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The map label for this gene is gloB [H]

Identifier: 220917082

GI number: 220917082

Start: 2234243

End: 2235010

Strand: Direct

Name: gloB [H]

Synonym: A2cp1_1979

Alternate gene names: 220917082

Gene position: 2234243-2235010 (Clockwise)

Preceding gene: 220917081

Following gene: 220917083

Centisome position: 44.42

GC content: 80.99

Gene sequence:

>768_bases
GTGACCTTCGACCGCCGCCGGTACGGGAAGGACAACTACACCTACCTGCTCGCCGCGGGCGGGGACGCGGCGCTGGTGGA
TCCCGGCGATCCGGACGCCGCGCTCGCGCTCGCCGCCGCGCACGGCGTCCGCCCGCGCTGGATCCTCCACACGCACGGCC
ACGCCGACCACACCGGCGGCACCGCCGCGGTGGCGCGCGCGCTCGGGGCTCGGGTGCTCGGGCACGGCGGCGACGCGGAG
CGCTTCCGGCCCGACGTGGACCTGGCCGGCCGCGCCGAGGTGGCGCTCGGGGCGCTCGCGCTGCGGGTGCACCCGGTCCC
GGGCCACACGCCGGGCTCGGTGCTGCTGGAGTGGGAGGGGCGGCTGCTGACCGGCGACACGCTGTTCTGGGCCGGGTGCG
GCAACTGCCGGCACGGCGGCGATCCCGCCCGGCTGGCGGAGAGCTTCCTCGGCCCCATCGCGCGGCTCGACGGCGCGCTG
GAGGTCCACCCCGGCCACGACTACGCCGCGCCCAACCTCGCGTTCGCGCTCGCGCTGGAGCCGGACGGCGCGGCGGCGCG
CGCGCGGCTGGCGGAGGTGGAGGCGGCGCACGCCGCCGGGCGCGAGCCCGCGCCCGGCACGCTCGCCGGCGAGCGCGCGG
TCAACCCGTTCCTGCGGCTCGACGCGCCCGGCGTGGCCGCCGCGGTGGCGCGCGCCGACCCGGCCGCCGCGGCCGCCGGC
CCGGTGCGGCGCTTCGTGGCGCTGCGCGCGCTGCGCGACCGGGCGTGA

Upstream 100 bases:

>100_bases
TGGTCCACCGGACCCGCTGGACCATCTACGTGCTCGACCCCGAGGGGAACCGCATCGGGCTCAGCCACCACCCGCACGAC
GCCGCGGGTGGGGAGCGGCC

Downstream 100 bases:

>100_bases
GGCGTCGTGAGCGTCCCGCCCCCGCGCCCGCTCGACGACGAGCCCCGCCCGGCCGAGGACGAGGGCTCGCCGGTGAACCT
CGCGAACGCGCTCACCGCGC

Product: Hydroxyacylglutathione hydrolase

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MTFDRRRYGKDNYTYLLAAGGDAALVDPGDPDAALALAAAHGVRPRWILHTHGHADHTGGTAAVARALGARVLGHGGDAE
RFRPDVDLAGRAEVALGALALRVHPVPGHTPGSVLLEWEGRLLTGDTLFWAGCGNCRHGGDPARLAESFLGPIARLDGAL
EVHPGHDYAAPNLAFALALEPDGAAARARLAEVEAAHAAGREPAPGTLAGERAVNPFLRLDAPGVAAAVARADPAAAAAG
PVRRFVALRALRDRA

Sequences:

>Translated_255_residues
MTFDRRRYGKDNYTYLLAAGGDAALVDPGDPDAALALAAAHGVRPRWILHTHGHADHTGGTAAVARALGARVLGHGGDAE
RFRPDVDLAGRAEVALGALALRVHPVPGHTPGSVLLEWEGRLLTGDTLFWAGCGNCRHGGDPARLAESFLGPIARLDGAL
EVHPGHDYAAPNLAFALALEPDGAAARARLAEVEAAHAAGREPAPGTLAGERAVNPFLRLDAPGVAAAVARADPAAAAAG
PVRRFVALRALRDRA
>Mature_254_residues
TFDRRRYGKDNYTYLLAAGGDAALVDPGDPDAALALAAAHGVRPRWILHTHGHADHTGGTAAVARALGARVLGHGGDAER
FRPDVDLAGRAEVALGALALRVHPVPGHTPGSVLLEWEGRLLTGDTLFWAGCGNCRHGGDPARLAESFLGPIARLDGALE
VHPGHDYAAPNLAFALALEPDGAAARARLAEVEAAHAAGREPAPGTLAGERAVNPFLRLDAPGVAAAVARADPAAAAAGP
VRRFVALRALRDRA

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI94538320, Length=252, Percent_Identity=30.952380952381, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI94538322, Length=252, Percent_Identity=30.952380952381, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI116642887, Length=219, Percent_Identity=34.703196347032, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI21703352, Length=229, Percent_Identity=33.6244541484716, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI14150041, Length=236, Percent_Identity=33.4745762711864, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI46361987, Length=196, Percent_Identity=33.6734693877551, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1786406, Length=246, Percent_Identity=29.6747967479675, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17536925, Length=257, Percent_Identity=26.4591439688716, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320478, Length=267, Percent_Identity=29.5880149812734, Blast_Score=92, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324614, Length=264, Percent_Identity=29.9242424242424, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356335, Length=244, Percent_Identity=27.4590163934426, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667711, Length=244, Percent_Identity=27.4590163934426, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667703, Length=244, Percent_Identity=27.4590163934426, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 26311; Mature: 26180

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00743 BETA_LACTAMASE_B_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDRRRYGKDNYTYLLAAGGDAALVDPGDPDAALALAAAHGVRPRWILHTHGHADHTGG
CCCCCCCCCCCCEEEEEEECCCEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCC
TAAVARALGARVLGHGGDAERFRPDVDLAGRAEVALGALALRVHPVPGHTPGSVLLEWEG
HHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHEEEEEEEEECCCCCCCCCEEEEECC
RLLTGDTLFWAGCGNCRHGGDPARLAESFLGPIARLDGALEVHPGHDYAAPNLAFALALE
EEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEEEC
PDGAAARARLAEVEAAHAAGREPAPGTLAGERAVNPFLRLDAPGVAAAVARADPAAAAAG
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEEECCCCHHHHHHHCCCHHHHHH
PVRRFVALRALRDRA
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
TFDRRRYGKDNYTYLLAAGGDAALVDPGDPDAALALAAAHGVRPRWILHTHGHADHTGG
CCCCCCCCCCCEEEEEEECCCEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCC
TAAVARALGARVLGHGGDAERFRPDVDLAGRAEVALGALALRVHPVPGHTPGSVLLEWEG
HHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHEEEEEEEEECCCCCCCCCEEEEECC
RLLTGDTLFWAGCGNCRHGGDPARLAESFLGPIARLDGALEVHPGHDYAAPNLAFALALE
EEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEEEC
PDGAAARARLAEVEAAHAAGREPAPGTLAGERAVNPFLRLDAPGVAAAVARADPAAAAAG
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEEECCCCHHHHHHHCCCHHHHHH
PVRRFVALRALRDRA
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA