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The map label for this gene is degS [H]

Identifier: 220917069

GI number: 220917069

Start: 2218378

End: 2220366

Strand: Direct

Name: degS [H]

Synonym: A2cp1_1965

Alternate gene names: 220917069

Gene position: 2218378-2220366 (Clockwise)

Preceding gene: 220917068

Following gene: 220917070

Centisome position: 44.11

GC content: 76.57

Gene sequence:

>1989_bases
ATGAGGCCCGGGCCCGAGGCCGGCGCGCCGCCCGCGCTGCCGGTGCCGCCCGCGCCCCCGCCTGCCCCGGCGGCGTACCG
GACCGCGCCGCACCCGGCCATGCCGGGCGGCATCCGCCGGCGCGTCTATCTGCTGATGGCCACCGGCATCGCCGTCCCGC
TCGTCATCATGGGCGCGACCGGGATCCACTGGGCGCGCACCCTCGACGAACGGGTGGTGGCGGGCCGCATGTCCGCCGCG
GCCATGGCGGCGACGCACTTCGACGGCGTGCTGACCGAGGACCTCGAGGTGCTGCAGCGGCTCGCCTCCGGCGTGGCCCA
GACCATGGGCAACGCGGACCTCGAGGAGGAGCGGCGCGTGGTGGCCGACACGTACCACCAGTTCCGCCACCGCGAGGGCG
TCTACCTGCTGGACGCCGAGCGCAACGTGCTCGCGGAGGCGCCGGGCGGCCCGCGGTCGGCGGCGCCGGCCGACGACCTC
ACGGTGGTGGACGAGGTGCTGCGCACCGGGCTGCCGCGCCTCTCCGGCGCGGAGCAGGGCGCGCGCGGGCGGGTGGTGCA
CGAGCTCGTCCCGGTGCGGAGCTGGCAGAACCAGATCATCGGGATCGCCGGCGGCACGTTCGACCCGTCGCGGCGCGGCT
TCGATCGCGTGCTGCAGCACCTGCGCCGCGGGGAGAGCGGCTTCGCCGAGCTGATCGACGCGGGCGGCACCATCATCGCG
AGCACCGTGCCGGCCCGGGTCGGGCGCCGCACCGAGTGCCGGGCGCACCTCGGCGAGCTGGTGAAGGACAAGCGGGCGCA
GGCGGCGCGCTGCGACGGGTGCCACGGCGACTGGGGCGTGAAGGCGGCGGCGCCGGCCGAGCTGATGGTGTTCGCGCCGC
TGGCCGCGGCGCCGTGGGGCGTGGTGGTGCGGCAGCGCACCGCCGAGGCGCTGCCGACCGAGGGCGACGTGCCCTGGTGG
CTGGTCGCGGCCGGCCTGGCGGCGCACCTCGGCATCGCGGCGGCGTTCGCCTGGGGCGCGGCGCGCAGCGTGACCCGGCC
CATCGGCGTCCTCACCGGCGAGGCGGAGCGCATCGCCGGGGGCGAGCTGGACTGGTCCATCCCCGACCTCGGCACCGACG
AGGTGGGGCGGCTGGGGCGCTCGCTGGATCGCATGCGCCTGGCGCTCCGGCGCCTGCTCGACGACGTGGCGCGGGTGAAC
GCCGAGCTGGAGCAGCGGGTGGAGGAGCGCACGCACGCGCTCAACGAGGCCTACGCCCAGCTCGCCGCGCGCGACGAGGC
CCGCGCGCAGCTCCTCCGCAAGCTCATCTCTGCGCAGGAGGACGAGCGCAAGCGCATCGCCCGCGAGCTGCACGACGAGA
CCAGCCAGAGCCTGGCGGTGCTGGCCATGGGGCTCGAGGCGGCCCAGGACGCGATGCGCGGCGGCAAGGCGCCGCGCCTC
GAGGAGGTGAAGGCGGTGGCGGTGCGCACGCTGGAGGACGTGCACCGCATCATCCTGGACCTCCGCCCGTCGGTGCTCGA
CGACCTCGGGCTGCTGTCCGCGATCCGCTGGTACGCGGAGCGCCAGCTCGGCACGCGCGGCATGTCGGTGCGCTGCGAGT
TCGGGGAGCTGGACCGGCGGCTGCCGCCCGAGATGGAGACGGCGCTGTTCCGCATCTGCCAGGAGGCGATGAGCAACATC
GCCCGCCACGCCCAGGCGACCGCGGTGCTGGTGGAGGTCGCGCTGGAGGACGACGTGTTCCGCATCGACATCGAGGACGA
CGGGCGAGGCTTCGACGCGGAGGCCGTCGCGCGCCGCGAGGGGCGGCGCTCCTGGGGCCTCATGGGCATCCGCGAGCGCG
CCGAGATCCTGGGCGGCAGCGCCACGGTGGAGTCCGCGCCGGGGAAGGGCACCCGCGTCGAGGTGCGCATCCCGGTGCCG
CGCGCCACGACCGAGCCGGGCCCCGCCGCCGCCGGAGCGGACGCGGACGCCGAGGGGAGGGGAACGTGA

Upstream 100 bases:

>100_bases
TGGCCTGGGAGCAGCGCGGCCGGACGGTGCTGCTCCGCACGCGCGGCGACCTCGACGAGCTGTACCACATGGCCCACAGC
ACGCACCCCGGAGGCGGCCG

Downstream 100 bases:

>100_bases
GCGACAAGATCCGGGTGGTCATCGTGGACGACCACGCCATCCTGCGCGAGGGCGTGCGTGCGCTGCTCCAGCTCCAGCCC
GACATCGAGGTGGTCGGCGA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MRPGPEAGAPPALPVPPAPPPAPAAYRTAPHPAMPGGIRRRVYLLMATGIAVPLVIMGATGIHWARTLDERVVAGRMSAA
AMAATHFDGVLTEDLEVLQRLASGVAQTMGNADLEEERRVVADTYHQFRHREGVYLLDAERNVLAEAPGGPRSAAPADDL
TVVDEVLRTGLPRLSGAEQGARGRVVHELVPVRSWQNQIIGIAGGTFDPSRRGFDRVLQHLRRGESGFAELIDAGGTIIA
STVPARVGRRTECRAHLGELVKDKRAQAARCDGCHGDWGVKAAAPAELMVFAPLAAAPWGVVVRQRTAEALPTEGDVPWW
LVAAGLAAHLGIAAAFAWGAARSVTRPIGVLTGEAERIAGGELDWSIPDLGTDEVGRLGRSLDRMRLALRRLLDDVARVN
AELEQRVEERTHALNEAYAQLAARDEARAQLLRKLISAQEDERKRIARELHDETSQSLAVLAMGLEAAQDAMRGGKAPRL
EEVKAVAVRTLEDVHRIILDLRPSVLDDLGLLSAIRWYAERQLGTRGMSVRCEFGELDRRLPPEMETALFRICQEAMSNI
ARHAQATAVLVEVALEDDVFRIDIEDDGRGFDAEAVARREGRRSWGLMGIRERAEILGGSATVESAPGKGTRVEVRIPVP
RATTEPGPAAAGADADAEGRGT

Sequences:

>Translated_662_residues
MRPGPEAGAPPALPVPPAPPPAPAAYRTAPHPAMPGGIRRRVYLLMATGIAVPLVIMGATGIHWARTLDERVVAGRMSAA
AMAATHFDGVLTEDLEVLQRLASGVAQTMGNADLEEERRVVADTYHQFRHREGVYLLDAERNVLAEAPGGPRSAAPADDL
TVVDEVLRTGLPRLSGAEQGARGRVVHELVPVRSWQNQIIGIAGGTFDPSRRGFDRVLQHLRRGESGFAELIDAGGTIIA
STVPARVGRRTECRAHLGELVKDKRAQAARCDGCHGDWGVKAAAPAELMVFAPLAAAPWGVVVRQRTAEALPTEGDVPWW
LVAAGLAAHLGIAAAFAWGAARSVTRPIGVLTGEAERIAGGELDWSIPDLGTDEVGRLGRSLDRMRLALRRLLDDVARVN
AELEQRVEERTHALNEAYAQLAARDEARAQLLRKLISAQEDERKRIARELHDETSQSLAVLAMGLEAAQDAMRGGKAPRL
EEVKAVAVRTLEDVHRIILDLRPSVLDDLGLLSAIRWYAERQLGTRGMSVRCEFGELDRRLPPEMETALFRICQEAMSNI
ARHAQATAVLVEVALEDDVFRIDIEDDGRGFDAEAVARREGRRSWGLMGIRERAEILGGSATVESAPGKGTRVEVRIPVP
RATTEPGPAAAGADADAEGRGT
>Mature_662_residues
MRPGPEAGAPPALPVPPAPPPAPAAYRTAPHPAMPGGIRRRVYLLMATGIAVPLVIMGATGIHWARTLDERVVAGRMSAA
AMAATHFDGVLTEDLEVLQRLASGVAQTMGNADLEEERRVVADTYHQFRHREGVYLLDAERNVLAEAPGGPRSAAPADDL
TVVDEVLRTGLPRLSGAEQGARGRVVHELVPVRSWQNQIIGIAGGTFDPSRRGFDRVLQHLRRGESGFAELIDAGGTIIA
STVPARVGRRTECRAHLGELVKDKRAQAARCDGCHGDWGVKAAAPAELMVFAPLAAAPWGVVVRQRTAEALPTEGDVPWW
LVAAGLAAHLGIAAAFAWGAARSVTRPIGVLTGEAERIAGGELDWSIPDLGTDEVGRLGRSLDRMRLALRRLLDDVARVN
AELEQRVEERTHALNEAYAQLAARDEARAQLLRKLISAQEDERKRIARELHDETSQSLAVLAMGLEAAQDAMRGGKAPRL
EEVKAVAVRTLEDVHRIILDLRPSVLDDLGLLSAIRWYAERQLGTRGMSVRCEFGELDRRLPPEMETALFRICQEAMSNI
ARHAQATAVLVEVALEDDVFRIDIEDDGRGFDAEAVARREGRRSWGLMGIRERAEILGGSATVESAPGKGTRVEVRIPVP
RATTEPGPAAAGADADAEGRGT

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=235, Percent_Identity=32.3404255319149, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1787474, Length=206, Percent_Identity=28.1553398058252, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71336; Mature: 71336

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPGPEAGAPPALPVPPAPPPAPAAYRTAPHPAMPGGIRRRVYLLMATGIAVPLVIMGAT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GIHWARTLDERVVAGRMSAAAMAATHFDGVLTEDLEVLQRLASGVAQTMGNADLEEERRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VADTYHQFRHREGVYLLDAERNVLAEAPGGPRSAAPADDLTVVDEVLRTGLPRLSGAEQG
HHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
ARGRVVHELVPVRSWQNQIIGIAGGTFDPSRRGFDRVLQHLRRGESGFAELIDAGGTIIA
CCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEE
STVPARVGRRTECRAHLGELVKDKRAQAARCDGCHGDWGVKAAAPAELMVFAPLAAAPWG
EHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHCCCHH
VVVRQRTAEALPTEGDVPWWLVAAGLAAHLGIAAAFAWGAARSVTRPIGVLTGEAERIAG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHCC
GELDWSIPDLGTDEVGRLGRSLDRMRLALRRLLDDVARVNAELEQRVEERTHALNEAYAQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAARDEARAQLLRKLISAQEDERKRIARELHDETSQSLAVLAMGLEAAQDAMRGGKAPRL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EEVKAVAVRTLEDVHRIILDLRPSVLDDLGLLSAIRWYAERQLGTRGMSVRCEFGELDRR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCCC
LPPEMETALFRICQEAMSNIARHAQATAVLVEVALEDDVFRIDIEDDGRGFDAEAVARRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCHHHHHHHH
GRRSWGLMGIRERAEILGGSATVESAPGKGTRVEVRIPVPRATTEPGPAAAGADADAEGR
CCHHCCCHHHHHHHHHHCCCCEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
GT
CC
>Mature Secondary Structure
MRPGPEAGAPPALPVPPAPPPAPAAYRTAPHPAMPGGIRRRVYLLMATGIAVPLVIMGAT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GIHWARTLDERVVAGRMSAAAMAATHFDGVLTEDLEVLQRLASGVAQTMGNADLEEERRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VADTYHQFRHREGVYLLDAERNVLAEAPGGPRSAAPADDLTVVDEVLRTGLPRLSGAEQG
HHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
ARGRVVHELVPVRSWQNQIIGIAGGTFDPSRRGFDRVLQHLRRGESGFAELIDAGGTIIA
CCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEE
STVPARVGRRTECRAHLGELVKDKRAQAARCDGCHGDWGVKAAAPAELMVFAPLAAAPWG
EHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHCCCHH
VVVRQRTAEALPTEGDVPWWLVAAGLAAHLGIAAAFAWGAARSVTRPIGVLTGEAERIAG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHCC
GELDWSIPDLGTDEVGRLGRSLDRMRLALRRLLDDVARVNAELEQRVEERTHALNEAYAQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAARDEARAQLLRKLISAQEDERKRIARELHDETSQSLAVLAMGLEAAQDAMRGGKAPRL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EEVKAVAVRTLEDVHRIILDLRPSVLDDLGLLSAIRWYAERQLGTRGMSVRCEFGELDRR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCCC
LPPEMETALFRICQEAMSNIARHAQATAVLVEVALEDDVFRIDIEDDGRGFDAEAVARRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCHHHHHHHH
GRRSWGLMGIRERAEILGGSATVESAPGKGTRVEVRIPVPRATTEPGPAAAGADADAEGR
CCHHCCCHHHHHHHHHHCCCCEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
GT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]