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The map label for this gene is hemE

Identifier: 221229983

GI number: 221229983

Start: 1208257

End: 1209330

Strand: Direct

Name: hemE

Synonym: MLBr_01043

Alternate gene names: 221229983

Gene position: 1208257-1209330 (Clockwise)

Preceding gene: 221229980

Following gene: 221229984

Centisome position: 36.97

GC content: 61.27

Gene sequence:

>1074_bases
ATGAGTACCCGTCGCGAGCTTCTCGAATCGCCGTATCTGGCCGCGGTCAGTGGACGCAAACCCTGCCGGGTTCCGGTGTG
GTTTATGCGGCAAGCCGGCCGCTCGTTGCCTGAATACCGGGCGCTGCGCGAGCGATACAGCATGTTGGCGGCGTGCTTCG
AGCCCGAAGTGGCCTGTGAAATCACTCTGCAGCCGTTACGTCGTTACGACGTTGATGCCGCGATCTTGTTCTCAGACATC
GTGGTGCCGCTGTGCGCGGCAGGAATCGATCTGGATATTGTGCCAGATGTCGGTCCAGTGATCGGGGACCCGGTCCGGAC
TGCCACCGATATCCACGCTATGAAACCCCTTGAACCACAAGCGATTCAGCCTATTTTTCAGGCTATTTCGTTGCTGGTCG
CAGCACTGGGTGATGTTCCGCTGATCGGTTTCGCCGGTGCGCCGTTTACGCTGGCGTCCTACCTGGTCGAAGGCGGTCCT
AGTCGTAATCATCCCCGCACTAAGGCCATGATGCTGGCCGAACCTGCGAGCTGGCATACGCTGATGGATAAGCTGACCGA
TCTGACTCTTGGATTTTTGCTTGGTCAAATCGACGCCGGAGTTGATGCCATCCAGGTATTCGACTCGTGGGCGGGAACGC
TGTCCCTGTCCGATTACCGCCAGTACGTGTTGCCACATAGCGCCCGGATTTTTGCCACGGTGGCCGAACACGGGGTGCCG
ATGACGCACTTCGGGGTTGGCACCGCCGACCTGCTGGGTGCGATGTCAGCGGCTGTGCGGTCAGGCGAAAAGCCTGGGCA
CCAGGCCGTCGTCGGCGTGGATTGGCGAACCTCGTTGACCGATGCTGCTGCCCGAGTGGAACCCTGTACCGCGCTGCAGG
GCAACCTCGACCCGGTGGTGCTGTTAGCGGGCTGGCCGGCTGTCGAACGTGTCGCACGGACTGTCGTCGACGACGGGCGC
CGTGCCGTCGTGGCCGGCGCGGCTGGCCACGTTTTCAATCTCGGCCATGGAGTGTTGCCGGAGACCGATCCCGGCGTGCT
GAGCGAATTAGTATCGTTCATCCACTCGCTATGA

Upstream 100 bases:

>100_bases
TCTGGGCGCTCCTGCATGGTCATTGATGTTACGCAGCGACGTCGGATATGCGAGACCGATCGTTAGGGGCTCGACCGGTC
CCGTGGCAGTATTGAGATCG

Downstream 100 bases:

>100_bases
CATCCCGCTCGTATTGTGTTGTGGGTGGCGGAATCTCGGGACTTACGGCGGCATATCGGTTAAGGGTGGCTACGGGTGAC
GATGTTGCTATCACTTTGTT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSTRRELLESPYLAAVSGRKPCRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPEVACEITLQPLRRYDVDAAILFSDI
VVPLCAAGIDLDIVPDVGPVIGDPVRTATDIHAMKPLEPQAIQPIFQAISLLVAALGDVPLIGFAGAPFTLASYLVEGGP
SRNHPRTKAMMLAEPASWHTLMDKLTDLTLGFLLGQIDAGVDAIQVFDSWAGTLSLSDYRQYVLPHSARIFATVAEHGVP
MTHFGVGTADLLGAMSAAVRSGEKPGHQAVVGVDWRTSLTDAAARVEPCTALQGNLDPVVLLAGWPAVERVARTVVDDGR
RAVVAGAAGHVFNLGHGVLPETDPGVLSELVSFIHSL

Sequences:

>Translated_357_residues
MSTRRELLESPYLAAVSGRKPCRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPEVACEITLQPLRRYDVDAAILFSDI
VVPLCAAGIDLDIVPDVGPVIGDPVRTATDIHAMKPLEPQAIQPIFQAISLLVAALGDVPLIGFAGAPFTLASYLVEGGP
SRNHPRTKAMMLAEPASWHTLMDKLTDLTLGFLLGQIDAGVDAIQVFDSWAGTLSLSDYRQYVLPHSARIFATVAEHGVP
MTHFGVGTADLLGAMSAAVRSGEKPGHQAVVGVDWRTSLTDAAARVEPCTALQGNLDPVVLLAGWPAVERVARTVVDDGR
RAVVAGAAGHVFNLGHGVLPETDPGVLSELVSFIHSL
>Mature_356_residues
STRRELLESPYLAAVSGRKPCRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPEVACEITLQPLRRYDVDAAILFSDIV
VPLCAAGIDLDIVPDVGPVIGDPVRTATDIHAMKPLEPQAIQPIFQAISLLVAALGDVPLIGFAGAPFTLASYLVEGGPS
RNHPRTKAMMLAEPASWHTLMDKLTDLTLGFLLGQIDAGVDAIQVFDSWAGTLSLSDYRQYVLPHSARIFATVAEHGVPM
THFGVGTADLLGAMSAAVRSGEKPGHQAVVGVDWRTSLTDAAARVEPCTALQGNLDPVVLLAGWPAVERVARTVVDDGRR
AVVAGAAGHVFNLGHGVLPETDPGVLSELVSFIHSL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=363, Percent_Identity=37.1900826446281, Blast_Score=218, Evalue=8e-57,
Organism=Escherichia coli, GI2367337, Length=360, Percent_Identity=39.7222222222222, Blast_Score=223, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6320252, Length=359, Percent_Identity=33.1476323119777, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI19921920, Length=353, Percent_Identity=35.4107648725212, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI221330099, Length=353, Percent_Identity=35.4107648725212, Blast_Score=201, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_MYCLB (B8ZQX2)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503399.1
- ProteinModelPortal:   B8ZQX2
- SMR:   B8ZQX2
- EnsemblBacteria:   EBMYCT00000085504
- GeneID:   7326521
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016469
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38211; Mature: 38080

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 79-79 BINDING 154-154 BINDING 209-209 BINDING 336-336

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRRELLESPYLAAVSGRKPCRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPEVACE
CCCHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEE
ITLQPLRRYDVDAAILFSDIVVPLCAAGIDLDIVPDVGPVIGDPVRTATDIHAMKPLEPQ
EEHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHCCCCCHH
AIQPIFQAISLLVAALGDVPLIGFAGAPFTLASYLVEGGPSRNHPRTKAMMLAEPASWHT
HHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCCCCHHEEEEECCCHHHH
LMDKLTDLTLGFLLGQIDAGVDAIQVFDSWAGTLSLSDYRQYVLPHSARIFATVAEHGVP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEHHHHHHHHCCCCHHHHHHHHHCCCC
MTHFGVGTADLLGAMSAAVRSGEKPGHQAVVGVDWRTSLTDAAARVEPCTALQGNLDPVV
EEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHCCCCCCEE
LLAGWPAVERVARTVVDDGRRAVVAGAAGHVFNLGHGVLPETDPGVLSELVSFIHSL
EEECCHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STRRELLESPYLAAVSGRKPCRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPEVACE
CCHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEE
ITLQPLRRYDVDAAILFSDIVVPLCAAGIDLDIVPDVGPVIGDPVRTATDIHAMKPLEPQ
EEHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHCCCCCHH
AIQPIFQAISLLVAALGDVPLIGFAGAPFTLASYLVEGGPSRNHPRTKAMMLAEPASWHT
HHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCCCCHHEEEEECCCHHHH
LMDKLTDLTLGFLLGQIDAGVDAIQVFDSWAGTLSLSDYRQYVLPHSARIFATVAEHGVP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEHHHHHHHHCCCCHHHHHHHHHCCCC
MTHFGVGTADLLGAMSAAVRSGEKPGHQAVVGVDWRTSLTDAAARVEPCTALQGNLDPVV
EEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHCCCCCCEE
LLAGWPAVERVARTVVDDGRRAVVAGAAGHVFNLGHGVLPETDPGVLSELVSFIHSL
EEECCHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA