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The map label for this gene is hmuU [H]

Identifier: 220918708

GI number: 220918708

Start: 4036675

End: 4037721

Strand: Direct

Name: hmuU [H]

Synonym: A2cp1_3616

Alternate gene names: 220918708

Gene position: 4036675-4037721 (Clockwise)

Preceding gene: 220918707

Following gene: 220918709

Centisome position: 80.26

GC content: 78.8

Gene sequence:

>1047_bases
GTGAGCCTGACCCGGCGCACGCGGCTCGCGCTGGCGCTCGCCGCCGGCGTGCTCGCGATCGCGGTCGCCGTGGCCATCTC
CTGCGGGCTCGGCCCGCAGCCCATCTCGTTCCGGGCCGCCTGGGCCGGCGCCGATCCCGACGCGGCCATCCTGTTCGGCC
TGCGGCTGCCCCGCGCGCTGCTCGCGGCGCTGGTCGGCTGCGCGCTCGCCGCGGCGGGCACCGCGCTCCAGGCGCTGCTG
CGCAACCCGCTCGCCGAGCCGTTCGTGCTCGGGGTCTCGGGCGGCGCCGCGCTGGGCGGCTCGCTGGTGCTGGTCGCCGC
CGCGGGCGTGACCCGGCTGGCGGGCCGCGCGGGCGAGGCGCTGGGCGGGGCGCCCCCCGTGGCGGCCGGCGCGGTGGCCG
GGGCGGTCGCCGCGACCGCCATCGTGTTCGGGCTGGGCCGGATCGGCGGCCGCCTGGTGCCCGAGGCCGCGCTGCTGGTG
GGCATCGTGTTCAACGCGTTCGCCGCCGGCGTCATCACCCTGCTCAAGATGCTCGTCCCGCCGGAGCAGGCCGGCCGGCT
CATGTACTGGCTGCTCGGCGCGGTCGGCTACGAGGCGCCGGGGACGCTGGCGCTCGGCGCCGTCCTGGTGCTGCTGTCGG
TGGGCGCGCTGGTGGCGCTCTCGGCGCGGCTCAACCTGCTCACGCTCGGCGACGAGGAGGCCGCGTCGCTCGGCCTCGAC
GTGCGGCGCGACCGCGCCGCGGTGTTCTTCGCGGCGAGCGCCGCCACCGGCGCCGCGGTGGCGCTGGCCGGCATGGTGGG
GTTCGTGGGGCTGATCGTCCCGCACCTGGTCCGGCGGGTGATCGGCCCCGACCACCGGCTGCTCGTGCCGGCCTCGGCGT
TGTTCGGCGCCGCGTTCCTGGTGCTCGCGGACGCGCTGGCGCGCCTCGCGTTCCTGCCCCTCGGCACCGAGCCGCCGGTG
GGCGCCGTGACGGCGTTCCTGGGTGGACCGTTCTTCCTGTGGCTGCTGCGGCGGAGCGGGCGGCCCGAGGCGGAGGGGGC
GCGATGA

Upstream 100 bases:

>100_bases
GCGCGGTGGTGCGCCTCCCGGACGACGCCCTGCTGCGCCCCGGGCCGCGGATGATCCGCGGGCTGGAGACGCTGTTCCGC
GGGCTGCACCCGGAGGCGCG

Downstream 100 bases:

>100_bases
GCGAGCCGGCCGGCGGCGCGGGGACGGCGCCGATGGTGGAGGTGCGCGGGGTCACGTTCCGCTACGGCGCCCACGCGGCG
CTCGAGGACGTCTCGTTCTC

Product: transport system permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSLTRRTRLALALAAGVLAIAVAVAISCGLGPQPISFRAAWAGADPDAAILFGLRLPRALLAALVGCALAAAGTALQALL
RNPLAEPFVLGVSGGAALGGSLVLVAAAGVTRLAGRAGEALGGAPPVAAGAVAGAVAATAIVFGLGRIGGRLVPEAALLV
GIVFNAFAAGVITLLKMLVPPEQAGRLMYWLLGAVGYEAPGTLALGAVLVLLSVGALVALSARLNLLTLGDEEAASLGLD
VRRDRAAVFFAASAATGAAVALAGMVGFVGLIVPHLVRRVIGPDHRLLVPASALFGAAFLVLADALARLAFLPLGTEPPV
GAVTAFLGGPFFLWLLRRSGRPEAEGAR

Sequences:

>Translated_348_residues
MSLTRRTRLALALAAGVLAIAVAVAISCGLGPQPISFRAAWAGADPDAAILFGLRLPRALLAALVGCALAAAGTALQALL
RNPLAEPFVLGVSGGAALGGSLVLVAAAGVTRLAGRAGEALGGAPPVAAGAVAGAVAATAIVFGLGRIGGRLVPEAALLV
GIVFNAFAAGVITLLKMLVPPEQAGRLMYWLLGAVGYEAPGTLALGAVLVLLSVGALVALSARLNLLTLGDEEAASLGLD
VRRDRAAVFFAASAATGAAVALAGMVGFVGLIVPHLVRRVIGPDHRLLVPASALFGAAFLVLADALARLAFLPLGTEPPV
GAVTAFLGGPFFLWLLRRSGRPEAEGAR
>Mature_347_residues
SLTRRTRLALALAAGVLAIAVAVAISCGLGPQPISFRAAWAGADPDAAILFGLRLPRALLAALVGCALAAAGTALQALLR
NPLAEPFVLGVSGGAALGGSLVLVAAAGVTRLAGRAGEALGGAPPVAAGAVAGAVAATAIVFGLGRIGGRLVPEAALLVG
IVFNAFAAGVITLLKMLVPPEQAGRLMYWLLGAVGYEAPGTLALGAVLVLLSVGALVALSARLNLLTLGDEEAASLGLDV
RRDRAAVFFAASAATGAAVALAGMVGFVGLIVPHLVRRVIGPDHRLLVPASALFGAAFLVLADALARLAFLPLGTEPPVG
AVTAFLGGPFFLWLLRRSGRPEAEGAR

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=326, Percent_Identity=35.8895705521472, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790741, Length=292, Percent_Identity=36.6438356164384, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1788004, Length=294, Percent_Identity=39.4557823129252, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786805, Length=296, Percent_Identity=34.7972972972973, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786347, Length=342, Percent_Identity=32.1637426900585, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786804, Length=293, Percent_Identity=32.0819112627986, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34558; Mature: 34426

Theoretical pI: Translated: 11.51; Mature: 11.51

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTRRTRLALALAAGVLAIAVAVAISCGLGPQPISFRAAWAGADPDAAILFGLRLPRAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
LAALVGCALAAAGTALQALLRNPLAEPFVLGVSGGAALGGSLVLVAAAGVTRLAGRAGEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHCCHHHHHHHHHHHHHHHCCCCC
LGGAPPVAAGAVAGAVAATAIVFGLGRIGGRLVPEAALLVGIVFNAFAAGVITLLKMLVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEQAGRLMYWLLGAVGYEAPGTLALGAVLVLLSVGALVALSARLNLLTLGDEEAASLGLD
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHCCCC
VRRDRAAVFFAASAATGAAVALAGMVGFVGLIVPHLVRRVIGPDHRLLVPASALFGAAFL
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHH
VLADALARLAFLPLGTEPPVGAVTAFLGGPFFLWLLRRSGRPEAEGAR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SLTRRTRLALALAAGVLAIAVAVAISCGLGPQPISFRAAWAGADPDAAILFGLRLPRAL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
LAALVGCALAAAGTALQALLRNPLAEPFVLGVSGGAALGGSLVLVAAAGVTRLAGRAGEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHCCHHHHHHHHHHHHHHHCCCCC
LGGAPPVAAGAVAGAVAATAIVFGLGRIGGRLVPEAALLVGIVFNAFAAGVITLLKMLVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEQAGRLMYWLLGAVGYEAPGTLALGAVLVLLSVGALVALSARLNLLTLGDEEAASLGLD
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHCCCC
VRRDRAAVFFAASAATGAAVALAGMVGFVGLIVPHLVRRVIGPDHRLLVPASALFGAAFL
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHH
VLADALARLAFLPLGTEPPVGAVTAFLGGPFFLWLLRRSGRPEAEGAR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]