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The map label for this gene is hemA1 [H]

Identifier: 220917073

GI number: 220917073

Start: 2222809

End: 2224077

Strand: Direct

Name: hemA1 [H]

Synonym: A2cp1_1969

Alternate gene names: 220917073

Gene position: 2222809-2224077 (Clockwise)

Preceding gene: 220917070

Following gene: 220917074

Centisome position: 44.2

GC content: 76.75

Gene sequence:

>1269_bases
GTGCTCGTCGCAGTCGGGCTGAACCAGAAGGGCGCCACCGTCGCAGACCGCGAGGTCCTCGCGCTGCCGTCGGAGGAGCT
GCTGGACGCGCTCACCGCCTTCCAGGCGCTCGACGGCGTGGACGAGGTCGCGATCGTCTCCACCTGCTACCGCGTGGAGA
TCTTCGCGGCCGCCCGCTGCCCCGCCGCCGCGGAGCTGTCGCTGCGCCACGCGATGGAGGCGCGCGCCGGCCGCCCGCTC
CCGCTGTTCGAGCTCCAGGGCGAGGAGGCGTTCCGGCACCTCGTCCGCGTCGCCTCCAGCCTCGAGTCCGCCATCCTGGG
CGAGCCGCAGATCCTGGGCCAGGTGAAGGACGCGTTCCACCGCGCCGCCGAGGCGGGCGCCGCCGGCAAGGAGCTCGCCT
CGGTGCTCTCCCGCGCGCTCGCGGCCGCGAAGCGCGTCCGCACCGAGACGGCGGTGGGCCGCGCCGGCGTGTCCTGGGGC
AACGCCGCGGCCGCGCTCGCCAGCAAGGTGCTCGGCCCGCTCGCCGGGCGCCGCGTGGCGGTGATCGGCGCCGGCGAGAT
GGCCCGCCTCACCGCCCAGCACATGCGCGACGAGCGCGCCTCGGTGGTGGTGCTGAACCGCACGCTCGCGAACGCGGAGG
CGCTGGCCGCCGAGGTGGGCGGCGAGGCCCGACCGCTCGAGGCGCTGGAGCAGGAGCTGCTGCGCGCCGACGTGGTGGTG
TCCGCCGCGCCGGCCGCGCCGCCGGCGCTGGCCCCGGCCGTCATGCAGCGCATCCTGCACGCCCGCCGCAAGCGGATCGT
CATGGTCGACCTGGCCGTCCCCCGCGCCATCCCCGCCGAGACCGGGGCGCTGCCGGACGTCTACCTGTGCGACGTCGACG
ACCTCGATCGCGTGATGAAGGCCGCCATGGCCGAGCGCGCCCAGGCGGCCCAGCACGCCGAGCGGATCGCCGACGAGGAG
GTGCAGAAGTTCGCGCGCGCCGAGGCCGAGCGCCGCGCCGCGCCGCTCATCCAGGAGATGCGCAGCCGCGCCAGCGCCAT
CGCGCGCGAGGAGGTGGAGCGCACGCTCCGCCGCCTCGGCGAGGACCCGGAGCTCGCGAAGCGGCTCGACGCCATGGCGG
GCTCGATCGTCTCCAAGATCCTGCACGCGCCCAGCACGCGCCTGCGCCAGGCGGTGTGCGACGGCGGGGCCAACGACCCG
CTGGTCGCGGCCGCCGTCCAGATCTTCGACCTGTCCGCGGCGCCGGCCGCCCGGGGCGACGCCGCCTAG

Upstream 100 bases:

>100_bases
ACCCTTGCGCGCTCCGGGGCGCGCCGATGCTGAAATCCTGCACGATCTCGTGGGGCACGCCGCTTGCTCGCATGCCGCCC
GTTCCCGAAAGGAGCGCCTC

Downstream 100 bases:

>100_bases
CGGGGAGGTCGGGCCTTCCCCAGGCCCGGAATTCCTGAGATATTGGCGCGCGTTGTCTCACGGGCCGACCGCATGAACCT
GCTCGAGCGCAGCTACCGGA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR 1 [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLVAVGLNQKGATVADREVLALPSEELLDALTAFQALDGVDEVAIVSTCYRVEIFAAARCPAAAELSLRHAMEARAGRPL
PLFELQGEEAFRHLVRVASSLESAILGEPQILGQVKDAFHRAAEAGAAGKELASVLSRALAAAKRVRTETAVGRAGVSWG
NAAAALASKVLGPLAGRRVAVIGAGEMARLTAQHMRDERASVVVLNRTLANAEALAAEVGGEARPLEALEQELLRADVVV
SAAPAAPPALAPAVMQRILHARRKRIVMVDLAVPRAIPAETGALPDVYLCDVDDLDRVMKAAMAERAQAAQHAERIADEE
VQKFARAEAERRAAPLIQEMRSRASAIAREEVERTLRRLGEDPELAKRLDAMAGSIVSKILHAPSTRLRQAVCDGGANDP
LVAAAVQIFDLSAAPAARGDAA

