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The map label for this gene is gcvPB [H]

Identifier: 220917816

GI number: 220917816

Start: 2996212

End: 2997780

Strand: Direct

Name: gcvPB [H]

Synonym: A2cp1_2717

Alternate gene names: 220917816

Gene position: 2996212-2997780 (Clockwise)

Preceding gene: 220917815

Following gene: 220917817

Centisome position: 59.57

GC content: 73.49

Gene sequence:

>1569_bases
ATGGCGAACCCGACCGGCTGGAAGCCCAGCATGGAGCAGGACGCGAAGGGCGGCGCCGCCGCGGCCGAGGCGCCCGGCCT
GGGCGGCGCGGTGCGCGGCCTCGCCTACGAGGAGCCGCTCGTGTTCGAGCACGGCTCGCGCGGGCGCTGCGGCGTCTCGT
TGCCGCCGCCCCCCGCCGACTTCGACGCGGGCGACCTCCCCGCCGCGCTGGTGCGCCCGGCGGTGGACGGGCTGCCGGAG
CTGTCCGAGCTGGAGGTGGTCCGGCACTTCACCCGGCTCTCCTCCTGGAACCACGGCATCGACACCGGGTTCTACCCGCT
CGGCTCCTGCACCATGAAGTACAACCCGAAGTCGAGCGAGGCCCTGGCGCGCCTGCCCGGCTTCGCCGACCTCCACCCGC
TCGCGCCCGCCGAGCTGGCGCAGGGCGCGCTCGAGCTCATGTACCGGCTGGAGCGGGCGCTGTCCGAGATCGCCGGGTTC
GACGCCACCACGCTCGCGCCCGCCGCGGGCGCGCAGGGCGAGCTGACCGGCCTCATGCTCATCCGCGCCTACCACGAGGC
GCGCGGCAACCCGCGCAAGAAGGTGCTCATCCCCGACACCGCGCACGGCACCAACCCCGCGTCGTCGGCGCTGAACGGCT
ACGCGGTGGTGCAGCTCGCCTCCGGCCCCGACGGCCGCCTCCACCCGGAGACGGTCCGCGCCGCCATGGACGAGGACGTC
GCGGCCATCATGATCACGAACCCGAACACGCTGGGCGTGTTCGAGTCGCACATCGCCGAGATCGCCGCGATCGTCCACGC
GAAGGGCGGGCTGGTGTACGGCGACGGCGCGAACATGAACGCGCTGCTCGGCGTGGCGCGGCCCGGCGACATGGGCTTCG
ACGTCATGCAGTACAACCTGCACAAGACGTTCGCGACGCCGCACGGCGGCGGCGGCCCGGGCTCGGGCCCGGTGGCGGTG
AAGGCGGCGCTCGCGCCGTACCTGCCGCTCCCGCTGGTGGTGAAGGAGGGCGAGCGGTTCCGGCTGGTCACCGAGGCGCG
CGAGCGGCCCGCCACCGTCGGCAAGCTGCGCGAGTTCTGGGGCAACTTCGGCATGTTCGTGCGGGCCTGGGCGCTCATCC
GCGAGTACGGCCCGGACGGCGTGCGCGCCACCGCCGAGCTGGCGGTGCTGAACGCGAACTACGTGCGCAAGCAGCTGGAG
GGCACCTACCACCTGCCCTACCCCACCGACTCGCTCCACGAGGTGGTGTTCGACGACGCCCAGCAGAAGGACGCCGGCGT
CACGACCATGGACGTGGCGAAGCGCCTCATCGACCACGGCTTCCACCCGCCCACCATCTACTTCCCGCTGGTGGTGCACG
GCGCGCTCATGATCGAGCCGACCGAGACCGAGTCGCGCGAGACGCTGGACGCGTTCGTCGCGGCGATGAAGGCCATCGCC
GAGGAGGCGAAGGCCGATCCGGAGGCGGTGCGTGCCGCGCCCACCCGGCCCGTCCGCGCGCGCCTCGACGAGACGCGCGC
GGCGCGCAAGCCCGTGCTGCGCTGGCAGCCGGGCATGAACGTCGAGTAG

Upstream 100 bases:

>100_bases
CGGACGCGCCGCACGCGAAGGGCGCGCTGCTCTGTGCGGCGACCGAGCTGCACGGCCCCGAGCTCATCCAGCTCTTCGCG
AGCACGGTGAGGAGCTAGCC

Downstream 100 bases:

>100_bases
ACGGGCGGCGGTCGCGCTATCATCGCGGCGCGCCCGCCCCACGGCGCCGCGGAGGAACCATGCGCAACCGCCTGCTCGCC
CTGTTCGTCGTCGCCGCCCT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MANPTGWKPSMEQDAKGGAAAAEAPGLGGAVRGLAYEEPLVFEHGSRGRCGVSLPPPPADFDAGDLPAALVRPAVDGLPE
LSELEVVRHFTRLSSWNHGIDTGFYPLGSCTMKYNPKSSEALARLPGFADLHPLAPAELAQGALELMYRLERALSEIAGF
DATTLAPAAGAQGELTGLMLIRAYHEARGNPRKKVLIPDTAHGTNPASSALNGYAVVQLASGPDGRLHPETVRAAMDEDV
AAIMITNPNTLGVFESHIAEIAAIVHAKGGLVYGDGANMNALLGVARPGDMGFDVMQYNLHKTFATPHGGGGPGSGPVAV
KAALAPYLPLPLVVKEGERFRLVTEARERPATVGKLREFWGNFGMFVRAWALIREYGPDGVRATAELAVLNANYVRKQLE
GTYHLPYPTDSLHEVVFDDAQQKDAGVTTMDVAKRLIDHGFHPPTIYFPLVVHGALMIEPTETESRETLDAFVAAMKAIA
EEAKADPEAVRAAPTRPVRARLDETRAARKPVLRWQPGMNVE

Sequences:

>Translated_522_residues
MANPTGWKPSMEQDAKGGAAAAEAPGLGGAVRGLAYEEPLVFEHGSRGRCGVSLPPPPADFDAGDLPAALVRPAVDGLPE
LSELEVVRHFTRLSSWNHGIDTGFYPLGSCTMKYNPKSSEALARLPGFADLHPLAPAELAQGALELMYRLERALSEIAGF
DATTLAPAAGAQGELTGLMLIRAYHEARGNPRKKVLIPDTAHGTNPASSALNGYAVVQLASGPDGRLHPETVRAAMDEDV
AAIMITNPNTLGVFESHIAEIAAIVHAKGGLVYGDGANMNALLGVARPGDMGFDVMQYNLHKTFATPHGGGGPGSGPVAV
KAALAPYLPLPLVVKEGERFRLVTEARERPATVGKLREFWGNFGMFVRAWALIREYGPDGVRATAELAVLNANYVRKQLE
GTYHLPYPTDSLHEVVFDDAQQKDAGVTTMDVAKRLIDHGFHPPTIYFPLVVHGALMIEPTETESRETLDAFVAAMKAIA
EEAKADPEAVRAAPTRPVRARLDETRAARKPVLRWQPGMNVE
>Mature_521_residues
ANPTGWKPSMEQDAKGGAAAAEAPGLGGAVRGLAYEEPLVFEHGSRGRCGVSLPPPPADFDAGDLPAALVRPAVDGLPEL
SELEVVRHFTRLSSWNHGIDTGFYPLGSCTMKYNPKSSEALARLPGFADLHPLAPAELAQGALELMYRLERALSEIAGFD
ATTLAPAAGAQGELTGLMLIRAYHEARGNPRKKVLIPDTAHGTNPASSALNGYAVVQLASGPDGRLHPETVRAAMDEDVA
AIMITNPNTLGVFESHIAEIAAIVHAKGGLVYGDGANMNALLGVARPGDMGFDVMQYNLHKTFATPHGGGGPGSGPVAVK
AALAPYLPLPLVVKEGERFRLVTEARERPATVGKLREFWGNFGMFVRAWALIREYGPDGVRATAELAVLNANYVRKQLEG
TYHLPYPTDSLHEVVFDDAQQKDAGVTTMDVAKRLIDHGFHPPTIYFPLVVHGALMIEPTETESRETLDAFVAAMKAIAE
EAKADPEAVRAAPTRPVRARLDETRAARKPVLRWQPGMNVE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=422, Percent_Identity=42.1800947867299, Blast_Score=280, Evalue=2e-75,
Organism=Escherichia coli, GI1789269, Length=410, Percent_Identity=41.219512195122, Blast_Score=273, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17535605, Length=411, Percent_Identity=42.0924574209246, Blast_Score=278, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI32564013, Length=367, Percent_Identity=43.0517711171662, Blast_Score=253, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6323843, Length=414, Percent_Identity=42.0289855072464, Blast_Score=286, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24645648, Length=423, Percent_Identity=43.2624113475177, Blast_Score=287, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 55777; Mature: 55646

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANPTGWKPSMEQDAKGGAAAAEAPGLGGAVRGLAYEEPLVFEHGSRGRCGVSLPPPPAD
CCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCC
FDAGDLPAALVRPAVDGLPELSELEVVRHFTRLSSWNHGIDTGFYPLGSCTMKYNPKSSE
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEECCCCHH
ALARLPGFADLHPLAPAELAQGALELMYRLERALSEIAGFDATTLAPAAGAQGELTGLML
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHH
IRAYHEARGNPRKKVLIPDTAHGTNPASSALNGYAVVQLASGPDGRLHPETVRAAMDEDV
HHHHHHHCCCCCCEEECCCCCCCCCHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHCCCC
AAIMITNPNTLGVFESHIAEIAAIVHAKGGLVYGDGANMNALLGVARPGDMGFDVMQYNL
EEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEECCCCCCCCHHHHHHH
HKTFATPHGGGGPGSGPVAVKAALAPYLPLPLVVKEGERFRLVTEARERPATVGKLREFW
HHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCEEEEEHHHHHCCHHHHHHHHHH
GNFGMFVRAWALIREYGPDGVRATAELAVLNANYVRKQLEGTYHLPYPTDSLHEVVFDDA
CCHHHHHHHHHHHHHHCCCCCCHHHEEEEECHHHHHHHHCCCEECCCCCCHHHHHHHCCC
QQKDAGVTTMDVAKRLIDHGFHPPTIYFPLVVHGALMIEPTETESRETLDAFVAAMKAIA
CHHCCCCHHHHHHHHHHHCCCCCCEEEHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHH
EEAKADPEAVRAAPTRPVRARLDETRAARKPVLRWQPGMNVE
HHHCCCHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure 
ANPTGWKPSMEQDAKGGAAAAEAPGLGGAVRGLAYEEPLVFEHGSRGRCGVSLPPPPAD
CCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCC
FDAGDLPAALVRPAVDGLPELSELEVVRHFTRLSSWNHGIDTGFYPLGSCTMKYNPKSSE
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEECCCCHH
ALARLPGFADLHPLAPAELAQGALELMYRLERALSEIAGFDATTLAPAAGAQGELTGLML
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHH
IRAYHEARGNPRKKVLIPDTAHGTNPASSALNGYAVVQLASGPDGRLHPETVRAAMDEDV
HHHHHHHCCCCCCEEECCCCCCCCCHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHCCCC
AAIMITNPNTLGVFESHIAEIAAIVHAKGGLVYGDGANMNALLGVARPGDMGFDVMQYNL
EEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEECCCCCCCCHHHHHHH
HKTFATPHGGGGPGSGPVAVKAALAPYLPLPLVVKEGERFRLVTEARERPATVGKLREFW
HHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCEEEEEHHHHHCCHHHHHHHHHH
GNFGMFVRAWALIREYGPDGVRATAELAVLNANYVRKQLEGTYHLPYPTDSLHEVVFDDA
CCHHHHHHHHHHHHHHCCCCCCHHHEEEEECHHHHHHHHCCCEECCCCCCHHHHHHHCCC
QQKDAGVTTMDVAKRLIDHGFHPPTIYFPLVVHGALMIEPTETESRETLDAFVAAMKAIA
CHHCCCCHHHHHHHHHHHCCCCCCEEEHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHH
EEAKADPEAVRAAPTRPVRARLDETRAARKPVLRWQPGMNVE
HHHCCCHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]