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The map label for this gene is hemY

Identifier: 221229984

GI number: 221229984

Start: 1209327

End: 1210682

Strand: Direct

Name: hemY

Synonym: MLBr_01044

Alternate gene names: 221229984

Gene position: 1209327-1210682 (Clockwise)

Preceding gene: 221229983

Following gene: 221229985

Centisome position: 37.0

GC content: 66.52

Gene sequence:

>1356_bases
ATGACATCCCGCTCGTATTGTGTTGTGGGTGGCGGAATCTCGGGACTTACGGCGGCATATCGGTTAAGGGTGGCTACGGG
TGACGATGTTGCTATCACTTTGTTCGATCCTGGTGACCGACTCGGCGGGGTGTTGCGCACCGAGTGCGTAGGCGGACAGC
CGATGGACTTGGGCGCCGAGGCATTCTTGCTGCGCCGTCCCGAGGTGCCGGCGTTGCTGGCCGAGTTGGGTTTGTCAGAG
CGCCAACGCGCCACCACCGATGCCCGACCATTGATCTACAGCCAGCAACGGCTGCATTCGTTGCCACCGGACACCGTCGC
CGGCATTCCGTCCTCGGCGACGTCGGTGGCCGGCTTGGTCGACGACGCCACAGTTGCGCGTATCGGCGCCGAAGCTGTCC
GTCCGCTGAGCTGGGAACCCGGCAGCGATCCCGCGATGGCCGAATTAGTGGCCGACCGGTTCGGCGAGCAGGCCGTGGCC
CGGTTGGTGGACCCGCTGTTGGGCGGCGTCTATGCTGGCTCGGCAGCGACGATCGGGCTGCGCGCGGGCGCCCCGAGTGT
GGCGGCTGCCCTCGACTGCGGGGCCACCAGTTTGATGGAGGCGGTTCGACAGGGGTTGCCGCCGGTAGCGGCCGGGCCGG
TTTTTGGAGCGCTAGACGGCGGCTACCAGGTGCTGATCGACGAGCTCGTCCGCCGCAGCCGACTGCAGTGGGTAGCTGCC
ACCGTGGTAGGGCTCGATCGTGGGACTTGCGGTTGGACGCTAGTGGACGACACCGGTGCTTGCTGGTCCGCCGACGGGGT
TATCCTGGCCGTTCCCGCCCCACGGCTCGTGCGCCTGTTGCAGCAGATCGCCCCCCGAACAGTCGCCGCCGCAAGCCGGA
TCGTGAGTGCCTCGTCGGCGGTGGTGGCACTGTCGGTGCCCCGGGACACCACATTCCCGCAGAATTCCGGTGTGTTGGTG
GCTAGCGGCGAGCGGCTGCGAGCTAAAGCGGTCACGTTGTCCTCACGAAAGTGGGGGCTTCAAGGGGACACACAGTTGGT
GCGGCTTTCGTTCGGGAAGTTTGGTGATCAGGTGGCCTCGACTGCCTCGGACGATGAGCTGCTGGCTTGGGCGGTGTCCG
ACCTGGCCGCGGTATTCGATGTGACCGTCGACCCCGTCGATGTATGCGTGCAGCGGTGGATCGACGCAATGCCGCAGTAT
GGCCCCGGTCACGCCGATCTGGTCGCCGAGGTGCGCGCCGGCTTGCCGCCGACGCTGGTCGTGGCTGGCAGCCATATGGA
CGGTATTGGTGTGCCTGCGTGTATCAGCGCTGCCGGGCGCGCGATCGAGGCCCTCCAAGCGGAAGTGGCACGATAA

Upstream 100 bases:

>100_bases
TGGCCGGCGCGGCTGGCCACGTTTTCAATCTCGGCCATGGAGTGTTGCCGGAGACCGATCCCGGCGTGCTGAGCGAATTA
GTATCGTTCATCCACTCGCT

Downstream 100 bases:

>100_bases
GTTTCATGGCCAAACTTGACTACAATACCCTGAACTCGACGATTCGTTACCTGATGTTCTCGGTGTTCTCGGTGCGGCCT
GGTGTTCTCGGTGCTCAGCG

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVLRTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSE
RQRATTDARPLIYSQQRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAEAVRPLSWEPGSDPAMAELVADRFGEQAVA
RLVDPLLGGVYAGSAATIGLRAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELVRRSRLQWVAA
TVVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQQIAPRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLV
ASGERLRAKAVTLSSRKWGLQGDTQLVRLSFGKFGDQVASTASDDELLAWAVSDLAAVFDVTVDPVDVCVQRWIDAMPQY
GPGHADLVAEVRAGLPPTLVVAGSHMDGIGVPACISAAGRAIEALQAEVAR

Sequences:

>Translated_451_residues
MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVLRTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSE
RQRATTDARPLIYSQQRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAEAVRPLSWEPGSDPAMAELVADRFGEQAVA
RLVDPLLGGVYAGSAATIGLRAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELVRRSRLQWVAA
TVVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQQIAPRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLV
ASGERLRAKAVTLSSRKWGLQGDTQLVRLSFGKFGDQVASTASDDELLAWAVSDLAAVFDVTVDPVDVCVQRWIDAMPQY
GPGHADLVAEVRAGLPPTLVVAGSHMDGIGVPACISAAGRAIEALQAEVAR
>Mature_450_residues
TSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVLRTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSER
QRATTDARPLIYSQQRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAEAVRPLSWEPGSDPAMAELVADRFGEQAVAR
LVDPLLGGVYAGSAATIGLRAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELVRRSRLQWVAAT
VVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQQIAPRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLVA
SGERLRAKAVTLSSRKWGLQGDTQLVRLSFGKFGDQVASTASDDELLAWAVSDLAAVFDVTVDPVDVCVQRWIDAMPQYG
PGHADLVAEVRAGLPPTLVVAGSHMDGIGVPACISAAGRAIEALQAEVAR

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPOX_MYCLE (Q50008)

Other databases:

- EMBL:   U15181
- EMBL:   AL583920
- PIR:   F87039
- RefSeq:   NP_301770.1
- ProteinModelPortal:   Q50008
- SMR:   Q50008
- EnsemblBacteria:   EBMYCT00000028575
- GeneID:   910131
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1044
- NMPDR:   fig|272631.1.peg.642
- Leproma:   ML1044
- GeneTree:   EBGT00050000016546
- HOGENOM:   HBG450176
- OMA:   ATHDALI
- ProtClustDB:   PRK11883
- BioCyc:   MLEP272631:ML1044-MONOMER
- BRENDA:   1.3.3.4
- GO:   GO:0005737
- InterPro:   IPR002937
- InterPro:   IPR004572
- TIGRFAMs:   TIGR00562

Pfam domain/function: PF01593 Amino_oxidase

EC number: =1.3.3.4

Molecular weight: Translated: 46581; Mature: 46449

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVLRTECVGGQPMDLGAE
CCCCCEEEEECCHHHHCEEEEEEEECCCCEEEEEECCCHHHCCHHHHHHCCCCCCCCCCC
AFLLRRPEVPALLAELGLSERQRATTDARPLIYSQQRLHSLPPDTVAGIPSSATSVAGLV
EEEEECCCHHHHHHHCCCCHHHHCCCCCCCHHCCHHHHHCCCCHHHHCCCCCHHHHHHHH
DDATVARIGAEAVRPLSWEPGSDPAMAELVADRFGEQAVARLVDPLLGGVYAGSAATIGL
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
RAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELVRRSRLQWVAA
ECCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TVVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQQIAPRTVAAASRIVSASSA
HHHCCCCCCCCEEEEECCCCEECCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCE
VVALSVPRDTTFPQNSGVLVASGERLRAKAVTLSSRKWGLQGDTQLVRLSFGKFGDQVAS
EEEEECCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHC
TASDDELLAWAVSDLAAVFDVTVDPVDVCVQRWIDAMPQYGPGHADLVAEVRAGLPPTLV
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEE
VAGSHMDGIGVPACISAAGRAIEALQAEVAR
EECCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVLRTECVGGQPMDLGAE
CCCCEEEEECCHHHHCEEEEEEEECCCCEEEEEECCCHHHCCHHHHHHCCCCCCCCCCC
AFLLRRPEVPALLAELGLSERQRATTDARPLIYSQQRLHSLPPDTVAGIPSSATSVAGLV
EEEEECCCHHHHHHHCCCCHHHHCCCCCCCHHCCHHHHHCCCCHHHHCCCCCHHHHHHHH
DDATVARIGAEAVRPLSWEPGSDPAMAELVADRFGEQAVARLVDPLLGGVYAGSAATIGL
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
RAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELVRRSRLQWVAA
ECCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TVVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQQIAPRTVAAASRIVSASSA
HHHCCCCCCCCEEEEECCCCEECCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCE
VVALSVPRDTTFPQNSGVLVASGERLRAKAVTLSSRKWGLQGDTQLVRLSFGKFGDQVAS
EEEEECCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHC
TASDDELLAWAVSDLAAVFDVTVDPVDVCVQRWIDAMPQYGPGHADLVAEVRAGLPPTLV
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEE
VAGSHMDGIGVPACISAAGRAIEALQAEVAR
EECCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002