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The map label for this gene is hisC

Identifier: 221230121

GI number: 221230121

Start: 1503667

End: 1504800

Strand: Direct

Name: hisC

Synonym: MLBr_01258

Alternate gene names: 221230121

Gene position: 1503667-1504800 (Clockwise)

Preceding gene: 221230120

Following gene: 221230122

Centisome position: 46.01

GC content: 58.11

Gene sequence:

>1134_bases
ATGAATGTACCTGAGCCCACACTCGACGATCTGCCGTTGCGCGATAATCTTCGCGGCAAATCACCTTATGGTGCAATGCA
ATTGCTGGTTCCAGTGCTACTGAACACCAACGAGAACCCGCACCCACCCACCAAGGCGTTGGTCGACGACGTGGTGCGGT
CAGTGCAAAAGGTGGCAGTCGACTTGCATCGCTACCCTGATCGCGATGCGGTGGCACTGCGTCAGGACTTGGCCTCCTAC
CTCACCGCGCAGACCGGTATCCGGCTTGGTGTCGAAAACATTTGGGCTGCCAATGGCTCCAACGAGATTCTGCAGCAGCT
TCTGCAGGCGTTCGGTGGTCCGGGGCGCAGTGCGATCGGCTTTGTCCCGTCCTATTCGATGCACCCTATAATCGCTGACG
GCACTCACACCGAGTGGCTAGAGACCGTTCGTGCTGACGATTTCAGCCTCGATGTCGAGGCCGCTGTCACCGCCGTCGCT
GACCGCAAGCCCGATGTAGTGTTTATAGCCAGCCCCAATAACCCTTCTGGGCAGAGTATTTCGTTGGCTGATTTACGGAG
GCTACTCGACGTGGTGCCGGGGATCTTGATTGTCGACGAGGCTTATGGCGAATTTTCCTCGCGTCCCAGCGCAGTGGCGC
TGGTAGGTGAGTATCCGACCAAAATCGTTGTTACCCGCACCACGAGTAAGGCATTTGCCTTCGCCGGCGGCAGGCTTGGA
TATTTGATCGCGACGCCTGCGCTGGTGGAAGCGATGTTGCTGGTGCGGTTGCCGTATCACCTATCATCGGTCACTCAGGC
GGCGGCCCGAGCGGCACTCCGGCACGCTGATGATACCCTAGGTAGTGTCGCGGCGTTGATCGCCGAACGAGAAAGGGTGA
CAAAATCTTTGGTCCACATGGGATTTCGTGTAATCCCTAGCGACGCAAACTTCGTGCTATTCGGACACTTCTCCGACGCG
GCTGGCGCTTGGCAGCATTATTTGGACACCGGTGTGCTGATCCGCGATGTCGGTATTCCCGGTTACCTGCGCGCTACCAC
GGGTTTGGCCGAAGAGAACGACGCGTTCCTTAAAGCCAGCTCCGAGATAGCTGCCACCGAATTGGCCCCAGCCACCACAC
TAGGAGCCTCGTGA

Upstream 100 bases:

>100_bases
CCAAGACGGCTCTCAAAGACATATCCGGACACGTTATCACGTTGGCCAAAGCCGAAGACCTGCCGGCGCATGGGGAGGCG
GTACGGCGGAGATTCGCGCG

Downstream 100 bases:

>100_bases
CCAACACCGAAGTAGGGAAAACAACGCGTCGTGCGCGTATTGAACGCCGCACCAGCGAATCTGATATCGTCGTTGAACTC
GACCTGGACGGCACCGGGCA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MNVPEPTLDDLPLRDNLRGKSPYGAMQLLVPVLLNTNENPHPPTKALVDDVVRSVQKVAVDLHRYPDRDAVALRQDLASY
LTAQTGIRLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIIADGTHTEWLETVRADDFSLDVEAAVTAVA
DRKPDVVFIASPNNPSGQSISLADLRRLLDVVPGILIVDEAYGEFSSRPSAVALVGEYPTKIVVTRTTSKAFAFAGGRLG
YLIATPALVEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVTKSLVHMGFRVIPSDANFVLFGHFSDA
AGAWQHYLDTGVLIRDVGIPGYLRATTGLAEENDAFLKASSEIAATELAPATTLGAS

Sequences:

>Translated_377_residues
MNVPEPTLDDLPLRDNLRGKSPYGAMQLLVPVLLNTNENPHPPTKALVDDVVRSVQKVAVDLHRYPDRDAVALRQDLASY
LTAQTGIRLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIIADGTHTEWLETVRADDFSLDVEAAVTAVA
DRKPDVVFIASPNNPSGQSISLADLRRLLDVVPGILIVDEAYGEFSSRPSAVALVGEYPTKIVVTRTTSKAFAFAGGRLG
YLIATPALVEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVTKSLVHMGFRVIPSDANFVLFGHFSDA
AGAWQHYLDTGVLIRDVGIPGYLRATTGLAEENDAFLKASSEIAATELAPATTLGAS
>Mature_377_residues
MNVPEPTLDDLPLRDNLRGKSPYGAMQLLVPVLLNTNENPHPPTKALVDDVVRSVQKVAVDLHRYPDRDAVALRQDLASY
LTAQTGIRLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIIADGTHTEWLETVRADDFSLDVEAAVTAVA
DRKPDVVFIASPNNPSGQSISLADLRRLLDVVPGILIVDEAYGEFSSRPSAVALVGEYPTKIVVTRTTSKAFAFAGGRLG
YLIATPALVEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVTKSLVHMGFRVIPSDANFVLFGHFSDA
AGAWQHYLDTGVLIRDVGIPGYLRATTGLAEENDAFLKASSEIAATELAPATTLGAS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=373, Percent_Identity=31.3672922252011, Blast_Score=147, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6322075, Length=359, Percent_Identity=29.5264623955432, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_MYCLB (B8ZRB0)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503537.1
- ProteinModelPortal:   B8ZRB0
- SMR:   B8ZRB0
- EnsemblBacteria:   EBMYCT00000087006
- GeneID:   7324682
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00070000031717
- HOGENOM:   HBG646350
- OMA:   NQAQTDY
- ProtClustDB:   PRK03317
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40351; Mature: 40351

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVPEPTLDDLPLRDNLRGKSPYGAMQLLVPVLLNTNENPHPPTKALVDDVVRSVQKVAV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
DLHRYPDRDAVALRQDLASYLTAQTGIRLGVENIWAANGSNEILQQLLQAFGGPGRSAIG
HHHCCCCHHHHHHHHHHHHHHHHHHCHHCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCEE
FVPSYSMHPIIADGTHTEWLETVRADDFSLDVEAAVTAVADRKPDVVFIASPNNPSGQSI
CCCCCCCCCEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEE
SLADLRRLLDVVPGILIVDEAYGEFSSRPSAVALVGEYPTKIVVTRTTSKAFAFAGGRLG
EHHHHHHHHHHCCCEEEEECCHHHCCCCCCEEEEEECCCCEEEEEECCCCHHEECCCCEE
YLIATPALVEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVTKSLVHM
HEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFRVIPSDANFVLFGHFSDAAGAWQHYLDTGVLIRDVGIPGYLRATTGLAEENDAFLKAS
CCEEEECCCCEEEEECCCCHHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCCHHEECC
SEIAATELAPATTLGAS
CCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNVPEPTLDDLPLRDNLRGKSPYGAMQLLVPVLLNTNENPHPPTKALVDDVVRSVQKVAV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
DLHRYPDRDAVALRQDLASYLTAQTGIRLGVENIWAANGSNEILQQLLQAFGGPGRSAIG
HHHCCCCHHHHHHHHHHHHHHHHHHCHHCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCEE
FVPSYSMHPIIADGTHTEWLETVRADDFSLDVEAAVTAVADRKPDVVFIASPNNPSGQSI
CCCCCCCCCEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEE
SLADLRRLLDVVPGILIVDEAYGEFSSRPSAVALVGEYPTKIVVTRTTSKAFAFAGGRLG
EHHHHHHHHHHCCCEEEEECCHHHCCCCCCEEEEEECCCCEEEEEECCCCHHEECCCCEE
YLIATPALVEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVTKSLVHM
HEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFRVIPSDANFVLFGHFSDAAGAWQHYLDTGVLIRDVGIPGYLRATTGLAEENDAFLKAS
CCEEEECCCCEEEEECCCCHHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCCHHEECC
SEIAATELAPATTLGAS
CCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA