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The map label for this gene is guaB [H]

Identifier: 220916721

GI number: 220916721

Start: 1805076

End: 1806539

Strand: Direct

Name: guaB [H]

Synonym: A2cp1_1615

Alternate gene names: 220916721

Gene position: 1805076-1806539 (Clockwise)

Preceding gene: 220916719

Following gene: 220916722

Centisome position: 35.89

GC content: 69.6

Gene sequence:

>1464_bases
ATGCTCAACCGCGACGACCTCCGCCTGGCGCTGACGTTCGACGACGTCCTGCTGCTCCCGGCCGAGTCGGACGTGCTCCC
GAAGTCGGTCGAGACGTCCACGCGACTCACCCGCAACATCCAGCTCAACATCCCCATCGTCTCGTCCGCGATGGACACCG
TCACCGAGGCGCGCATGGCCATCGCCATGGCGGCGGTCGGCGGGCTCGGCTTCATCCACAAGAACCTCACCGTCGAGGAT
CAGGCGGCGGAGGTCGTGAAGGTGAAGAAGTACGAGTCGGCGGTGGTCACCGAGCCGATCACCGTGGAGCCGGACGCGCC
GCTGCACCGGGCCGTCGCGCTCATGCGCGAGAACGGCATCAGCGGCATCCCGGTGGTGCAGGGCGGCCGCCTCCTCGGCA
TCCTCACCAACCGCGACCTGCGCTTCGAGAAGAACCTGGAGCAGCGGGTGGAGCAGGTGATGACGAAGGACCTCGTCACC
GCGCACGAGGGCGTCACCATCGAGCAGGCGAAGGAGCTGCTCCACCGGCACCGCATCGAGAAGCTGCTGGTGGTGAACGA
GCGGTACGAGCTCCGCGGCCTCGTCACCATCAAGGACATCGAGAAGATCCAGAAGCACCCCAACGCCGCGAAGGATCGCA
TGGGCCGGCTGCTCTGCGGCGCCGCCGTGGGCGTCGGCCCCGACCGCGAGGCGCGCATCCAGGCGCTGCTCAAGGCCGGC
GCGGACGTGATCGCGATCGACACCGCGCACGGCCACTCGAAGGGCGTGGTGGACGCGGTCCGCTCGACCAAGGCGAACTT
CAAGGGCATCGAGCTGGTCGCCGGCAACGTGGCCACCGCCGAGGCCGCCGAGGCGCTCTGCAAGGCCGGCGTGGACGCGG
TGAAGGTGGGCATCGGCCCCGGCTCCATCTGCACCACGCGCGTGGTCGCCGGCGTGGGCGTCCCGCAGATCACCGCGGTG
GACGAGTGCGCCCGGGCCGCCGAGAAGTACGGCGTGCCGGTCATCTCCGACGGCGGCGTGAAGTACTCGGGCGACATGGT
GAAGGCGCTCGCCGCCGGCGCGTCGTCGGTGATGATCGGGTCGCTGCTGGCCGGCACCGAGGAGGCGCCCGGCGAGGTCA
TCCTGTACCAGGGCCGCAGCTACAAGTCGTACCGCGGCATGGGCTCGATCGGCGCGATGAAGCTCGGCTCCAAGGACCGC
TACTTCCAGGGCGACGTCTCCGACGCGGACAAGCTGGTCCCCGAGGGCATCGAGGGCCGCGTGCCGTACAAGGGCACGGT
GGAGATGAACCTGTTCCAGCTGGTGGGCGGCCTGCGCAGCGGAATGGGGTACGTGGGGTGCCGGACCATCGCCGAGCTGC
GGACCAAGCCGCGCTTCGTGCGCATCTCCGCCTCCGGCCTGCGCGAGAGCCACGTCCACGACGTGATCATCACGCAGGAG
GCGCCGAACTACCGGGTCGACTGA

Upstream 100 bases:

>100_bases
CGAGATCGCGGTTGCAGGGGAACTCCCCGCGATCCCCGCAGCTTGGGCTCGCCGGAACGGCTGGCTTGACGCTCCCGGAC
GCGCTCGTCTATACGTCCGC

Downstream 100 bases:

>100_bases
CCCTCCCTCCTCACCCGCGCACCGCCGGGCGGCGCGCGGCCGGGCCGACATGGACATCCACTCAGAGAAGATCCTCATCC
TCGACTTCGGGTCGCAGTAC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MLNRDDLRLALTFDDVLLLPAESDVLPKSVETSTRLTRNIQLNIPIVSSAMDTVTEARMAIAMAAVGGLGFIHKNLTVED
QAAEVVKVKKYESAVVTEPITVEPDAPLHRAVALMRENGISGIPVVQGGRLLGILTNRDLRFEKNLEQRVEQVMTKDLVT
AHEGVTIEQAKELLHRHRIEKLLVVNERYELRGLVTIKDIEKIQKHPNAAKDRMGRLLCGAAVGVGPDREARIQALLKAG
ADVIAIDTAHGHSKGVVDAVRSTKANFKGIELVAGNVATAEAAEALCKAGVDAVKVGIGPGSICTTRVVAGVGVPQITAV
DECARAAEKYGVPVISDGGVKYSGDMVKALAAGASSVMIGSLLAGTEEAPGEVILYQGRSYKSYRGMGSIGAMKLGSKDR
YFQGDVSDADKLVPEGIEGRVPYKGTVEMNLFQLVGGLRSGMGYVGCRTIAELRTKPRFVRISASGLRESHVHDVIITQE
APNYRVD

Sequences:

>Translated_487_residues
MLNRDDLRLALTFDDVLLLPAESDVLPKSVETSTRLTRNIQLNIPIVSSAMDTVTEARMAIAMAAVGGLGFIHKNLTVED
QAAEVVKVKKYESAVVTEPITVEPDAPLHRAVALMRENGISGIPVVQGGRLLGILTNRDLRFEKNLEQRVEQVMTKDLVT
AHEGVTIEQAKELLHRHRIEKLLVVNERYELRGLVTIKDIEKIQKHPNAAKDRMGRLLCGAAVGVGPDREARIQALLKAG
ADVIAIDTAHGHSKGVVDAVRSTKANFKGIELVAGNVATAEAAEALCKAGVDAVKVGIGPGSICTTRVVAGVGVPQITAV
DECARAAEKYGVPVISDGGVKYSGDMVKALAAGASSVMIGSLLAGTEEAPGEVILYQGRSYKSYRGMGSIGAMKLGSKDR
YFQGDVSDADKLVPEGIEGRVPYKGTVEMNLFQLVGGLRSGMGYVGCRTIAELRTKPRFVRISASGLRESHVHDVIITQE
APNYRVD
>Mature_487_residues
MLNRDDLRLALTFDDVLLLPAESDVLPKSVETSTRLTRNIQLNIPIVSSAMDTVTEARMAIAMAAVGGLGFIHKNLTVED
QAAEVVKVKKYESAVVTEPITVEPDAPLHRAVALMRENGISGIPVVQGGRLLGILTNRDLRFEKNLEQRVEQVMTKDLVT
AHEGVTIEQAKELLHRHRIEKLLVVNERYELRGLVTIKDIEKIQKHPNAAKDRMGRLLCGAAVGVGPDREARIQALLKAG
ADVIAIDTAHGHSKGVVDAVRSTKANFKGIELVAGNVATAEAAEALCKAGVDAVKVGIGPGSICTTRVVAGVGVPQITAV
DECARAAEKYGVPVISDGGVKYSGDMVKALAAGASSVMIGSLLAGTEEAPGEVILYQGRSYKSYRGMGSIGAMKLGSKDR
YFQGDVSDADKLVPEGIEGRVPYKGTVEMNLFQLVGGLRSGMGYVGCRTIAELRTKPRFVRISASGLRESHVHDVIITQE
APNYRVD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=41.7879417879418, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=41.9624217118998, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=41.9624217118998, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=41.9624217118998, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=41.9624217118998, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI217035152, Length=462, Percent_Identity=42.8571428571429, Blast_Score=345, Evalue=7e-95,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=41.1273486430063, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=38.6221294363257, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI50541956, Length=245, Percent_Identity=41.2244897959184, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541954, Length=245, Percent_Identity=41.2244897959184, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541952, Length=245, Percent_Identity=41.2244897959184, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541948, Length=245, Percent_Identity=41.2244897959184, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI156104880, Length=242, Percent_Identity=40.495867768595, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788855, Length=480, Percent_Identity=59.1666666666667, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1786293, Length=236, Percent_Identity=40.6779661016949, Blast_Score=158, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=501, Percent_Identity=35.3293413173653, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71994389, Length=426, Percent_Identity=37.5586854460094, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=39.3305439330544, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=41.1522633744856, Blast_Score=355, Evalue=7e-99,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=39.7938144329897, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=486, Percent_Identity=40.9465020576132, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=340, Percent_Identity=40.2941176470588, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319353, Length=142, Percent_Identity=40.1408450704225, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=40.4564315352697, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=40.4564315352697, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=40.4977375565611, Blast_Score=306, Evalue=3e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52127; Mature: 52127

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRDDLRLALTFDDVLLLPAESDVLPKSVETSTRLTRNIQLNIPIVSSAMDTVTEARMA
CCCCCCEEEEEEECCEEEECCCCCCCCCCHHHHHHEEEEEEEECCCHHHHHHHHHHHHHH
IAMAAVGGLGFIHKNLTVEDQAAEVVKVKKYESAVVTEPITVEPDAPLHRAVALMRENGI
HHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHCCHHCCCCEEECCCCCHHHHHHHHHHCCC
SGIPVVQGGRLLGILTNRDLRFEKNLEQRVEQVMTKDLVTAHEGVTIEQAKELLHRHRIE
CCCCEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KLLVVNERYELRGLVTIKDIEKIQKHPNAAKDRMGRLLCGAAVGVGPDREARIQALLKAG
HEEEECCCEEEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
ADVIAIDTAHGHSKGVVDAVRSTKANFKGIELVAGNVATAEAAEALCKAGVDAVKVGIGP
CCEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
GSICTTRVVAGVGVPQITAVDECARAAEKYGVPVISDGGVKYSGDMVKALAAGASSVMIG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHHHHHH
SLLAGTEEAPGEVILYQGRSYKSYRGMGSIGAMKLGSKDRYFQGDVSDADKLVPEGIEGR
HHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCEECCCCCCEEECCCCCHHHHCCCCCCCC
VPYKGTVEMNLFQLVGGLRSGMGYVGCRTIAELRTKPRFVRISASGLRESHVHDVIITQE
CCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECC
APNYRVD
CCCCCCC
>Mature Secondary Structure
MLNRDDLRLALTFDDVLLLPAESDVLPKSVETSTRLTRNIQLNIPIVSSAMDTVTEARMA
CCCCCCEEEEEEECCEEEECCCCCCCCCCHHHHHHEEEEEEEECCCHHHHHHHHHHHHHH
IAMAAVGGLGFIHKNLTVEDQAAEVVKVKKYESAVVTEPITVEPDAPLHRAVALMRENGI
HHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHCCHHCCCCEEECCCCCHHHHHHHHHHCCC
SGIPVVQGGRLLGILTNRDLRFEKNLEQRVEQVMTKDLVTAHEGVTIEQAKELLHRHRIE
CCCCEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KLLVVNERYELRGLVTIKDIEKIQKHPNAAKDRMGRLLCGAAVGVGPDREARIQALLKAG
HEEEECCCEEEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
ADVIAIDTAHGHSKGVVDAVRSTKANFKGIELVAGNVATAEAAEALCKAGVDAVKVGIGP
CCEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
GSICTTRVVAGVGVPQITAVDECARAAEKYGVPVISDGGVKYSGDMVKALAAGASSVMIG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHHHHHH
SLLAGTEEAPGEVILYQGRSYKSYRGMGSIGAMKLGSKDRYFQGDVSDADKLVPEGIEGR
HHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCEECCCCCCEEECCCCCHHHHCCCCCCCC
VPYKGTVEMNLFQLVGGLRSGMGYVGCRTIAELRTKPRFVRISASGLRESHVHDVIITQE
CCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECC
APNYRVD
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]