Sequences:

>Translated_422_residues
MLVAVGLNQKGATVADREVLALPSEELLDALTAFQALDGVDEVAIVSTCYRVEIFAAARCPAAAELSLRHAMEARAGRPL
PLFELQGEEAFRHLVRVASSLESAILGEPQILGQVKDAFHRAAEAGAAGKELASVLSRALAAAKRVRTETAVGRAGVSWG
NAAAALASKVLGPLAGRRVAVIGAGEMARLTAQHMRDERASVVVLNRTLANAEALAAEVGGEARPLEALEQELLRADVVV
SAAPAAPPALAPAVMQRILHARRKRIVMVDLAVPRAIPAETGALPDVYLCDVDDLDRVMKAAMAERAQAAQHAERIADEE
VQKFARAEAERRAAPLIQEMRSRASAIAREEVERTLRRLGEDPELAKRLDAMAGSIVSKILHAPSTRLRQAVCDGGANDP
LVAAAVQIFDLSAAPAARGDAA
>Mature_422_residues
MLVAVGLNQKGATVADREVLALPSEELLDALTAFQALDGVDEVAIVSTCYRVEIFAAARCPAAAELSLRHAMEARAGRPL
PLFELQGEEAFRHLVRVASSLESAILGEPQILGQVKDAFHRAAEAGAAGKELASVLSRALAAAKRVRTETAVGRAGVSWG
NAAAALASKVLGPLAGRRVAVIGAGEMARLTAQHMRDERASVVVLNRTLANAEALAAEVGGEARPLEALEQELLRADVVV
SAAPAAPPALAPAVMQRILHARRKRIVMVDLAVPRAIPAETGALPDVYLCDVDDLDRVMKAAMAERAQAAQHAERIADEE
VQKFARAEAERRAAPLIQEMRSRASAIAREEVERTLRRLGEDPELAKRLDAMAGSIVSKILHAPSTRLRQAVCDGGANDP
LVAAAVQIFDLSAAPAARGDAA

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=402, Percent_Identity=33.5820895522388, Blast_Score=203, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 44504; Mature: 44504

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVAVGLNQKGATVADREVLALPSEELLDALTAFQALDGVDEVAIVSTCYRVEIFAAARC
CEEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
PAAAELSLRHAMEARAGRPLPLFELQGEEAFRHLVRVASSLESAILGEPQILGQVKDAFH
CCHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RAAEAGAAGKELASVLSRALAAAKRVRTETAVGRAGVSWGNAAAALASKVLGPLAGRRVA
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEE
VIGAGEMARLTAQHMRDERASVVVLNRTLANAEALAAEVGGEARPLEALEQELLRADVVV
EEECCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SAAPAAPPALAPAVMQRILHARRKRIVMVDLAVPRAIPAETGALPDVYLCDVDDLDRVMK
CCCCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHH
AAMAERAQAAQHAERIADEEVQKFARAEAERRAAPLIQEMRSRASAIAREEVERTLRRLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EDPELAKRLDAMAGSIVSKILHAPSTRLRQAVCDGGANDPLVAAAVQIFDLSAAPAARGD
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
AA
CC
>Mature Secondary Structure
MLVAVGLNQKGATVADREVLALPSEELLDALTAFQALDGVDEVAIVSTCYRVEIFAAARC
CEEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
PAAAELSLRHAMEARAGRPLPLFELQGEEAFRHLVRVASSLESAILGEPQILGQVKDAFH
CCHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RAAEAGAAGKELASVLSRALAAAKRVRTETAVGRAGVSWGNAAAALASKVLGPLAGRRVA
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEE
VIGAGEMARLTAQHMRDERASVVVLNRTLANAEALAAEVGGEARPLEALEQELLRADVVV
EEECCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SAAPAAPPALAPAVMQRILHARRKRIVMVDLAVPRAIPAETGALPDVYLCDVDDLDRVMK
CCCCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHH
AAMAERAQAAQHAERIADEEVQKFARAEAERRAAPLIQEMRSRASAIAREEVERTLRRLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EDPELAKRLDAMAGSIVSKILHAPSTRLRQAVCDGGANDPLVAAAVQIFDLSAAPAARGD
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA