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The map label for this gene is cphA [H]

Identifier: 220916778

GI number: 220916778

Start: 1865294

End: 1866250

Strand: Direct

Name: cphA [H]

Synonym: A2cp1_1673

Alternate gene names: 220916778

Gene position: 1865294-1866250 (Clockwise)

Preceding gene: 220916777

Following gene: 220916779

Centisome position: 37.09

GC content: 76.07

Gene sequence:

>957_bases
ATGGCGCCCGCGCTCGCCACGCTGCTCGCGGCGCTCGCCGCGGCCGCCCCCGCGCCGGCCCGCGCGGCCGATCCCGTCCT
CGAGCCGGTCCGGCTCGCGCCGCGGGTCTGGCTGGTGCAAGGCGACCCGGGCGTCGCCTCGGCGGCGAACCGCGGCTTCA
ACTCCAACGCGGCGTTCGTCGTGACCGGCGACGGCGTGGTGGTGATCGACGCCCTCGGCACGCCGGCGCTGGGCCGCGCG
CTGGTGCGCGCCATCCGCAAGGTGACCCGCCAGCCGATCCGGCGGGTGATCCTGACGCACTACCACGCCGACCACGTCTA
CGGCCTCGGCGCGCTGAAGGCGGCGGGGGCCGAGGTCTGGGCGAGCGCGGAGGGCAGGGCGTACCTCGAGGGCGAGGAGG
CGGCGAAGCGGCTCGAGCAGCGCCGGAAGGAGCTGGCGCCGTGGTTCGACGCCGGAAACCCGCTGCTCCCCGCGGACCGC
TGGCTCGACGGGGACGCCGCCTTCGAGCTGGGGGGCGCGCGCTTCGAGGTGGTCCGGCTCGGACCGGCGCACTCGCCCGA
GGACCTGATGGTGGTCCTGCCGGACGACGGCGTGGTCTTCTCCGGCGACGTCATCTTCGCCGGCCGCATCCCGTTCGTCG
GCGAGGCCGACAGCCGCCGCTGGCTGGCGGCGATCGACCGGCTCCTGGAGCGCCGCCCGAAGCTGCTCGTCGCGGGCCAC
GGCCCCGCGTCGCGGGACCCGGCCACCCACCTCGCCCTGACCCGCGACTACCTCCGCCACCTCCGCGCGGTGATGGGGGC
GGCGGTCCAGGACCTCGTCCCGTTCGAGGAGGCGTACGCCGCCGCCGACTGGAGCGCGTACGCGAAGCTCCCCGCGTTCG
AGCCGGCGAACCGCATCAACGCCTACGGGACCTACCTCACCATGGAGCGCGAGATGCTCGAGGCGGGCCGGCAGTGA

Upstream 100 bases:

>100_bases
TGGTGGGCCGCTGGCTGCGCGCCCAGAAGACGATCACGCCGCGCACGCCGAACCTGCCGCGCCTGGTCGGCGTGGGCCGG
GATCCGGGGATGTCCACCTG

Downstream 100 bases:

>100_bases
GCCGGCCGCGCGGAGAGCGCGACGCTCCCGTTCAACCCCGCAACCGGAGGAACCCCACATGAAGAAGTCGATCGCGATGT
CCCTCGCCGCCGCCGCCATC

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MAPALATLLAALAAAAPAPARAADPVLEPVRLAPRVWLVQGDPGVASAANRGFNSNAAFVVTGDGVVVIDALGTPALGRA
LVRAIRKVTRQPIRRVILTHYHADHVYGLGALKAAGAEVWASAEGRAYLEGEEAAKRLEQRRKELAPWFDAGNPLLPADR
WLDGDAAFELGGARFEVVRLGPAHSPEDLMVVLPDDGVVFSGDVIFAGRIPFVGEADSRRWLAAIDRLLERRPKLLVAGH
GPASRDPATHLALTRDYLRHLRAVMGAAVQDLVPFEEAYAAADWSAYAKLPAFEPANRINAYGTYLTMEREMLEAGRQ

Sequences:

>Translated_318_residues
MAPALATLLAALAAAAPAPARAADPVLEPVRLAPRVWLVQGDPGVASAANRGFNSNAAFVVTGDGVVVIDALGTPALGRA
LVRAIRKVTRQPIRRVILTHYHADHVYGLGALKAAGAEVWASAEGRAYLEGEEAAKRLEQRRKELAPWFDAGNPLLPADR
WLDGDAAFELGGARFEVVRLGPAHSPEDLMVVLPDDGVVFSGDVIFAGRIPFVGEADSRRWLAAIDRLLERRPKLLVAGH
GPASRDPATHLALTRDYLRHLRAVMGAAVQDLVPFEEAYAAADWSAYAKLPAFEPANRINAYGTYLTMEREMLEAGRQ
>Mature_317_residues
APALATLLAALAAAAPAPARAADPVLEPVRLAPRVWLVQGDPGVASAANRGFNSNAAFVVTGDGVVVIDALGTPALGRAL
VRAIRKVTRQPIRRVILTHYHADHVYGLGALKAAGAEVWASAEGRAYLEGEEAAKRLEQRRKELAPWFDAGNPLLPADRW
LDGDAAFELGGARFEVVRLGPAHSPEDLMVVLPDDGVVFSGDVIFAGRIPFVGEADSRRWLAAIDRLLERRPKLLVAGHG
PASRDPATHLALTRDYLRHLRAVMGAAVQDLVPFEEAYAAADWSAYAKLPAFEPANRINAYGTYLTMEREMLEAGRQ

Specific function: Can hydrolyze carbapenem compounds [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 34166; Mature: 34035

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPALATLLAALAAAAPAPARAADPVLEPVRLAPRVWLVQGDPGVASAANRGFNSNAAFV
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCEEE
VTGDGVVVIDALGTPALGRALVRAIRKVTRQPIRRVILTHYHADHVYGLGALKAAGAEVW
EECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHCCHHHE
ASAEGRAYLEGEEAAKRLEQRRKELAPWFDAGNPLLPADRWLDGDAAFELGGARFEVVRL
ECCCCCEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCHHEEECCCEEEEEEE
GPAHSPEDLMVVLPDDGVVFSGDVIFAGRIPFVGEADSRRWLAAIDRLLERRPKLLVAGH
CCCCCCCCEEEEECCCCEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
GPASRDPATHLALTRDYLRHLRAVMGAAVQDLVPFEEAYAAADWSAYAKLPAFEPANRIN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHCCCCCCCHHHHH
AYGTYLTMEREMLEAGRQ
HHHHEEEEHHHHHHCCCC
>Mature Secondary Structure 
APALATLLAALAAAAPAPARAADPVLEPVRLAPRVWLVQGDPGVASAANRGFNSNAAFV
CHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCEEE
VTGDGVVVIDALGTPALGRALVRAIRKVTRQPIRRVILTHYHADHVYGLGALKAAGAEVW
EECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHCCHHHE
ASAEGRAYLEGEEAAKRLEQRRKELAPWFDAGNPLLPADRWLDGDAAFELGGARFEVVRL
ECCCCCEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCHHEEECCCEEEEEEE
GPAHSPEDLMVVLPDDGVVFSGDVIFAGRIPFVGEADSRRWLAAIDRLLERRPKLLVAGH
CCCCCCCCEEEEECCCCEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
GPASRDPATHLALTRDYLRHLRAVMGAAVQDLVPFEEAYAAADWSAYAKLPAFEPANRIN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHCCCCCCCHHHHH
AYGTYLTMEREMLEAGRQ
HHHHEEEEHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1856163 [H]