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The map label for this gene is mdtA [H]

Identifier: 220917581

GI number: 220917581

Start: 2740850

End: 2741953

Strand: Reverse

Name: mdtA [H]

Synonym: A2cp1_2481

Alternate gene names: 220917581

Gene position: 2741953-2740850 (Counterclockwise)

Preceding gene: 220917583

Following gene: 220917580

Centisome position: 54.52

GC content: 77.99

Gene sequence:

>1104_bases
ATGATCCCGTCCCGACGCTTCCTCCTGATCTCCACCCTCGCCGCCGCCACGCACCTCGGCTGCTCGCGCGGCGACGCCGC
GGCGCTGCCCAGCGCGAAGGGCGAGCAGCCCGCCCTGGCGGTGCGGGCCGAGCGCCCCCGCGAGCGCCTGGAGGGCGAGA
CGGCGCGCGCCACCGGCGAGCTGCGCGCGAAGCTGCAGGCGACCGTCTCGGCCAAGGTCTCCGGGACCATCCTCCGCGTC
CGCGCGCAGGTGGGCGATCGCGTCCGCAAGGGCGACCCCATCGTCGAGCTCGATCCGGCGACGATCGCCATCCAGCTCGA
CCAGGCCCGCGCCGCGCGCAAGATGGCGCTCGCGGTCCGCGACAACGCCCGCTCCGATCTCGCCCGCACCGAGCAGCTCG
CGCGGGCGGACGCCGCGGCGCCGGCGGTCCTCGACAAGGCCCGCGCGGGCGCGCAGCAGGCGGAGGCCTCGCTCGAGCAG
GCCGACGCCCAGGTGCGGCTGCTGGAGCAGAACCTCCGCGACCTGGTGGTCCGGGCGCCGTTCGACGGCGTCGTCACGGC
CCGCCCGAAGAACGTCGGCGACTACCTCGTGACCATGCCACCGACGCCGGTCGCGACGGTGGTGGCGTCGGACGCGCTGG
AGGTGCGCCTCTCGGTCCCCGAGGGCCTGGTGGACCCCCTGAAGCCGGGCGCGGCGCTTCGCGGCCGGAGCATCCCGGGC
GGCGCGCCGTTCGAGGCGAAGGTGACGAGCGTGGGCGCCACGGTGGACCCGCAGACGCGGTCGGTCGAGGTGCTGGCCGA
CGTGCGCGCGGCCGCGGGCGCGAGCGTCGGCGCGCTCCGCTCGGGCGGCCTCGCCGAGGTGGACCTGGGCGGCTCGTCGG
CGGCGCAGGGGCCGTTCGTGCCGGCGCAGGCCGTGGTGCGGGAGGGGGCGCGCCGGTTCGTGTGGGTGGCGGACGAGGGC
GTGGCGCGGCGCCGCGAGGTGCAGGCAGAGCCGGTGACGCCGCAGTGGACGCGCGTGCGCGCCGGCCTGTCCGCGGGCGA
CGCGGTGGTGGTCGAGGGCGTGGCGGGGCTGATCGACGGCGCGCGCGTCGCGGTCGCGCAGTAG

Upstream 100 bases:

>100_bases
ACTTATCGGTTGCGTTTACAGCACGAGACGAGCAGATTAACGAAACTTTCAGTTGCGTTAGCCAGCCGGACCCGCTCGGC
CCGGCGCCCCGAGGCCCCCG

Downstream 100 bases:

>100_bases
CGGGAGCGAGCCATGGACGTGATCAAGACCTTCATCACCCGGCCGGTGTTCACCGCGATGCTCGTGCTCGCGGTGGTCGT
CTTCGGCCTGAACGCGTACC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MIPSRRFLLISTLAAATHLGCSRGDAAALPSAKGEQPALAVRAERPRERLEGETARATGELRAKLQATVSAKVSGTILRV
RAQVGDRVRKGDPIVELDPATIAIQLDQARAARKMALAVRDNARSDLARTEQLARADAAAPAVLDKARAGAQQAEASLEQ
ADAQVRLLEQNLRDLVVRAPFDGVVTARPKNVGDYLVTMPPTPVATVVASDALEVRLSVPEGLVDPLKPGAALRGRSIPG
GAPFEAKVTSVGATVDPQTRSVEVLADVRAAAGASVGALRSGGLAEVDLGGSSAAQGPFVPAQAVVREGARRFVWVADEG
VARRREVQAEPVTPQWTRVRAGLSAGDAVVVEGVAGLIDGARVAVAQ

Sequences:

>Translated_367_residues
MIPSRRFLLISTLAAATHLGCSRGDAAALPSAKGEQPALAVRAERPRERLEGETARATGELRAKLQATVSAKVSGTILRV
RAQVGDRVRKGDPIVELDPATIAIQLDQARAARKMALAVRDNARSDLARTEQLARADAAAPAVLDKARAGAQQAEASLEQ
ADAQVRLLEQNLRDLVVRAPFDGVVTARPKNVGDYLVTMPPTPVATVVASDALEVRLSVPEGLVDPLKPGAALRGRSIPG
GAPFEAKVTSVGATVDPQTRSVEVLADVRAAAGASVGALRSGGLAEVDLGGSSAAQGPFVPAQAVVREGARRFVWVADEG
VARRREVQAEPVTPQWTRVRAGLSAGDAVVVEGVAGLIDGARVAVAQ
>Mature_367_residues
MIPSRRFLLISTLAAATHLGCSRGDAAALPSAKGEQPALAVRAERPRERLEGETARATGELRAKLQATVSAKVSGTILRV
RAQVGDRVRKGDPIVELDPATIAIQLDQARAARKMALAVRDNARSDLARTEQLARADAAAPAVLDKARAGAQQAEASLEQ
ADAQVRLLEQNLRDLVVRAPFDGVVTARPKNVGDYLVTMPPTPVATVVASDALEVRLSVPEGLVDPLKPGAALRGRSIPG
GAPFEAKVTSVGATVDPQTRSVEVLADVRAAAGASVGALRSGGLAEVDLGGSSAAQGPFVPAQAVVREGARRFVWVADEG
VARRREVQAEPVTPQWTRVRAGLSAGDAVVVEGVAGLIDGARVAVAQ

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=320, Percent_Identity=26.25, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789929, Length=305, Percent_Identity=27.2131147540984, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38085; Mature: 38085

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPSRRFLLISTLAAATHLGCSRGDAAALPSAKGEQPALAVRAERPRERLEGETARATGE
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCHHHHHHH
LRAKLQATVSAKVSGTILRVRAQVGDRVRKGDPIVELDPATIAIQLDQARAARKMALAVR
HHHHHHHEEEEEECCEEEEEEHHHCCHHHCCCCEEEECCCEEEEEEHHHHHHHHHHHHEC
DNARSDLARTEQLARADAAAPAVLDKARAGAQQAEASLEQADAQVRLLEQNLRDLVVRAP
CCCHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
FDGVVTARPKNVGDYLVTMPPTPVATVVASDALEVRLSVPEGLVDPLKPGAALRGRSIPG
CCCEEEECCCCCCCEEEECCCCCHHHHEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
GAPFEAKVTSVGATVDPQTRSVEVLADVRAAAGASVGALRSGGLAEVDLGGSSAAQGPFV
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCEEEEECCCCCCCCCCCC
PAQAVVREGARRFVWVADEGVARRREVQAEPVTPQWTRVRAGLSAGDAVVVEGVAGLIDG
CHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEHHHHHHHCC
ARVAVAQ
CEEEECC
>Mature Secondary Structure
MIPSRRFLLISTLAAATHLGCSRGDAAALPSAKGEQPALAVRAERPRERLEGETARATGE
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCHHHHHHH
LRAKLQATVSAKVSGTILRVRAQVGDRVRKGDPIVELDPATIAIQLDQARAARKMALAVR
HHHHHHHEEEEEECCEEEEEEHHHCCHHHCCCCEEEECCCEEEEEEHHHHHHHHHHHHEC
DNARSDLARTEQLARADAAAPAVLDKARAGAQQAEASLEQADAQVRLLEQNLRDLVVRAP
CCCHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
FDGVVTARPKNVGDYLVTMPPTPVATVVASDALEVRLSVPEGLVDPLKPGAALRGRSIPG
CCCEEEECCCCCCCEEEECCCCCHHHHEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
GAPFEAKVTSVGATVDPQTRSVEVLADVRAAAGASVGALRSGGLAEVDLGGSSAAQGPFV
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCEEEEECCCCCCCCCCCC
PAQAVVREGARRFVWVADEGVARRREVQAEPVTPQWTRVRAGLSAGDAVVVEGVAGLIDG
CHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEHHHHHHHCC
ARVAVAQ
CEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]