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The map label for this gene is hisD

Identifier: 221230120

GI number: 221230120

Start: 1502321

End: 1503670

Strand: Direct

Name: hisD

Synonym: MLBr_01257

Alternate gene names: 221230120

Gene position: 1502321-1503670 (Clockwise)

Preceding gene: 221230119

Following gene: 221230121

Centisome position: 45.97

GC content: 63.78

Gene sequence:

>1350_bases
GTGAGCATCACGCCACCATTCCTGCTAGCCTGCATTGATCTGCGGGGAGCTGAGTTGACGGCTACCCAGTTGCGGGCCAC
GCTGCCGCGCGGTGGCGCCGACGTGGAGGCTGTGCTGCCTACGGTGTGGCCGATCGTGCAGGCCGTCGCCGAGTGCGGGG
CCGATGCGGCTTTGGAATTCGGGGCGTTATTCGACGGCGTGCGGCCCCCGACTGTCCGGGTGCCCGACGCCGCGCTGGAC
GCCGCGCTGGCAGGATTGGACCCCGATGTCCGCGACGCGTTGCAGGTGATGATCGAGCGGACCCGCGTTGTGCATGCCGA
CCAGCGCCGCACCGACGTCACTACCGCGCTCGGCCCGGGTGCGACGGTCACCGAACGGTGGGTTCCCGTTGAGCGGGTGG
GCCTTTATGTACCCGGCGGCAATGCGGTGTACCCGTCCAGCGTGGTGATGAACGTGGTGCCGGCACAGACCGCGGGTGTC
GATTCCCTGGTGGTGGCCAGCCCTCCGCAGTTCACTTCCGGTGGCCGGTTTCACGGACTGCCGCATCCGACGATTCTGGC
CGCGGCACGGCTACTGGGAGTTGACGAAGTCTGGGCCGTCGGCGGGGCACAGGCAGTGGCGTTGCTTGCTTACGGAGGCA
CCGATAGTGACGATTGCGAGCTGGCACCGGTCGACATGATCACCGGGCCAGGCAATATCTACGTCACTGCCGCCAAGCGG
TTATGTCGCTCTCGGGTGGGTATCGACGGCGAGGCCGGTCCGACCGAGATTGCCATCCTCGCCGACCATACCGCAGATCC
AGCACATGTGGCTGCCGACATGATCAGCCAGGCCGAACATGACGAAATGGCTGCCAGTGTATTGGTGACCCCAAGTACGG
ATCTGGCTGATGCCACCGACGCCGAATTGGCTGCCCAGCTGCGGACCACGGTGCATCGGAAACGGGTGGTGGCAGCACTA
GGAGGACGCCAGTCAGCTATCATTTTGGTCGACGATCTGGAGGCTGGTGTCAAAGTTGTCAATCTCTACGCAGCTGAACA
TCTGGAGATCCAGACTGCTGAAGCTTCACGAGTCGCGAGCAGAATACGTTGTGCAGGAGCTATTTTCGTTGGCCCGTGGG
CACCGGTCAGCCTCGGTGACTACTGCGCTGGGTCCAACCACGTATTGCCGACCGCGGGCTTTGCCCGGCATTCCGGCGGC
CTGTCAGTGCAGACCTTCCTGCGTGGCATCCATGTTGTCAACTACACCAAGACGGCTCTCAAAGACATATCCGGACACGT
TATCACGTTGGCCAAAGCCGAAGACCTGCCGGCGCATGGGGAGGCGGTACGGCGGAGATTCGCGCGATGA

Upstream 100 bases:

>100_bases
GCGGCCATGTCAGCCAAGTGGAGACAAACGCGGTGCAGGCTTGTTAGTGGCACTGTACCGGCCGGCTATCGACTCGAGCT
GCTCTGGGACAATGGTCGTT

Downstream 100 bases:

>100_bases
ATGTACCTGAGCCCACACTCGACGATCTGCCGTTGCGCGATAATCTTCGCGGCAAATCACCTTATGGTGCAATGCAATTG
CTGGTTCCAGTGCTACTGAA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPIVQAVAECGADAALEFGALFDGVRPPTVRVPDAALD
AALAGLDPDVRDALQVMIERTRVVHADQRRTDVTTALGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGV
DSLVVASPPQFTSGGRFHGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDSDDCELAPVDMITGPGNIYVTAAKR
LCRSRVGIDGEAGPTEIAILADHTADPAHVAADMISQAEHDEMAASVLVTPSTDLADATDAELAAQLRTTVHRKRVVAAL
GGRQSAIILVDDLEAGVKVVNLYAAEHLEIQTAEASRVASRIRCAGAIFVGPWAPVSLGDYCAGSNHVLPTAGFARHSGG
LSVQTFLRGIHVVNYTKTALKDISGHVITLAKAEDLPAHGEAVRRRFAR

Sequences:

>Translated_449_residues
MSITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPIVQAVAECGADAALEFGALFDGVRPPTVRVPDAALD
AALAGLDPDVRDALQVMIERTRVVHADQRRTDVTTALGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGV
DSLVVASPPQFTSGGRFHGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDSDDCELAPVDMITGPGNIYVTAAKR
LCRSRVGIDGEAGPTEIAILADHTADPAHVAADMISQAEHDEMAASVLVTPSTDLADATDAELAAQLRTTVHRKRVVAAL
GGRQSAIILVDDLEAGVKVVNLYAAEHLEIQTAEASRVASRIRCAGAIFVGPWAPVSLGDYCAGSNHVLPTAGFARHSGG
LSVQTFLRGIHVVNYTKTALKDISGHVITLAKAEDLPAHGEAVRRRFAR
>Mature_448_residues
SITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPIVQAVAECGADAALEFGALFDGVRPPTVRVPDAALDA
ALAGLDPDVRDALQVMIERTRVVHADQRRTDVTTALGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGVD
SLVVASPPQFTSGGRFHGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDSDDCELAPVDMITGPGNIYVTAAKRL
CRSRVGIDGEAGPTEIAILADHTADPAHVAADMISQAEHDEMAASVLVTPSTDLADATDAELAAQLRTTVHRKRVVAALG
GRQSAIILVDDLEAGVKVVNLYAAEHLEIQTAEASRVASRIRCAGAIFVGPWAPVSLGDYCAGSNHVLPTAGFARHSGGL
SVQTFLRGIHVVNYTKTALKDISGHVITLAKAEDLPAHGEAVRRRFAR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=435, Percent_Identity=36.551724137931, Blast_Score=233, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319819, Length=425, Percent_Identity=35.7647058823529, Blast_Score=236, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_MYCLE (Q9CC57)

Other databases:

- EMBL:   AL049913
- EMBL:   AL583921
- PIR:   C87066
- PIR:   T45246
- RefSeq:   NP_301906.1
- ProteinModelPortal:   Q9CC57
- SMR:   Q9CC57
- EnsemblBacteria:   EBMYCT00000027981
- GeneID:   910363
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1257
- NMPDR:   fig|272631.1.peg.778
- Leproma:   ML1257
- GeneTree:   EBGT00050000017368
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- ProtClustDB:   PRK00877
- BioCyc:   MLEP272631:ML1257-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46829; Mature: 46698

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 346-346 ACT_SITE 347-347 BINDING 136-136 BINDING 204-204 BINDING 232-232 BINDING 255-255 BINDING 277-277 BINDING 280-280 BINDING 347-347 BINDING 380-380 BINDING 434-434 BINDING 439-439

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPIVQAVAECGADAALEF
CCCCCCHHHHEECCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
GALFDGVRPPTVRVPDAALDAALAGLDPDVRDALQVMIERTRVVHADQRRTDVTTALGPG
HHHHCCCCCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCC
ATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSLVVASPPQFTSGGRFHGL
CCHHHCCCCHHHEEEEECCCCCCCCCHHHEEECCCCCCCCCEEEEECCCCCCCCCCCCCC
PHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDSDDCELAPVDMITGPGNIYVTAAKR
CCHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCCCCCEEECEEEEECCCCEEEHHHHH
LCRSRVGIDGEAGPTEIAILADHTADPAHVAADMISQAEHDEMAASVLVTPSTDLADATD
HHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCH
AELAAQLRTTVHRKRVVAALGGRQSAIILVDDLEAGVKVVNLYAAEHLEIQTAEASRVAS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEEEHHCEEEEEHHHHHHHH
RIRCAGAIFVGPWAPVSLGDYCAGSNHVLPTAGFARHSGGLSVQTFLRGIHVVNYTKTAL
HHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHEEEHHHHHH
KDISGHVITLAKAEDLPAHGEAVRRRFAR
HHCCCCEEEEEECCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPIVQAVAECGADAALEF
CCCCCHHHHEECCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
GALFDGVRPPTVRVPDAALDAALAGLDPDVRDALQVMIERTRVVHADQRRTDVTTALGPG
HHHHCCCCCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCC
ATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSLVVASPPQFTSGGRFHGL
CCHHHCCCCHHHEEEEECCCCCCCCCHHHEEECCCCCCCCCEEEEECCCCCCCCCCCCCC
PHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDSDDCELAPVDMITGPGNIYVTAAKR
CCHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCCCCCEEECEEEEECCCCEEEHHHHH
LCRSRVGIDGEAGPTEIAILADHTADPAHVAADMISQAEHDEMAASVLVTPSTDLADATD
HHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCH
AELAAQLRTTVHRKRVVAALGGRQSAIILVDDLEAGVKVVNLYAAEHLEIQTAEASRVAS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEEEHHCEEEEEHHHHHHHH
RIRCAGAIFVGPWAPVSLGDYCAGSNHVLPTAGFARHSGGLSVQTFLRGIHVVNYTKTAL
HHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHEEEHHHHHH
KDISGHVITLAKAEDLPAHGEAVRRRFAR
HHCCCCEEEEEECCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002