Click here to switch to the map view.

The map label for this gene is zraS [H]

Identifier: 220917492

GI number: 220917492

Start: 2650097

End: 2651665

Strand: Reverse

Name: zraS [H]

Synonym: A2cp1_2392

Alternate gene names: 220917492

Gene position: 2651665-2650097 (Counterclockwise)

Preceding gene: 220917493

Following gene: 220917489

Centisome position: 52.72

GC content: 79.16

Gene sequence:

>1569_bases
GTGACGCGCGAGAAGGTGGCGGCGCGCCTGATCGTCATGCTGGCGCTCACCGGCGTCGCGCCGATCGTGGCGCTCGGGGC
GGTCGGCATCGAGGCGATGCGCCGGCACACCGAGGCGTCCACCATCGCGACCATGCAGGAGCTGGCGCGCCAGGCCGCCG
AGCGGATCGACGCGTACCTCGCGGCGCAGGAGGAGGCCCTGCGGGTCGGCGCCGCCGCGTCGGTCGCCGACGCGCACTCG
GGCCAGCGGCTGGAGGAGCTGGTGCTGGAGGCGCCCGGCCTGGGCCGGGTGGTGCGCGTGGGGCCGGAGACGCCGCCGTC
GGCGCTGCCCGAGCGGATCACGCCGGCGCTGGCCGCCCGCGCGCGGGCCGGGTCGCCGGTGCGCTCCTCCTTCTACCTCG
CGCGCGATCTCACCCCGGCCCAGGACCTGTGCGTGCCGGCGCCGAGCCAGCCGGACGTGGCGGTCTGCGCCAGCCTGGAT
CTGCTGGAGCTGTGGCGCTTCGTGGGGCGCGTCCACGGCGGCGGCGCGGGGACCGTCCTCGCGTTCGACGAGTCGGGCCG
GCTGGTCGCGTCCGGCGCGGGCGCGCTGCGCGCGGCCGTGCTCACCGGCGAGCGGGTGCCGGAGGCCGAGGTGGCGGTCC
GGGTCGCCCGCGGCGAAGGCACCGCGCCGACGCACTGGGTGGGGCTGGACGGCGACGAGCTGCTGGGCGGCTGGGCACGG
CTGCCGCGCTCCGGCTGGGCGGTGGCGGTGGCGCGGCCCGCCGGCGAGGCGGCGCGGGCCGCCCGGACCGCGCAGTGGGC
GCTCGCCGCCGTGGTCCTGGCGGCGCTCGCGCTCTCGCTCGCGGTGGGGCTGGCGCAGTCGAAGCGCGTGCTCGCCGAGC
TCGAGCGCGAGGAGCGCTGGCGCACCGCCGGCCGCATCGCGGCGGGCGTGACGCACGACCTCGGGCATCGGGTCGCCATC
CTGCAGCAGCTCGCCGGGCTCGCCGAGGAAGGGCGCAGCGAGGCGCTGCCGCGGCTCCGGGACGGGCTGCGCGCGGAGGT
GGCGGCGCTGCGCGCGTTCGTGGCCGACTTCTCCGACCTCTCGCGCGACGTGCGCGCGGCGGAGCGCCGCCCGCTGGAGC
TCGGCGCCTTCGCGGCCAGCCTGGTCCGCACCGCGGGGCCGCACGCCGGCCGCGACGGTCTGACGCTCGCGCTCGACGCG
GGCGCGCAGGCCTGGATCCGCGCCGACCGGCACCTGCTGGAGCGCGCCGCGCTGAACCTCGTCTGGAACGCCTGCGAGGC
GTCGCCGGCCGGAGCCGAGGTGCGGCTGCGCGCGGCGGTCGAAGGCGGGCGCGGGCTGCTGTCGGTGGCGGATCGCGGCG
CCGGCATGCCCCCGGAGCGGCTCGCCTCGCTGTTCGACCTCGGCTCGACCAAGCGCGGGGCCGGCCACCTCGGGCTCGGG
CTCGCGAACGTGAAGCGGATCGTGGAGGGGCTCGGCGGGGCGGTGGAGGTGGCGAGCGCCGAGGGCGCCGGGACCACGTT
CACGCTCTCCTTCCCGGCGATCGCGCCGCCGCTCGACGAGGAGGGCTAG

Upstream 100 bases:

>100_bases
TGTGCCGGACCACGCGCGCCGGCGCGGTGGACGCGCGGATCCGCGGGGCGGTCTTCGGCTGGGGCGCGCTCGACACGCTG
CCGGACTGGGAGGTCGCGCC

Downstream 100 bases:

>100_bases
GCGGCCAGCGGGGCGCCCATCACGGAACGTGAATCCCCGGCGCGCGCCGGCTCAGGACGTCGCGCCGCCCTTGCCCGCAC
CGGGGGCCGCGGGTGCTGCG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MTREKVAARLIVMLALTGVAPIVALGAVGIEAMRRHTEASTIATMQELARQAAERIDAYLAAQEEALRVGAAASVADAHS
GQRLEELVLEAPGLGRVVRVGPETPPSALPERITPALAARARAGSPVRSSFYLARDLTPAQDLCVPAPSQPDVAVCASLD
LLELWRFVGRVHGGGAGTVLAFDESGRLVASGAGALRAAVLTGERVPEAEVAVRVARGEGTAPTHWVGLDGDELLGGWAR
LPRSGWAVAVARPAGEAARAARTAQWALAAVVLAALALSLAVGLAQSKRVLAELEREERWRTAGRIAAGVTHDLGHRVAI
LQQLAGLAEEGRSEALPRLRDGLRAEVAALRAFVADFSDLSRDVRAAERRPLELGAFAASLVRTAGPHAGRDGLTLALDA
GAQAWIRADRHLLERAALNLVWNACEASPAGAEVRLRAAVEGGRGLLSVADRGAGMPPERLASLFDLGSTKRGAGHLGLG
LANVKRIVEGLGGAVEVASAEGAGTTFTLSFPAIAPPLDEEG

Sequences:

>Translated_522_residues
MTREKVAARLIVMLALTGVAPIVALGAVGIEAMRRHTEASTIATMQELARQAAERIDAYLAAQEEALRVGAAASVADAHS
GQRLEELVLEAPGLGRVVRVGPETPPSALPERITPALAARARAGSPVRSSFYLARDLTPAQDLCVPAPSQPDVAVCASLD
LLELWRFVGRVHGGGAGTVLAFDESGRLVASGAGALRAAVLTGERVPEAEVAVRVARGEGTAPTHWVGLDGDELLGGWAR
LPRSGWAVAVARPAGEAARAARTAQWALAAVVLAALALSLAVGLAQSKRVLAELEREERWRTAGRIAAGVTHDLGHRVAI
LQQLAGLAEEGRSEALPRLRDGLRAEVAALRAFVADFSDLSRDVRAAERRPLELGAFAASLVRTAGPHAGRDGLTLALDA
GAQAWIRADRHLLERAALNLVWNACEASPAGAEVRLRAAVEGGRGLLSVADRGAGMPPERLASLFDLGSTKRGAGHLGLG
LANVKRIVEGLGGAVEVASAEGAGTTFTLSFPAIAPPLDEEG
>Mature_521_residues
TREKVAARLIVMLALTGVAPIVALGAVGIEAMRRHTEASTIATMQELARQAAERIDAYLAAQEEALRVGAAASVADAHSG
QRLEELVLEAPGLGRVVRVGPETPPSALPERITPALAARARAGSPVRSSFYLARDLTPAQDLCVPAPSQPDVAVCASLDL
LELWRFVGRVHGGGAGTVLAFDESGRLVASGAGALRAAVLTGERVPEAEVAVRVARGEGTAPTHWVGLDGDELLGGWARL
PRSGWAVAVARPAGEAARAARTAQWALAAVVLAALALSLAVGLAQSKRVLAELEREERWRTAGRIAAGVTHDLGHRVAIL
QQLAGLAEEGRSEALPRLRDGLRAEVAALRAFVADFSDLSRDVRAAERRPLELGAFAASLVRTAGPHAGRDGLTLALDAG
AQAWIRADRHLLERAALNLVWNACEASPAGAEVRLRAAVEGGRGLLSVADRGAGMPPERLASLFDLGSTKRGAGHLGLGL
ANVKRIVEGLGGAVEVASAEGAGTTFTLSFPAIAPPLDEEG

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=281, Percent_Identity=29.1814946619217, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788549, Length=241, Percent_Identity=27.8008298755187, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786912, Length=119, Percent_Identity=35.2941176470588, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1789808, Length=214, Percent_Identity=28.0373831775701, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54124; Mature: 53993

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTREKVAARLIVMLALTGVAPIVALGAVGIEAMRRHTEASTIATMQELARQAAERIDAYL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAQEEALRVGAAASVADAHSGQRLEELVLEAPGLGRVVRVGPETPPSALPERITPALAAR
HHHHHHHHHCCHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCHHHCHHHHHHHHHHH
ARAGSPVRSSFYLARDLTPAQDLCVPAPSQPDVAVCASLDLLELWRFVGRVHGGGAGTVL
HCCCCCCHHHEEHHHCCCCHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCEEE
AFDESGRLVASGAGALRAAVLTGERVPEAEVAVRVARGEGTAPTHWVGLDGDELLGGWAR
EECCCCCEEECCCCHHHHHHHCCCCCCCHHHEEEEECCCCCCCCEEECCCHHHHHHHHHH
LPRSGWAVAVARPAGEAARAARTAQWALAAVVLAALALSLAVGLAQSKRVLAELEREERW
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTAGRIAAGVTHDLGHRVAILQQLAGLAEEGRSEALPRLRDGLRAEVAALRAFVADFSDL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
SRDVRAAERRPLELGAFAASLVRTAGPHAGRDGLTLALDAGAQAWIRADRHLLERAALNL
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
VWNACEASPAGAEVRLRAAVEGGRGLLSVADRGAGMPPERLASLFDLGSTKRGAGHLGLG
HHHHHCCCCCCCCEEEEEEECCCCCEEHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
LANVKRIVEGLGGAVEVASAEGAGTTFTLSFPAIAPPLDEEG
HHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TREKVAARLIVMLALTGVAPIVALGAVGIEAMRRHTEASTIATMQELARQAAERIDAYL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAQEEALRVGAAASVADAHSGQRLEELVLEAPGLGRVVRVGPETPPSALPERITPALAAR
HHHHHHHHHCCHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCHHHCHHHHHHHHHHH
ARAGSPVRSSFYLARDLTPAQDLCVPAPSQPDVAVCASLDLLELWRFVGRVHGGGAGTVL
HCCCCCCHHHEEHHHCCCCHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCEEE
AFDESGRLVASGAGALRAAVLTGERVPEAEVAVRVARGEGTAPTHWVGLDGDELLGGWAR
EECCCCCEEECCCCHHHHHHHCCCCCCCHHHEEEEECCCCCCCCEEECCCHHHHHHHHHH
LPRSGWAVAVARPAGEAARAARTAQWALAAVVLAALALSLAVGLAQSKRVLAELEREERW
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTAGRIAAGVTHDLGHRVAILQQLAGLAEEGRSEALPRLRDGLRAEVAALRAFVADFSDL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
SRDVRAAERRPLELGAFAASLVRTAGPHAGRDGLTLALDAGAQAWIRADRHLLERAALNL
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
VWNACEASPAGAEVRLRAAVEGGRGLLSVADRGAGMPPERLASLFDLGSTKRGAGHLGLG
HHHHHCCCCCCCCEEEEEEECCCCCEEHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
LANVKRIVEGLGGAVEVASAEGAGTTFTLSFPAIAPPLDEEG
HHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]