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The map label for this gene is fdh [H]

Identifier: 220917735

GI number: 220917735

Start: 2908745

End: 2909899

Strand: Reverse

Name: fdh [H]

Synonym: A2cp1_2636

Alternate gene names: 220917735

Gene position: 2909899-2908745 (Counterclockwise)

Preceding gene: 220917737

Following gene: 220917734

Centisome position: 57.86

GC content: 74.2

Gene sequence:

>1155_bases
ATGCGCGCGCTCGTCTACGAGGGGCCGTACCGGGTCAAGGTGAGGGACAAGCCCGCGCCCCGGATCGAGCACGGGGAGGA
CGTGGTGCTCCGGGTGACGCGGGCCGCCATCTGCGGCTCGGACCTGCACCTGCTCCACGGGTTCGTCCCGGACACGCGGG
TGGGGAGCACGTTCGGCCACGAGTTCACCGGCGTGGTCGAGGAGACCGGGCCCGCGGTGCGGACGCTGCGGCGCGGCGAC
CGGGTGGTGGTCCCGTTCAACATCTCGTGCGGGCGCTGCTTCTACTGCGCGCGCGGCCTCTACGGCGACTGCGAGTCCTC
GAACCCCATGTCCGACCTGGCCTCGGGCGTGTACGGCTACTCGCACACCACCGGCGGCTACGACGGCGGGCAGGCGGAGT
ACGTGCGCGTCCCGTTCGCGGACGTCGGGCCCATGAAGATCCCGGACGACCTCGAGGACGAGGACGTCCTGCTGCTCTCC
GACGTGCTCCCGACCGGCTACCAGGCGGCCGAGATGGGCGGCGTCCGCGAGGGCGACGTGGTGGCGGTGTTCGGCTGCGG
CCCGGTGGGCCTGGTGGCCGCGCGCTCGGCCTGGCTGCTCGGGGCGAGGCGGGTGATCGCCATCGACCGCGTGCCGGCGC
GGCTTCGCTTCGCGGAGCGCTGGGCCGGCGCCGAGACGCTCGACCTGGAGGCGGCCGGGTGGGATCCGGTGCCGGTGCTG
AAGGAGCAGACCGGCGGACGCGGGCCGGACGTGTGCGTGGACGCGGTCGGGCTGGAGGCGTCCGGCTCGCCGTGGCAGAC
GCTGCTCGGCCGCGGCCTGAAGCTGCAGGCCGGGTCGGCCGTGGCGCTCTCCTGGGCCATCCACGCGGTCAGGAAGGGCG
GGACCGTGTCGATCGTGGGCGTGTACGGGCCGCCCGCGAACCTGGTGCCGATCGGCGCCGCGATGAACAAGGGGCTCACG
CTCCGGACCGCGCAGGCGAACGTGAAGCGCTACATGCCGCACCTGCTGGAGCACGTGCGCGCGGGGCGCCTCGACGGGAA
GGGGCTCATCACGCACCGGTTCCCGCTGGAGCGCGCCGCGCACGCGTACGCGCTGTTCGGCGACCGGGCCGACGGCTGCG
TGAAGTGCGTGCTGGTCCCGGGCGCCCAGGCCTGA

Upstream 100 bases:

>100_bases
GACCATAGCAGCCGGCGGGCGCTCCCGCCGCCGCCGGCCCGGGTGGCGCCCGGCGTTTGCGGCGCGCACGGGCCGGGAGA
ACCTTGACCCCGGGGGTGGG

Downstream 100 bases:

>100_bases
CCGGCGCGGCGGCGAAGGGGGGGACGGATGCAGGGGATGGGGCCAGGCGCGATGCACCGGGGGGACGGGCCGCCGCCGGG
CGCGGGCGTGGACGGCGCCC

Product: alcohol dehydrogenase GroES domain-containing protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MRALVYEGPYRVKVRDKPAPRIEHGEDVVLRVTRAAICGSDLHLLHGFVPDTRVGSTFGHEFTGVVEETGPAVRTLRRGD
RVVVPFNISCGRCFYCARGLYGDCESSNPMSDLASGVYGYSHTTGGYDGGQAEYVRVPFADVGPMKIPDDLEDEDVLLLS
DVLPTGYQAAEMGGVREGDVVAVFGCGPVGLVAARSAWLLGARRVIAIDRVPARLRFAERWAGAETLDLEAAGWDPVPVL
KEQTGGRGPDVCVDAVGLEASGSPWQTLLGRGLKLQAGSAVALSWAIHAVRKGGTVSIVGVYGPPANLVPIGAAMNKGLT
LRTAQANVKRYMPHLLEHVRAGRLDGKGLITHRFPLERAAHAYALFGDRADGCVKCVLVPGAQA

Sequences:

>Translated_384_residues
MRALVYEGPYRVKVRDKPAPRIEHGEDVVLRVTRAAICGSDLHLLHGFVPDTRVGSTFGHEFTGVVEETGPAVRTLRRGD
RVVVPFNISCGRCFYCARGLYGDCESSNPMSDLASGVYGYSHTTGGYDGGQAEYVRVPFADVGPMKIPDDLEDEDVLLLS
DVLPTGYQAAEMGGVREGDVVAVFGCGPVGLVAARSAWLLGARRVIAIDRVPARLRFAERWAGAETLDLEAAGWDPVPVL
KEQTGGRGPDVCVDAVGLEASGSPWQTLLGRGLKLQAGSAVALSWAIHAVRKGGTVSIVGVYGPPANLVPIGAAMNKGLT
LRTAQANVKRYMPHLLEHVRAGRLDGKGLITHRFPLERAAHAYALFGDRADGCVKCVLVPGAQA
>Mature_384_residues
MRALVYEGPYRVKVRDKPAPRIEHGEDVVLRVTRAAICGSDLHLLHGFVPDTRVGSTFGHEFTGVVEETGPAVRTLRRGD
RVVVPFNISCGRCFYCARGLYGDCESSNPMSDLASGVYGYSHTTGGYDGGQAEYVRVPFADVGPMKIPDDLEDEDVLLLS
DVLPTGYQAAEMGGVREGDVVAVFGCGPVGLVAARSAWLLGARRVIAIDRVPARLRFAERWAGAETLDLEAAGWDPVPVL
KEQTGGRGPDVCVDAVGLEASGSPWQTLLGRGLKLQAGSAVALSWAIHAVRKGGTVSIVGVYGPPANLVPIGAAMNKGLT
LRTAQANVKRYMPHLLEHVRAGRLDGKGLITHRFPLERAAHAYALFGDRADGCVKCVLVPGAQA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=375, Percent_Identity=29.0666666666667, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI156523966, Length=382, Percent_Identity=24.869109947644, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4501929, Length=378, Percent_Identity=27.2486772486773, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4501939, Length=369, Percent_Identity=24.9322493224932, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI34577061, Length=359, Percent_Identity=27.5766016713092, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501933, Length=377, Percent_Identity=26.2599469496021, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=23.8726790450928, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI71565154, Length=256, Percent_Identity=28.90625, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786825, Length=394, Percent_Identity=44.9238578680203, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI1788073, Length=360, Percent_Identity=26.1111111111111, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787863, Length=379, Percent_Identity=25.065963060686, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87082125, Length=376, Percent_Identity=29.5212765957447, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI87081918, Length=247, Percent_Identity=33.1983805668016, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788407, Length=232, Percent_Identity=28.0172413793103, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790045, Length=352, Percent_Identity=25.5681818181818, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI226510992, Length=369, Percent_Identity=25.4742547425474, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788075, Length=367, Percent_Identity=26.7029972752044, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786552, Length=213, Percent_Identity=30.5164319248826, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790718, Length=233, Percent_Identity=26.6094420600858, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=351, Percent_Identity=27.0655270655271, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=247, Percent_Identity=29.5546558704453, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=362, Percent_Identity=25.9668508287293, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=354, Percent_Identity=25.7062146892655, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=206, Percent_Identity=28.1553398058252, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=368, Percent_Identity=26.9021739130435, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=399, Percent_Identity=27.3182957393484, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=374, Percent_Identity=25.9358288770053, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=374, Percent_Identity=25.9358288770053, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=417, Percent_Identity=24.9400479616307, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=358, Percent_Identity=26.2569832402235, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=322, Percent_Identity=27.3291925465839, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=307, Percent_Identity=26.7100977198697, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=263, Percent_Identity=27.7566539923954, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319621, Length=268, Percent_Identity=29.1044776119403, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17737897, Length=364, Percent_Identity=30.2197802197802, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17137530, Length=363, Percent_Identity=29.7520661157025, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17737895, Length=234, Percent_Identity=27.3504273504274, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45550770, Length=199, Percent_Identity=32.1608040201005, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45551930, Length=199, Percent_Identity=32.1608040201005, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221457811, Length=199, Percent_Identity=32.1608040201005, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 40890; Mature: 40890

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALVYEGPYRVKVRDKPAPRIEHGEDVVLRVTRAAICGSDLHLLHGFVPDTRVGSTFGH
CCEEEECCCEEEEECCCCCCCCCCCCCEEEEEEHHHHCCCCHHHHHCCCCCCCCCCCCCC
EFTGVVEETGPAVRTLRRGDRVVVPFNISCGRCFYCARGLYGDCESSNPMSDLASGVYGY
CHHHHHHHCCHHHHHHHCCCEEEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCC
SHTTGGYDGGQAEYVRVPFADVGPMKIPDDLEDEDVLLLSDVLPTGYQAAEMGGVREGDV
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHCCCCCCCE
VAVFGCGPVGLVAARSAWLLGARRVIAIDRVPARLRFAERWAGAETLDLEAAGWDPVPVL
EEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCCCH
KEQTGGRGPDVCVDAVGLEASGSPWQTLLGRGLKLQAGSAVALSWAIHAVRKGGTVSIVG
HHCCCCCCCCEEEEEECCCCCCCCHHHHHCCCEEEECCCEEEHHHHHHHHHCCCEEEEEE
VYGPPANLVPIGAAMNKGLTLRTAQANVKRYMPHLLEHVRAGRLDGKGLITHRFPLERAA
EECCCCCEEEECHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHH
HAYALFGDRADGCVKCVLVPGAQA
CEEEEECCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MRALVYEGPYRVKVRDKPAPRIEHGEDVVLRVTRAAICGSDLHLLHGFVPDTRVGSTFGH
CCEEEECCCEEEEECCCCCCCCCCCCCEEEEEEHHHHCCCCHHHHHCCCCCCCCCCCCCC
EFTGVVEETGPAVRTLRRGDRVVVPFNISCGRCFYCARGLYGDCESSNPMSDLASGVYGY
CHHHHHHHCCHHHHHHHCCCEEEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCC
SHTTGGYDGGQAEYVRVPFADVGPMKIPDDLEDEDVLLLSDVLPTGYQAAEMGGVREGDV
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHCCCCCCCE
VAVFGCGPVGLVAARSAWLLGARRVIAIDRVPARLRFAERWAGAETLDLEAAGWDPVPVL
EEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCCCH
KEQTGGRGPDVCVDAVGLEASGSPWQTLLGRGLKLQAGSAVALSWAIHAVRKGGTVSIVG
HHCCCCCCCCEEEEEECCCCCCCCHHHHHCCCEEEECCCEEEHHHHHHHHHCCCEEEEEE
VYGPPANLVPIGAAMNKGLTLRTAQANVKRYMPHLLEHVRAGRLDGKGLITHRFPLERAA
EECCCCCEEEECHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHH
HAYALFGDRADGCVKCVLVPGAQA
CEEEEECCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]