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The map label for this gene is cysK [H]

Identifier: 220917952

GI number: 220917952

Start: 3154823

End: 3155758

Strand: Direct

Name: cysK [H]

Synonym: A2cp1_2853

Alternate gene names: 220917952

Gene position: 3154823-3155758 (Clockwise)

Preceding gene: 220917942

Following gene: 220917953

Centisome position: 62.73

GC content: 71.9

Gene sequence:

>936_bases
ATGCGGATCGCGGACGACGTCACGAAGCTCATCGGAAACACGCCGCTGGTGCGGCTCAACCGGATCACCGACGGCGCCCG
GGCGACCGTGGTGGCGAAGCTGGAGAGCTTCAACCCCGCCTCCAGCGTGAAGGACCGCATCGGCGTGGCGATGATCGAGG
CGGCCGAGCGCGACGGGAAGATCAAGCCGGACACCATCCTGCTCGAGCCGACCAGCGGCAACACCGGCGTCGGCCTGGCG
TTCGCGGCCGCGGCCAAGGGCTACAAGCTCGTCCTGACGATGCCCGACAGCATGAGCCTGGAGCGGCGGCGGCTGCTGGC
CGCGTTCGGCGCGAAGCTGGTGCTCACGCCGGGCGCCGAGGGCATGAAGGGCGCCATCGCGAAGGCGCAGGCGCTCGCGG
CCGAGGATCCGCGGCACCTCATCCTCCAGCAGTTCGAGAACCCGGCCAACCCCGAGATCCACCGCCGCACCACCGCGGAG
GAGATCTGGCGCGACACCGACGGCAAGGTGGACATCGTCGTCGCCGGGACCGGCACCGGCGGGACGCTCACCGGCGTCGC
CCAGGTGCTGAAGGCACGCAAGCCGTCGCTCCGCATCGTGGCCGCCGAGCCTGCCGACTCGCCGGTGATCTCCGGCGGCA
AGCCGGGGCCGCACAAGATCCAGGGCTGGGGGCCGGGCTTCGTGCCGAAGGTGCTCGACACCTCGCTCATCGACGAGGTG
ATCACGGTCCAGAACGCCGACGCCGGCGACTTCGGGCGCCGGCTCACGCGCGAGGAAGGCATCCTGTCCGGCATCTCCTG
CGGCGGCGCGGCCTGGGCGGCGCGCGAGCTGGCACGGCGGCCCGAGAACGCGGGCAAGCTCATCGTGGTGGTGCTGCCCG
ACACCGGCGAGCGGTACCTGACGACGTGGCTGTTCGAGGAGGCGCCCGCGGCCTAG

Upstream 100 bases:

>100_bases
GCGGCGACCGCCGTCGCGTCCGCTTGACAGGAGGCGCGTCCGCTTCTAAGGATGTCCGCTATAACGGAATCCGCCGGACG
TCCGGCGGGAGCGAGGGCGC

Downstream 100 bases:

>100_bases
CATCGGGCGCAGACGGACGATCCAGCGCGGCGGCGCTCCCGGCCCGGGACACCGCCGCGCTGCGTCATGACCGCGCGTGA
CAGACGGGCTCCTTGCGGGG

Product: cysteine synthase A

Products: NA

Alternate protein names: OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MRIADDVTKLIGNTPLVRLNRITDGARATVVAKLESFNPASSVKDRIGVAMIEAAERDGKIKPDTILLEPTSGNTGVGLA
FAAAAKGYKLVLTMPDSMSLERRRLLAAFGAKLVLTPGAEGMKGAIAKAQALAAEDPRHLILQQFENPANPEIHRRTTAE
EIWRDTDGKVDIVVAGTGTGGTLTGVAQVLKARKPSLRIVAAEPADSPVISGGKPGPHKIQGWGPGFVPKVLDTSLIDEV
ITVQNADAGDFGRRLTREEGILSGISCGGAAWAARELARRPENAGKLIVVVLPDTGERYLTTWLFEEAPAA

Sequences:

>Translated_311_residues
MRIADDVTKLIGNTPLVRLNRITDGARATVVAKLESFNPASSVKDRIGVAMIEAAERDGKIKPDTILLEPTSGNTGVGLA
FAAAAKGYKLVLTMPDSMSLERRRLLAAFGAKLVLTPGAEGMKGAIAKAQALAAEDPRHLILQQFENPANPEIHRRTTAE
EIWRDTDGKVDIVVAGTGTGGTLTGVAQVLKARKPSLRIVAAEPADSPVISGGKPGPHKIQGWGPGFVPKVLDTSLIDEV
ITVQNADAGDFGRRLTREEGILSGISCGGAAWAARELARRPENAGKLIVVVLPDTGERYLTTWLFEEAPAA
>Mature_311_residues
MRIADDVTKLIGNTPLVRLNRITDGARATVVAKLESFNPASSVKDRIGVAMIEAAERDGKIKPDTILLEPTSGNTGVGLA
FAAAAKGYKLVLTMPDSMSLERRRLLAAFGAKLVLTPGAEGMKGAIAKAQALAAEDPRHLILQQFENPANPEIHRRTTAE
EIWRDTDGKVDIVVAGTGTGGTLTGVAQVLKARKPSLRIVAAEPADSPVISGGKPGPHKIQGWGPGFVPKVLDTSLIDEV
ITVQNADAGDFGRRLTREEGILSGISCGGAAWAARELARRPENAGKLIVVVLPDTGERYLTTWLFEEAPAA

Specific function: Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=317, Percent_Identity=41.0094637223975, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI295821200, Length=317, Percent_Identity=41.0094637223975, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI4557415, Length=317, Percent_Identity=41.0094637223975, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI1788754, Length=313, Percent_Identity=57.1884984025559, Blast_Score=313, Evalue=8e-87,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=41.5282392026578, Blast_Score=222, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=51.6666666666667, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=54.2483660130719, Blast_Score=306, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=48.6928104575163, Blast_Score=286, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=49.1638795986622, Blast_Score=280, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=48.0263157894737, Blast_Score=260, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=50, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17534315, Length=319, Percent_Identity=39.8119122257053, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25147552, Length=317, Percent_Identity=38.1703470031546, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=46.6101694915254, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=37.8125, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=32.5301204819277, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24643623, Length=313, Percent_Identity=39.9361022364217, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI20129101, Length=313, Percent_Identity=39.9361022364217, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32876; Mature: 32876

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIADDVTKLIGNTPLVRLNRITDGARATVVAKLESFNPASSVKDRIGVAMIEAAERDGK
CCCHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEHHHCCCC
IKPDTILLEPTSGNTGVGLAFAAAAKGYKLVLTMPDSMSLERRRLLAAFGAKLVLTPGAE
CCCCEEEEECCCCCCCCCCCEEHHCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECCCCC
GMKGAIAKAQALAAEDPRHLILQQFENPANPEIHRRTTAEEIWRDTDGKVDIVVAGTGTG
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCHHHHHCCCCCCEEEEEEECCCC
GTLTGVAQVLKARKPSLRIVAAEPADSPVISGGKPGPHKIQGWGPGFVPKVLDTSLIDEV
CHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ITVQNADAGDFGRRLTREEGILSGISCGGAAWAARELARRPENAGKLIVVVLPDTGERYL
HHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHH
TTWLFEEAPAA
HHHHHHCCCCC
>Mature Secondary Structure
MRIADDVTKLIGNTPLVRLNRITDGARATVVAKLESFNPASSVKDRIGVAMIEAAERDGK
CCCHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEHHHCCCC
IKPDTILLEPTSGNTGVGLAFAAAAKGYKLVLTMPDSMSLERRRLLAAFGAKLVLTPGAE
CCCCEEEEECCCCCCCCCCCEEHHCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECCCCC
GMKGAIAKAQALAAEDPRHLILQQFENPANPEIHRRTTAEEIWRDTDGKVDIVVAGTGTG
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCHHHHHCCCCCCEEEEEEECCCC
GTLTGVAQVLKARKPSLRIVAAEPADSPVISGGKPGPHKIQGWGPGFVPKVLDTSLIDEV
CHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ITVQNADAGDFGRRLTREEGILSGISCGGAAWAARELARRPENAGKLIVVVLPDTGERYL
HHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHH
TTWLFEEAPAA
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]