGCCGACGTCATCGCTGACGTGGTCGGGTCC
GGACGCACCCTGAGCTTGCATGACCTCGTGGCTTTTGGCGAGCCGCTGTGTGATTCGGAGGCGGTGTTGATCGAGCGTGG
TGATCGGGGCAGCCTCGATCACCACGAGACCGTTGCAGCTCGCGATCAATTGGTCGCTCGGGTCCAAGGGGTGGTGTTTG
GTCAACAATACTTGATGCTGGACTACGACTGCCCGCGCTCAGTACTGGACAAGGCTACGTTGATCACGTCGGGACTGGAG
TCACCGACCATAGCTCCACTAGCCGAGCCAGGCTGGGTGGCAATTCGTGCATTGGTGCCCCGCCGAGACATCAACGGGAT
TATGGACGAGCTTGCCGCCATCGGAGCCAAAGCGATTCTGGCTTCTGACATTAGGTTTTGCCGGTTTTGA

Upstream 100 bases:

>100_bases
CCAAGGAAGTGTTGGCCGAAGAGATCAGCCAGTTGCTGTACTGGACCCAGGTGCTGATGATCTCGCGCGGACTGTCGCTC
GATGACGTCTATCGGAAGCT

Downstream 100 bases:

>100_bases
AACTTCGTTGTGTTAGTCGTTCGGCTACGGCTGATTTCCATCGGACTAATGGCACCCCCTGTGGGTTATAATCCGTATTG
GTTGCCGAGCTGTTCCTCTT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSMLRVAVPNKGALSEPATEILAEAGYRRRTDPKDLTVVDPVNRVEFFFLRPKDIAIYVGSGDLDFGITGRDLVHDSDAS
VCERLALGFGSSSFRYAGPAGRDWTTSDLAGKRIATAYSNLVRKDLVAKGIEATVIRLDGAVEISVQLGVADVIADVVGS
GRTLSLHDLVAFGEPLCDSEAVLIERGDRGSLDHHETVAARDQLVARVQGVVFGQQYLMLDYDCPRSVLDKATLITSGLE
SPTIAPLAEPGWVAIRALVPRRDINGIMDELAAIGAKAILASDIRFCRF

Sequences:

>Translated_289_residues
MSMLRVAVPNKGALSEPATEILAEAGYRRRTDPKDLTVVDPVNRVEFFFLRPKDIAIYVGSGDLDFGITGRDLVHDSDAS
VCERLALGFGSSSFRYAGPAGRDWTTSDLAGKRIATAYSNLVRKDLVAKGIEATVIRLDGAVEISVQLGVADVIADVVGS
GRTLSLHDLVAFGEPLCDSEAVLIERGDRGSLDHHETVAARDQLVARVQGVVFGQQYLMLDYDCPRSVLDKATLITSGLE
SPTIAPLAEPGWVAIRALVPRRDINGIMDELAAIGAKAILASDIRFCRF
>Mature_288_residues
SMLRVAVPNKGALSEPATEILAEAGYRRRTDPKDLTVVDPVNRVEFFFLRPKDIAIYVGSGDLDFGITGRDLVHDSDASV
CERLALGFGSSSFRYAGPAGRDWTTSDLAGKRIATAYSNLVRKDLVAKGIEATVIRLDGAVEISVQLGVADVIADVVGSG
RTLSLHDLVAFGEPLCDSEAVLIERGDRGSLDHHETVAARDQLVARVQGVVFGQQYLMLDYDCPRSVLDKATLITSGLES
PTIAPLAEPGWVAIRALVPRRDINGIMDELAAIGAKAILASDIRFCRF

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=288, Percent_Identity=29.8611111111111, Blast_Score=107, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320896, Length=293, Percent_Identity=31.3993174061433, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 31112; Mature: 30981

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMLRVAVPNKGALSEPATEILAEAGYRRRTDPKDLTVVDPVNRVEFFFLRPKDIAIYVG
CCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEECCCEEEEEEC
SGDLDFGITGRDLVHDSDASVCERLALGFGSSSFRYAGPAGRDWTTSDLAGKRIATAYSN
CCCCCCCCCCCHHCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHCCHHHHHHHHH
LVRKDLVAKGIEATVIRLDGAVEISVQLGVADVIADVVGSGRTLSLHDLVAFGEPLCDSE
HHHHHHHHCCCEEEEEEECCEEEEEEECCHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCC
AVLIERGDRGSLDHHETVAARDQLVARVQGVVFGQQYLMLDYDCPRSVLDKATLITSGLE
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCC
SPTIAPLAEPGWVAIRALVPRRDINGIMDELAAIGAKAILASDIRFCRF
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SMLRVAVPNKGALSEPATEILAEAGYRRRTDPKDLTVVDPVNRVEFFFLRPKDIAIYVG
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEECCCEEEEEEC
SGDLDFGITGRDLVHDSDASVCERLALGFGSSSFRYAGPAGRDWTTSDLAGKRIATAYSN
CCCCCCCCCCCHHCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHCCHHHHHHHHH
LVRKDLVAKGIEATVIRLDGAVEISVQLGVADVIADVVGSGRTLSLHDLVAFGEPLCDSE
HHHHHHHHCCCEEEEEEECCEEEEEEECCHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCC
AVLIERGDRGSLDHHETVAARDQLVARVQGVVFGQQYLMLDYDCPRSVLDKATLITSGLE
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCC
SPTIAPLAEPGWVAIRALVPRRDINGIMDELAAIGAKAILASDIRFCRF
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]