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The map label for this gene is zwf [H]

Identifier: 220917608

GI number: 220917608

Start: 2769866

End: 2771371

Strand: Reverse

Name: zwf [H]

Synonym: A2cp1_2508

Alternate gene names: 220917608

Gene position: 2771371-2769866 (Counterclockwise)

Preceding gene: 220917609

Following gene: 220917607

Centisome position: 55.1

GC content: 72.31

Gene sequence:

>1506_bases
ATGACCGCGCTCCCCGACCGCCCCGGCGACCCCTGCGCGTTCGTGATCTTCGGCGCGATGGGCGATCTCGCCCGGCGCAA
GCTCCTCCCGTCGCTCTACAACCTGCGCCTGAACGGCCTCTTGCCGCGCGAGTTCGCCATCGTGGGCGTCTCGCGCCGGG
CGCTCGACGACGCGGCCTACCGCGACGCCGTCACCGGCGCGCTCCGCACCTTCGCGACGCGCCCGGTGGACGACGCGGTC
TGGTCGGAGTACGCCGAGCGCGTCCACCACGTGCAGGGGGACTTCGAGGACCCGGCCACCTACGAGCGGATCGGGGCCGC
GCTCGCGCACGCCGCGCAGAAGCACGGGACCGCGGGCAACGCGCTGTTCTACCTGGCCACGCCGCCGGGCGAGTTCTGCC
ACATCGTGCGCGGGCTGGGCGCGGCGGGGCTGCTCGGGGAGAGCGCCGGCTGGCGGCGCGTCGTGATCGAGAAGCCGTTC
GGCCGCGACCTGGAGTCGGCGGTGGCGCTGAACCGCGAGCTCGCCTCGATCGTGCGCGAGGAGCAGATCTACCGGATCGA
CCACTACCTCGGGAAGGAGACCGTCCAGAACCTGATGGTGTTCCGGTTCGCGAACGGGATCTTCGAGCCGATCTGGAACC
GCCGCTACGTGGACCACGTGCAGGTCACCGTGGCGGAGGAGCTGGGGGTGGAGGGGCGGGGCGACTACTACGAGCAGGCC
GGCGCGCTCCGCGACATCGTCCAGAACCACATCCTGCAGCTCCTCACGCTGGTGGCGATGGAGCCGCCCTCGACGCTCGC
CGCCGAGGCCGTGCGCAACGAGAAGACGAAGGTGCTCGAGTCGATCCGGCCCATGTCGCCGGAGGACGTGCTGCGGAACA
CGGTGCGCGGCCAGTACGGCGAGGGCTACCTGGGCGGCCAGAAGGTGCCCGGGTACCGGGCCGAGCCGAGCGTGTCGCCC
GCCTCGCAGATCGAGACCTACGCCGCGCTGAAGCTCCAGGTGGAGAACTGGCGCTGGGCCGGGGTGCCGTTCTACGTGCG
CGCCGGCAAGCGGCTCGCGCGGCGCGACACGCAGATCTCGATCCAGTTCCGGCGGCCGCCGCTGCTCCTGTTCCAGGAGG
CCGGGGTGGAGGGCATCGAGCCGAACCGGCTCGACATCCTCATCCAGCCGGAGGAGGCCATCTGCATCTCGATGAAGGCG
AAGCGCCCCGGCCCCTCGATCCAGCTCCAGCCGGTGCGCCTCGACTTCAGCTACGCCGACTTCGGCGGCCTGCCGCCCGC
CACCGGCTACGAGCGACTGCTCCACGACGCGATGATCGGCGACGCGACGCTGTTCCACCGCGCCGACATGGTGGAGGCGA
GCTGGCGCATCGCCACCCCGGTGCTCGACGTCTGGTCCACGCTGCCCGCGCGCGACTTCCCGAACTACGCCGCGGGGAGC
TGGGGGCCCGCGGCGGCGTCCGAGCTGCTCGCGCGCGACGGGCGGCGCTGGGCGGACCGGGAGTGA

Upstream 100 bases:

>100_bases
GCTTCCGCTCGCGCCGGGCGCACACGTTCGGCGAGAAGCTGCTGAGCGCGATGCGCCGCGGGTTCGGCGGGCACCACGAG
GCGGTGAAGGGGGGCTCCCG

Downstream 100 bases:

>100_bases
CCCCGGTGGCGCGTCCCCCGGGGCCGGCGCTGGTGCGGGCCGCGGACGCGGCGGCCCTGGCGCGCGTGGCCGCCGAGGAG
GTGGCGCGGCGGGCCGAGGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTALPDRPGDPCAFVIFGAMGDLARRKLLPSLYNLRLNGLLPREFAIVGVSRRALDDAAYRDAVTGALRTFATRPVDDAV
WSEYAERVHHVQGDFEDPATYERIGAALAHAAQKHGTAGNALFYLATPPGEFCHIVRGLGAAGLLGESAGWRRVVIEKPF
GRDLESAVALNRELASIVREEQIYRIDHYLGKETVQNLMVFRFANGIFEPIWNRRYVDHVQVTVAEELGVEGRGDYYEQA
GALRDIVQNHILQLLTLVAMEPPSTLAAEAVRNEKTKVLESIRPMSPEDVLRNTVRGQYGEGYLGGQKVPGYRAEPSVSP
ASQIETYAALKLQVENWRWAGVPFYVRAGKRLARRDTQISIQFRRPPLLLFQEAGVEGIEPNRLDILIQPEEAICISMKA
KRPGPSIQLQPVRLDFSYADFGGLPPATGYERLLHDAMIGDATLFHRADMVEASWRIATPVLDVWSTLPARDFPNYAAGS
WGPAAASELLARDGRRWADRE

Sequences:

>Translated_501_residues
MTALPDRPGDPCAFVIFGAMGDLARRKLLPSLYNLRLNGLLPREFAIVGVSRRALDDAAYRDAVTGALRTFATRPVDDAV
WSEYAERVHHVQGDFEDPATYERIGAALAHAAQKHGTAGNALFYLATPPGEFCHIVRGLGAAGLLGESAGWRRVVIEKPF
GRDLESAVALNRELASIVREEQIYRIDHYLGKETVQNLMVFRFANGIFEPIWNRRYVDHVQVTVAEELGVEGRGDYYEQA
GALRDIVQNHILQLLTLVAMEPPSTLAAEAVRNEKTKVLESIRPMSPEDVLRNTVRGQYGEGYLGGQKVPGYRAEPSVSP
ASQIETYAALKLQVENWRWAGVPFYVRAGKRLARRDTQISIQFRRPPLLLFQEAGVEGIEPNRLDILIQPEEAICISMKA
KRPGPSIQLQPVRLDFSYADFGGLPPATGYERLLHDAMIGDATLFHRADMVEASWRIATPVLDVWSTLPARDFPNYAAGS
WGPAAASELLARDGRRWADRE
>Mature_500_residues
TALPDRPGDPCAFVIFGAMGDLARRKLLPSLYNLRLNGLLPREFAIVGVSRRALDDAAYRDAVTGALRTFATRPVDDAVW
SEYAERVHHVQGDFEDPATYERIGAALAHAAQKHGTAGNALFYLATPPGEFCHIVRGLGAAGLLGESAGWRRVVIEKPFG
RDLESAVALNRELASIVREEQIYRIDHYLGKETVQNLMVFRFANGIFEPIWNRRYVDHVQVTVAEELGVEGRGDYYEQAG
ALRDIVQNHILQLLTLVAMEPPSTLAAEAVRNEKTKVLESIRPMSPEDVLRNTVRGQYGEGYLGGQKVPGYRAEPSVSPA
SQIETYAALKLQVENWRWAGVPFYVRAGKRLARRDTQISIQFRRPPLLLFQEAGVEGIEPNRLDILIQPEEAICISMKAK
RPGPSIQLQPVRLDFSYADFGGLPPATGYERLLHDAMIGDATLFHRADMVEASWRIATPVLDVWSTLPARDFPNYAAGSW
GPAAASELLARDGRRWADRE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=491, Percent_Identity=39.1038696537678, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI108773793, Length=491, Percent_Identity=39.1038696537678, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI52145310, Length=495, Percent_Identity=30.5050505050505, Blast_Score=169, Evalue=8e-42,
Organism=Escherichia coli, GI1788158, Length=494, Percent_Identity=44.1295546558704, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17538218, Length=488, Percent_Identity=35.8606557377049, Blast_Score=318, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=34.8360655737705, Blast_Score=286, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24643350, Length=493, Percent_Identity=36.5111561866126, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24643352, Length=493, Percent_Identity=36.5111561866126, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI221513548, Length=486, Percent_Identity=31.8930041152263, Blast_Score=235, Evalue=5e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55695; Mature: 55564

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALPDRPGDPCAFVIFGAMGDLARRKLLPSLYNLRLNGLLPREFAIVGVSRRALDDAAY
CCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEECHHHHHHHHHH
RDAVTGALRTFATRPVDDAVWSEYAERVHHVQGDFEDPATYERIGAALAHAAQKHGTAGN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
ALFYLATPPGEFCHIVRGLGAAGLLGESAGWRRVVIEKPFGRDLESAVALNRELASIVRE
EEEEEECCCHHHHHHHHHCCCHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
EQIYRIDHYLGKETVQNLMVFRFANGIFEPIWNRRYVDHVQVTVAEELGVEGRGDYYEQA
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEHHHCCCCCCCCHHHHH
GALRDIVQNHILQLLTLVAMEPPSTLAAEAVRNEKTKVLESIRPMSPEDVLRNTVRGQYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
EGYLGGQKVPGYRAEPSVSPASQIETYAALKLQVENWRWAGVPFYVRAGKRLARRDTQIS
CCCCCCCCCCCCCCCCCCCCHHHHHHEEEEEEEECCEEECCCCCEEHHCHHHHHCCCEEE
IQFRRPPLLLFQEAGVEGIEPNRLDILIQPEEAICISMKAKRPGPSIQLQPVRLDFSYAD
EEECCCCEEEEHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCEEEEEEEEEECHHC
FGGLPPATGYERLLHDAMIGDATLFHRADMVEASWRIATPVLDVWSTLPARDFPNYAAGS
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCC
WGPAAASELLARDGRRWADRE
CCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TALPDRPGDPCAFVIFGAMGDLARRKLLPSLYNLRLNGLLPREFAIVGVSRRALDDAAY
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEECHHHHHHHHHH
RDAVTGALRTFATRPVDDAVWSEYAERVHHVQGDFEDPATYERIGAALAHAAQKHGTAGN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
ALFYLATPPGEFCHIVRGLGAAGLLGESAGWRRVVIEKPFGRDLESAVALNRELASIVRE
EEEEEECCCHHHHHHHHHCCCHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
EQIYRIDHYLGKETVQNLMVFRFANGIFEPIWNRRYVDHVQVTVAEELGVEGRGDYYEQA
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEHHHCCCCCCCCHHHHH
GALRDIVQNHILQLLTLVAMEPPSTLAAEAVRNEKTKVLESIRPMSPEDVLRNTVRGQYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
EGYLGGQKVPGYRAEPSVSPASQIETYAALKLQVENWRWAGVPFYVRAGKRLARRDTQIS
CCCCCCCCCCCCCCCCCCCCHHHHHHEEEEEEEECCEEECCCCCEEHHCHHHHHCCCEEE
IQFRRPPLLLFQEAGVEGIEPNRLDILIQPEEAICISMKAKRPGPSIQLQPVRLDFSYAD
EEECCCCEEEEHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCEEEEEEEEEECHHC
FGGLPPATGYERLLHDAMIGDATLFHRADMVEASWRIATPVLDVWSTLPARDFPNYAAGS
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCC
WGPAAASELLARDGRRWADRE
CCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]