Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 220917778

GI number: 220917778

Start: 2956600

End: 2958699

Strand: Reverse

Name: uvrB [H]

Synonym: A2cp1_2679

Alternate gene names: 220917778

Gene position: 2958699-2956600 (Counterclockwise)

Preceding gene: 220917782

Following gene: 220917777

Centisome position: 58.83

GC content: 70.76

Gene sequence:

>2100_bases
GTGCCCTTCGACCTCCAGAGCGCGTTCCAGCCCACCGGCGACCAGCCGCGGGCCATCACCGAGCTGACCGACGGCCTGCG
CCGCGGCGAGCGCCACCAGGTGCTGCTCGGCGTCACCGGCTCCGGGAAGACGTTCACCGTCGCGAACGTGGTCGCCGAGG
TGAAGCGCCCCACGCTCGTCATCGCCCACAACAAGACGCTGGCGGCCCAGCTCTACGCGGAGTTCAAGGAGCTCTTCCCG
ACCGCCGCGGTGCACTACTTCGTCAGCTACTACGACTACTACCAGCCCGAGGCGTACGTCCCCTCGACGGACACGTACAT
CGAGAAGGACTCGTCCATCAACGACGAGATCGACCGGATGCGCCACGCGGCCACCCACGCGCTGCTCACCCGGAACGACG
TGCTCATCGTGGCCTCCGTCTCGTGCATCTACGGCCTCGGCACCGCCGAGGCCTACCACGGCCTGCTGCAGCGCCTCGAG
CGCGGCCAGGAGTTCCTGCGCGACCGCTTCATCCGCTCGCTCATCGACATCCAGTACGAGCGGAACGACCTCGACTTCCA
CCGCGGCACGTTCCGGGTGCGCGGCGACACCATCGAGGTGTTCCCGCCGTACGAGGAGGACCGCGCGGTCCGCATCGAGT
TCTTCGGCGACGTGGTCGAGTCGATCCACGAGTTCGACCCGCTCCGCGGCGCCACGCTCGCCGAGCTGGACAAGGTCGCG
ATCTTCCCGAACAGCCACTACGTGTCGGCGCCGGAGGTCCGGGCGCGCGCCATCGCCGGCGTCCGCGAGGAGCTGCGCGA
GCGGCTCGGCGAGCTGAAGGCGGCGAACAAGCTGGTCGAGGCGCAGCGGCTCGAGCAGCGGACGATGTTCGACCTGGAGA
TGCTGGAGCAGATGGGCTTCTGCCCGGGCATCGAGAACTACTCGCGGTGGCTCTCCGGACGGAAGGCGGGCGATCCGCCG
CCCTGCCTCCTCGACTACTTCCCGGAGGACTTCCTCCTCGTCATCGACGAGTCGCACCAGACGGTCCCGCAGATCGGGTC
GATGTACCGGGGCGATCGCTCGCGCAAGGAGACGCTGGTGGAGTTCGGGTTCCGGCTCCCCTCCGCGCTCGACAACCGCC
CGCTCAAGTTCGAGGAGTTCCAGGCGCTGGTCCGCCAGGCCATCTACGTGTCCGCGACGCCCGCCGCGTACGAGCTGGAG
CAGGCGCAGGGCGTCGTCGTCGAGCAGCTCATCCGGCCCACCGGGCTGGTGGATCCGCACATCGAGGTCCGGCCGGTGGG
CTCCCAGGTGGACGACCTGCTGGGCGAGGTGCGCAAGCGGGCCGAGGCGGGGGAGCGGGTGCTCGTGACCACGCTCACCA
AGCGCATGGCGGAGGATCTCACCGAGTACTTCACCGACGTCGGCGTGCGCTGCCGGTACCTGCACTCGGACATCGACACG
CTGGAGCGGAGCGCGGTGATCCGCGACCTGCGCCGCGGCGAGTTCGACGTGCTCATCGGCATCAACCTGCTGCGCGAGGG
GCTCGACATCCCCGAGGTCTCGCTGGTGGCCGTGCTCGACGCGGACAAGGAGGGCTTCCTGCGCTCGGCGGTGTCGCTCA
TCCAGACCATCGGGCGCGCCGCGCGCAACGTGAACGGCCGGGTGCTGCTCTACGCGGACGCGATCACCGCCTCGATGCGC
CAGGCGATCGACGAGACCGGGCGCCGCCGCGAGATCCAGGAGCGCTACAACGCGGAGCACGGCATCACGCCCACCACCGT
GAAGCGGAACATCAGCGACCTCGGCATGGCGGTGGTCGAGGCGGACTACGTGACCGTGCCGCTCGCGGCCGAGGAGGGCG
CCGAGTACCGGCCCGAGCAGCTCCCGGAGATCGTGGCGGCGCTCGAGCGCGAGATGCAGGACGCGGCCCGCGCGCTGGAG
TTCGAGAAGGCGGCGCAGCTGCGCGACCGGGTGCAGGCGCTGAAGGACCTGCAGCTCGGGCTGCCGGCGCGCGCCGCGGG
GGCGAGGGGGTCGCTGGGGAGCGGGGCGGTGGCGAGCGCGGCCGCCATGGGCAAGCTGCGCGGGGCGAAGCGGCCCATGC
AGCGCCGGCGCCGGCGCTGA

Upstream 100 bases:

>100_bases
AGCGGGGCTCCAGATTACTCTGGGTGGGAAGCGAGGTGGGGCCTGGAACCCGCGGCAAGGGGCCGCTGAACCCGCCGGGG
AGGGCTGTTACATTCCCGCG

Downstream 100 bases:

>100_bases
GCGCGGGCGCGCCGCGGGCGCGCACGGCACCGCCACCGGCGGCAGCCCCGGACGCCCGCCCGCCGCCCGCCCGGGCGGAC
GGGCGTGATCGGCGCCCCGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 699; Mature: 698

Protein sequence:

>699_residues
MPFDLQSAFQPTGDQPRAITELTDGLRRGERHQVLLGVTGSGKTFTVANVVAEVKRPTLVIAHNKTLAAQLYAEFKELFP
TAAVHYFVSYYDYYQPEAYVPSTDTYIEKDSSINDEIDRMRHAATHALLTRNDVLIVASVSCIYGLGTAEAYHGLLQRLE
RGQEFLRDRFIRSLIDIQYERNDLDFHRGTFRVRGDTIEVFPPYEEDRAVRIEFFGDVVESIHEFDPLRGATLAELDKVA
IFPNSHYVSAPEVRARAIAGVREELRERLGELKAANKLVEAQRLEQRTMFDLEMLEQMGFCPGIENYSRWLSGRKAGDPP
PCLLDYFPEDFLLVIDESHQTVPQIGSMYRGDRSRKETLVEFGFRLPSALDNRPLKFEEFQALVRQAIYVSATPAAYELE
QAQGVVVEQLIRPTGLVDPHIEVRPVGSQVDDLLGEVRKRAEAGERVLVTTLTKRMAEDLTEYFTDVGVRCRYLHSDIDT
LERSAVIRDLRRGEFDVLIGINLLREGLDIPEVSLVAVLDADKEGFLRSAVSLIQTIGRAARNVNGRVLLYADAITASMR
QAIDETGRRREIQERYNAEHGITPTTVKRNISDLGMAVVEADYVTVPLAAEEGAEYRPEQLPEIVAALEREMQDAARALE
FEKAAQLRDRVQALKDLQLGLPARAAGARGSLGSGAVASAAAMGKLRGAKRPMQRRRRR

Sequences:

>Translated_699_residues
MPFDLQSAFQPTGDQPRAITELTDGLRRGERHQVLLGVTGSGKTFTVANVVAEVKRPTLVIAHNKTLAAQLYAEFKELFP
TAAVHYFVSYYDYYQPEAYVPSTDTYIEKDSSINDEIDRMRHAATHALLTRNDVLIVASVSCIYGLGTAEAYHGLLQRLE
RGQEFLRDRFIRSLIDIQYERNDLDFHRGTFRVRGDTIEVFPPYEEDRAVRIEFFGDVVESIHEFDPLRGATLAELDKVA
IFPNSHYVSAPEVRARAIAGVREELRERLGELKAANKLVEAQRLEQRTMFDLEMLEQMGFCPGIENYSRWLSGRKAGDPP
PCLLDYFPEDFLLVIDESHQTVPQIGSMYRGDRSRKETLVEFGFRLPSALDNRPLKFEEFQALVRQAIYVSATPAAYELE
QAQGVVVEQLIRPTGLVDPHIEVRPVGSQVDDLLGEVRKRAEAGERVLVTTLTKRMAEDLTEYFTDVGVRCRYLHSDIDT
LERSAVIRDLRRGEFDVLIGINLLREGLDIPEVSLVAVLDADKEGFLRSAVSLIQTIGRAARNVNGRVLLYADAITASMR
QAIDETGRRREIQERYNAEHGITPTTVKRNISDLGMAVVEADYVTVPLAAEEGAEYRPEQLPEIVAALEREMQDAARALE
FEKAAQLRDRVQALKDLQLGLPARAAGARGSLGSGAVASAAAMGKLRGAKRPMQRRRRR
>Mature_698_residues
PFDLQSAFQPTGDQPRAITELTDGLRRGERHQVLLGVTGSGKTFTVANVVAEVKRPTLVIAHNKTLAAQLYAEFKELFPT
AAVHYFVSYYDYYQPEAYVPSTDTYIEKDSSINDEIDRMRHAATHALLTRNDVLIVASVSCIYGLGTAEAYHGLLQRLER
GQEFLRDRFIRSLIDIQYERNDLDFHRGTFRVRGDTIEVFPPYEEDRAVRIEFFGDVVESIHEFDPLRGATLAELDKVAI
FPNSHYVSAPEVRARAIAGVREELRERLGELKAANKLVEAQRLEQRTMFDLEMLEQMGFCPGIENYSRWLSGRKAGDPPP
CLLDYFPEDFLLVIDESHQTVPQIGSMYRGDRSRKETLVEFGFRLPSALDNRPLKFEEFQALVRQAIYVSATPAAYELEQ
AQGVVVEQLIRPTGLVDPHIEVRPVGSQVDDLLGEVRKRAEAGERVLVTTLTKRMAEDLTEYFTDVGVRCRYLHSDIDTL
ERSAVIRDLRRGEFDVLIGINLLREGLDIPEVSLVAVLDADKEGFLRSAVSLIQTIGRAARNVNGRVLLYADAITASMRQ
AIDETGRRREIQERYNAEHGITPTTVKRNISDLGMAVVEADYVTVPLAAEEGAEYRPEQLPEIVAALEREMQDAARALEF
EKAAQLRDRVQALKDLQLGLPARAAGARGSLGSGAVASAAAMGKLRGAKRPMQRRRRR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=673, Percent_Identity=59.4353640416048, Blast_Score=786, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 78578; Mature: 78447

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFDLQSAFQPTGDQPRAITELTDGLRRGERHQVLLGVTGSGKTFTVANVVAEVKRPTLV
CCCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEHHHHHHHHHCCCEEE
IAHNKTLAAQLYAEFKELFPTAAVHYFVSYYDYYQPEAYVPSTDTYIEKDSSINDEIDRM
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
RHAATHALLTRNDVLIVASVSCIYGLGTAEAYHGLLQRLERGQEFLRDRFIRSLIDIQYE
HHHHHHHHHCCCCEEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNDLDFHRGTFRVRGDTIEVFPPYEEDRAVRIEFFGDVVESIHEFDPLRGATLAELDKVA
CCCCCCCCCEEEEECCEEEECCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHCCCEE
IFPNSHYVSAPEVRARAIAGVREELRERLGELKAANKLVEAQRLEQRTMFDLEMLEQMGF
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CPGIENYSRWLSGRKAGDPPPCLLDYFPEDFLLVIDESHQTVPQIGSMYRGDRSRKETLV
CCCHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHH
EFGFRLPSALDNRPLKFEEFQALVRQAIYVSATPAAYELEQAQGVVVEQLIRPTGLVDPH
HHHHHCCHHHCCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHCCHHHHHHHCCCCCCCCC
IEVRPVGSQVDDLLGEVRKRAEAGERVLVTTLTKRMAEDLTEYFTDVGVRCRYLHSDIDT
CEEEECCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHH
LERSAVIRDLRRGEFDVLIGINLLREGLDIPEVSLVAVLDADKEGFLRSAVSLIQTIGRA
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
ARNVNGRVLLYADAITASMRQAIDETGRRREIQERYNAEHGITPTTVKRNISDLGMAVVE
HHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHHC
ADYVTVPLAAEEGAEYRPEQLPEIVAALEREMQDAARALEFEKAAQLRDRVQALKDLQLG
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPARAAGARGSLGSGAVASAAAMGKLRGAKRPMQRRRRR
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure 
PFDLQSAFQPTGDQPRAITELTDGLRRGERHQVLLGVTGSGKTFTVANVVAEVKRPTLV
CCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEHHHHHHHHHCCCEEE
IAHNKTLAAQLYAEFKELFPTAAVHYFVSYYDYYQPEAYVPSTDTYIEKDSSINDEIDRM
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
RHAATHALLTRNDVLIVASVSCIYGLGTAEAYHGLLQRLERGQEFLRDRFIRSLIDIQYE
HHHHHHHHHCCCCEEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNDLDFHRGTFRVRGDTIEVFPPYEEDRAVRIEFFGDVVESIHEFDPLRGATLAELDKVA
CCCCCCCCCEEEEECCEEEECCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHCCCEE
IFPNSHYVSAPEVRARAIAGVREELRERLGELKAANKLVEAQRLEQRTMFDLEMLEQMGF
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CPGIENYSRWLSGRKAGDPPPCLLDYFPEDFLLVIDESHQTVPQIGSMYRGDRSRKETLV
CCCHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHH
EFGFRLPSALDNRPLKFEEFQALVRQAIYVSATPAAYELEQAQGVVVEQLIRPTGLVDPH
HHHHHCCHHHCCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHCCHHHHHHHCCCCCCCCC
IEVRPVGSQVDDLLGEVRKRAEAGERVLVTTLTKRMAEDLTEYFTDVGVRCRYLHSDIDT
CEEEECCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHH
LERSAVIRDLRRGEFDVLIGINLLREGLDIPEVSLVAVLDADKEGFLRSAVSLIQTIGRA
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
ARNVNGRVLLYADAITASMRQAIDETGRRREIQERYNAEHGITPTTVKRNISDLGMAVVE
HHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHHC
ADYVTVPLAAEEGAEYRPEQLPEIVAALEREMQDAARALEFEKAAQLRDRVQALKDLQLG
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPARAAGARGSLGSGAVASAAAMGKLRGAKRPMQRRRRR
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA