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The map label for this gene is hpd [H]

Identifier: 220918663

GI number: 220918663

Start: 3990977

End: 3992164

Strand: Direct

Name: hpd [H]

Synonym: A2cp1_3571

Alternate gene names: 220918663

Gene position: 3990977-3992164 (Clockwise)

Preceding gene: 220918662

Following gene: 220918664

Centisome position: 79.35

GC content: 71.13

Gene sequence:

>1188_bases
ATGACCTCGCACTCGCAGAAGACGCAGCTCGAGCCGCTCGGCATCGTCCGCATCGAGGGGCTGCATTACTACGTGCACGA
CCTCGAGCGCAGCCGCCGCTTCTACACGCAGAAGATGGACTTCGCGGAGGTGGCCCGCAGCGCGCCCGCGCTGGAGCGGG
AGGGCCGGCAGCGCTCGGCGGTGTTCGAGGCGGGCGACGTCCGGGTGGTGTGCTCGGAGCCGGTGGGCGAGGGCGGCCGC
GCCTGGCGCTGGCTGCGCAAGCACCCCGACGGCGTGGGCACGGTGGTGTTCCAGGTGGAGGACGCGGACCGCTGCTTCCG
GCTGCTGGAGGAGCGCGGGGCGACGCCCATCACCGACGTGCAGGAGCACCGCGACGACGGAGGGACGCTGCGCACGTTCA
ACATCACCACCCCGCTCGGCGACACCACCTTCCGCTTCGTGGAGCGCCGCGGCTACCGCGCCGTCTACCCGGGCATCGAG
CCGCTCGCCGCGCCGGAGGGCGGGCGCAACGCGTTCGGCTTCGGCCACGTGGACCACCTCACCAACAACTTCCAGACCAT
GAAGCCGGCGCTCCTGTGGATGGAGCACGTCATGGGGATGGAGGAGTTCTGGGAGGTGGAGTTCCACACCAAGGACGCGG
CCGGCGCGCGCCGGGCCGCGCTCGAGGCGCAGAAGGGCTCGGGCCTGCGCTCGGTGGTGATGCGCGAGCCGCGCTCCGGC
GTGAAGTTCGCGAACAACGAGCCGTGGCGCCCCGCGTTCAAGTCCTCGCAGATCAACGTCTTCAACGAGGACCACCGCGG
CGACGGCGTGCAGCACGCCGCGCTGACGGTGCAGGACATCCTCTCCTCGGTGCGCGGCATGCGCGCCCGCGGGGTGGAGT
TCATGCCCACGCCGGCGACGTACTACGAGGCGCTGCCGGAGCGGATCCGCAGCACCGGCATCGGCCGGATCGACGAGGAC
CCGCGCGTGCTGCAGGAGCTCGAGATCCTGGTGGACGGCGCCGGCGACCACTCCTACCTGCTGCAGATCTTCCTGCGCGA
CGCGGCCGGCCTGTACCACGAGCCCGACGCCGGGCCGTTCTTCTTCGAGATCATCCAGCGCAAGGGCGACCAGGGCTTCG
GCGCGGGCAACTTCCGCGCGCTGTTCGAGTCCATCGAGCGCGAGCAGGTGAAGGAAGGGCGGGCCTGA

Upstream 100 bases:

>100_bases
CGCTGCGCCGCGTGGACGAGGCCTGCGCGGCGCTCGCGCCGTTCCAGGCCGCCCACCCCGACCGCCAGCCCGACGCGCCG
CCGCCCGACCGGAGGACCCC

Downstream 100 bases:

>100_bases
GCGGATGCTCGACCGGATCGTCCAGGGAGAGGTGCCGCGCAAGCACCACCTCGCGTTCCGCGACGCGGAGGGGCGGCTCC
TCCACGAGGAGGCGTACACC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTSHSQKTQLEPLGIVRIEGLHYYVHDLERSRRFYTQKMDFAEVARSAPALEREGRQRSAVFEAGDVRVVCSEPVGEGGR
AWRWLRKHPDGVGTVVFQVEDADRCFRLLEERGATPITDVQEHRDDGGTLRTFNITTPLGDTTFRFVERRGYRAVYPGIE
PLAAPEGGRNAFGFGHVDHLTNNFQTMKPALLWMEHVMGMEEFWEVEFHTKDAAGARRAALEAQKGSGLRSVVMREPRSG
VKFANNEPWRPAFKSSQINVFNEDHRGDGVQHAALTVQDILSSVRGMRARGVEFMPTPATYYEALPERIRSTGIGRIDED
PRVLQELEILVDGAGDHSYLLQIFLRDAAGLYHEPDAGPFFFEIIQRKGDQGFGAGNFRALFESIEREQVKEGRA

Sequences:

>Translated_395_residues
MTSHSQKTQLEPLGIVRIEGLHYYVHDLERSRRFYTQKMDFAEVARSAPALEREGRQRSAVFEAGDVRVVCSEPVGEGGR
AWRWLRKHPDGVGTVVFQVEDADRCFRLLEERGATPITDVQEHRDDGGTLRTFNITTPLGDTTFRFVERRGYRAVYPGIE
PLAAPEGGRNAFGFGHVDHLTNNFQTMKPALLWMEHVMGMEEFWEVEFHTKDAAGARRAALEAQKGSGLRSVVMREPRSG
VKFANNEPWRPAFKSSQINVFNEDHRGDGVQHAALTVQDILSSVRGMRARGVEFMPTPATYYEALPERIRSTGIGRIDED
PRVLQELEILVDGAGDHSYLLQIFLRDAAGLYHEPDAGPFFFEIIQRKGDQGFGAGNFRALFESIEREQVKEGRA
>Mature_394_residues
TSHSQKTQLEPLGIVRIEGLHYYVHDLERSRRFYTQKMDFAEVARSAPALEREGRQRSAVFEAGDVRVVCSEPVGEGGRA
WRWLRKHPDGVGTVVFQVEDADRCFRLLEERGATPITDVQEHRDDGGTLRTFNITTPLGDTTFRFVERRGYRAVYPGIEP
LAAPEGGRNAFGFGHVDHLTNNFQTMKPALLWMEHVMGMEEFWEVEFHTKDAAGARRAALEAQKGSGLRSVVMREPRSGV
KFANNEPWRPAFKSSQINVFNEDHRGDGVQHAALTVQDILSSVRGMRARGVEFMPTPATYYEALPERIRSTGIGRIDEDP
RVLQELEILVDGAGDHSYLLQIFLRDAAGLYHEPDAGPFFFEIIQRKGDQGFGAGNFRALFESIEREQVKEGRA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=403, Percent_Identity=32.5062034739454, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI285002264, Length=343, Percent_Identity=33.8192419825073, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI14249394, Length=355, Percent_Identity=28.4507042253521, Blast_Score=109, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17555220, Length=317, Percent_Identity=36.5930599369085, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17550752, Length=385, Percent_Identity=29.6103896103896, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24667510, Length=403, Percent_Identity=34.4913151364764, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI21356105, Length=316, Percent_Identity=38.2911392405063, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 44621; Mature: 44490

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSHSQKTQLEPLGIVRIEGLHYYVHDLERSRRFYTQKMDFAEVARSAPALEREGRQRSA
CCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHCCCHHHH
VFEAGDVRVVCSEPVGEGGRAWRWLRKHPDGVGTVVFQVEDADRCFRLLEERGATPITDV
EEECCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCCCCCHH
QEHRDDGGTLRTFNITTPLGDTTFRFVERRGYRAVYPGIEPLAAPEGGRNAFGFGHVDHL
HHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCHHHH
TNNFQTMKPALLWMEHVMGMEEFWEVEFHTKDAAGARRAALEAQKGSGLRSVVMREPRSG
HCCHHHHHHHHHHHHHHHCHHHHHEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCCCC
VKFANNEPWRPAFKSSQINVFNEDHRGDGVQHAALTVQDILSSVRGMRARGVEFMPTPAT
CCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCHH
YYEALPERIRSTGIGRIDEDPRVLQELEILVDGAGDHSYLLQIFLRDAAGLYHEPDAGPF
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHH
FFEIIQRKGDQGFGAGNFRALFESIEREQVKEGRA
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSHSQKTQLEPLGIVRIEGLHYYVHDLERSRRFYTQKMDFAEVARSAPALEREGRQRSA
CCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHCCCHHHH
VFEAGDVRVVCSEPVGEGGRAWRWLRKHPDGVGTVVFQVEDADRCFRLLEERGATPITDV
EEECCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCCCCCHH
QEHRDDGGTLRTFNITTPLGDTTFRFVERRGYRAVYPGIEPLAAPEGGRNAFGFGHVDHL
HHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCHHHH
TNNFQTMKPALLWMEHVMGMEEFWEVEFHTKDAAGARRAALEAQKGSGLRSVVMREPRSG
HCCHHHHHHHHHHHHHHHCHHHHHEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCCCC
VKFANNEPWRPAFKSSQINVFNEDHRGDGVQHAALTVQDILSSVRGMRARGVEFMPTPAT
CCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCHH
YYEALPERIRSTGIGRIDEDPRVLQELEILVDGAGDHSYLLQIFLRDAAGLYHEPDAGPF
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHH
FFEIIQRKGDQGFGAGNFRALFESIEREQVKEGRA
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]