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The map label for this gene is uvrC

Identifier: 220917777

GI number: 220917777

Start: 2954354

End: 2956477

Strand: Reverse

Name: uvrC

Synonym: A2cp1_2678

Alternate gene names: 220917777

Gene position: 2956477-2954354 (Counterclockwise)

Preceding gene: 220917778

Following gene: 220917776

Centisome position: 58.78

GC content: 74.15

Gene sequence:

>2124_bases
ATGGACGCGAACCTGCGCAGGAAGCTGGACGAGCTGCCCGCCGAGCCGGGCTGCTACCTCATGAAGGACCGGGCCGGCGA
GGTGGTCTACGTCGGCAAGGCGTCCAGCCTGCGCTCGCGCGTGCGCTCCTACTTCGACCCGGGCCGCGGCGATCAGCGCG
CGTTCGTGGCGCTGCTCGACGAGCTGCTCGGCGACCTCGAGGTGATCGTCACCCGCTCCGAGAAGGAGGCGGTGCTCCTC
GAGAACGAGCTCATCAAGAAGCACCGCCCGCGCTTCAACGTCCGGCTGCGCGACGACAAGGACTTCATCGTCCTGAAGCT
CGACGAGCGCCACCCGTACCCGCGCCTGGAGGTGCGGCGCGCCCGGGAGAAGCGGCAGCCGGGGGCGCGCTACTTCGGCC
CGTACTCCTCGGCCTCGTCCATCCGCGAGACGCTGCGCATGGTGAACCGGCACTTCCAGCTCCGGACCTGCAGCGACCAC
GTCTTCGACCACCGCAAGCGGCCCTGCATCCTGTACCAGATCCACCGCTGCCCGGCGCCCTGCGTCTACGAGGTGGCGGC
GGAGGAGTACCGGCAGTCGGTCGAGGACGCGGTGGAGTTCCTGGAGGGCCGCGAGGGCGAGCTGGTGGAGCGCCTGCGCG
GGCGCATGGCGGGCGCGGCGGAGGGGTTGCGGTTCGAGGAGGCGGCGCGGCTCCGCGACCAGCTCCAGGCGGTGGAGCGG
AGCCTCGAGAAGCAGCGGGTGCTGATGTCGGATCGCGGCGATCGCGACGTCATCGGCCTCTACCGCGAGGGGCCGGACCT
GGTGGTCCAGGTCCTCTCCATGCGCGCCGGCAAGCTGCAGGACGCGCAGGCGCACCCGTTCCGCGAGCAGGAGTTCCCCG
ACGAGGAGATCCTGTCCTCGTTCCTGTCGCTCTACTACGAGCACACCGACGCGCCGGACGAGATCCTGGTGCCGCTCGAG
CCGGTCCAGGCCGAGGCGCTCGCCGACGTGCTCTCGGAGCGGCGCGGGCGGCGGGTGCGGCTGCTCACCCCGCAGCGCGG
CGCGAAGGCCGACCTGCTCGACGTGGCCCGCCGCAACGCGGAGCAGGGGTTCCGGGCCTGGCACGAGCACGACGAGCGGC
GCGAGCAGGCGCTGGCCGCCGTGGCCCGGGCGCTGCACCTGGCGCGGCCGCCGCGCTGGATGGAGTGCTACGACATCTCG
ACGTTCCAGGGCGCGCTCGCGGTCGGCTCGGGCGTGTCGATGAAGGACGGCGAGCCGGACAAGGCGAACTACCGCCGCTA
CAAGGTGAAGGCGGTGGCGGGGCAGGACGACTTCGCCATGCTGCACGAGGTCATCACCCGCCGGCTGCGGCGGGCGCTGG
GGGAGGGACAGCTGCCCGACCTCATCGTGATCGACGGCGGGAAGGGCCAGCTCAACGCGGCGCTGGCGGCGGCGAAGGAC
CTGGGCGTCCCGACGCGCCCGTCGCCGGGCAACCCCGACGCGCCGTTCGTCGAGCTGGTGGGGCTCGCCAAGAGCCGGCT
GGTGGACGGCCCGTCGCTCGGGACGGCGCGGGTGGTGGGCCGGCGCGGGCGGCGCGCGGAGGCGCGCCTGGCGGACGCGG
CCGAGGCGGCGGAGAAGGGGTTCGTGTCCGAGCTGGCGCGCAGCCCGGAGCGCGTGTTCCTGCCCGGCCGCAAGGACCCG
GTGGTGCTGCGGCAGAACTCCGCGGAGCTGTTCCTGCTGGCCCGGCTGCGCGACGAGGCGCACCGCTTCGCCATCACGTT
CCACCGCAAGCTGCGGCGCGAGCGGAACTTCCAGAGCGTGCTCGAGGAGATCCCGGGGATCGGGGAGGGCCGCAAGCGGG
CGCTGCTGCGCCACTTCGGCGCGCTGCGCCGCGTCCGGGAGGCGACGCCCGAGGAGATCGCGCAGGTGGAGGGCTTCGGG
CCGAGGCAGGCGGCGGCCGTGCACGCGTTCTTCCACCGACCGGACGCGCCGCCGATCGCCGCGGACGAGCCGTCCGGCGC
GCCCGCCGGCGCGCCCGGCGGGGGTCCCGCCGAGGCGAGCCCGGAGGCGGTGGCCGCCGCCACCGAGGCCGAGATCGACG
CCGCGCTGGCCGACGAGGATGCGTCCCCGGAGCCCGCGGCTTAA

Upstream 100 bases:

>100_bases
CACGGCACCGCCACCGGCGGCAGCCCCGGACGCCCGCCCGCCGCCCGCCCGGGCGGACGGGCGTGATCGGCGCCCCGTTT
CCGGGTAATTCCTTGCCCGG

Downstream 100 bases:

>100_bases
GTCGGACGGCGGCCGGCCGGTTTGATAAGGTCGGGGCTCCCGAGGAGACGACATGCGGATCGCGGACGACGTCACGAAGC
TCATCGGCAACACGCCGCTG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 707; Mature: 707

Protein sequence:

>707_residues
MDANLRRKLDELPAEPGCYLMKDRAGEVVYVGKASSLRSRVRSYFDPGRGDQRAFVALLDELLGDLEVIVTRSEKEAVLL
ENELIKKHRPRFNVRLRDDKDFIVLKLDERHPYPRLEVRRAREKRQPGARYFGPYSSASSIRETLRMVNRHFQLRTCSDH
VFDHRKRPCILYQIHRCPAPCVYEVAAEEYRQSVEDAVEFLEGREGELVERLRGRMAGAAEGLRFEEAARLRDQLQAVER
SLEKQRVLMSDRGDRDVIGLYREGPDLVVQVLSMRAGKLQDAQAHPFREQEFPDEEILSSFLSLYYEHTDAPDEILVPLE
PVQAEALADVLSERRGRRVRLLTPQRGAKADLLDVARRNAEQGFRAWHEHDERREQALAAVARALHLARPPRWMECYDIS
TFQGALAVGSGVSMKDGEPDKANYRRYKVKAVAGQDDFAMLHEVITRRLRRALGEGQLPDLIVIDGGKGQLNAALAAAKD
LGVPTRPSPGNPDAPFVELVGLAKSRLVDGPSLGTARVVGRRGRRAEARLADAAEAAEKGFVSELARSPERVFLPGRKDP
VVLRQNSAELFLLARLRDEAHRFAITFHRKLRRERNFQSVLEEIPGIGEGRKRALLRHFGALRRVREATPEEIAQVEGFG
PRQAAAVHAFFHRPDAPPIAADEPSGAPAGAPGGGPAEASPEAVAAATEAEIDAALADEDASPEPAA

Sequences:

>Translated_707_residues
MDANLRRKLDELPAEPGCYLMKDRAGEVVYVGKASSLRSRVRSYFDPGRGDQRAFVALLDELLGDLEVIVTRSEKEAVLL
ENELIKKHRPRFNVRLRDDKDFIVLKLDERHPYPRLEVRRAREKRQPGARYFGPYSSASSIRETLRMVNRHFQLRTCSDH
VFDHRKRPCILYQIHRCPAPCVYEVAAEEYRQSVEDAVEFLEGREGELVERLRGRMAGAAEGLRFEEAARLRDQLQAVER
SLEKQRVLMSDRGDRDVIGLYREGPDLVVQVLSMRAGKLQDAQAHPFREQEFPDEEILSSFLSLYYEHTDAPDEILVPLE
PVQAEALADVLSERRGRRVRLLTPQRGAKADLLDVARRNAEQGFRAWHEHDERREQALAAVARALHLARPPRWMECYDIS
TFQGALAVGSGVSMKDGEPDKANYRRYKVKAVAGQDDFAMLHEVITRRLRRALGEGQLPDLIVIDGGKGQLNAALAAAKD
LGVPTRPSPGNPDAPFVELVGLAKSRLVDGPSLGTARVVGRRGRRAEARLADAAEAAEKGFVSELARSPERVFLPGRKDP
VVLRQNSAELFLLARLRDEAHRFAITFHRKLRRERNFQSVLEEIPGIGEGRKRALLRHFGALRRVREATPEEIAQVEGFG
PRQAAAVHAFFHRPDAPPIAADEPSGAPAGAPGGGPAEASPEAVAAATEAEIDAALADEDASPEPAA
>Mature_707_residues
MDANLRRKLDELPAEPGCYLMKDRAGEVVYVGKASSLRSRVRSYFDPGRGDQRAFVALLDELLGDLEVIVTRSEKEAVLL
ENELIKKHRPRFNVRLRDDKDFIVLKLDERHPYPRLEVRRAREKRQPGARYFGPYSSASSIRETLRMVNRHFQLRTCSDH
VFDHRKRPCILYQIHRCPAPCVYEVAAEEYRQSVEDAVEFLEGREGELVERLRGRMAGAAEGLRFEEAARLRDQLQAVER
SLEKQRVLMSDRGDRDVIGLYREGPDLVVQVLSMRAGKLQDAQAHPFREQEFPDEEILSSFLSLYYEHTDAPDEILVPLE
PVQAEALADVLSERRGRRVRLLTPQRGAKADLLDVARRNAEQGFRAWHEHDERREQALAAVARALHLARPPRWMECYDIS
TFQGALAVGSGVSMKDGEPDKANYRRYKVKAVAGQDDFAMLHEVITRRLRRALGEGQLPDLIVIDGGKGQLNAALAAAKD
LGVPTRPSPGNPDAPFVELVGLAKSRLVDGPSLGTARVVGRRGRRAEARLADAAEAAEKGFVSELARSPERVFLPGRKDP
VVLRQNSAELFLLARLRDEAHRFAITFHRKLRRERNFQSVLEEIPGIGEGRKRALLRHFGALRRVREATPEEIAQVEGFG
PRQAAAVHAFFHRPDAPPIAADEPSGAPAGAPGGGPAEASPEAVAAATEAEIDAALADEDASPEPAA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=648, Percent_Identity=35.3395061728395, Blast_Score=334, Evalue=1e-92,
Organism=Escherichia coli, GI1788037, Length=203, Percent_Identity=31.0344827586207, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_ANAD2 (B8JDG6)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002493081.1
- ProteinModelPortal:   B8JDG6
- GeneID:   7299679
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2678
- HOGENOM:   HBG566029
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 78993; Mature: 78993

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDANLRRKLDELPAEPGCYLMKDRAGEVVYVGKASSLRSRVRSYFDPGRGDQRAFVALLD
CCCHHHHHHHHCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHH
ELLGDLEVIVTRSEKEAVLLENELIKKHRPRFNVRLRDDKDFIVLKLDERHPYPRLEVRR
HHHCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHH
AREKRQPGARYFGPYSSASSIRETLRMVNRHFQLRTCSDHVFDHRKRPCILYQIHRCPAP
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHCCCCCEEEEEECCCCCH
CVYEVAAEEYRQSVEDAVEFLEGREGELVERLRGRMAGAAEGLRFEEAARLRDQLQAVER
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SLEKQRVLMSDRGDRDVIGLYREGPDLVVQVLSMRAGKLQDAQAHPFREQEFPDEEILSS
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
FLSLYYEHTDAPDEILVPLEPVQAEALADVLSERRGRRVRLLTPQRGAKADLLDVARRNA
HHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
EQGFRAWHEHDERREQALAAVARALHLARPPRWMECYDISTFQGALAVGSGVSMKDGEPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCC
KANYRRYKVKAVAGQDDFAMLHEVITRRLRRALGEGQLPDLIVIDGGKGQLNAALAAAKD
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHH
LGVPTRPSPGNPDAPFVELVGLAKSRLVDGPSLGTARVVGRRGRRAEARLADAAEAAEKG
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHH
FVSELARSPERVFLPGRKDPVVLRQNSAELFLLARLRDEAHRFAITFHRKLRRERNFQSV
HHHHHHCCCCEEECCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LEEIPGIGEGRKRALLRHFGALRRVREATPEEIAQVEGFGPRQAAAVHAFFHRPDAPPIA
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
ADEPSGAPAGAPGGGPAEASPEAVAAATEAEIDAALADEDASPEPAA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDANLRRKLDELPAEPGCYLMKDRAGEVVYVGKASSLRSRVRSYFDPGRGDQRAFVALLD
CCCHHHHHHHHCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHH
ELLGDLEVIVTRSEKEAVLLENELIKKHRPRFNVRLRDDKDFIVLKLDERHPYPRLEVRR
HHHCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHH
AREKRQPGARYFGPYSSASSIRETLRMVNRHFQLRTCSDHVFDHRKRPCILYQIHRCPAP
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHCCCCCEEEEEECCCCCH
CVYEVAAEEYRQSVEDAVEFLEGREGELVERLRGRMAGAAEGLRFEEAARLRDQLQAVER
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SLEKQRVLMSDRGDRDVIGLYREGPDLVVQVLSMRAGKLQDAQAHPFREQEFPDEEILSS
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
FLSLYYEHTDAPDEILVPLEPVQAEALADVLSERRGRRVRLLTPQRGAKADLLDVARRNA
HHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
EQGFRAWHEHDERREQALAAVARALHLARPPRWMECYDISTFQGALAVGSGVSMKDGEPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCC
KANYRRYKVKAVAGQDDFAMLHEVITRRLRRALGEGQLPDLIVIDGGKGQLNAALAAAKD
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHH
LGVPTRPSPGNPDAPFVELVGLAKSRLVDGPSLGTARVVGRRGRRAEARLADAAEAAEKG
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHH
FVSELARSPERVFLPGRKDPVVLRQNSAELFLLARLRDEAHRFAITFHRKLRRERNFQSV
HHHHHHCCCCEEECCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LEEIPGIGEGRKRALLRHFGALRRVREATPEEIAQVEGFGPRQAAAVHAFFHRPDAPPIA
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
ADEPSGAPAGAPGGGPAEASPEAVAAATEAEIDAALADEDASPEPAA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA