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The map label for this gene is trpC [H]

Identifier: 221230130

GI number: 221230130

Start: 1514524

End: 1515342

Strand: Direct

Name: trpC [H]

Synonym: MLBr_01271

Alternate gene names: 221230130

Gene position: 1514524-1515342 (Clockwise)

Preceding gene: 221230129

Following gene: 221230131

Centisome position: 46.34

GC content: 60.56

Gene sequence:

>819_bases
ATGTGTCCGGCAACTGTGCTTGACTCCATTCTAAAGGGAGTCCGGGCCGACGTTGCCGCACGCGAAGCCTGCATCAGCCT
GTCCGAAATCAAAGCCGCCGCCGCGGCCGCACCAGCACCGCTGGACGCTATGGCCGCTTTACGTGAGCCCGGTATTGGTG
TTATCGCCGAGGTCAAGCGCGCCAGTCCATCGGTGGGCTCATTGGCCACCATCGCTGATCCGGCAAAGCTGGCCCAGGCC
TACGAGGACGGCGGTGCTCGGATCATCAGCGTTTTGACCGAGGAACGTCGCTTTAACGGTTCACTCGACGATCTCGATGC
AGTGCGCGCCGCGGTTTCAGTACCGGTGTTGCGCAAAGACTTTGTGGTGCAGCCATATCAGATCCATGAGGCGCGCGCGC
ACGGTGCCGATATGTTGTTGTTGATCGTTGCTGCGTTGGACCAATCGGCGTTGATGTCTATGCTGGACCGCACCGAATCA
CTTGGTATGATTGCTCTCGTTGAAGTCCGCACGGAACAGGAAGCGGACCGGGCCCTAAAGGCAGGGGCCAAGGTGATAGG
TGTAAACGCTCGCGATTTAATGACGTTGGAAGTGGACCGGGATTGCTTCTCGCGAATTGCTCCTGGGTTGCCGAGTAACG
TGATCAGGATCGCCGAATCCGGTGTACGTGGCCCCGCGGATCTGTTGGCTTACGCTGGTGCGGGAGCGGACGCCGTGTTG
GTCGGCGAAGGCCTGGTGAAAAGTGGTGACCCGCGGGCAGCGGTTGCCGATCTGGTCACCGCGGGTACCCACCCGTCATG
CCCAAAACCGGCTCGCTAG

Upstream 100 bases:

>100_bases
TGTCGACGGTCGCTACCCTTCATGAACGTCGTCGAAATCGGCGGGTGTACCGGTTCGGTAGCCGGTCGGTGGGTGACAAG
CGGGAAAGGAAACGACACGC

Downstream 100 bases:

>100_bases
TCATTCGACAAGATGCAGTGGTGAAACATTGAACGCTATCAGCCGACTGCCCGTTGAGTTCCGGTGATGCCGAATCTATC
CTGTTTTAGCGTGGCCATCT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MCPATVLDSILKGVRADVAAREACISLSEIKAAAAAAPAPLDAMAALREPGIGVIAEVKRASPSVGSLATIADPAKLAQA
YEDGGARIISVLTEERRFNGSLDDLDAVRAAVSVPVLRKDFVVQPYQIHEARAHGADMLLLIVAALDQSALMSMLDRTES
LGMIALVEVRTEQEADRALKAGAKVIGVNARDLMTLEVDRDCFSRIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVL
VGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR

Sequences:

>Translated_272_residues
MCPATVLDSILKGVRADVAAREACISLSEIKAAAAAAPAPLDAMAALREPGIGVIAEVKRASPSVGSLATIADPAKLAQA
YEDGGARIISVLTEERRFNGSLDDLDAVRAAVSVPVLRKDFVVQPYQIHEARAHGADMLLLIVAALDQSALMSMLDRTES
LGMIALVEVRTEQEADRALKAGAKVIGVNARDLMTLEVDRDCFSRIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVL
VGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR
>Mature_272_residues
MCPATVLDSILKGVRADVAAREACISLSEIKAAAAAAPAPLDAMAALREPGIGVIAEVKRASPSVGSLATIADPAKLAQA
YEDGGARIISVLTEERRFNGSLDDLDAVRAAVSVPVLRKDFVVQPYQIHEARAHGADMLLLIVAALDQSALMSMLDRTES
LGMIALVEVRTEQEADRALKAGAKVIGVNARDLMTLEVDRDCFSRIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVL
VGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=218, Percent_Identity=38.5321100917431, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322638, Length=213, Percent_Identity=43.6619718309859, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28146; Mature: 28146

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCPATVLDSILKGVRADVAAREACISLSEIKAAAAAAPAPLDAMAALREPGIGVIAEVKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHH
ASPSVGSLATIADPAKLAQAYEDGGARIISVLTEERRFNGSLDDLDAVRAAVSVPVLRKD
CCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHH
FVVQPYQIHEARAHGADMLLLIVAALDQSALMSMLDRTESLGMIALVEVRTEQEADRALK
HCCCCHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHH
AGAKVIGVNARDLMTLEVDRDCFSRIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVL
CCCEEEECCCHHEEEEEECHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCEEE
VGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR
ECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MCPATVLDSILKGVRADVAAREACISLSEIKAAAAAAPAPLDAMAALREPGIGVIAEVKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHH
ASPSVGSLATIADPAKLAQAYEDGGARIISVLTEERRFNGSLDDLDAVRAAVSVPVLRKD
CCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHH
FVVQPYQIHEARAHGADMLLLIVAALDQSALMSMLDRTESLGMIALVEVRTEQEADRALK
HCCCCHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHH
AGAKVIGVNARDLMTLEVDRDCFSRIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVL
CCCEEEECCCHHEEEEEECHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCEEE
VGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR
ECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA