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The map label for this gene is nuoH [H]

Identifier: 220916480

GI number: 220916480

Start: 1539744

End: 1541138

Strand: Reverse

Name: nuoH [H]

Synonym: A2cp1_1374

Alternate gene names: 220916480

Gene position: 1541138-1539744 (Counterclockwise)

Preceding gene: 220916481

Following gene: 220916479

Centisome position: 30.64

GC content: 70.04

Gene sequence:

>1395_bases
ATGAACGCCCCCGCCATCAAGAACCAGGACCTGAGCAAGGGGCCGGGCAGGACGGCCCGCGGCGTCGTGCTCGCGACGCT
CGCGGTCGGGTTCGGGCTGCCCACCATCCTGCTCGGCGCGGTGCTGGTGCTGTCGCCGCTCTCCAAGCCCGCCATGCTCG
CGGCGGCGCTCCGCGCGGCCGGGGTGGACGTCTCCGGGTGGTCGCAGGGCGGCCGGTACGCGCTGTGGCTGGTGGCCATG
GCGGTGCTGGCGCTGATCCTCGTGTCCTTCGGCGCGGTCATCTCCGGCATGACGGTGTGGTGGGAGATGCGGGTCAGCGC
CCGCATGCAGAGCCGCATCGGCTACAACCGCGTGGGCGCGGCCGGCTTCTTCCAGTGGATCGCCGACGCGGTGAAGCTCC
TCCTCAAGGAGGACCTCATCCCCGCCGAGGCGGACCGGCTGCTCTTCCGCGCGGCGCCCTACTTCGTGATGGTGGGCTTC
GCGCTGGTGTTCGTGGCCCTGCCGTTCGGCGAGAGCCTCATCGCCGCGGACCTGAACGTCGGCATCTTCTACATCACCGC
GGTCACCGCGCTCATCGTGGTCGGCATCCTGATCGCCGGCTGGTCCTCCAACTCCAAGTGGGCGCTGTTCGGCGGCATGC
GGTCCGCCGCCCAGGTGATCTCCTACGAGATCCCGGCCGGCCTGGCCGTGATGGTGCCGGTGCTCATGTCCGGCACGCTC
TCGATGCAGGGCATCATCCGCTCGCAGGGCGCCTGGCCGTGGGAGTGGCACGCGCTCACGAACCCGTTCGCGCTGGTCGC
GTTCGGGATCTTCTTCGTGGCGCAGCTCGCCGAGGGCAACCGCACCCCGTTCGACCTCCCCGAGGCCGAGTCGGAGCTGG
TGGCCGGCTATCTCTCCGAGTACTCCGCCTTCCGCTTCGCGCTCTTCTTCCTGGTCGAGTTCGGCAACCTCTGGGTGATG
TCGGCGATCAGCGTGACGCTGTTCTTCGGCGGCTGGCAGGTGCCGTTCGCCGGCCCCGAGGTGTTCGCGGCGGCGCGCGG
CGCCGGCGACCTCCCCGGCCTGGCCTGGTGGGGCCTCCAGCTCGCCTCGATGCTGATCTTCGTCGCGAAGACGCTGGTGC
TCCTCAACGTGGTGGTGTGGGTCCGCTGGACGCTGCCCCGCATCCGCGTGGACCAGATGATGAGCCTCTGCTGGAAGTAC
CTGGTCCCGTTCGCCTTCGTCTGCTTCGTCGCCACGCTGCTCTGGCAGATCCTGGTGACGCGCGTCCCGGCGACCGCGCC
GGTGATCGGGGGCCTGATGGTCGCCGCGGCGGTGGTGGCGGGCTTCTTCTTCCTCCGCCTGACGCGGCGGAACATCTCCG
CGGTCGGCGACCGCGTCGACTTCACCAACTGGTAA

Upstream 100 bases:

>100_bases
CCGCCATGTGCATCATCGAGGACATCTCGCGCGGCCTGATGGTCGCCGACCTGGTGGCCCTCATCTCGTCGCTCGACGTC
GTCGCCCCGGAGATCGATCG

Downstream 100 bases:

>100_bases
GGGGACCGGAACGATGCCTCAGACCGTCCGCGAGTACACCGGCGCCATCCGGGACACGGTGAAGTCCTTCTGGCACGGCC
TCTCGATCACGCTCTCGTAC

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MNAPAIKNQDLSKGPGRTARGVVLATLAVGFGLPTILLGAVLVLSPLSKPAMLAAALRAAGVDVSGWSQGGRYALWLVAM
AVLALILVSFGAVISGMTVWWEMRVSARMQSRIGYNRVGAAGFFQWIADAVKLLLKEDLIPAEADRLLFRAAPYFVMVGF
ALVFVALPFGESLIAADLNVGIFYITAVTALIVVGILIAGWSSNSKWALFGGMRSAAQVISYEIPAGLAVMVPVLMSGTL
SMQGIIRSQGAWPWEWHALTNPFALVAFGIFFVAQLAEGNRTPFDLPEAESELVAGYLSEYSAFRFALFFLVEFGNLWVM
SAISVTLFFGGWQVPFAGPEVFAAARGAGDLPGLAWWGLQLASMLIFVAKTLVLLNVVVWVRWTLPRIRVDQMMSLCWKY
LVPFAFVCFVATLLWQILVTRVPATAPVIGGLMVAAAVVAGFFFLRLTRRNISAVGDRVDFTNW

Sequences:

>Translated_464_residues
MNAPAIKNQDLSKGPGRTARGVVLATLAVGFGLPTILLGAVLVLSPLSKPAMLAAALRAAGVDVSGWSQGGRYALWLVAM
AVLALILVSFGAVISGMTVWWEMRVSARMQSRIGYNRVGAAGFFQWIADAVKLLLKEDLIPAEADRLLFRAAPYFVMVGF
ALVFVALPFGESLIAADLNVGIFYITAVTALIVVGILIAGWSSNSKWALFGGMRSAAQVISYEIPAGLAVMVPVLMSGTL
SMQGIIRSQGAWPWEWHALTNPFALVAFGIFFVAQLAEGNRTPFDLPEAESELVAGYLSEYSAFRFALFFLVEFGNLWVM
SAISVTLFFGGWQVPFAGPEVFAAARGAGDLPGLAWWGLQLASMLIFVAKTLVLLNVVVWVRWTLPRIRVDQMMSLCWKY
LVPFAFVCFVATLLWQILVTRVPATAPVIGGLMVAAAVVAGFFFLRLTRRNISAVGDRVDFTNW
>Mature_464_residues
MNAPAIKNQDLSKGPGRTARGVVLATLAVGFGLPTILLGAVLVLSPLSKPAMLAAALRAAGVDVSGWSQGGRYALWLVAM
AVLALILVSFGAVISGMTVWWEMRVSARMQSRIGYNRVGAAGFFQWIADAVKLLLKEDLIPAEADRLLFRAAPYFVMVGF
ALVFVALPFGESLIAADLNVGIFYITAVTALIVVGILIAGWSSNSKWALFGGMRSAAQVISYEIPAGLAVMVPVLMSGTL
SMQGIIRSQGAWPWEWHALTNPFALVAFGIFFVAQLAEGNRTPFDLPEAESELVAGYLSEYSAFRFALFFLVEFGNLWVM
SAISVTLFFGGWQVPFAGPEVFAAARGAGDLPGLAWWGLQLASMLIFVAKTLVLLNVVVWVRWTLPRIRVDQMMSLCWKY
LVPFAFVCFVATLLWQILVTRVPATAPVIGGLMVAAAVVAGFFFLRLTRRNISAVGDRVDFTNW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=316, Percent_Identity=35.7594936708861, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1788618, Length=338, Percent_Identity=37.5739644970414, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1789077, Length=335, Percent_Identity=28.6567164179104, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 50215; Mature: 50215

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2 ; PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPAIKNQDLSKGPGRTARGVVLATLAVGFGLPTILLGAVLVLSPLSKPAMLAAALRAA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHC
GVDVSGWSQGGRYALWLVAMAVLALILVSFGAVISGMTVWWEMRVSARMQSRIGYNRVGA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
AGFFQWIADAVKLLLKEDLIPAEADRLLFRAAPYFVMVGFALVFVALPFGESLIAADLNV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
GIFYITAVTALIVVGILIAGWSSNSKWALFGGMRSAAQVISYEIPAGLAVMVPVLMSGTL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHCCH
SMQGIIRSQGAWPWEWHALTNPFALVAFGIFFVAQLAEGNRTPFDLPEAESELVAGYLSE
HHHHHHHCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YSAFRFALFFLVEFGNLWVMSAISVTLFFGGWQVPFAGPEVFAAARGAGDLPGLAWWGLQ
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEECCCCCHHHHHHHCCCCCCCCHHHHHHH
LASMLIFVAKTLVLLNVVVWVRWTLPRIRVDQMMSLCWKYLVPFAFVCFVATLLWQILVT
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVPATAPVIGGLMVAAAVVAGFFFLRLTRRNISAVGDRVDFTNW
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNAPAIKNQDLSKGPGRTARGVVLATLAVGFGLPTILLGAVLVLSPLSKPAMLAAALRAA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHC
GVDVSGWSQGGRYALWLVAMAVLALILVSFGAVISGMTVWWEMRVSARMQSRIGYNRVGA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
AGFFQWIADAVKLLLKEDLIPAEADRLLFRAAPYFVMVGFALVFVALPFGESLIAADLNV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
GIFYITAVTALIVVGILIAGWSSNSKWALFGGMRSAAQVISYEIPAGLAVMVPVLMSGTL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHCCH
SMQGIIRSQGAWPWEWHALTNPFALVAFGIFFVAQLAEGNRTPFDLPEAESELVAGYLSE
HHHHHHHCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YSAFRFALFFLVEFGNLWVMSAISVTLFFGGWQVPFAGPEVFAAARGAGDLPGLAWWGLQ
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEECCCCCHHHHHHHCCCCCCCCHHHHHHH
LASMLIFVAKTLVLLNVVVWVRWTLPRIRVDQMMSLCWKYLVPFAFVCFVATLLWQILVT
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVPATAPVIGGLMVAAAVVAGFFFLRLTRRNISAVGDRVDFTNW
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA