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The map label for this gene is top6A [H]

Identifier: 220918120

GI number: 220918120

Start: 3346805

End: 3347908

Strand: Reverse

Name: top6A [H]

Synonym: A2cp1_3023

Alternate gene names: 220918120

Gene position: 3347908-3346805 (Counterclockwise)

Preceding gene: 220918121

Following gene: 220918119

Centisome position: 66.57

GC content: 65.31

Gene sequence:

>1104_bases
ATGGCCAGGCTCGACGCCACCGACAAGAAGACCGTCCAGAAGATCGAGAAGCTCGCCGAGACGGTGCTGCGCTCGGTGAA
GGGCGGCAAGAACCCGTTCCTCGAGATCCCGGTCCGCTCGCTCGCGAACGTGCAGTTCAACCCGCGCAAGCGGCTCATCG
AGCTGAAGGACCAGAAGCAGCGGCGCTACTTCTTCAACGTCTCCATGGCGAAGAAGTTCATGCAGACGTTCCTGGTCTCG
GACGCGTGCAAGGAGCTCATCGACGCCGGCAAGACGACGAGCATCCGCGACCTGTACTACATGACGAAGCACGCGCTCGG
CGAGACGCGGCAGAACACGTTCGAGGAGCAGGAGGAGTCCGACCCGATCATCGAGGACCTGGAGGTCGCGATCGACGCGC
TCCGCGAGGAGCTGCACCTGTTCGCGAGCGGCCGCGGCTCGATGGTGGGCCCGCTCTCCATCCGCGACGCGGGCGACGCC
ATCGACCTGCGCCGCATGGGCTCGGGCGGCTGGTCGGTGCCGTCCATCGTGGAGGAGCACGTCGTCCAGTTCGGCAAGAG
CGAGGCGAAGTACGTCCTGCTCATCGAGAAGGACGCCGTCTGGAAGCGCTTCAACGAGGACAAGTTCTGGGCGCGCGAGA
AGTGCATCATCGTCACCGGCCTGGGCCAGCCGCCGCGCGGCGTGCGCCGCATCGTGCAGCGGCTCCACTCCGAGCTCGGA
CTGCCGGTGTACGTGCTCGTGGACAACGACCCCTGGGGCTTCTACATCTACTCGGTGCTGAAGCAGGGCTCGATCAACCT
GGCCTACGAGTCGATGCGCATGGCGGTGCCGAAGGCGCGCTTCATCGGGCTGTCCTCCTTCGACAAGGCCAAGTTCAAGC
TGCCCGGCAACGTGTCGATCCGCATGAACGACCAGGACGATGCGCGCGCGAAGCAGATGCTCGCCTACCCCTGGTTCAAG
GATCCGAAGTGGCAGCGCGAGATCCAGGAGATGGTCCGCTCCGGCGAGAAGTACGAGCTCGAGGCGCTGTCGCGCCGCGG
GATCAGCTTCGTCACCGAGGAGTACCTGCCGAGGAAGCTGCGCGATCGCGACTGGCTGGAGTAG

Upstream 100 bases:

>100_bases
GGGCGCCGGCGACGGGCTCGACGACGCCGCGCTGGAGGAGCAGTCGAGGAAGATCACGCGGCGGCCGCGCAGGGCCGAGG
AAGAGGAGCAGGGGTAGGCC

Downstream 100 bases:

>100_bases
CGCCGGCGCCGCCCTCCCGGCCCGGGGCCGGCGGGCGGGCTTGACCGAACACCCCCGGAGCGGCGAGACTCCGCCGCCTT
TCACGACGGACACCAAGGAG

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MARLDATDKKTVQKIEKLAETVLRSVKGGKNPFLEIPVRSLANVQFNPRKRLIELKDQKQRRYFFNVSMAKKFMQTFLVS
DACKELIDAGKTTSIRDLYYMTKHALGETRQNTFEEQEESDPIIEDLEVAIDALREELHLFASGRGSMVGPLSIRDAGDA
IDLRRMGSGGWSVPSIVEEHVVQFGKSEAKYVLLIEKDAVWKRFNEDKFWAREKCIIVTGLGQPPRGVRRIVQRLHSELG
LPVYVLVDNDPWGFYIYSVLKQGSINLAYESMRMAVPKARFIGLSSFDKAKFKLPGNVSIRMNDQDDARAKQMLAYPWFK
DPKWQREIQEMVRSGEKYELEALSRRGISFVTEEYLPRKLRDRDWLE

Sequences:

>Translated_367_residues
MARLDATDKKTVQKIEKLAETVLRSVKGGKNPFLEIPVRSLANVQFNPRKRLIELKDQKQRRYFFNVSMAKKFMQTFLVS
DACKELIDAGKTTSIRDLYYMTKHALGETRQNTFEEQEESDPIIEDLEVAIDALREELHLFASGRGSMVGPLSIRDAGDA
IDLRRMGSGGWSVPSIVEEHVVQFGKSEAKYVLLIEKDAVWKRFNEDKFWAREKCIIVTGLGQPPRGVRRIVQRLHSELG
LPVYVLVDNDPWGFYIYSVLKQGSINLAYESMRMAVPKARFIGLSSFDKAKFKLPGNVSIRMNDQDDARAKQMLAYPWFK
DPKWQREIQEMVRSGEKYELEALSRRGISFVTEEYLPRKLRDRDWLE
>Mature_366_residues
ARLDATDKKTVQKIEKLAETVLRSVKGGKNPFLEIPVRSLANVQFNPRKRLIELKDQKQRRYFFNVSMAKKFMQTFLVSD
ACKELIDAGKTTSIRDLYYMTKHALGETRQNTFEEQEESDPIIEDLEVAIDALREELHLFASGRGSMVGPLSIRDAGDAI
DLRRMGSGGWSVPSIVEEHVVQFGKSEAKYVLLIEKDAVWKRFNEDKFWAREKCIIVTGLGQPPRGVRRIVQRLHSELGL
PVYVLVDNDPWGFYIYSVLKQGSINLAYESMRMAVPKARFIGLSSFDKAKFKLPGNVSIRMNDQDDARAKQMLAYPWFKD
PKWQREIQEMVRSGEKYELEALSRRGISFVTEEYLPRKLRDRDWLE

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity [H]

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family [H]

Homologues:

Organism=Homo sapiens, GI6912680, Length=366, Percent_Identity=26.775956284153, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI38201680, Length=300, Percent_Identity=28.6666666666667, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17542064, Length=282, Percent_Identity=25.177304964539, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45552753, Length=363, Percent_Identity=25.068870523416, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04406 TP6A_N [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 42421; Mature: 42290

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLDATDKKTVQKIEKLAETVLRSVKGGKNPFLEIPVRSLANVQFNPRKRLIELKDQKQ
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHCCCCCCCHHHHHHHHCCHH
RRYFFNVSMAKKFMQTFLVSDACKELIDAGKTTSIRDLYYMTKHALGETRQNTFEEQEES
HHHHEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPIIEDLEVAIDALREELHLFASGRGSMVGPLSIRDAGDAIDLRRMGSGGWSVPSIVEEH
CCHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEECCCCCCHHHHHCCCCCCCHHHHHHHH
VVQFGKSEAKYVLLIEKDAVWKRFNEDKFWAREKCIIVTGLGQPPRGVRRIVQRLHSELG
HHHHCCCCCCEEEEEECHHHHHHCCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
LPVYVLVDNDPWGFYIYSVLKQGSINLAYESMRMAVPKARFIGLSSFDKAKFKLPGNVSI
CEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHEECCCCCCCCEEECCCCEEE
RMNDQDDARAKQMLAYPWFKDPKWQREIQEMVRSGEKYELEALSRRGISFVTEEYLPRKL
EECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHCCHHHHHHHHHHHHH
RDRDWLE
CCCCCCC
>Mature Secondary Structure 
ARLDATDKKTVQKIEKLAETVLRSVKGGKNPFLEIPVRSLANVQFNPRKRLIELKDQKQ
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHCCCCCCCHHHHHHHHCCHH
RRYFFNVSMAKKFMQTFLVSDACKELIDAGKTTSIRDLYYMTKHALGETRQNTFEEQEES
HHHHEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPIIEDLEVAIDALREELHLFASGRGSMVGPLSIRDAGDAIDLRRMGSGGWSVPSIVEEH
CCHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEECCCCCCHHHHHCCCCCCCHHHHHHHH
VVQFGKSEAKYVLLIEKDAVWKRFNEDKFWAREKCIIVTGLGQPPRGVRRIVQRLHSELG
HHHHCCCCCCEEEEEECHHHHHHCCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
LPVYVLVDNDPWGFYIYSVLKQGSINLAYESMRMAVPKARFIGLSSFDKAKFKLPGNVSI
CEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHEECCCCCCCCEEECCCCEEE
RMNDQDDARAKQMLAYPWFKDPKWQREIQEMVRSGEKYELEALSRRGISFVTEEYLPRKL
EECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHCCHHHHHHHHHHHHH
RDRDWLE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA