Click here to switch to the map view.

The map label for this gene is 220918664

Identifier: 220918664

GI number: 220918664

Start: 3992169

End: 3993326

Strand: Direct

Name: 220918664

Synonym: A2cp1_3572

Alternate gene names: NA

Gene position: 3992169-3993326 (Clockwise)

Preceding gene: 220918663

Following gene: 220918665

Centisome position: 79.38

GC content: 74.01

Gene sequence:

>1158_bases
ATGCTCGACCGGATCGTCCAGGGAGAGGTGCCGCGCAAGCACCACCTCGCGTTCCGCGACGCGGAGGGGCGGCTCCTCCA
CGAGGAGGCGTACACCCGCGCCGGCTTCGACGGACCGTACGCGCTGCTCTACCACCGCAACCGGCCGCACGCGGTCCACG
CCGCCCAGGCCCGGAACGGCTTCCCCCTGCCGCAGCCCGCGCCGGCGCGGGCGCTGCTGAAGCGCCACTACCGCACCCAG
GACCTCGCGGCGCGCGGCGGGCCGCCGGTCGACGCGCGGCGCCCGCTCCTGTTCAACGCCGACGTGGTGGTCGGCCTGGT
GACGCCCACCTCCGAGGACCCGGTCTACTTCGCGAACGGCGACGGCGACGACCTCTACTTCGTCGCCGAGGGGGGCGGCC
TGCTGCGCTCGCCCATGGGCGACCTGCGCTTCGGGCAGCACGACTACGTCTACGTGCCGAGGGGCCTGCTGCACCGGTTC
GTGCCCGATGCCGGGCCGCAGCGCTGGCTGTCGCTCGAGCTCCCCGGCGGCATGCACCTGCCGGCGCAGTGGCGGAACGA
GACCGGCCAGCTCCGCATGGACGCCCCCTACTCCCACCGCGACTTCCGGCGGGTGGAGCTGAAGGGCCCGGTGGACGAGG
GCCTCCGCGACCTGGTGGTGAAGCGGGCCGGCGCGTTCCACGGGTTCCGCTACGACGCGTCGCCGCTCGACGTGGTGGGG
TGGGACGGCGCGCTCTACCCGTTCGCCTTCCCCATCCTGAACTTCCAGCCGCGGGCCGGGCTGGTGCACCTGCCGCCGAC
GTGGCACGGCACCTTCGCGGCGCGCGGCGCGCTGGTCTGCTCGTTCGTGCCGCGGGTGACCGACTTCCACCCGGAGGCCG
TGCCCTGCCCCTACCCGCACGCCTCGGTGGACGTGGACGAGATCCTGTTCTACGTGCGGGGGGAGTTCACCAGCCGCCGC
GGCGTCGGCCCGGGCTCGATCTCGCACCACCCCGCCGGCACCATGCACGGCCCGCACCCCGGCGCCTACGAGGCGTCGAT
CGGCACGCGCAGCACGAACGAGCTGGCGGTGATGCTCGACTGCTACCTGCCGCTGCAGCCCACGGCGATCGCGCTCGGCA
TCGAGGACCCCGGCTACCAGGAGAGCTTCGTCGGCTGA

Upstream 100 bases:

>100_bases
ATCCAGCGCAAGGGCGACCAGGGCTTCGGCGCGGGCAACTTCCGCGCGCTGTTCGAGTCCATCGAGCGCGAGCAGGTGAA
GGAAGGGCGGGCCTGAGCGG

Downstream 100 bases:

>100_bases
CGCGGCGCCCCTCCCCCCGGCGGCGCGCATCCGCTATGGTGTCCCGCCATGCCCTTCCGCGTCGCCCGCCCGCCCACGCC
GCCGGTCACCCGCTACCGCG

Product: homogentisate 12-dioxygenase

Products: 4-maleylacetoacetate

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MLDRIVQGEVPRKHHLAFRDAEGRLLHEEAYTRAGFDGPYALLYHRNRPHAVHAAQARNGFPLPQPAPARALLKRHYRTQ
DLAARGGPPVDARRPLLFNADVVVGLVTPTSEDPVYFANGDGDDLYFVAEGGGLLRSPMGDLRFGQHDYVYVPRGLLHRF
VPDAGPQRWLSLELPGGMHLPAQWRNETGQLRMDAPYSHRDFRRVELKGPVDEGLRDLVVKRAGAFHGFRYDASPLDVVG
WDGALYPFAFPILNFQPRAGLVHLPPTWHGTFAARGALVCSFVPRVTDFHPEAVPCPYPHASVDVDEILFYVRGEFTSRR
GVGPGSISHHPAGTMHGPHPGAYEASIGTRSTNELAVMLDCYLPLQPTAIALGIEDPGYQESFVG

Sequences:

>Translated_385_residues
MLDRIVQGEVPRKHHLAFRDAEGRLLHEEAYTRAGFDGPYALLYHRNRPHAVHAAQARNGFPLPQPAPARALLKRHYRTQ
DLAARGGPPVDARRPLLFNADVVVGLVTPTSEDPVYFANGDGDDLYFVAEGGGLLRSPMGDLRFGQHDYVYVPRGLLHRF
VPDAGPQRWLSLELPGGMHLPAQWRNETGQLRMDAPYSHRDFRRVELKGPVDEGLRDLVVKRAGAFHGFRYDASPLDVVG
WDGALYPFAFPILNFQPRAGLVHLPPTWHGTFAARGALVCSFVPRVTDFHPEAVPCPYPHASVDVDEILFYVRGEFTSRR
GVGPGSISHHPAGTMHGPHPGAYEASIGTRSTNELAVMLDCYLPLQPTAIALGIEDPGYQESFVG
>Mature_385_residues
MLDRIVQGEVPRKHHLAFRDAEGRLLHEEAYTRAGFDGPYALLYHRNRPHAVHAAQARNGFPLPQPAPARALLKRHYRTQ
DLAARGGPPVDARRPLLFNADVVVGLVTPTSEDPVYFANGDGDDLYFVAEGGGLLRSPMGDLRFGQHDYVYVPRGLLHRF
VPDAGPQRWLSLELPGGMHLPAQWRNETGQLRMDAPYSHRDFRRVELKGPVDEGLRDLVVKRAGAFHGFRYDASPLDVVG
WDGALYPFAFPILNFQPRAGLVHLPPTWHGTFAARGALVCSFVPRVTDFHPEAVPCPYPHASVDVDEILFYVRGEFTSRR
GVGPGSISHHPAGTMHGPHPGAYEASIGTRSTNELAVMLDCYLPLQPTAIALGIEDPGYQESFVG

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: 1.13.11.5

Molecular weight: Translated: 42560; Mature: 42560

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRIVQGEVPRKHHLAFRDAEGRLLHEEAYTRAGFDGPYALLYHRNRPHAVHAAQARNG
CCCCCCCCCCCHHHCEEEECCCCCEEHHHHHHHCCCCCCEEEEEECCCCCEEEEHHCCCC
FPLPQPAPARALLKRHYRTQDLAARGGPPVDARRPLLFNADVVVGLVTPTSEDPVYFANG
CCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCEEEECCEEEEEECCCCCCCEEEECC
DGDDLYFVAEGGGLLRSPMGDLRFGQHDYVYVPRGLLHRFVPDAGPQRWLSLELPGGMHL
CCCEEEEEECCCCEECCCCCCCCCCCCCEEEECHHHHHHHCCCCCCCCEEEEECCCCCCC
PAQWRNETGQLRMDAPYSHRDFRRVELKGPVDEGLRDLVVKRAGAFHGFRYDASPLDVVG
CHHHCCCCCCEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCEEEE
WDGALYPFAFPILNFQPRAGLVHLPPTWHGTFAARGALVCSFVPRVTDFHPEAVPCPYPH
CCCCHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ASVDVDEILFYVRGEFTSRRGVGPGSISHHPAGTMHGPHPGAYEASIGTRSTNELAVMLD
CCCCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEEE
CYLPLQPTAIALGIEDPGYQESFVG
EECCCCCCEEEEECCCCCCHHCCCC
>Mature Secondary Structure
MLDRIVQGEVPRKHHLAFRDAEGRLLHEEAYTRAGFDGPYALLYHRNRPHAVHAAQARNG
CCCCCCCCCCCHHHCEEEECCCCCEEHHHHHHHCCCCCCEEEEEECCCCCEEEEHHCCCC
FPLPQPAPARALLKRHYRTQDLAARGGPPVDARRPLLFNADVVVGLVTPTSEDPVYFANG
CCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCEEEECCEEEEEECCCCCCCEEEECC
DGDDLYFVAEGGGLLRSPMGDLRFGQHDYVYVPRGLLHRFVPDAGPQRWLSLELPGGMHL
CCCEEEEEECCCCEECCCCCCCCCCCCCEEEECHHHHHHHCCCCCCCCEEEEECCCCCCC
PAQWRNETGQLRMDAPYSHRDFRRVELKGPVDEGLRDLVVKRAGAFHGFRYDASPLDVVG
CHHHCCCCCCEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCEEEE
WDGALYPFAFPILNFQPRAGLVHLPPTWHGTFAARGALVCSFVPRVTDFHPEAVPCPYPH
CCCCHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ASVDVDEILFYVRGEFTSRRGVGPGSISHHPAGTMHGPHPGAYEASIGTRSTNELAVMLD
CCCCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEEE
CYLPLQPTAIALGIEDPGYQESFVG
EECCCCCCEEEEECCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: homogentisate; O2

Specific reaction: homogentisate + O2 = 4-maleylacetoacetate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]