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The map label for this gene is top6B [H]

Identifier: 220918121

GI number: 220918121

Start: 3347912

End: 3350005

Strand: Reverse

Name: top6B [H]

Synonym: A2cp1_3024

Alternate gene names: 220918121

Gene position: 3350005-3347912 (Counterclockwise)

Preceding gene: 220918123

Following gene: 220918120

Centisome position: 66.61

GC content: 71.59

Gene sequence:

>2094_bases
ATGGCGGCTCGGAAGGCGGCGGCGGTGAGGGCGAAGGGGAAGGCCACGGGGCGGGACCGGGAGCGCGACCAGCTCGAGCT
GGCGGTGGTCGGGGGACCGGCCCCGCGCCGGTCGAAGGGCGCCGCGACGCCTCCCCCCCGGGCGCCGGCGCGCAAGCCCG
CCGGGCGGGCGCGCCCCGCGCCGGTCGAGGAGCCGGAGCTCCTGCCGCCCGCGCCCGAGGCCGAGCCCGAGGCGGCGCCG
GCGGCGCGCTCGCCGAAGCGCCGCGCCACCGCCGAGCAGATGGCGCAGCAGCAGCGCGAGATCTCCATCTCCGAGTTCTT
CACCAAGAACCGGCACCTGCTCGGCTTCGACAACGCCTCGAAGGCGCTGCTCACCACCATCAAGGAGGCGGTGGACAACT
CGCTCGACGCCTGCGAGGAGGCGGGCATCCTCCCCGAGATCACCATCGAGGTCCGCGACCTCGGGCTGAACGAGCAGGGC
GAGGGCGAGCTGACGAAGGGCGAGGGACGCTTCGTGGTGGTGGTGGAGGACAACGGCCCGGGCATCGTGAAGGCGCAGGC
GCCGAAGATCTTCGGCAAGCTCCTCTACGGCTCGAAGTTCCACCGCCTGAAGCAGAGCCGCGGCCAGCAGGGCATCGGCA
TCAGCGCGGCCGCCATGTACGGCCAGCTCACCACCGGCCAGCCGATCCGGATGATCTCGCGGACCGGCAAGGGCAAGCCG
GCGTTCGGGCTCGAGATCCAGATCGACACCCGCAAGAACAATCCGGTGGTCACGGCGGAGCGGCAGCTCGACGACTGGCA
CGAGCACGGCACGCGCGTGGAGCTGGAGATCGTCGCGAACTGGCAGCAGGGGCAGCGGTTCGTGAACCGCTACGTGGAGC
ACACCGCGCTCTCCAACCCGCACGCCGCCTTCCACTACCTGCGCCCGCGGCAGCCGCCGCTCTCCTTCCCGCGCGCCACC
GACGAGCTGCCCAAGGAGGCGCAGGAGATCAAGCCGCACCCGCACGGCGTGGAGCTGGGCGCGCTGATGCGGATGGCGGC
GGACTCGAAGAGCCACGACGTGCGCGGGTTCCTGCAGGCCGCGTTCTCGCGCGTCTCCTCGACGGTCGCCGACGAGATCG
TGAAGAAGGCCGGCTTCAAGGCCCGGGTGCGCCCCCGCGACGTCGCCGCCGACCGCGAGGTCGCGCGCAAGCTCCACCAG
GCCATCGGCGCCACCAAGATCATGGCGCCGCCGACGCAGATCCTCTCGCCCATCGGCGACACGCTCATGCGCAAGGGCCT
CGTGTCCTTCCTGAACGTGATCGAGACCGAGGGGCCGGAGGAGGAGGAGCAGCTCGACCTCGACGCGGCCCGGAAGAAGA
AGGCCACCAGGAAGGGCAAGGCGGCCAAGGCCGAGGCGCCCGAGGTGCCGGACGCGCCGCCGGAGGAGGGCGTCGAGAAG
ATCAAGGGCCACAACTACTTCATCGCGACGGTGACCCGGCCGCCCAAGGTGTACCGCGGCAACCCGTTCCAGGTGGAGGT
GGGGCTCGCGTACGGCGGGAGCTGGCCGGCAGACAAGCCCATCGAGCTGTTCCGCTTCGCGAACCGCGTGCCGCTGCTGT
TCCAGCGCGGCGCGTGCGGGATGACCGAGGCCATCGTCAAGACCGACTGGCGCAACTACCTGCTCAGCCAGCCGCGCGGC
TCGCTGCCGGTCGGGCCCATGGCGCTGCTCGTGCACATCGCCTCGGTGTGGGTGCCGTTCACCAGCGAGGCGAAGGAGGC
GGTGGCCCACTACCCGGAGATCACGCGCGAGATCCAGCTCGCGGCCCAGGAGTGCGGCCGCAAGCTCGCGGCGCACATCC
GCAAGCGCAAGCACGCCGACTACCAGGCGCAGCGGCGCAGCCTGTTCGAGCTGTACATCCAGGAGGTGGCGCAGGCGATC
GGCAAGATCGTGAAGCGCAGCCCCGATCCCATCAAGCGCGAGTTCCTGCGGCTCGCCGATCAGGTGACCGAGCAGGAGGG
CGCCGGCGACGGGCTCGACGACGCCGCGCTGGAGGAGCAGTCGAGGAAGATCACGCGGCGGCCGCGCAGGGCCGAGGAAG
AGGAGCAGGGGTAG

Upstream 100 bases:

>100_bases
GCTCGCGCGCACGCGGCGCCGCGATCTCGCGCGGGATCCCCCGCCGTGCTATTGGGGCGAGGCAGGCGATATCGCGGGGT
TGCGAGGTCAGCGCGTCCAT

Downstream 100 bases:

>100_bases
GCCATGGCCAGGCTCGACGCCACCGACAAGAAGACCGTCCAGAAGATCGAGAAGCTCGCCGAGACGGTGCTGCGCTCGGT
GAAGGGCGGCAAGAACCCGT

Product: DNA topoisomerase VI subunit B

Products: NA

Alternate protein names: Type II DNA topoisomerase VI subunit B; TopoVI-B [H]

Number of amino acids: Translated: 697; Mature: 696

Protein sequence:

>697_residues
MAARKAAAVRAKGKATGRDRERDQLELAVVGGPAPRRSKGAATPPPRAPARKPAGRARPAPVEEPELLPPAPEAEPEAAP
AARSPKRRATAEQMAQQQREISISEFFTKNRHLLGFDNASKALLTTIKEAVDNSLDACEEAGILPEITIEVRDLGLNEQG
EGELTKGEGRFVVVVEDNGPGIVKAQAPKIFGKLLYGSKFHRLKQSRGQQGIGISAAAMYGQLTTGQPIRMISRTGKGKP
AFGLEIQIDTRKNNPVVTAERQLDDWHEHGTRVELEIVANWQQGQRFVNRYVEHTALSNPHAAFHYLRPRQPPLSFPRAT
DELPKEAQEIKPHPHGVELGALMRMAADSKSHDVRGFLQAAFSRVSSTVADEIVKKAGFKARVRPRDVAADREVARKLHQ
AIGATKIMAPPTQILSPIGDTLMRKGLVSFLNVIETEGPEEEEQLDLDAARKKKATRKGKAAKAEAPEVPDAPPEEGVEK
IKGHNYFIATVTRPPKVYRGNPFQVEVGLAYGGSWPADKPIELFRFANRVPLLFQRGACGMTEAIVKTDWRNYLLSQPRG
SLPVGPMALLVHIASVWVPFTSEAKEAVAHYPEITREIQLAAQECGRKLAAHIRKRKHADYQAQRRSLFELYIQEVAQAI
GKIVKRSPDPIKREFLRLADQVTEQEGAGDGLDDAALEEQSRKITRRPRRAEEEEQG

Sequences:

>Translated_697_residues
MAARKAAAVRAKGKATGRDRERDQLELAVVGGPAPRRSKGAATPPPRAPARKPAGRARPAPVEEPELLPPAPEAEPEAAP
AARSPKRRATAEQMAQQQREISISEFFTKNRHLLGFDNASKALLTTIKEAVDNSLDACEEAGILPEITIEVRDLGLNEQG
EGELTKGEGRFVVVVEDNGPGIVKAQAPKIFGKLLYGSKFHRLKQSRGQQGIGISAAAMYGQLTTGQPIRMISRTGKGKP
AFGLEIQIDTRKNNPVVTAERQLDDWHEHGTRVELEIVANWQQGQRFVNRYVEHTALSNPHAAFHYLRPRQPPLSFPRAT
DELPKEAQEIKPHPHGVELGALMRMAADSKSHDVRGFLQAAFSRVSSTVADEIVKKAGFKARVRPRDVAADREVARKLHQ
AIGATKIMAPPTQILSPIGDTLMRKGLVSFLNVIETEGPEEEEQLDLDAARKKKATRKGKAAKAEAPEVPDAPPEEGVEK
IKGHNYFIATVTRPPKVYRGNPFQVEVGLAYGGSWPADKPIELFRFANRVPLLFQRGACGMTEAIVKTDWRNYLLSQPRG
SLPVGPMALLVHIASVWVPFTSEAKEAVAHYPEITREIQLAAQECGRKLAAHIRKRKHADYQAQRRSLFELYIQEVAQAI
GKIVKRSPDPIKREFLRLADQVTEQEGAGDGLDDAALEEQSRKITRRPRRAEEEEQG
>Mature_696_residues
AARKAAAVRAKGKATGRDRERDQLELAVVGGPAPRRSKGAATPPPRAPARKPAGRARPAPVEEPELLPPAPEAEPEAAPA
ARSPKRRATAEQMAQQQREISISEFFTKNRHLLGFDNASKALLTTIKEAVDNSLDACEEAGILPEITIEVRDLGLNEQGE
GELTKGEGRFVVVVEDNGPGIVKAQAPKIFGKLLYGSKFHRLKQSRGQQGIGISAAAMYGQLTTGQPIRMISRTGKGKPA
FGLEIQIDTRKNNPVVTAERQLDDWHEHGTRVELEIVANWQQGQRFVNRYVEHTALSNPHAAFHYLRPRQPPLSFPRATD
ELPKEAQEIKPHPHGVELGALMRMAADSKSHDVRGFLQAAFSRVSSTVADEIVKKAGFKARVRPRDVAADREVARKLHQA
IGATKIMAPPTQILSPIGDTLMRKGLVSFLNVIETEGPEEEEQLDLDAARKKKATRKGKAAKAEAPEVPDAPPEEGVEKI
KGHNYFIATVTRPPKVYRGNPFQVEVGLAYGGSWPADKPIELFRFANRVPLLFQRGACGMTEAIVKTDWRNYLLSQPRGS
LPVGPMALLVHIASVWVPFTSEAKEAVAHYPEITREIQLAAQECGRKLAAHIRKRKHADYQAQRRSLFELYIQEVAQAIG
KIVKRSPDPIKREFLRLADQVTEQEGAGDGLDDAALEEQSRKITRRPRRAEEEEQG

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP [H]

COG id: COG1389

COG function: function code L; DNA topoisomerase VI, subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR010979
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005734
- InterPro:   IPR015320
- ProDom:   PD013790 [H]

Pfam domain/function: PF02518 HATPase_c; PF09239 Topo-VIb_trans [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 76878; Mature: 76746

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARKAAAVRAKGKATGRDRERDQLELAVVGGPAPRRSKGAATPPPRAPARKPAGRARPA
CCCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PVEEPELLPPAPEAEPEAAPAARSPKRRATAEQMAQQQREISISEFFTKNRHLLGFDNAS
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCEEECCCHH
KALLTTIKEAVDNSLDACEEAGILPEITIEVRDLGLNEQGEGELTKGEGRFVVVVEDNGP
HHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEECCCCEEEEEEECCCC
GIVKAQAPKIFGKLLYGSKFHRLKQSRGQQGIGISAAAMYGQLTTGQPIRMISRTGKGKP
CEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHCCCCCC
AFGLEIQIDTRKNNPVVTAERQLDDWHEHGTRVELEIVANWQQGQRFVNRYVEHTALSNP
CEEEEEEEECCCCCCEEEEHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCC
HAAFHYLRPRQPPLSFPRATDELPKEAQEIKPHPHGVELGALMRMAADSKSHDVRGFLQA
CHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
AFSRVSSTVADEIVKKAGFKARVRPRDVAADREVARKLHQAIGATKIMAPPTQILSPIGD
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
TLMRKGLVSFLNVIETEGPEEEEQLDLDAARKKKATRKGKAAKAEAPEVPDAPPEEGVEK
HHHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
IKGHNYFIATVTRPPKVYRGNPFQVEVGLAYGGSWPADKPIELFRFANRVPLLFQRGACG
HCCCCEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHCCCCCEEECCCCC
MTEAIVKTDWRNYLLSQPRGSLPVGPMALLVHIASVWVPFTSEAKEAVAHYPEITREIQL
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AAQECGRKLAAHIRKRKHADYQAQRRSLFELYIQEVAQAIGKIVKRSPDPIKREFLRLAD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
QVTEQEGAGDGLDDAALEEQSRKITRRPRRAEEEEQG
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHCCC
>Mature Secondary Structure 
AARKAAAVRAKGKATGRDRERDQLELAVVGGPAPRRSKGAATPPPRAPARKPAGRARPA
CCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PVEEPELLPPAPEAEPEAAPAARSPKRRATAEQMAQQQREISISEFFTKNRHLLGFDNAS
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCEEECCCHH
KALLTTIKEAVDNSLDACEEAGILPEITIEVRDLGLNEQGEGELTKGEGRFVVVVEDNGP
HHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEECCCCEEEEEEECCCC
GIVKAQAPKIFGKLLYGSKFHRLKQSRGQQGIGISAAAMYGQLTTGQPIRMISRTGKGKP
CEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHCCCCCC
AFGLEIQIDTRKNNPVVTAERQLDDWHEHGTRVELEIVANWQQGQRFVNRYVEHTALSNP
CEEEEEEEECCCCCCEEEEHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCC
HAAFHYLRPRQPPLSFPRATDELPKEAQEIKPHPHGVELGALMRMAADSKSHDVRGFLQA
CHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
AFSRVSSTVADEIVKKAGFKARVRPRDVAADREVARKLHQAIGATKIMAPPTQILSPIGD
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
TLMRKGLVSFLNVIETEGPEEEEQLDLDAARKKKATRKGKAAKAEAPEVPDAPPEEGVEK
HHHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
IKGHNYFIATVTRPPKVYRGNPFQVEVGLAYGGSWPADKPIELFRFANRVPLLFQRGACG
HCCCCEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHCCCCCEEECCCCC
MTEAIVKTDWRNYLLSQPRGSLPVGPMALLVHIASVWVPFTSEAKEAVAHYPEITREIQL
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AAQECGRKLAAHIRKRKHADYQAQRRSLFELYIQEVAQAIGKIVKRSPDPIKREFLRLAD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
QVTEQEGAGDGLDDAALEEQSRKITRRPRRAEEEEQG
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]