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The map label for this gene is cysQ

Identifier: 221230149

GI number: 221230149

Start: 1549242

End: 1550057

Strand: Direct

Name: cysQ

Synonym: MLBr_01301

Alternate gene names: 221230149

Gene position: 1549242-1550057 (Clockwise)

Preceding gene: 221230148

Following gene: 221230150

Centisome position: 47.41

GC content: 63.73

Gene sequence:

>816_bases
ATGGCCTCCCATGACAAAAGGGATTACCAGGCAGAGTTAACGGATGCTGCACTGGCTGCCGATCTCGCCACGGCAGCGGG
GGAGTTACTCCTCGAAATTCGCGAGGAGATCGGTTTCGACCAACCGCGGGCGCTCGGCGATGCTGGTGACAGGCTGGCAA
ATTCCCTGCTGCTGAGCCGGCTGCGGGCCGAGCGCCCGGGTGATGCGGTACTCAGCGAGGAAGCACATGATGATCGTGTT
CGGCTGCAGGCTGGCCGGGTATGGATCATCGACCCACTGGATGGTACCCGCGAATTCTCCACAGCGGGGCGCACTGACTG
GGCGGTACATATAGCGCTGTGGCAACGTACCACCGGCGGCGTCGCAGACGGCCGGCGCGAGATCACTGATGCGGCGGTGG
CGCTGCCGGCCCGCGGTAACAGGGTGTACCGCAGTGACACCGTGACCGCCGGCGCTGTGACTGGTGGTGTTCCCAACATT
CTCCGGATTGCTGTCAGCGCCACCCGGCCGCCCACAATCTTGCACCGGATACGGCAAAAGTTGGCCATCGAACCGGTGGC
TATCGGGTCGGCGGGGGCTAAAGCGATGGCGGTTGTCGACGGCGATGTGGACGCCTACCTGCATGTCGGGGGCCAATGGG
AATGGGATTCGGCAGCGCCAGCCGGGGTGGTGTTGGCAGCCGGTATGCACGCATCGCGCCTGGACGGCTCGCCGCTGCGT
TACAACCAGCTCGATCCGTATCTACCCGACTTTGTTATGTGTCGCGCCGATATCGCGCCGATACTGCTCGGTGTCATCCG
TGAGGTGTGGCAATGA

Upstream 100 bases:

>100_bases
TAGACAACCCGGTGATGCCCGGACCGAACCGGGATCGTGCCATTCCATGGCCGGCATTTTAAGGACTAGCTGTGCCCTCG
GCGATACTGAAGCGGTGAAC

Downstream 100 bases:

>100_bases
ACCGCCTTCGCGTGCGCCAAGATTGCCATGAGGGCTGTGGTGTGGGTGGGAACCACGATCATCGTGGCAATTTCGTTGGA
TGCTTGGCTTAAAGTCAACG

Product: putative inositol monophosphatase family protein

Products: NA

Alternate protein names: PAP phosphatase; 3'(2'),5'-bisphosphate nucleotidase; 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; D-fructose-1,6-bisphosphate 1-phosphohydrolase; DPNPase; Fructose-1,6-bisphosphatase; FBPase; Inositol-1-monophosphatase; I-1-Pase; IMPase; Inositol-1-phosphatase

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MASHDKRDYQAELTDAALAADLATAAGELLLEIREEIGFDQPRALGDAGDRLANSLLLSRLRAERPGDAVLSEEAHDDRV
RLQAGRVWIIDPLDGTREFSTAGRTDWAVHIALWQRTTGGVADGRREITDAAVALPARGNRVYRSDTVTAGAVTGGVPNI
LRIAVSATRPPTILHRIRQKLAIEPVAIGSAGAKAMAVVDGDVDAYLHVGGQWEWDSAAPAGVVLAAGMHASRLDGSPLR
YNQLDPYLPDFVMCRADIAPILLGVIREVWQ

Sequences:

>Translated_271_residues
MASHDKRDYQAELTDAALAADLATAAGELLLEIREEIGFDQPRALGDAGDRLANSLLLSRLRAERPGDAVLSEEAHDDRV
RLQAGRVWIIDPLDGTREFSTAGRTDWAVHIALWQRTTGGVADGRREITDAAVALPARGNRVYRSDTVTAGAVTGGVPNI
LRIAVSATRPPTILHRIRQKLAIEPVAIGSAGAKAMAVVDGDVDAYLHVGGQWEWDSAAPAGVVLAAGMHASRLDGSPLR
YNQLDPYLPDFVMCRADIAPILLGVIREVWQ
>Mature_270_residues
ASHDKRDYQAELTDAALAADLATAAGELLLEIREEIGFDQPRALGDAGDRLANSLLLSRLRAERPGDAVLSEEAHDDRVR
LQAGRVWIIDPLDGTREFSTAGRTDWAVHIALWQRTTGGVADGRREITDAAVALPARGNRVYRSDTVTAGAVTGGVPNIL
RIAVSATRPPTILHRIRQKLAIEPVAIGSAGAKAMAVVDGDVDAYLHVGGQWEWDSAAPAGVVLAAGMHASRLDGSPLRY
NQLDPYLPDFVMCRADIAPILLGVIREVWQ

Specific function: Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can ser

COG id: COG1218

COG function: function code P; 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase

Gene ontology:

Cell location: Localized On The Inner Face Of The Cytoplasm Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSQ_MYCLE (P46726)

Other databases:

- EMBL:   U00017
- EMBL:   AL583921
- PIR:   G87071
- RefSeq:   NP_301935.1
- ProteinModelPortal:   P46726
- EnsemblBacteria:   EBMYCT00000028155
- GeneID:   910420
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1301
- NMPDR:   fig|272631.1.peg.807
- Leproma:   ML1301
- GeneTree:   EBGT00050000015695
- HOGENOM:   HBG730251
- OMA:   CHEELCE
- ProtClustDB:   CLSK872017
- BioCyc:   MLEP272631:ML1301-MONOMER
- InterPro:   IPR020583
- InterPro:   IPR000760
- PANTHER:   PTHR20854

Pfam domain/function: PF00459 Inositol_P

EC number: =3.1.3.7; =3.1.3.11; =3.1.3.25

Molecular weight: Translated: 29119; Mature: 28988

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00629 IMP_1; PS00630 IMP_2

Important sites: BINDING 73-73 BINDING 216-216

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHDKRDYQAELTDAALAADLATAAGELLLEIREEIGFDQPRALGDAGDRLANSLLLSR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHH
LRAERPGDAVLSEEAHDDRVRLQAGRVWIIDPLDGTREFSTAGRTDWAVHIALWQRTTGG
HHCCCCCCCHHCCCCCCCEEEEEECCEEEECCCCCCHHHCCCCCCCEEEEEEEEECCCCC
VADGRREITDAAVALPARGNRVYRSDTVTAGAVTGGVPNILRIAVSATRPPTILHRIRQK
CCCCHHHHHHHHEECCCCCCEEEECCCCEECCCCCCCHHHHHHEECCCCCHHHHHHHHHH
LAIEPVAIGSAGAKAMAVVDGDVDAYLHVGGQWEWDSAAPAGVVLAAGMHASRLDGSPLR
HCCCCEEECCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCEEEECCCCHHCCCCCCCC
YNQLDPYLPDFVMCRADIAPILLGVIREVWQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASHDKRDYQAELTDAALAADLATAAGELLLEIREEIGFDQPRALGDAGDRLANSLLLSR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHH
LRAERPGDAVLSEEAHDDRVRLQAGRVWIIDPLDGTREFSTAGRTDWAVHIALWQRTTGG
HHCCCCCCCHHCCCCCCCEEEEEECCEEEECCCCCCHHHCCCCCCCEEEEEEEEECCCCC
VADGRREITDAAVALPARGNRVYRSDTVTAGAVTGGVPNILRIAVSATRPPTILHRIRQK
CCCCHHHHHHHHEECCCCCCEEEECCCCEECCCCCCCHHHHHHEECCCCCHHHHHHHHHH
LAIEPVAIGSAGAKAMAVVDGDVDAYLHVGGQWEWDSAAPAGVVLAAGMHASRLDGSPLR
HCCCCEEECCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCEEEECCCCHHCCCCCCCC
YNQLDPYLPDFVMCRADIAPILLGVIREVWQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002