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The map label for this gene is argE [C]

Identifier: 221230139

GI number: 221230139

Start: 1536172

End: 1537575

Strand: Direct

Name: argE [C]

Synonym: MLBr_01288

Alternate gene names: 221230139

Gene position: 1536172-1537575 (Clockwise)

Preceding gene: 221230138

Following gene: 221230140

Centisome position: 47.01

GC content: 60.26

Gene sequence:

>1404_bases
GTGCAGAAGACGAAGGTGTTGCGCTCGCTCGTCGTGGCGGTGGTAGGAAAGGTGACTGTGACAGTTGAGACCGACGTCCT
AGTCAATCCGAGCGATGATGTGGTAGAGGTTGTCAGCAGGTTGATTCGTTTTGACACCACCAACACCGGTGACCCCGAGA
CCACACGGGGTGAGGCTGAGTGCGCGCAATGGGTAGCCTCCCAGCTAGCTGAGGTTGGCTACCAGCCTGAATATTTGGAA
TCCGGGGCACCCGGTCGAGGCAATGTGTTTGCCCGTCTTGCGGGTGAGGATAGTTCGCGCGGCGCCCTGCTTATCCATGG
GCATCTCGACGTGGTGCCCGCGGAAACCGCCGAATGGAGCGTGCACCCATTTTCCGGTGCGGTCGAAGGAGGTCAGGTCT
GGGGTCGCGGCGCGATCGACATGAAAGACATGGTGGGCATGATGATTGTGGTAGCCCGGCAGCTAAAGCAGGCCGGCATC
GCGCCACCGCGAGACCTCGTATTCGCATTCGTTGCCGACGAAGAGCATGGTGGCAGTTACGGATCCCAATGGCTGGTCGA
TAACAGGCCCGATTTGTTCGACGGCGTCACCGAAGCTATCGGCGAAGTCGGCGGCTTTTCGTTAACTGTGCCGTGCCGCA
ACGGTGGTGAGCGTCGGCTCTACCTGATTGAGACGGCCGAGAAGGGCATGCAGTGGATGCGGCTGACCGCACGGGGCAGA
GCGGGGCACGGCTCGATGGTGCACAATCAGAACGCGGTCACCGCGGTTGCCGAGGCGGTTGCGCGGCTGGGGCGCCATCA
GTTTCCGCTCGTGACGACCGATACCGTGGTCCAATTTCTGGCCGCGATCAGCGAGGAAACTGGCCTCGAATTCGACATTG
GGTCGCCCGACTTGGAAGGAGCGATCGAAAAGCTTGGCCCGATGGCTCGCATGTTGAAAGCCGTGCTGTATGACACCGCG
AACCCGACGGTACTCAAGGCAGGATATAAGGTCAACGTGGTGCCGGCGACTGCGGAAGCTATGGTTGACTGTCGTATACT
GCCCGGGCGGCAGGCGGCATTCGAGGCCGCGATCGATGAATTGATCGGTCCTGATGTGACTCGGGAGTGGATCAAGGACT
TGCCCCCGTACGAGACTGCCTTCGACGGGGATTTGGTCGATGCAATGAACGCTGCTGTGCTGGCGGTCGACCCCGATGGT
CGAACGGTGCCTTATATGGCTTCCGGCGGCACCGATGCGAAAGCTTTCGCGCGCTTGGGTATTCGCTGCTTCGGCTTTAC
TCCGCTGCGGTTGCCACCGGAATTGGATTTCACCGCGCTGTTTCACGGTGTCGACGAGCGGGTCTCCATCGATGCGCTCA
AGTTTGGCATCGATGTGCTGGCGCACTTCCTGACACATTGCTAA

Upstream 100 bases:

>100_bases
AAAGTTGGGCAGCTAAGGCTATCGGATTGGTCCGCGCCGGACCAACCTAGCTCGGCGCACCGAACCTGTCGAGCGAACCG
ACAAGCGGCTGCCGCAAGTC

Downstream 100 bases:

>100_bases
TCGCAAAGTATCAATCACGAGAGGATCGCCCATGAGTTTGCCGCCTGACCCGTATGCTGCATTGCCCAAGCTGCCGTCGT
TTCACCTGACGTCGGATTCG

Product: hypothetical protein

Products: Acetate; Ornithine [C]

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MQKTKVLRSLVVAVVGKVTVTVETDVLVNPSDDVVEVVSRLIRFDTTNTGDPETTRGEAECAQWVASQLAEVGYQPEYLE
SGAPGRGNVFARLAGEDSSRGALLIHGHLDVVPAETAEWSVHPFSGAVEGGQVWGRGAIDMKDMVGMMIVVARQLKQAGI
APPRDLVFAFVADEEHGGSYGSQWLVDNRPDLFDGVTEAIGEVGGFSLTVPCRNGGERRLYLIETAEKGMQWMRLTARGR
AGHGSMVHNQNAVTAVAEAVARLGRHQFPLVTTDTVVQFLAAISEETGLEFDIGSPDLEGAIEKLGPMARMLKAVLYDTA
NPTVLKAGYKVNVVPATAEAMVDCRILPGRQAAFEAAIDELIGPDVTREWIKDLPPYETAFDGDLVDAMNAAVLAVDPDG
RTVPYMASGGTDAKAFARLGIRCFGFTPLRLPPELDFTALFHGVDERVSIDALKFGIDVLAHFLTHC

Sequences:

>Translated_467_residues
MQKTKVLRSLVVAVVGKVTVTVETDVLVNPSDDVVEVVSRLIRFDTTNTGDPETTRGEAECAQWVASQLAEVGYQPEYLE
SGAPGRGNVFARLAGEDSSRGALLIHGHLDVVPAETAEWSVHPFSGAVEGGQVWGRGAIDMKDMVGMMIVVARQLKQAGI
APPRDLVFAFVADEEHGGSYGSQWLVDNRPDLFDGVTEAIGEVGGFSLTVPCRNGGERRLYLIETAEKGMQWMRLTARGR
AGHGSMVHNQNAVTAVAEAVARLGRHQFPLVTTDTVVQFLAAISEETGLEFDIGSPDLEGAIEKLGPMARMLKAVLYDTA
NPTVLKAGYKVNVVPATAEAMVDCRILPGRQAAFEAAIDELIGPDVTREWIKDLPPYETAFDGDLVDAMNAAVLAVDPDG
RTVPYMASGGTDAKAFARLGIRCFGFTPLRLPPELDFTALFHGVDERVSIDALKFGIDVLAHFLTHC
>Mature_467_residues
MQKTKVLRSLVVAVVGKVTVTVETDVLVNPSDDVVEVVSRLIRFDTTNTGDPETTRGEAECAQWVASQLAEVGYQPEYLE
SGAPGRGNVFARLAGEDSSRGALLIHGHLDVVPAETAEWSVHPFSGAVEGGQVWGRGAIDMKDMVGMMIVVARQLKQAGI
APPRDLVFAFVADEEHGGSYGSQWLVDNRPDLFDGVTEAIGEVGGFSLTVPCRNGGERRLYLIETAEKGMQWMRLTARGR
AGHGSMVHNQNAVTAVAEAVARLGRHQFPLVTTDTVVQFLAAISEETGLEFDIGSPDLEGAIEKLGPMARMLKAVLYDTA
NPTVLKAGYKVNVVPATAEAMVDCRILPGRQAAFEAAIDELIGPDVTREWIKDLPPYETAFDGDLVDAMNAAVLAVDPDG
RTVPYMASGGTDAKAFARLGIRCFGFTPLRLPPELDFTALFHGVDERVSIDALKFGIDVLAHFLTHC

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=389, Percent_Identity=28.7917737789203, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI4501901, Length=398, Percent_Identity=25.8793969849246, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193211059, Length=190, Percent_Identity=28.9473684210526, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322289, Length=410, Percent_Identity=22.1951219512195, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24649206, Length=415, Percent_Identity=26.5060240963855, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24649210, Length=420, Percent_Identity=25, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24649202, Length=414, Percent_Identity=26.3285024154589, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24649204, Length=414, Percent_Identity=26.3285024154589, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24649208, Length=397, Percent_Identity=26.7002518891688, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24649212, Length=419, Percent_Identity=24.1050119331742, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 50231; Mature: 50231

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKTKVLRSLVVAVVGKVTVTVETDVLVNPSDDVVEVVSRLIRFDTTNTGDPETTRGEAE
CCHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
CAQWVASQLAEVGYQPEYLESGAPGRGNVFARLAGEDSSRGALLIHGHLDVVPAETAEWS
HHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEEEECCCCCCCEEEEECCEEEECCCCCCCE
VHPFSGAVEGGQVWGRGAIDMKDMVGMMIVVARQLKQAGIAPPRDLVFAFVADEEHGGSY
ECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEECCCCCCCC
GSQWLVDNRPDLFDGVTEAIGEVGGFSLTVPCRNGGERRLYLIETAEKGMQWMRLTARGR
CCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECHHHCHHHHHHHHCCC
AGHGSMVHNQNAVTAVAEAVARLGRHQFPLVTTDTVVQFLAAISEETGLEFDIGSPDLEG
CCCCCCEECCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCHHH
AIEKLGPMARMLKAVLYDTANPTVLKAGYKVNVVPATAEAMVDCRILPGRQAAFEAAIDE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHEEEEECCCCHHHHHHHHHH
LIGPDVTREWIKDLPPYETAFDGDLVDAMNAAVLAVDPDGRTVPYMASGGTDAKAFARLG
HHCCHHHHHHHHCCCCCCCCCCCCHHHHCCCEEEEECCCCCEECEEECCCCCHHHHHHHC
IRCFGFTPLRLPPELDFTALFHGVDERVSIDALKFGIDVLAHFLTHC
CEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQKTKVLRSLVVAVVGKVTVTVETDVLVNPSDDVVEVVSRLIRFDTTNTGDPETTRGEAE
CCHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
CAQWVASQLAEVGYQPEYLESGAPGRGNVFARLAGEDSSRGALLIHGHLDVVPAETAEWS
HHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEEEECCCCCCCEEEEECCEEEECCCCCCCE
VHPFSGAVEGGQVWGRGAIDMKDMVGMMIVVARQLKQAGIAPPRDLVFAFVADEEHGGSY
ECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEECCCCCCCC
GSQWLVDNRPDLFDGVTEAIGEVGGFSLTVPCRNGGERRLYLIETAEKGMQWMRLTARGR
CCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECHHHCHHHHHHHHCCC
AGHGSMVHNQNAVTAVAEAVARLGRHQFPLVTTDTVVQFLAAISEETGLEFDIGSPDLEG
CCCCCCEECCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCHHH
AIEKLGPMARMLKAVLYDTANPTVLKAGYKVNVVPATAEAMVDCRILPGRQAAFEAAIDE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHEEEEECCCCHHHHHHHHHH
LIGPDVTREWIKDLPPYETAFDGDLVDAMNAAVLAVDPDGRTVPYMASGGTDAKAFARLG
HHCCHHHHHHHHCCCCCCCCCCCCHHHHCCCEEEEECCCCCEECEEECCCCCHHHHHHHC
IRCFGFTPLRLPPELDFTALFHGVDERVSIDALKFGIDVLAHFLTHC
CEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]