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The map label for this gene is guaA [H]

Identifier: 220916722

GI number: 220916722

Start: 1806589

End: 1808145

Strand: Direct

Name: guaA [H]

Synonym: A2cp1_1616

Alternate gene names: 220916722

Gene position: 1806589-1808145 (Clockwise)

Preceding gene: 220916721

Following gene: 220916723

Centisome position: 35.92

GC content: 72.25

Gene sequence:

>1557_bases
ATGGACATCCACTCAGAGAAGATCCTCATCCTCGACTTCGGGTCGCAGTACACGCAGCTCATCGCGAGGCGGCTGCGCGA
GCTGGGCGTCTACTGCGAGATCCACCCCTGCACCGCGAAGGCGGAGGCGATCCGCGCGTTCCGGCCCCGCGGCGTGGTGC
TCTCCGGCGGCCCGGCCTCGGTGCTCGCCGAGGGCAGCCCGCGCTGCGACCGGGTGGTGTTCGAGCTGGGCGTGCCGGTG
CTCGGCATCTGCTACGGCCTCCAGGTCTTCGCCGCCGAGCTGGGCGGCCGGGTCGACCAGGCGGCGCACCGCGAGTTCGG
GCCGGCCACCATCGAGGTGAAGGCGACCTCGCCGCTGTTCCAGGGCCTGCCCGCCACGCTGGACGTGTGGATGAGCCACG
GCGACCGGGTCGAGGCGCTGCCCCCCGGCTTCGAGCCCATCGCCGCCACCGCCTCGGCCCCGTACGCCGCGGTGGAGGAT
CGCGCCCGCCGCTTCTACGGCGTGCAGTTCCACCCCGAGGTGGTCCACACGCCGCGCGGCAAGGACGTGCTGCGCAACTT
CGCCTACGGCGTGTGCGGGTGCTCCGGCACCTGGTCGATGCGCGGCTACGCCGAGGCGGCGGTGGAGCAGATCCGCGCCC
AGGTGAAGGACGGCCACGTCATCTGCGCGCTGTCCGGCGGGGTGGACTCCGCGGTGGCCGCGCTGCTGGTGCACCGGGCC
ATCGGCGACCGGCTGCGCTGCATCTTCGTGGACAACGGCGTGCTCCGCGCCGGCGAGCGCCAGCAGGTCGAGGACGTGTT
CGGCGCCATGTTCCACCTGCCGCTCGTGACCGTGGACGCCTCGCGGCGCTTCCTCGGCGCGCTGGCGGGCGTCACCGACC
CCGAGCGCAAGCGCAAGATCATCGGGCACGAGTTCATCGCGGTGTTCGAGCAGGAGGTGGAGCGGCTCGCGGCGCACGGC
GCCCGCGCGAAGTTCCTGGTGCAGGGCACGCTCTACCCGGACGTCATCGAGTCGGTCTCGTTCCGCGGGCCGTCCGCCAC
CATCAAGAGCCACCACAACGTCGGCGGCCTGCCCGAGAAGATGAACCTCTCGCTGGTGGAGCCGCTCCGCGAGCTGTTCA
AGGACGAGGTGCGCCAGCTCGGCCTCGAGCTGGGCCTGCCCGAGGCGATCGTCCGGCGGCAGCCGTTCCCCGGCCCCGGG
CTCGCCATCCGCGTGCTCGGCGAGGTCACCGAGGAGCGGCTGGCGGTGCTGCGCCGCGCCGACACGATCGTGCAGGAGGA
GGTCCGCGCCGCCGGGCTGTACGAGAAGCTCTGGCAGGGGTTCGCGGTGCTCCTGCCGGTCCGCAGCGTCGGCGTCATGG
GCGACGAGCGCACCTACGAGTCCACCTGCGCGATCCGCGCGGTGGAGTCCACCGACGGCATGACCGGCGACTGGGCGCGG
CTGCCGTACGACCTGCTGGCCCGGCTGTCGTCGCGCATCATCAACGAGGTCCGCGGCATCAACCGCGTGGTCTACGACAT
CTCCTCCAAGCCGCCCGCCACCATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
GTCCACGACGTGATCATCACGCAGGAGGCGCCGAACTACCGGGTCGACTGACCCTCCCTCCTCACCCGCGCACCGCCGGG
CGGCGCGCGGCCGGGCCGAC

Downstream 100 bases:

>100_bases
CCGCGGCCGCGGCGGCGGCCTCCGGGCCGCCGCGCGCCGTGGTGGGCGCAGGTGGGCGCTCCTGCGTGCCGCCGACGGTC
GGTGAACGTGGGATTGCTGC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MDIHSEKILILDFGSQYTQLIARRLRELGVYCEIHPCTAKAEAIRAFRPRGVVLSGGPASVLAEGSPRCDRVVFELGVPV
LGICYGLQVFAAELGGRVDQAAHREFGPATIEVKATSPLFQGLPATLDVWMSHGDRVEALPPGFEPIAATASAPYAAVED
RARRFYGVQFHPEVVHTPRGKDVLRNFAYGVCGCSGTWSMRGYAEAAVEQIRAQVKDGHVICALSGGVDSAVAALLVHRA
IGDRLRCIFVDNGVLRAGERQQVEDVFGAMFHLPLVTVDASRRFLGALAGVTDPERKRKIIGHEFIAVFEQEVERLAAHG
ARAKFLVQGTLYPDVIESVSFRGPSATIKSHHNVGGLPEKMNLSLVEPLRELFKDEVRQLGLELGLPEAIVRRQPFPGPG
LAIRVLGEVTEERLAVLRRADTIVQEEVRAAGLYEKLWQGFAVLLPVRSVGVMGDERTYESTCAIRAVESTDGMTGDWAR
LPYDLLARLSSRIINEVRGINRVVYDISSKPPATIEWE

Sequences:

>Translated_518_residues
MDIHSEKILILDFGSQYTQLIARRLRELGVYCEIHPCTAKAEAIRAFRPRGVVLSGGPASVLAEGSPRCDRVVFELGVPV
LGICYGLQVFAAELGGRVDQAAHREFGPATIEVKATSPLFQGLPATLDVWMSHGDRVEALPPGFEPIAATASAPYAAVED
RARRFYGVQFHPEVVHTPRGKDVLRNFAYGVCGCSGTWSMRGYAEAAVEQIRAQVKDGHVICALSGGVDSAVAALLVHRA
IGDRLRCIFVDNGVLRAGERQQVEDVFGAMFHLPLVTVDASRRFLGALAGVTDPERKRKIIGHEFIAVFEQEVERLAAHG
ARAKFLVQGTLYPDVIESVSFRGPSATIKSHHNVGGLPEKMNLSLVEPLRELFKDEVRQLGLELGLPEAIVRRQPFPGPG
LAIRVLGEVTEERLAVLRRADTIVQEEVRAAGLYEKLWQGFAVLLPVRSVGVMGDERTYESTCAIRAVESTDGMTGDWAR
LPYDLLARLSSRIINEVRGINRVVYDISSKPPATIEWE
>Mature_518_residues
MDIHSEKILILDFGSQYTQLIARRLRELGVYCEIHPCTAKAEAIRAFRPRGVVLSGGPASVLAEGSPRCDRVVFELGVPV
LGICYGLQVFAAELGGRVDQAAHREFGPATIEVKATSPLFQGLPATLDVWMSHGDRVEALPPGFEPIAATASAPYAAVED
RARRFYGVQFHPEVVHTPRGKDVLRNFAYGVCGCSGTWSMRGYAEAAVEQIRAQVKDGHVICALSGGVDSAVAALLVHRA
IGDRLRCIFVDNGVLRAGERQQVEDVFGAMFHLPLVTVDASRRFLGALAGVTDPERKRKIIGHEFIAVFEQEVERLAAHG
ARAKFLVQGTLYPDVIESVSFRGPSATIKSHHNVGGLPEKMNLSLVEPLRELFKDEVRQLGLELGLPEAIVRRQPFPGPG
LAIRVLGEVTEERLAVLRRADTIVQEEVRAAGLYEKLWQGFAVLLPVRSVGVMGDERTYESTCAIRAVESTDGMTGDWAR
LPYDLLARLSSRIINEVRGINRVVYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=548, Percent_Identity=37.4087591240876, Blast_Score=319, Evalue=4e-87,
Organism=Escherichia coli, GI1788854, Length=526, Percent_Identity=57.0342205323194, Blast_Score=596, Evalue=1e-171,
Organism=Escherichia coli, GI1789760, Length=186, Percent_Identity=30.1075268817204, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71992710, Length=570, Percent_Identity=36.4912280701754, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI133901714, Length=570, Percent_Identity=36.4912280701754, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71992717, Length=570, Percent_Identity=36.4912280701754, Blast_Score=309, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=53.4883720930233, Blast_Score=575, Evalue=1e-165,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=36, Blast_Score=296, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56729; Mature: 56729

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIHSEKILILDFGSQYTQLIARRLRELGVYCEIHPCTAKAEAIRAFRPRGVVLSGGPAS
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCEEEECCCHH
VLAEGSPRCDRVVFELGVPVLGICYGLQVFAAELGGRVDQAAHREFGPATIEVKATSPLF
HEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCHHH
QGLPATLDVWMSHGDRVEALPPGFEPIAATASAPYAAVEDRARRFYGVQFHPEVVHTPRG
HCCCHHHHHHHCCCCEECCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCEECCCCEECCCC
KDVLRNFAYGVCGCSGTWSMRGYAEAAVEQIRAQVKDGHVICALSGGVDSAVAALLVHRA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
IGDRLRCIFVDNGVLRAGERQQVEDVFGAMFHLPLVTVDASRRFLGALAGVTDPERKRKI
HCCCEEEEEEECCEECCCCHHHHHHHHHHHHHCCEEEECHHHHHHHHHHCCCCHHHHHHH
IGHEFIAVFEQEVERLAAHGARAKFLVQGTLYPDVIESVSFRGPSATIKSHHNVGGLPEK
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCHHHCCCCCCCCCCC
MNLSLVEPLRELFKDEVRQLGLELGLPEAIVRRQPFPGPGLAIRVLGEVTEERLAVLRRA
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DTIVQEEVRAAGLYEKLWQGFAVLLPVRSVGVMGDERTYESTCAIRAVESTDGMTGDWAR
HHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCCCHHHHHEEEEECCCCCCCCCHHH
LPYDLLARLSSRIINEVRGINRVVYDISSKPPATIEWE
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC
>Mature Secondary Structure
MDIHSEKILILDFGSQYTQLIARRLRELGVYCEIHPCTAKAEAIRAFRPRGVVLSGGPAS
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCEEEECCCHH
VLAEGSPRCDRVVFELGVPVLGICYGLQVFAAELGGRVDQAAHREFGPATIEVKATSPLF
HEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCHHH
QGLPATLDVWMSHGDRVEALPPGFEPIAATASAPYAAVEDRARRFYGVQFHPEVVHTPRG
HCCCHHHHHHHCCCCEECCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCEECCCCEECCCC
KDVLRNFAYGVCGCSGTWSMRGYAEAAVEQIRAQVKDGHVICALSGGVDSAVAALLVHRA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
IGDRLRCIFVDNGVLRAGERQQVEDVFGAMFHLPLVTVDASRRFLGALAGVTDPERKRKI
HCCCEEEEEEECCEECCCCHHHHHHHHHHHHHCCEEEECHHHHHHHHHHCCCCHHHHHHH
IGHEFIAVFEQEVERLAAHGARAKFLVQGTLYPDVIESVSFRGPSATIKSHHNVGGLPEK
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCHHHCCCCCCCCCCC
MNLSLVEPLRELFKDEVRQLGLELGLPEAIVRRQPFPGPGLAIRVLGEVTEERLAVLRRA
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DTIVQEEVRAAGLYEKLWQGFAVLLPVRSVGVMGDERTYESTCAIRAVESTDGMTGDWAR
HHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCCCHHHHHEEEEECCCCCCCCCHHH
LPYDLLARLSSRIINEVRGINRVVYDISSKPPATIEWE
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA