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The map label for this gene is gcvPA

Identifier: 220917815

GI number: 220917815

Start: 2994872

End: 2996209

Strand: Direct

Name: gcvPA

Synonym: A2cp1_2716

Alternate gene names: 220917815

Gene position: 2994872-2996209 (Clockwise)

Preceding gene: 220917814

Following gene: 220917816

Centisome position: 59.55

GC content: 74.14

Gene sequence:

>1338_bases
TTGCGATACCACCCGCACACCCCGGACGACGTCCGCGCCATGCTCGACGTCGTCGGCGCGGAGCGCGTCGACGACCTGTT
CCGCTCGATCCCGCAGGCGCTCCGGCTCGACCGCCCGCTCGACCTGCCGCCCGCGGCGGACGAGATCGCGCTGTTCTCCG
AGCTGCGGCGCCTGGCGGCGCGCAACGAGACGGCCCACCCGCCGTTCGTCGGCGCGGGGTGCTACCCGCACCACGTGCCA
CCGGTGGTGGACCAGCTCCTGCTCCGCGGCGAGTTCTTCACCGCGTACACGCCCTACCAGCCGGAGATCTCGCAGGGCAC
GCTGCAGGCGCTGTTCGAGTGGCAGACGTTCGTGTGCCTGCTGACCGGCATGGACGTGTCGAACGCGTCCATGTACGACG
GCGCGACCGCCACCGCCGAGGCGGCGCTCATGGCCGGCCGCATCACCGGGCGCGACAAGGTGGTGGTCTCCGCCGCGCTG
CACCCCGAGTACCGCAAGGTGCTCGCCACGTACCTGCGCTCGACCGGCGACGAGATCGTCACGGTGCCGTTCGGCGCCGA
CGGGCGCACCGACCTCGCCGCGCTGGCGCAGGCGGTGGACGGCCGGACCGCCTGCGTCATCCTCGGCTACCCGAACTTCC
TCGGCGTGGTGGACGCGCTGCCCGAGGCGGCCGCCCTCGCCCGGGCGGCCGGCGCGCTCACCGTCGCGGCCACCGCCGAG
GCGGTCTCGCTCGGCCTCCTCCAGGCGCCGGGCGCGCTCGGCGCGGACGTCGCGGTGGGCACGTTCCAGAGCTTCGGCAA
CCCCATGTCCTTCGGCGGCCCGGCGCCGGGGTTCTTCGCCACCCGCGAGAAGAGCCTGCGCCAGATGCCCGGCCGCGTGG
CGGGCGCGACGGTGGACAAGCAGGGGCGGCGCGGCTTCGTGCTCACGCTCTCCACCCGCGAGCAGCACATCCGCCGCGAG
AAGGCCACGTCCAACATCTGCACCAACTCCGGCCTGTGCGCGCTGGCCTCCACCATCCACCTGTCGCTCCTCGGCAAGCG
CGGCCTCGCCGAGCTGGCGCGCCTCAACCACGGGCGCGCCCGCATGCTGCGCGACGCGATGGAGCGGGCCGGCTGCCGCC
CGGTGTTCTCCGGGCCGTACTTCAACGAGCAGGTGTTCGACGTGGGCGACGCGGAGGCGGTGGTGGCGAAGCTCGCGAAG
CGCGGCATCGTGGCCGGCGCGCCGCTGGCGCGCTGGTACCCGGACGCGCCGCACGCGAAGGGCGCGCTGCTCTGTGCGGC
GACCGAGCTGCACGGCCCCGAGCTCATCCAGCTCTTCGCGAGCACGGTGAGGAGCTAG

Upstream 100 bases:

>100_bases
CGCCGCCTACAAGGCGTTCGTCGAGGAGCAGGAGTAGCGCCGAGCGCCGCCCGCCGGGCGGTCCCCCTCCCTCGCGGCGC
CGTCGCCGCGGAGCCAAGCC

Downstream 100 bases:

>100_bases
CCATGGCGAACCCGACCGGCTGGAAGCCCAGCATGGAGCAGGACGCGAAGGGCGGCGCCGCCGCGGCCGAGGCGCCCGGC
CTGGGCGGCGCGGTGCGCGG

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MRYHPHTPDDVRAMLDVVGAERVDDLFRSIPQALRLDRPLDLPPAADEIALFSELRRLAARNETAHPPFVGAGCYPHHVP
PVVDQLLLRGEFFTAYTPYQPEISQGTLQALFEWQTFVCLLTGMDVSNASMYDGATATAEAALMAGRITGRDKVVVSAAL
HPEYRKVLATYLRSTGDEIVTVPFGADGRTDLAALAQAVDGRTACVILGYPNFLGVVDALPEAAALARAAGALTVAATAE
AVSLGLLQAPGALGADVAVGTFQSFGNPMSFGGPAPGFFATREKSLRQMPGRVAGATVDKQGRRGFVLTLSTREQHIRRE
KATSNICTNSGLCALASTIHLSLLGKRGLAELARLNHGRARMLRDAMERAGCRPVFSGPYFNEQVFDVGDAEAVVAKLAK
RGIVAGAPLARWYPDAPHAKGALLCAATELHGPELIQLFASTVRS

Sequences:

>Translated_445_residues
MRYHPHTPDDVRAMLDVVGAERVDDLFRSIPQALRLDRPLDLPPAADEIALFSELRRLAARNETAHPPFVGAGCYPHHVP
PVVDQLLLRGEFFTAYTPYQPEISQGTLQALFEWQTFVCLLTGMDVSNASMYDGATATAEAALMAGRITGRDKVVVSAAL
HPEYRKVLATYLRSTGDEIVTVPFGADGRTDLAALAQAVDGRTACVILGYPNFLGVVDALPEAAALARAAGALTVAATAE
AVSLGLLQAPGALGADVAVGTFQSFGNPMSFGGPAPGFFATREKSLRQMPGRVAGATVDKQGRRGFVLTLSTREQHIRRE
KATSNICTNSGLCALASTIHLSLLGKRGLAELARLNHGRARMLRDAMERAGCRPVFSGPYFNEQVFDVGDAEAVVAKLAK
RGIVAGAPLARWYPDAPHAKGALLCAATELHGPELIQLFASTVRS
>Mature_445_residues
MRYHPHTPDDVRAMLDVVGAERVDDLFRSIPQALRLDRPLDLPPAADEIALFSELRRLAARNETAHPPFVGAGCYPHHVP
PVVDQLLLRGEFFTAYTPYQPEISQGTLQALFEWQTFVCLLTGMDVSNASMYDGATATAEAALMAGRITGRDKVVVSAAL
HPEYRKVLATYLRSTGDEIVTVPFGADGRTDLAALAQAVDGRTACVILGYPNFLGVVDALPEAAALARAAGALTVAATAE
AVSLGLLQAPGALGADVAVGTFQSFGNPMSFGGPAPGFFATREKSLRQMPGRVAGATVDKQGRRGFVLTLSTREQHIRRE
KATSNICTNSGLCALASTIHLSLLGKRGLAELARLNHGRARMLRDAMERAGCRPVFSGPYFNEQVFDVGDAEAVVAKLAK
RGIVAGAPLARWYPDAPHAKGALLCAATELHGPELIQLFASTVRS

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=364, Percent_Identity=37.3626373626374, Blast_Score=232, Evalue=5e-61,
Organism=Escherichia coli, GI1789269, Length=393, Percent_Identity=33.0788804071247, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17535605, Length=390, Percent_Identity=36.9230769230769, Blast_Score=225, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6323843, Length=401, Percent_Identity=34.1645885286783, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24645648, Length=387, Percent_Identity=37.984496124031, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_ANAD2 (B8JDY8)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002493119.1
- ProteinModelPortal:   B8JDY8
- SMR:   B8JDY8
- GeneID:   7299717
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2716
- HOGENOM:   HBG288345
- ProtClustDB:   PRK00451
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 47422; Mature: 47422

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYHPHTPDDVRAMLDVVGAERVDDLFRSIPQALRLDRPLDLPPAADEIALFSELRRLAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
RNETAHPPFVGAGCYPHHVPPVVDQLLLRGEFFTAYTPYQPEISQGTLQALFEWQTFVCL
CCCCCCCCEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
LTGMDVSNASMYDGATATAEAALMAGRITGRDKVVVSAALHPEYRKVLATYLRSTGDEIV
HCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEE
TVPFGADGRTDLAALAQAVDGRTACVILGYPNFLGVVDALPEAAALARAAGALTVAATAE
EEECCCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEHHHH
AVSLGLLQAPGALGADVAVGTFQSFGNPMSFGGPAPGFFATREKSLRQMPGRVAGATVDK
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCCC
QGRRGFVLTLSTREQHIRREKATSNICTNSGLCALASTIHLSLLGKRGLAELARLNHGRA
CCCCEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHH
RMLRDAMERAGCRPVFSGPYFNEQVFDVGDAEAVVAKLAKRGIVAGAPLARWYPDAPHAK
HHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCCCC
GALLCAATELHGPELIQLFASTVRS
CEEEEEEHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRYHPHTPDDVRAMLDVVGAERVDDLFRSIPQALRLDRPLDLPPAADEIALFSELRRLAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
RNETAHPPFVGAGCYPHHVPPVVDQLLLRGEFFTAYTPYQPEISQGTLQALFEWQTFVCL
CCCCCCCCEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
LTGMDVSNASMYDGATATAEAALMAGRITGRDKVVVSAALHPEYRKVLATYLRSTGDEIV
HCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEE
TVPFGADGRTDLAALAQAVDGRTACVILGYPNFLGVVDALPEAAALARAAGALTVAATAE
EEECCCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEHHHH
AVSLGLLQAPGALGADVAVGTFQSFGNPMSFGGPAPGFFATREKSLRQMPGRVAGATVDK
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCCC
QGRRGFVLTLSTREQHIRREKATSNICTNSGLCALASTIHLSLLGKRGLAELARLNHGRA
CCCCEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHH
RMLRDAMERAGCRPVFSGPYFNEQVFDVGDAEAVVAKLAKRGIVAGAPLARWYPDAPHAK
HHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCCCC
GALLCAATELHGPELIQLFASTVRS
CEEEEEEHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA