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The map label for this gene is metX [H]

Identifier: 220917652

GI number: 220917652

Start: 2830465

End: 2832699

Strand: Reverse

Name: metX [H]

Synonym: A2cp1_2553

Alternate gene names: 220917652

Gene position: 2832699-2830465 (Counterclockwise)

Preceding gene: 220917669

Following gene: 220917650

Centisome position: 56.32

GC content: 76.29

Gene sequence:

>2235_bases
ATGGCCCACCGCAACGGCAGCGCCGGCGCGACCGCAGCCGCCGGGCGCGCCGCCTTCGTCTCCCCGGAGACGCGCTCGTT
CCAGATCCCCGGTCCGTTCCCGCTGGAGCTGGGGGGCGCGCTGCCGGGCGTGACGGTCGGGTACCGCACCTGGGGGACGC
TCGACGCCGACGGCGGCAACGCGGTGGTGGTGTGCCACGCGCTGACCGGCTCGGCCGACGCCGATCTGTGGTGGACGCAG
ATGTTCGGGCCGGGCCGCGCGCTGGACCCGGAGCGCGACTTCATCGTCTGCTCCAACATCCTGGGGAGCTGCTACGGCAC
CACCGGGCCGACCTCGATCGACCCGGCCACCGGCGCGCCCTGGCACGGCACCTTCCCCGCCATCACCATCCGCGACATGG
TCCGCGTCCAGCGCGCCCTCGTCGACGGGCTCGGCGTGCGCCGCGTCCGCATGGCGGTGGGCGGCTCGCTGGGCGGCATG
CAGGTGCTGGAGTGGGCGCTGCTCTACCCGGACCTGGTCGAGTCGGTGGTGTTCGTGGCCTCGACCGCGCGCCACTCGGC
CTGGTGCATCGGCCTCTCCGAGGCGCAGCGCCAGGCCATCTACGCCGACCCGCTCTGGAAGGACGGGCGCTACCCCGCCG
ACGAGCCGCCGGTGGCCGGCCTCGCCGCGGCCCGGATGATGGCGATGCTGTCCTACCGGAGCCAGCCGTCCTTCGAGGAG
CGCTTCGGGCGCCGGCCGCAGACCGAGGACCTGTTCGCGGTGGAGAGCTACCTCCGCTACCAGGGCAAGCAGCTGGTGGA
TCGCTTCGACCCGGCCACGTACGTCACGCTCACCCGCGCCATGGACACGCACGACGTGGCGCGCGGCCGCGGCGACTTCG
AGGAGGTCCTGCGCGGCCTCCGGCAGCCGACGCTGGTGGTGTCGATCGACTCGGACGTCCTCTACTGGCCCTGGGAGCAG
CGCGAGGTGGCGATGCTGGTCCCGGGCGCGCGGCTCGCGGTGATGGACTCGCCGCACGGGCACGACGCGTTCCTCATCGA
CGTGGACCGGCTGAGCGACATGGTGGCCGACTTCCGCGGCCGACCCGCCGCCGCGGCGGCAGCGCCGGCCATGCCGGGGG
AGGAGGCGTTCGCCGAGCGCGGCCTGTCGCTGCTCGTGCTCGGGAAGGGGAAGGTCGGGCGCGAGCTGCTGGAGCAGGTC
CGGGTGCAGCGCACCGAGCTGGAGCGCGACTACGACGTGCTGCTGCGGGTGGTCGGCGTGGCGGACACGCGGGGCACGCT
GCTCGAGCCGCGCGGCGTGGACCTGGCGCGGTGGGAGGAGGCGCTCGCCGCCGCCCCGGCCACCGGCCCGGTGGACGCGC
GCTCGGCGCCGGCGCTGCTCGACCGGCTCGCGGCCCTTCCGCGGCCGGTGCTGGTGGACCTCACCGCCGCCGACGGCATG
GAGGACGTGTACGAGCAGGCGTTCCGGCGCGGCATCGACGTCATCGCCTCGAACAAGCGGCCCCTGGCGGTCGCGCCGCG
GCGGCTCGAGGCGCTCCGGGCGATGCGCCGCCAGCACCACCGGCACTGGCACTACGACACGGCGGTGGGCGCGAGCCTGC
CGGTGATCGGGACGCTGCGCCGCCTGGTCCGGACCGGCGACCGGGTGCAGCGCGTGGAGGGCTCGCTGTCGGGGACGCTC
GGGTACCTCTGCACCGAGCTCGCGCGCGGGACGCCGCTGTCCCTGGCGGCGCGCTGGGCGATGGGGCTCGGCTACTGCGA
GGCCGACCCGCGCGACGACCTGTCCGGCGTGGACTCCGCCCGGAAGGCGCTCATCCTGGCGCGCGAGCTGGGGGCGACGC
TGGCGCTGGAGGACGTCGAGGTCGAGCCGCTCGTGCCGCCGGCGCTGCTCGCGCCCGGCACGCCGGACGCGCTCATCGCG
GCGCTGCGCGGGCACGACGAGGCGATGGCCGCGCGGGTGGAGCGCCTGCGGCGCGCCGGCGAGGTGCTGCGCTACGTGGC
GCGCGTGACGGTGGGGGAGGGCGGGCGCGTCGCAGCGCGGGTCGGGCCGGAGGCGGTGCCGCTCGAGCACCCGCTGGCGC
GGCTCGTGGGCGTGGAGGCCCACGTCGCGTTCACCACCGCGCGGCACGCCGAGCGGCCGCTGGTGGTGCAGGGCGCGGGC
GTGGGCGGCGCGAACACCGCCGGCGGCGTCATCGCCGAGATCTTCCGGATCACGAGCGGGCGCGGGGCGCGGTAG

Upstream 100 bases:

>100_bases
CGCCGGCGGCGCGCGCGGAGCAGGCGGCCGCGGAGCGCGGCGGAGGGCCGGCGCCGCCGCCTTGACACCCCCGATCGGCC
GCCGATACCCTCCGCGCTCC

Downstream 100 bases:

>100_bases
CCGCCCGCCGGCCCCGGGGCTACGTGCCGGTCGGCCGGCCCGGGTTGCCCACCCCGTACTTCTTCATCTTCCCCTGCAGC
GTGGTGGGGCGCAGGCCGAG

Product: homoserine O-acetyltransferase

Products: NA

Alternate protein names: Homoserine O-trans-acetylase; HTA; Homoserine transacetylase [H]

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MAHRNGSAGATAAAGRAAFVSPETRSFQIPGPFPLELGGALPGVTVGYRTWGTLDADGGNAVVVCHALTGSADADLWWTQ
MFGPGRALDPERDFIVCSNILGSCYGTTGPTSIDPATGAPWHGTFPAITIRDMVRVQRALVDGLGVRRVRMAVGGSLGGM
QVLEWALLYPDLVESVVFVASTARHSAWCIGLSEAQRQAIYADPLWKDGRYPADEPPVAGLAAARMMAMLSYRSQPSFEE
RFGRRPQTEDLFAVESYLRYQGKQLVDRFDPATYVTLTRAMDTHDVARGRGDFEEVLRGLRQPTLVVSIDSDVLYWPWEQ
REVAMLVPGARLAVMDSPHGHDAFLIDVDRLSDMVADFRGRPAAAAAAPAMPGEEAFAERGLSLLVLGKGKVGRELLEQV
RVQRTELERDYDVLLRVVGVADTRGTLLEPRGVDLARWEEALAAAPATGPVDARSAPALLDRLAALPRPVLVDLTAADGM
EDVYEQAFRRGIDVIASNKRPLAVAPRRLEALRAMRRQHHRHWHYDTAVGASLPVIGTLRRLVRTGDRVQRVEGSLSGTL
GYLCTELARGTPLSLAARWAMGLGYCEADPRDDLSGVDSARKALILARELGATLALEDVEVEPLVPPALLAPGTPDALIA
ALRGHDEAMAARVERLRRAGEVLRYVARVTVGEGGRVAARVGPEAVPLEHPLARLVGVEAHVAFTTARHAERPLVVQGAG
VGGANTAGGVIAEIFRITSGRGAR

Sequences:

>Translated_744_residues
MAHRNGSAGATAAAGRAAFVSPETRSFQIPGPFPLELGGALPGVTVGYRTWGTLDADGGNAVVVCHALTGSADADLWWTQ
MFGPGRALDPERDFIVCSNILGSCYGTTGPTSIDPATGAPWHGTFPAITIRDMVRVQRALVDGLGVRRVRMAVGGSLGGM
QVLEWALLYPDLVESVVFVASTARHSAWCIGLSEAQRQAIYADPLWKDGRYPADEPPVAGLAAARMMAMLSYRSQPSFEE
RFGRRPQTEDLFAVESYLRYQGKQLVDRFDPATYVTLTRAMDTHDVARGRGDFEEVLRGLRQPTLVVSIDSDVLYWPWEQ
REVAMLVPGARLAVMDSPHGHDAFLIDVDRLSDMVADFRGRPAAAAAAPAMPGEEAFAERGLSLLVLGKGKVGRELLEQV
RVQRTELERDYDVLLRVVGVADTRGTLLEPRGVDLARWEEALAAAPATGPVDARSAPALLDRLAALPRPVLVDLTAADGM
EDVYEQAFRRGIDVIASNKRPLAVAPRRLEALRAMRRQHHRHWHYDTAVGASLPVIGTLRRLVRTGDRVQRVEGSLSGTL
GYLCTELARGTPLSLAARWAMGLGYCEADPRDDLSGVDSARKALILARELGATLALEDVEVEPLVPPALLAPGTPDALIA
ALRGHDEAMAARVERLRRAGEVLRYVARVTVGEGGRVAARVGPEAVPLEHPLARLVGVEAHVAFTTARHAERPLVVQGAG
VGGANTAGGVIAEIFRITSGRGAR
>Mature_743_residues
AHRNGSAGATAAAGRAAFVSPETRSFQIPGPFPLELGGALPGVTVGYRTWGTLDADGGNAVVVCHALTGSADADLWWTQM
FGPGRALDPERDFIVCSNILGSCYGTTGPTSIDPATGAPWHGTFPAITIRDMVRVQRALVDGLGVRRVRMAVGGSLGGMQ
VLEWALLYPDLVESVVFVASTARHSAWCIGLSEAQRQAIYADPLWKDGRYPADEPPVAGLAAARMMAMLSYRSQPSFEER
FGRRPQTEDLFAVESYLRYQGKQLVDRFDPATYVTLTRAMDTHDVARGRGDFEEVLRGLRQPTLVVSIDSDVLYWPWEQR
EVAMLVPGARLAVMDSPHGHDAFLIDVDRLSDMVADFRGRPAAAAAAPAMPGEEAFAERGLSLLVLGKGKVGRELLEQVR
VQRTELERDYDVLLRVVGVADTRGTLLEPRGVDLARWEEALAAAPATGPVDARSAPALLDRLAALPRPVLVDLTAADGME
DVYEQAFRRGIDVIASNKRPLAVAPRRLEALRAMRRQHHRHWHYDTAVGASLPVIGTLRRLVRTGDRVQRVEGSLSGTLG
YLCTELARGTPLSLAARWAMGLGYCEADPRDDLSGVDSARKALILARELGATLALEDVEVEPLVPPALLAPGTPDALIAA
LRGHDEAMAARVERLRRAGEVLRYVARVTVGEGGRVAARVGPEAVPLEHPLARLVGVEAHVAFTTARHAERPLVVQGAGV
GGANTAGGVIAEIFRITSGRGAR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG2021

COG function: function code E; Homoserine acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. HTA family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=350, Percent_Identity=38.2857142857143, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1790376, Length=360, Percent_Identity=34.4444444444444, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324052, Length=222, Percent_Identity=50, Blast_Score=236, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6322599, Length=350, Percent_Identity=29.4285714285714, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR008220 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =2.3.1.31 [H]

Molecular weight: Translated: 80029; Mature: 79898

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHRNGSAGATAAAGRAAFVSPETRSFQIPGPFPLELGGALPGVTVGYRTWGTLDADGGN
CCCCCCCCCCCHHCCCEEEECCCCCEEECCCCCCHHCCCCCCCCEECEEECCCEECCCCC
AVVVCHALTGSADADLWWTQMFGPGRALDPERDFIVCSNILGSCYGTTGPTSIDPATGAP
EEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCC
WHGTFPAITIRDMVRVQRALVDGLGVRRVRMAVGGSLGGMQVLEWALLYPDLVESVVFVA
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
STARHSAWCIGLSEAQRQAIYADPLWKDGRYPADEPPVAGLAAARMMAMLSYRSQPSFEE
HHCCCCEEEEEHHHHHCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
RFGRRPQTEDLFAVESYLRYQGKQLVDRFDPATYVTLTRAMDTHDVARGRGDFEEVLRGL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCHHHHHCCCCCHHHHHHHC
RQPTLVVSIDSDVLYWPWEQREVAMLVPGARLAVMDSPHGHDAFLIDVDRLSDMVADFRG
CCCEEEEEECCCEEECCCCCCCEEEEECCCEEEEEECCCCCCEEEEEHHHHHHHHHHHCC
RPAAAAAAPAMPGEEAFAERGLSLLVLGKGKVGRELLEQVRVQRTELERDYDVLLRVVGV
CCCHHHCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADTRGTLLEPRGVDLARWEEALAAAPATGPVDARSAPALLDRLAALPRPVLVDLTAADGM
CCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCH
EDVYEQAFRRGIDVIASNKRPLAVAPRRLEALRAMRRQHHRHWHYDTAVGASLPVIGTLR
HHHHHHHHHCCCCEEECCCCCCEECHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHH
RLVRTGDRVQRVEGSLSGTLGYLCTELARGTPLSLAARWAMGLGYCEADPRDDLSGVDSA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RKALILARELGATLALEDVEVEPLVPPALLAPGTPDALIAALRGHDEAMAARVERLRRAG
HHHHHHHHHHCCEEEEECCCCCCCCCCHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
EVLRYVARVTVGEGGRVAARVGPEAVPLEHPLARLVGVEAHVAFTTARHAERPLVVQGAG
HHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCHHHEEEHHHHHCCCCEEEEECC
VGGANTAGGVIAEIFRITSGRGAR
CCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AHRNGSAGATAAAGRAAFVSPETRSFQIPGPFPLELGGALPGVTVGYRTWGTLDADGGN
CCCCCCCCCCHHCCCEEEECCCCCEEECCCCCCHHCCCCCCCCEECEEECCCEECCCCC
AVVVCHALTGSADADLWWTQMFGPGRALDPERDFIVCSNILGSCYGTTGPTSIDPATGAP
EEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCC
WHGTFPAITIRDMVRVQRALVDGLGVRRVRMAVGGSLGGMQVLEWALLYPDLVESVVFVA
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
STARHSAWCIGLSEAQRQAIYADPLWKDGRYPADEPPVAGLAAARMMAMLSYRSQPSFEE
HHCCCCEEEEEHHHHHCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
RFGRRPQTEDLFAVESYLRYQGKQLVDRFDPATYVTLTRAMDTHDVARGRGDFEEVLRGL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCHHHHHCCCCCHHHHHHHC
RQPTLVVSIDSDVLYWPWEQREVAMLVPGARLAVMDSPHGHDAFLIDVDRLSDMVADFRG
CCCEEEEEECCCEEECCCCCCCEEEEECCCEEEEEECCCCCCEEEEEHHHHHHHHHHHCC
RPAAAAAAPAMPGEEAFAERGLSLLVLGKGKVGRELLEQVRVQRTELERDYDVLLRVVGV
CCCHHHCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADTRGTLLEPRGVDLARWEEALAAAPATGPVDARSAPALLDRLAALPRPVLVDLTAADGM
CCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCH
EDVYEQAFRRGIDVIASNKRPLAVAPRRLEALRAMRRQHHRHWHYDTAVGASLPVIGTLR
HHHHHHHHHCCCCEEECCCCCCEECHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHH
RLVRTGDRVQRVEGSLSGTLGYLCTELARGTPLSLAARWAMGLGYCEADPRDDLSGVDSA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RKALILARELGATLALEDVEVEPLVPPALLAPGTPDALIAALRGHDEAMAARVERLRRAG
HHHHHHHHHHCCEEEEECCCCCCCCCCHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
EVLRYVARVTVGEGGRVAARVGPEAVPLEHPLARLVGVEAHVAFTTARHAERPLVVQGAG
HHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCHHHEEEHHHHHCCCCEEEEECC
VGGANTAGGVIAEIFRITSGRGAR
CCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA