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The map label for this gene is rio1 [H]

Identifier: 220916857

GI number: 220916857

Start: 1958442

End: 1959695

Strand: Direct

Name: rio1 [H]

Synonym: A2cp1_1753

Alternate gene names: 220916857

Gene position: 1958442-1959695 (Clockwise)

Preceding gene: 220916856

Following gene: 220916858

Centisome position: 38.94

GC content: 80.7

Gene sequence:

>1254_bases
ATGCACGACCCCCTCGCACCGCTCCTCGCCGACGGCGTGGTCGAAGCCGTCGGCGCGCGCCTGAAGACCGGCAAGGAGGC
CGAGGTCTGGCTCGTCCAGTCCGGCGGCGAGGTGGTCGCGGCCAAGGTCTACAAGGCCCGCCAGACCCGCACCTTCCGCA
ACGACGCGGCCTACCGCGAGGGCCGCCGCGTCCGCGACAGCCGCACGCAGCGCGCCATGGACCGCGGGAGCCGCTTCGGC
CAGGCGGCCGCGGAGGAGGCGTGGAAGGCGCGCGAGGCCGACGCGCTGCACGCGCTCCACGCCGCGGGCGTGCGGGTCCC
GCGCCCGGTGCTGTTCTACGAGGGCGTGCTGCTCATGGAGCTGGTGGTCGGGCCCGACGGCCACCCCGCGCCGCGCCTGG
TGGACGCGCGCGTGCCGCGCGAGCGCGCCGCCGCGCTCTACGCCGACCTGCGCGCGCAGGCGGTGCGCATGCTCTGCTGC
GACCTCATCCACGGTGACCTGTCACCGTACAACGTGCTGCTCGGGCACGACGGCCCGGTGGTGATCGACTTCCCGCAGGT
GGTCGGCGCCGCGCACAACGGGCAGGCGGAGGCGTTCTTCCGCCGCGACCTCGAGAACCTGCGCCGCTTCTTCGCCGCCC
TCGATCCCGCGCTCCACGCCGCCGCCGGGGACGCACGGGAGATCTGGCGCGCGTATGTCCGGCGCGAGCTGACCCCCGAC
TTCGTCCCGTCCGGCCGCGCCCCGGAGCCCGCGCCCCGCGCGCCCGCGCACCCGTCCGCCCGCGCCGGGGGTCATGGACA
GCCGCCGCGGCCGCACGCCGCGGCCCCGCGCGCCGCACCCGCGCACCCGGCGCCTGGCCCCGCGCACCCGACGCCCGCGC
CCACGCACCCGGCGCCCCCGCGCGCTGCGCCCGCGCATGGCGACGCGCCGCAGCGGCGCGGGCCCGGGAACCGGCAGCGC
GGACCGGGCGCCGGCGACCGCGGCGGCCGCCCGAGCGACCGCGGCGCCCGCCCTGCAGACCGCGGGGGCCGCCCAGCCGA
TCGCCGCGAGCACGGAGGGGATCGCGGCGGCGAACGGCGCCGCGCCGGCGCCGCCGCCGGACCCGAGGTGATCCGCGTCG
AGCGCCTGCCGCTCGCCGCCCCCCGCGACCGGCCGGGCCACGCGCAGCCGCGCCCCGGGTCAGGGGCGCCCTCCCAGCAC
GGTCGCGGGCCCGGGCCCCGGCCCGGGGCCCCGCGGCGCGGTCCGCGGCGCTGA

Upstream 100 bases:

>100_bases
GCGGCCGGGCGGCGGCGGCCGGCGGCCGGGTGGCCCGGGCGGCGGGCGCGGTCCCGGCGGCCCCGGCGGCGGCGCGCCGA
AGAAGTAGCGCCTCTCGCGC

Downstream 100 bases:

>100_bases
CGGGCCCCTGCGTGCGGCGCGATGTCGCGCCCCGCCCACGCCCGCCAGAAGAGCCCTCGCCTCCGCCACTTACCCCTGCG
CCGCGCCGGCCGTCGGCGGC

Product: hypothetical protein

Products: NA

Alternate protein names: AfRio1 [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MHDPLAPLLADGVVEAVGARLKTGKEAEVWLVQSGGEVVAAKVYKARQTRTFRNDAAYREGRRVRDSRTQRAMDRGSRFG
QAAAEEAWKAREADALHALHAAGVRVPRPVLFYEGVLLMELVVGPDGHPAPRLVDARVPRERAAALYADLRAQAVRMLCC
DLIHGDLSPYNVLLGHDGPVVIDFPQVVGAAHNGQAEAFFRRDLENLRRFFAALDPALHAAAGDAREIWRAYVRRELTPD
FVPSGRAPEPAPRAPAHPSARAGGHGQPPRPHAAAPRAAPAHPAPGPAHPTPAPTHPAPPRAAPAHGDAPQRRGPGNRQR
GPGAGDRGGRPSDRGARPADRGGRPADRREHGGDRGGERRRAGAAAGPEVIRVERLPLAAPRDRPGHAQPRPGSGAPSQH
GRGPGPRPGAPRRGPRR

Sequences:

>Translated_417_residues
MHDPLAPLLADGVVEAVGARLKTGKEAEVWLVQSGGEVVAAKVYKARQTRTFRNDAAYREGRRVRDSRTQRAMDRGSRFG
QAAAEEAWKAREADALHALHAAGVRVPRPVLFYEGVLLMELVVGPDGHPAPRLVDARVPRERAAALYADLRAQAVRMLCC
DLIHGDLSPYNVLLGHDGPVVIDFPQVVGAAHNGQAEAFFRRDLENLRRFFAALDPALHAAAGDAREIWRAYVRRELTPD
FVPSGRAPEPAPRAPAHPSARAGGHGQPPRPHAAAPRAAPAHPAPGPAHPTPAPTHPAPPRAAPAHGDAPQRRGPGNRQR
GPGAGDRGGRPSDRGARPADRGGRPADRREHGGDRGGERRRAGAAAGPEVIRVERLPLAAPRDRPGHAQPRPGSGAPSQH
GRGPGPRPGAPRRGPRR
>Mature_417_residues
MHDPLAPLLADGVVEAVGARLKTGKEAEVWLVQSGGEVVAAKVYKARQTRTFRNDAAYREGRRVRDSRTQRAMDRGSRFG
QAAAEEAWKAREADALHALHAAGVRVPRPVLFYEGVLLMELVVGPDGHPAPRLVDARVPRERAAALYADLRAQAVRMLCC
DLIHGDLSPYNVLLGHDGPVVIDFPQVVGAAHNGQAEAFFRRDLENLRRFFAALDPALHAAAGDAREIWRAYVRRELTPD
FVPSGRAPEPAPRAPAHPSARAGGHGQPPRPHAAAPRAAPAHPAPGPAHPTPAPTHPAPPRAAPAHGDAPQRRGPGNRQR
GPGAGDRGGRPSDRGARPADRGGRPADRREHGGDRGGERRRAGAAAGPEVIRVERLPLAAPRDRPGHAQPRPGSGAPSQH
GRGPGPRPGAPRRGPRR

Specific function: Autophosphorylation of the rio1 protein is not necessary for maintenance of kinase activity. Prefers ATP over GTP. The yeast ortholog is involved in ribosome biogenesis [H]

COG id: COG1718

COG function: function code TD; Serine/threonine protein kinase involved in cell cycle control

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI23510356, Length=214, Percent_Identity=29.9065420560748, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI229331967, Length=209, Percent_Identity=29.1866028708134, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI229331971, Length=209, Percent_Identity=29.1866028708134, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI22325377, Length=221, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115532073, Length=212, Percent_Identity=32.5471698113208, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32564178, Length=215, Percent_Identity=32.093023255814, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324122, Length=216, Percent_Identity=27.3148148148148, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324693, Length=239, Percent_Identity=26.7782426778243, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24662811, Length=214, Percent_Identity=32.7102803738318, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356879, Length=214, Percent_Identity=32.7102803738318, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24649986, Length=209, Percent_Identity=30.622009569378, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR000687
- InterPro:   IPR018935 [H]

Pfam domain/function: PF01163 RIO1 [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 44469; Mature: 44469

Theoretical pI: Translated: 11.76; Mature: 11.76

Prosite motif: PS00109 PROTEIN_KINASE_TYR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDPLAPLLADGVVEAVGARLKTGKEAEVWLVQSGGEVVAAKVYKARQTRTFRNDAAYRE
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHH
GRRVRDSRTQRAMDRGSRFGQAAAEEAWKAREADALHALHAAGVRVPRPVLFYEGVLLME
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LVVGPDGHPAPRLVDARVPRERAAALYADLRAQAVRMLCCDLIHGDLSPYNVLLGHDGPV
HHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCE
VIDFPQVVGAAHNGQAEAFFRRDLENLRRFFAALDPALHAAAGDAREIWRAYVRRELTPD
EEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
FVPSGRAPEPAPRAPAHPSARAGGHGQPPRPHAAAPRAAPAHPAPGPAHPTPAPTHPAPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RAAPAHGDAPQRRGPGNRQRGPGAGDRGGRPSDRGARPADRGGRPADRREHGGDRGGERR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHH
RAGAAAGPEVIRVERLPLAAPRDRPGHAQPRPGSGAPSQHGRGPGPRPGAPRRGPRR
HCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHDPLAPLLADGVVEAVGARLKTGKEAEVWLVQSGGEVVAAKVYKARQTRTFRNDAAYRE
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHH
GRRVRDSRTQRAMDRGSRFGQAAAEEAWKAREADALHALHAAGVRVPRPVLFYEGVLLME
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LVVGPDGHPAPRLVDARVPRERAAALYADLRAQAVRMLCCDLIHGDLSPYNVLLGHDGPV
HHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCE
VIDFPQVVGAAHNGQAEAFFRRDLENLRRFFAALDPALHAAAGDAREIWRAYVRRELTPD
EEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
FVPSGRAPEPAPRAPAHPSARAGGHGQPPRPHAAAPRAAPAHPAPGPAHPTPAPTHPAPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RAAPAHGDAPQRRGPGNRQRGPGAGDRGGRPSDRGARPADRGGRPADRREHGGDRGGERR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHH
RAGAAAGPEVIRVERLPLAAPRDRPGHAQPRPGSGAPSQHGRGPGPRPGAPRRGPRR
HCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]