Click here to switch to the map view.

The map label for this gene is metC [H]

Identifier: 220918429

GI number: 220918429

Start: 3711751

End: 3713031

Strand: Direct

Name: metC [H]

Synonym: A2cp1_3333

Alternate gene names: 220918429

Gene position: 3711751-3713031 (Clockwise)

Preceding gene: 220918428

Following gene: 220918430

Centisome position: 73.8

GC content: 73.77

Gene sequence:

>1281_bases
ATGTCCGAAGACGTCCACCTCGACTCCAACGTGCCAGGCAACCCGGCCTACCACTTCACCATCGTCGCGCCCGGCACGCC
GGCACGGGCGGGCTGGGCGGAGCGTGCGCCGCTCGTCCCCGGGGCCGCGCTCGCCACGCAGTGCGTCCACGCGGGCGTGC
AGCCCGACCCCGCCTACGGCGCGGTGATGCCGCCCATCTACCAGTCGTCCACGTTCGCGTTCCGCGACGTGTGCACCAAC
GCCGGCTACGACTACACGCGCAGCGGCAACCCGACGCGCGCCGCGCTCGAGGAGGCCATCGCCACGCTGGAGGGAGGCGC
CGGGGCGACCTGCACCACCACCGGCATGGCCGCGGTGCTGGTGGCGCTCAACCTGCTCCCGCACGGCAGCCACCTGCTCT
GTACCGTGGACTGCTACGGCGGCACGTTCCGGACGCTCGAGCACGCGCGGCAGGCGTACGGGCTGGAGGTCACCTACCTC
GACCTCGCCGACCTCGGCGCGGTCGAGCGCGCGCTGCGGCCGAACACCGGGATGGTCTGGATCGAGACGCCGTCGAACCC
GCTGCTCCGCCTCACCGACATCCGCGCGGTGGCCGAGCTGGCGCACCGGCGCGGCGCGCTCGTGGTGGTGGACAACACGT
TCCTCTCGCCGGCGCTCCAGCGCCCGTTCGAGCACGGCGCCGATCTGGTGGTGCACTCCACCACCAAGTACCTGAACGGC
CACAGCGACGTGGTCGGCGGTGCGGTGGTCGCGCCCCGCGGCCGCACCGCGCTCCTGCAGCGCATCCAGTCGATGAACAA
CCTGCTCGGCACCTCCCAGAGCCCGCACGACGCCTTCCTGGTGCTCCGCGGCCTGAAGACGCTGGCGCTGCGCGTGAAGG
CGCACGAGGCCGGCGCGCAGCGGGTGGCGGAGTTCCTGGCCGGCCACCCGCAGGTGGCGCGGGTTCACTACCCCGGCCTC
CCGTCGCACCCGCAGCACGCGCTCGCGCGCGCGCAGCAGCGCGGCTTCGGCGCCATGCTCAGCTTCGAGCTCCGCGACGG
CCGCCCGGATCGGGTGGACCACGTGCTGCGCACGCTGCGCTGGTTCACGCTGGCGGAGTCGCTGGGCGGCGTCGAGAGCC
TGGTGGCGCACCCGGCCTCGATGACGCACGCGTCGATGACGCCGGAGGCGCGGCAGCGGGCGGGCATCACCGACTCCGTG
ATCCGGCTCTCCATCGGCATCGAGGACCCCGCGGACCTGATCGGCGACCTCGACCGCGCGCTCGCGTCGCTGCCGGCCTG
A

Upstream 100 bases:

>100_bases
GGGCATCTACATAAAACGGACGCACGTCCTAGAAAACGGATTCGCGGTCTGATAGGAACATCCGCCCGGCCGCGCCCGCC
GCACGGCCCCAGGAGCCGCC

Downstream 100 bases:

>100_bases
GCGCCGCCGCGCTCGCCGCGGTCGTCTATACTCCGCCGCGACATGGCGACGGCCGAGAAGACGCGCACCGTGTTCGCGGT
GCCGAGGATGGATTGCCCCT

Product: Cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSEDVHLDSNVPGNPAYHFTIVAPGTPARAGWAERAPLVPGAALATQCVHAGVQPDPAYGAVMPPIYQSSTFAFRDVCTN
AGYDYTRSGNPTRAALEEAIATLEGGAGATCTTTGMAAVLVALNLLPHGSHLLCTVDCYGGTFRTLEHARQAYGLEVTYL
DLADLGAVERALRPNTGMVWIETPSNPLLRLTDIRAVAELAHRRGALVVVDNTFLSPALQRPFEHGADLVVHSTTKYLNG
HSDVVGGAVVAPRGRTALLQRIQSMNNLLGTSQSPHDAFLVLRGLKTLALRVKAHEAGAQRVAEFLAGHPQVARVHYPGL
PSHPQHALARAQQRGFGAMLSFELRDGRPDRVDHVLRTLRWFTLAESLGGVESLVAHPASMTHASMTPEARQRAGITDSV
IRLSIGIEDPADLIGDLDRALASLPA

Sequences:

>Translated_426_residues
MSEDVHLDSNVPGNPAYHFTIVAPGTPARAGWAERAPLVPGAALATQCVHAGVQPDPAYGAVMPPIYQSSTFAFRDVCTN
AGYDYTRSGNPTRAALEEAIATLEGGAGATCTTTGMAAVLVALNLLPHGSHLLCTVDCYGGTFRTLEHARQAYGLEVTYL
DLADLGAVERALRPNTGMVWIETPSNPLLRLTDIRAVAELAHRRGALVVVDNTFLSPALQRPFEHGADLVVHSTTKYLNG
HSDVVGGAVVAPRGRTALLQRIQSMNNLLGTSQSPHDAFLVLRGLKTLALRVKAHEAGAQRVAEFLAGHPQVARVHYPGL
PSHPQHALARAQQRGFGAMLSFELRDGRPDRVDHVLRTLRWFTLAESLGGVESLVAHPASMTHASMTPEARQRAGITDSV
IRLSIGIEDPADLIGDLDRALASLPA
>Mature_425_residues
SEDVHLDSNVPGNPAYHFTIVAPGTPARAGWAERAPLVPGAALATQCVHAGVQPDPAYGAVMPPIYQSSTFAFRDVCTNA
GYDYTRSGNPTRAALEEAIATLEGGAGATCTTTGMAAVLVALNLLPHGSHLLCTVDCYGGTFRTLEHARQAYGLEVTYLD
LADLGAVERALRPNTGMVWIETPSNPLLRLTDIRAVAELAHRRGALVVVDNTFLSPALQRPFEHGADLVVHSTTKYLNGH
SDVVGGAVVAPRGRTALLQRIQSMNNLLGTSQSPHDAFLVLRGLKTLALRVKAHEAGAQRVAEFLAGHPQVARVHYPGLP
SHPQHALARAQQRGFGAMLSFELRDGRPDRVDHVLRTLRWFTLAESLGGVESLVAHPASMTHASMTPEARQRAGITDSVI
RLSIGIEDPADLIGDLDRALASLPA

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=365, Percent_Identity=43.5616438356164, Blast_Score=304, Evalue=9e-83,
Organism=Homo sapiens, GI299473759, Length=365, Percent_Identity=40.8219178082192, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI25453487, Length=364, Percent_Identity=37.6373626373626, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=47.0899470899471, Blast_Score=329, Evalue=3e-91,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=30.6329113924051, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=369, Percent_Identity=45.7994579945799, Blast_Score=321, Evalue=4e-88,
Organism=Caenorhabditis elegans, GI17538055, Length=369, Percent_Identity=46.070460704607, Blast_Score=316, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI71980708, Length=374, Percent_Identity=38.7700534759358, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319307, Length=387, Percent_Identity=43.6692506459948, Blast_Score=296, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6321254, Length=403, Percent_Identity=31.5136476426799, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323333, Length=443, Percent_Identity=29.1196388261851, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6321170, Length=309, Percent_Identity=30.7443365695793, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=398, Percent_Identity=28.643216080402, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI19922554, Length=383, Percent_Identity=42.2976501305483, Blast_Score=317, Evalue=8e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45417; Mature: 45286

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDVHLDSNVPGNPAYHFTIVAPGTPARAGWAERAPLVPGAALATQCVHAGVQPDPAYG
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
AVMPPIYQSSTFAFRDVCTNAGYDYTRSGNPTRAALEEAIATLEGGAGATCTTTGMAAVL
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VALNLLPHGSHLLCTVDCYGGTFRTLEHARQAYGLEVTYLDLADLGAVERALRPNTGMVW
HHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHCCCCCEEE
IETPSNPLLRLTDIRAVAELAHRRGALVVVDNTFLSPALQRPFEHGADLVVHSTTKYLNG
EECCCCCCEEEHHHHHHHHHHHHCCCEEEEECCHHCHHHHCHHHCCCCEEEECHHHHHCC
HSDVVGGAVVAPRGRTALLQRIQSMNNLLGTSQSPHDAFLVLRGLKTLALRVKAHEAGAQ
CCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RVAEFLAGHPQVARVHYPGLPSHPQHALARAQQRGFGAMLSFELRDGRPDRVDHVLRTLR
HHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHH
WFTLAESLGGVESLVAHPASMTHASMTPEARQRAGITDSVIRLSIGIEDPADLIGDLDRA
HHHHHHHHCCHHHHHHCCCHHHHCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHH
LASLPA
HHHCCC
>Mature Secondary Structure 
SEDVHLDSNVPGNPAYHFTIVAPGTPARAGWAERAPLVPGAALATQCVHAGVQPDPAYG
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
AVMPPIYQSSTFAFRDVCTNAGYDYTRSGNPTRAALEEAIATLEGGAGATCTTTGMAAVL
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VALNLLPHGSHLLCTVDCYGGTFRTLEHARQAYGLEVTYLDLADLGAVERALRPNTGMVW
HHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHCCCCCEEE
IETPSNPLLRLTDIRAVAELAHRRGALVVVDNTFLSPALQRPFEHGADLVVHSTTKYLNG
EECCCCCCEEEHHHHHHHHHHHHCCCEEEEECCHHCHHHHCHHHCCCCEEEECHHHHHCC
HSDVVGGAVVAPRGRTALLQRIQSMNNLLGTSQSPHDAFLVLRGLKTLALRVKAHEAGAQ
CCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RVAEFLAGHPQVARVHYPGLPSHPQHALARAQQRGFGAMLSFELRDGRPDRVDHVLRTLR
HHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHH
WFTLAESLGGVESLVAHPASMTHASMTPEARQRAGITDSVIRLSIGIEDPADLIGDLDRA
HHHHHHHHCCHHHHHHCCCHHHHCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHH
LASLPA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]