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The map label for this gene is groEL [H]

Identifier: 220916671

GI number: 220916671

Start: 1749153

End: 1750796

Strand: Direct

Name: groEL [H]

Synonym: A2cp1_1565

Alternate gene names: 220916671

Gene position: 1749153-1750796 (Clockwise)

Preceding gene: 220916668

Following gene: 220916673

Centisome position: 34.78

GC content: 68.61

Gene sequence:

>1644_bases
ATGCCCGCCAAGGAAATCGCATTCCACCAGCCCGCCCGCGAGGCCATCCTCCGCGGGGTGCAGACGCTGGCCGAAGCCGT
CGCGGTGACCCTCGGCCCGAAGGGCCGGAACGTGGTCATCGAGAAGAGCTACGGCGCGCCGACCATCACCAAGGACGGCG
TCACGGTCGCGAAGGAGATCGAGCTCGAGAACAAGTTCGAGAACATGGGCGCGCAGATGGTGAAGGAGGTCGCGTCGCAG
ACCTCCGACAAGGCCGGCGACGGCACCACCACCGCCACCGTGCTCGCGCGCTCGATCTACGAGGAGGGCCTGAAGCTGGT
CGCGGCCGGCCACAACCCCATGGACCTGAAGCGCGGCATCGACCGCGCGGTCGAGGTGGTGGTGGCCCATCTGAAGAGCC
TGTCCACCCCGACGAAGGGCAAGGACGACATCGCCCAGGTCGGCACCATCTCCGCGAACGGCGACACCACCATCGGCAAC
ATCATTGCCGAGGCGATGGAGAAGGTCGGCAAGGAGGGCGTGATCACGGTCGAGGAGGCGAAGGGCCTCGAGACCACGCT
CGACGTGGTCGAGGGCATGCAGTTCGACCGCGGCTACTCGTCGCCGTACTTCGTCACCAACCCCGACCGGATGGAGGCGG
TGCTGGAGGATCCGTACGTCCTCGTCACCGAGAAGAAGATCACGGCGATGGCCGACCTCGTCCCGGTGCTCGAGCAGGTG
GCGCGCTCCGGCAAGCCGCTCCTCATCATCGCGGAGGAGGTCGAGGGCGAGGCGCTCGCGACGCTGGTGGTCAACAAGCT
GCGCGGCACGCTGCACGTCTGCGCGGTGAAGGCCCCCGGCTTCGGCGACCGCCGCAAGGAGATGCTGAAGGACATCGCCA
CCCTCACCGGCGGCACGGTGGTGGCCGAGGAGCTCGGCATCAAGCTCGACCAGCTCGGCCTGAAGGACCTCGGCCGCGCC
AAGCGCATCACGGTGGACAAGGACAACACCACCATCGTGGACGGCGAGGGCAAGAAGGAGGACATCCAGGCCCGCATCAA
GGTGATGCGCGGCCAGATCGAGGAGACCACCTCGGAGTACGACCGCGAGAAGCTGCAGGAGCGGCTCGCCAAGCTGGTGG
GCGGCGTGGCGGTCATCAACGTGGGCGCCGCCACCGAGACCGAGATGAAGGAGAAGAAGGCCCGGGTCGAGGACGCGCTC
CACGCCACCCGCGCCGCGGTCGAGGAGGGCATCGTCCCCGGCGGCGGCGTGGCGTATCTCCGCGCACTGGCCGAGCTCCA
GAAGCTCGACGTCGGGCAGGGCGACCAGCGGTTCGGCGTGCAGATCGTGGTGAAGGCGCTCGAGTGGCCGGCCCGGCGCA
TCGCCGAGAACGCCGGCTGGGATGGGCCGGTGGTGGTGAACAAGATCCTCGAGGGGCAGGGCGCGTTCGGCTTCAACGCC
GCGACCGACACGTTCGAGGACCTGACCAAGGCCGGCGTCATCGATCCGACCAAGGTCTCCCGCACCGCGCTCCAGAACGC
GGCGTCCGTCGCGAGCCTCCTGCTCACCACCGAGGCGATGGTGGCGGACAAGCCGAAGAAGAAGGCGGCGGCCGCGGCAG
GTGGTGCCGGCATGGGCGGCGGCATGGACGAGATGGACTACTAG

Upstream 100 bases:

>100_bases
CGGGGAGCGGTTATGTTAGCGGCCGCCCGGGGCGACTGCCAACCCGAGTTGCCCCACAACATCTCAGAATCATTGCAGTT
CTCTGAAAAGGAGACCCGGC

Downstream 100 bases:

>100_bases
CCGCCCGCCGTCCCGAGGGTTTTCCCCCTGCGCCGCCCGCGGTGCAGGGGGTTTCCTGTCCCCCGACGGGGTGCGTCATT
GACACCGGGCCCTCGGTCGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MPAKEIAFHQPAREAILRGVQTLAEAVAVTLGPKGRNVVIEKSYGAPTITKDGVTVAKEIELENKFENMGAQMVKEVASQ
TSDKAGDGTTTATVLARSIYEEGLKLVAAGHNPMDLKRGIDRAVEVVVAHLKSLSTPTKGKDDIAQVGTISANGDTTIGN
IIAEAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYSSPYFVTNPDRMEAVLEDPYVLVTEKKITAMADLVPVLEQV
ARSGKPLLIIAEEVEGEALATLVVNKLRGTLHVCAVKAPGFGDRRKEMLKDIATLTGGTVVAEELGIKLDQLGLKDLGRA
KRITVDKDNTTIVDGEGKKEDIQARIKVMRGQIEETTSEYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDAL
HATRAAVEEGIVPGGGVAYLRALAELQKLDVGQGDQRFGVQIVVKALEWPARRIAENAGWDGPVVVNKILEGQGAFGFNA
ATDTFEDLTKAGVIDPTKVSRTALQNAASVASLLLTTEAMVADKPKKKAAAAAGGAGMGGGMDEMDY

Sequences:

>Translated_547_residues
MPAKEIAFHQPAREAILRGVQTLAEAVAVTLGPKGRNVVIEKSYGAPTITKDGVTVAKEIELENKFENMGAQMVKEVASQ
TSDKAGDGTTTATVLARSIYEEGLKLVAAGHNPMDLKRGIDRAVEVVVAHLKSLSTPTKGKDDIAQVGTISANGDTTIGN
IIAEAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYSSPYFVTNPDRMEAVLEDPYVLVTEKKITAMADLVPVLEQV
ARSGKPLLIIAEEVEGEALATLVVNKLRGTLHVCAVKAPGFGDRRKEMLKDIATLTGGTVVAEELGIKLDQLGLKDLGRA
KRITVDKDNTTIVDGEGKKEDIQARIKVMRGQIEETTSEYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDAL
HATRAAVEEGIVPGGGVAYLRALAELQKLDVGQGDQRFGVQIVVKALEWPARRIAENAGWDGPVVVNKILEGQGAFGFNA
ATDTFEDLTKAGVIDPTKVSRTALQNAASVASLLLTTEAMVADKPKKKAAAAAGGAGMGGGMDEMDY
>Mature_546_residues
PAKEIAFHQPAREAILRGVQTLAEAVAVTLGPKGRNVVIEKSYGAPTITKDGVTVAKEIELENKFENMGAQMVKEVASQT
SDKAGDGTTTATVLARSIYEEGLKLVAAGHNPMDLKRGIDRAVEVVVAHLKSLSTPTKGKDDIAQVGTISANGDTTIGNI
IAEAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYSSPYFVTNPDRMEAVLEDPYVLVTEKKITAMADLVPVLEQVA
RSGKPLLIIAEEVEGEALATLVVNKLRGTLHVCAVKAPGFGDRRKEMLKDIATLTGGTVVAEELGIKLDQLGLKDLGRAK
RITVDKDNTTIVDGEGKKEDIQARIKVMRGQIEETTSEYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALH
ATRAAVEEGIVPGGGVAYLRALAELQKLDVGQGDQRFGVQIVVKALEWPARRIAENAGWDGPVVVNKILEGQGAFGFNAA
TDTFEDLTKAGVIDPTKVSRTALQNAASVASLLLTTEAMVADKPKKKAAAAAGGAGMGGGMDEMDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=51.8026565464896, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=51.8026565464896, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI5453607, Length=541, Percent_Identity=22.181146025878, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI24307939, Length=540, Percent_Identity=22.037037037037, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=64.1509433962264, Blast_Score=676, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=50.6616257088847, Blast_Score=522, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=49.2890995260664, Blast_Score=198, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17564182, Length=555, Percent_Identity=23.0630630630631, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=54.9618320610687, Blast_Score=558, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6322524, Length=211, Percent_Identity=22.2748815165877, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=52.0912547528517, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=52.0912547528517, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=50.5725190839695, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=50.5725190839695, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=50.5725190839695, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=546, Percent_Identity=45.6043956043956, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=38.4905660377359, Blast_Score=335, Evalue=6e-92,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=38.4905660377359, Blast_Score=335, Evalue=6e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58134; Mature: 58003

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKEIAFHQPAREAILRGVQTLAEAVAVTLGPKGRNVVIEKSYGAPTITKDGVTVAKEI
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHH
ELENKFENMGAQMVKEVASQTSDKAGDGTTTATVLARSIYEEGLKLVAAGHNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHH
DRAVEVVVAHLKSLSTPTKGKDDIAQVGTISANGDTTIGNIIAEAMEKVGKEGVITVEEA
HHHHHHHHHHHHHCCCCCCCCHHHHHHCEEECCCCCHHHHHHHHHHHHHCCCCEEEECCC
KGLETTLDVVEGMQFDRGYSSPYFVTNPDRMEAVLEDPYVLVTEKKITAMADLVPVLEQV
CCHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHH
ARSGKPLLIIAEEVEGEALATLVVNKLRGTLHVCAVKAPGFGDRRKEMLKDIATLTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
VAEELGIKLDQLGLKDLGRAKRITVDKDNTTIVDGEGKKEDIQARIKVMRGQIEETTSEY
HHHHHCCCHHHCCHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALHATRAAVEEGIVPGGGVAYL
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RALAELQKLDVGQGDQRFGVQIVVKALEWPARRIAENAGWDGPVVVNKILEGQGAFGFNA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCC
ATDTFEDLTKAGVIDPTKVSRTALQNAASVASLLLTTEAMVADKPKKKAAAAAGGAGMGG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
GMDEMDY
CCCCCCC
>Mature Secondary Structure 
PAKEIAFHQPAREAILRGVQTLAEAVAVTLGPKGRNVVIEKSYGAPTITKDGVTVAKEI
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHH
ELENKFENMGAQMVKEVASQTSDKAGDGTTTATVLARSIYEEGLKLVAAGHNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHH
DRAVEVVVAHLKSLSTPTKGKDDIAQVGTISANGDTTIGNIIAEAMEKVGKEGVITVEEA
HHHHHHHHHHHHHCCCCCCCCHHHHHHCEEECCCCCHHHHHHHHHHHHHCCCCEEEECCC
KGLETTLDVVEGMQFDRGYSSPYFVTNPDRMEAVLEDPYVLVTEKKITAMADLVPVLEQV
CCHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHH
ARSGKPLLIIAEEVEGEALATLVVNKLRGTLHVCAVKAPGFGDRRKEMLKDIATLTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
VAEELGIKLDQLGLKDLGRAKRITVDKDNTTIVDGEGKKEDIQARIKVMRGQIEETTSEY
HHHHHCCCHHHCCHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALHATRAAVEEGIVPGGGVAYL
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RALAELQKLDVGQGDQRFGVQIVVKALEWPARRIAENAGWDGPVVVNKILEGQGAFGFNA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCC
ATDTFEDLTKAGVIDPTKVSRTALQNAASVASLLLTTEAMVADKPKKKAAAAAGGAGMGG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
GMDEMDY
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA