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The map label for this gene is hisS

Identifier: 220917545

GI number: 220917545

Start: 2702863

End: 2704107

Strand: Reverse

Name: hisS

Synonym: A2cp1_2445

Alternate gene names: 220917545

Gene position: 2704107-2702863 (Counterclockwise)

Preceding gene: 220917546

Following gene: 220917544

Centisome position: 53.77

GC content: 73.17

Gene sequence:

>1245_bases
GTGAAGATCAACGGCGTGAAGGGCATGAACGACGTCCTCCCCGCGGACGTCGCCCGCTGGCACGAGATGGAGGCGGTCGC
GCGCGAGGTGTTCGCGCTGTACGGCTACCGCGAGGTGCGGACCCCGGCCGTGGAGCACGCGGCGCTGTTCGCCCGCGGCG
TCGGCGAGGCCACCGACATCGTCAACAAGGAGATGTACGTCTTCGAGGACAAGGGCGAGGAGCTGCTCGCGCTGCGCCCC
GAGGGCACCGCCGGCACGGTGCGCGCGTTCATCGAGCACGGCGCGTTCGTGGAGGGCCCGCAGAAGTGGTTCTACATGGG
CCCGATGTTCCGGCGCGAGCGGCCGCAGAAGGGCCGCTACCGCCAGTTCCACCAGATCGGCTGCGAGGCGTTCGGCGTCG
CCGAGCCGTACCTCGACGCGGAGCAGATCGCGCTGCTCGCCGACTACTTCGCGCGCCTGGGCGTGACCGCGGAGCTGAAG
CTCAACTCGGTGGGCGATGCGCAGTGCCGCCCCGCCTACCTCGCCGACCTGAAGGCGTACCTGGTCGCGAACCAGGGCGC
GCTCTGCGCCGACTGCAAGGACCGCATCGAGCGCAACCCACTCCGCGTGCTCGACTGCAAGGTCGAGTCCTGCCAGCCGG
TGCTGGAGCAGGCGCCGCGGCTGCTGGAGCGGCTCTGCGAGCCGTGCCGGGCGCACTTCGACCAGGTGAAGGCCGGCCTC
GACGCGCTCGGCGTCGCCTACCGCGTCGAGCCGCGGCTGGTGCGCGGGCTCGACTACTACGTGCGCACCGCGTACGAGTT
CACCTCCGACGCGCTCGGGTCCCAGTCCGCCGTCGCGGGTGGCGGCCGGTACGACCGGCTGGTCGAGACGCTCGGCGGCC
CGCCCACGCCGGGCATCGGCTTCGCCCTCGGCGAGGAGCGCCTCTCGATGATCCTGGAGAAGGTGGGCCGCGCCGCGCCG
GAGCGGCGGCCGGCGGTGTTCTTCGTCAGCGCGGACGCGACCGGCGCGCTCGAGGCGCTGCGGCTCGCGGCCGGGCTGCG
GCGGGCAGGGATCGCCTGCGAGCTCGATCCGCGCGGCGGCAAGCTGAAGGCGCAGTTCAAGCAGGCGGAGCGGGTCGGCG
CGCGGTGGGCGGTGGTGCTCGGCGGCAACGAGGTCGCGACCGGGCAGGCCAAGCTGAAGGACCTGCAGACGCGCGAGGAG
ACGCCGGTGGCGCTCTCGGAGCTCGCCGCGCGGGTCTCGGGGTAG

Upstream 100 bases:

>100_bases
GGGTCGGCGAGCCGCTCGGCGGCGCGGCGTAGGCCGCGGCGCGCCGCCGGCCTGCCACCTCCCCGTGCATCACGCGCGGG
GCTCTGGTATCCATGCCGGC

Downstream 100 bases:

>100_bases
CCGCCATGCCGCTCGCGCCCCTCGCCGCGCTCGCGCTCGCCCTCGCCGCCGCGCCCGGGCCGGCCCCGACGACCGCCCCG
AAGCCTGCCTCGACGCCGGC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MKINGVKGMNDVLPADVARWHEMEAVAREVFALYGYREVRTPAVEHAALFARGVGEATDIVNKEMYVFEDKGEELLALRP
EGTAGTVRAFIEHGAFVEGPQKWFYMGPMFRRERPQKGRYRQFHQIGCEAFGVAEPYLDAEQIALLADYFARLGVTAELK
LNSVGDAQCRPAYLADLKAYLVANQGALCADCKDRIERNPLRVLDCKVESCQPVLEQAPRLLERLCEPCRAHFDQVKAGL
DALGVAYRVEPRLVRGLDYYVRTAYEFTSDALGSQSAVAGGGRYDRLVETLGGPPTPGIGFALGEERLSMILEKVGRAAP
ERRPAVFFVSADATGALEALRLAAGLRRAGIACELDPRGGKLKAQFKQAERVGARWAVVLGGNEVATGQAKLKDLQTREE
TPVALSELAARVSG

Sequences:

>Translated_414_residues
MKINGVKGMNDVLPADVARWHEMEAVAREVFALYGYREVRTPAVEHAALFARGVGEATDIVNKEMYVFEDKGEELLALRP
EGTAGTVRAFIEHGAFVEGPQKWFYMGPMFRRERPQKGRYRQFHQIGCEAFGVAEPYLDAEQIALLADYFARLGVTAELK
LNSVGDAQCRPAYLADLKAYLVANQGALCADCKDRIERNPLRVLDCKVESCQPVLEQAPRLLERLCEPCRAHFDQVKAGL
DALGVAYRVEPRLVRGLDYYVRTAYEFTSDALGSQSAVAGGGRYDRLVETLGGPPTPGIGFALGEERLSMILEKVGRAAP
ERRPAVFFVSADATGALEALRLAAGLRRAGIACELDPRGGKLKAQFKQAERVGARWAVVLGGNEVATGQAKLKDLQTREE
TPVALSELAARVSG
>Mature_414_residues
MKINGVKGMNDVLPADVARWHEMEAVAREVFALYGYREVRTPAVEHAALFARGVGEATDIVNKEMYVFEDKGEELLALRP
EGTAGTVRAFIEHGAFVEGPQKWFYMGPMFRRERPQKGRYRQFHQIGCEAFGVAEPYLDAEQIALLADYFARLGVTAELK
LNSVGDAQCRPAYLADLKAYLVANQGALCADCKDRIERNPLRVLDCKVESCQPVLEQAPRLLERLCEPCRAHFDQVKAGL
DALGVAYRVEPRLVRGLDYYVRTAYEFTSDALGSQSAVAGGGRYDRLVETLGGPPTPGIGFALGEERLSMILEKVGRAAP
ERRPAVFFVSADATGALEALRLAAGLRRAGIACELDPRGGKLKAQFKQAERVGARWAVVLGGNEVATGQAKLKDLQTREE
TPVALSELAARVSG

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15029520, Length=461, Percent_Identity=26.0303687635575, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI6996014, Length=455, Percent_Identity=25.7142857142857, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1788861, Length=419, Percent_Identity=47.7326968973747, Blast_Score=366, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI71993693, Length=466, Percent_Identity=25.7510729613734, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71993686, Length=466, Percent_Identity=25.7510729613734, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24643061, Length=473, Percent_Identity=27.906976744186, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24643059, Length=418, Percent_Identity=28.9473684210526, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_ANAD2 (B8JBF6)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002492849.1
- ProteinModelPortal:   B8JBF6
- SMR:   B8JBF6
- GeneID:   7300105
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2445
- HOGENOM:   HBG616575
- ProtClustDB:   CLSK945678
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 45346; Mature: 45346

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINGVKGMNDVLPADVARWHEMEAVAREVFALYGYREVRTPAVEHAALFARGVGEATDI
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHCCCHHHHH
VNKEMYVFEDKGEELLALRPEGTAGTVRAFIEHGAFVEGPQKWFYMGPMFRRERPQKGRY
HCCCEEEEECCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECCHHHHCCCCCCHH
RQFHQIGCEAFGVAEPYLDAEQIALLADYFARLGVTAELKLNSVGDAQCRPAYLADLKAY
HHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHH
LVANQGALCADCKDRIERNPLRVLDCKVESCQPVLEQAPRLLERLCEPCRAHFDQVKAGL
HEECCCCEEHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DALGVAYRVEPRLVRGLDYYVRTAYEFTSDALGSQSAVAGGGRYDRLVETLGGPPTPGIG
HHHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
FALGEERLSMILEKVGRAAPERRPAVFFVSADATGALEALRLAAGLRRAGIACELDPRGG
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCC
KLKAQFKQAERVGARWAVVLGGNEVATGQAKLKDLQTREETPVALSELAARVSG
CCHHHHHHHHHCCCEEEEEECCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKINGVKGMNDVLPADVARWHEMEAVAREVFALYGYREVRTPAVEHAALFARGVGEATDI
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHCCCHHHHH
VNKEMYVFEDKGEELLALRPEGTAGTVRAFIEHGAFVEGPQKWFYMGPMFRRERPQKGRY
HCCCEEEEECCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECCHHHHCCCCCCHH
RQFHQIGCEAFGVAEPYLDAEQIALLADYFARLGVTAELKLNSVGDAQCRPAYLADLKAY
HHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHH
LVANQGALCADCKDRIERNPLRVLDCKVESCQPVLEQAPRLLERLCEPCRAHFDQVKAGL
HEECCCCEEHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DALGVAYRVEPRLVRGLDYYVRTAYEFTSDALGSQSAVAGGGRYDRLVETLGGPPTPGIG
HHHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
FALGEERLSMILEKVGRAAPERRPAVFFVSADATGALEALRLAAGLRRAGIACELDPRGG
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCC
KLKAQFKQAERVGARWAVVLGGNEVATGQAKLKDLQTREETPVALSELAARVSG
CCHHHHHHHHHCCCEEEEEECCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA