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The map label for this gene is nuoD1 [H]

Identifier: 220916481

GI number: 220916481

Start: 1541135

End: 1542274

Strand: Reverse

Name: nuoD1 [H]

Synonym: A2cp1_1375

Alternate gene names: 220916481

Gene position: 1542274-1541135 (Counterclockwise)

Preceding gene: 220916482

Following gene: 220916480

Centisome position: 30.67

GC content: 67.19

Gene sequence:

>1140_bases
ATGGAAAAGCTCATCCTCCGCCGCGTGGACCGCCAGAACGAGGAGATGATCCTCAACTTCGGCCCGCAGCACCCGTCCAC
CCACGGCGTCATCAACTTCCTGGTCGAGACCGACGGTGAGGTGCTGAAGCGCGCCACGCCGGACGTCGGCTACCTGCACC
GCTCGATCGAGAAGATCGGCGAGATGGTCGGGTATCCCGGCTTCATGCCGTACACCGACCGCGTGGATTACGTGGCGGCG
ATGTTCGCCAACGAGGGCTACGCCATCGCGGTCGAGCGCCTGCTCAAGATCGAGGTGCCGCAGCGGGCCCAGTGGCTGCG
CGCCATCTCCTGCGAGCTGTGCCGCATCGCCTCCCACCTGGTGTCGGTGGGCACGATGGTCATGGACATCGGCGCGTTCA
CGCCGATGCTCCACGGCATCCGCGAGCGCGAGACCATCAACGACCTGCTCGAGGCGCTCTGCGGCGCGCGGCTGACCTAC
AACTACCACCGCATCGGCGGCGTCGCGTTCGACCTGCCGGAGGGCTGGCGAGACAAGGTCCTCCACTTCCTCGACCACTT
CGACAAGTTCCTGGCCGAGTTCGACCGGCTGATCTCGTTCAACGAGATCTACGTGAAGCGCCTCGCGAACGTGGCGGTGA
TCCCGGGCCCGATGGCGATCAACTACGGCCTGGTCGGCCCGAACCTGCGCGGCTCGGGCGTGGACTGGGACGTCCGCCGC
GACCTGCCCTACGGCGCCTACCCGAACTTCAAGTTCGACGTGCCGGTGGGCAAGGGCTTCTACGGCACCTCGGGCGACTC
GTTCGACCGGTACTACGTGCGCTGCCTGGAGATGGCCGAGTCCTCGAAGATCGTCCGCCAGGCGCTGGACTCGCTGCCGG
AGGGCGAGATCACCGCCAAGGTGCCCCGCAACATCAAGCCGGAGGCGGGCGAGGCGATCGGGCGCGTGGAGAGCGCGCGC
GGCGAGCTCGCCTACTACGTGATCTCCGACGGCACCAACAAGGCGTACCGGGTGCGCGCCCGCACCGGCTCCTTCACCGC
CATGTGCATCATCGAGGACATCTCGCGCGGCCTGATGGTCGCCGACCTGGTGGCCCTCATCTCGTCGCTCGACGTCGTCG
CCCCGGAGATCGATCGATGA

Upstream 100 bases:

>100_bases
GCGGCTCGACGACCAGCGCCGCGCCGAGGCCGCCGCCAGGGCGGCGCCGCCGGCCGCGCCCGACGCCGCCGCGGCCGCCC
CCAAGGCGTAGGGAGACGAC

Downstream 100 bases:

>100_bases
ACGCCCCCGCCATCAAGAACCAGGACCTGAGCAAGGGGCCGGGCAGGACGGCCCGCGGCGTCGTGCTCGCGACGCTCGCG
GTCGGGTTCGGGCTGCCCAC

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 1; NDH-1 subunit D 1 [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MEKLILRRVDRQNEEMILNFGPQHPSTHGVINFLVETDGEVLKRATPDVGYLHRSIEKIGEMVGYPGFMPYTDRVDYVAA
MFANEGYAIAVERLLKIEVPQRAQWLRAISCELCRIASHLVSVGTMVMDIGAFTPMLHGIRERETINDLLEALCGARLTY
NYHRIGGVAFDLPEGWRDKVLHFLDHFDKFLAEFDRLISFNEIYVKRLANVAVIPGPMAINYGLVGPNLRGSGVDWDVRR
DLPYGAYPNFKFDVPVGKGFYGTSGDSFDRYYVRCLEMAESSKIVRQALDSLPEGEITAKVPRNIKPEAGEAIGRVESAR
GELAYYVISDGTNKAYRVRARTGSFTAMCIIEDISRGLMVADLVALISSLDVVAPEIDR

Sequences:

>Translated_379_residues
MEKLILRRVDRQNEEMILNFGPQHPSTHGVINFLVETDGEVLKRATPDVGYLHRSIEKIGEMVGYPGFMPYTDRVDYVAA
MFANEGYAIAVERLLKIEVPQRAQWLRAISCELCRIASHLVSVGTMVMDIGAFTPMLHGIRERETINDLLEALCGARLTY
NYHRIGGVAFDLPEGWRDKVLHFLDHFDKFLAEFDRLISFNEIYVKRLANVAVIPGPMAINYGLVGPNLRGSGVDWDVRR
DLPYGAYPNFKFDVPVGKGFYGTSGDSFDRYYVRCLEMAESSKIVRQALDSLPEGEITAKVPRNIKPEAGEAIGRVESAR
GELAYYVISDGTNKAYRVRARTGSFTAMCIIEDISRGLMVADLVALISSLDVVAPEIDR
>Mature_379_residues
MEKLILRRVDRQNEEMILNFGPQHPSTHGVINFLVETDGEVLKRATPDVGYLHRSIEKIGEMVGYPGFMPYTDRVDYVAA
MFANEGYAIAVERLLKIEVPQRAQWLRAISCELCRIASHLVSVGTMVMDIGAFTPMLHGIRERETINDLLEALCGARLTY
NYHRIGGVAFDLPEGWRDKVLHFLDHFDKFLAEFDRLISFNEIYVKRLANVAVIPGPMAINYGLVGPNLRGSGVDWDVRR
DLPYGAYPNFKFDVPVGKGFYGTSGDSFDRYYVRCLEMAESSKIVRQALDSLPEGEITAKVPRNIKPEAGEAIGRVESAR
GELAYYVISDGTNKAYRVRARTGSFTAMCIIEDISRGLMVADLVALISSLDVVAPEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=391, Percent_Identity=37.3401534526854, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI260898743, Length=385, Percent_Identity=36.8831168831169, Blast_Score=265, Evalue=4e-71,
Organism=Escherichia coli, GI145693162, Length=403, Percent_Identity=35.7320099255583, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI1789076, Length=375, Percent_Identity=27.4666666666667, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788832, Length=364, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17568379, Length=398, Percent_Identity=36.4321608040201, Blast_Score=283, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17555284, Length=398, Percent_Identity=36.4321608040201, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24638644, Length=396, Percent_Identity=38.8888888888889, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI221459469, Length=396, Percent_Identity=37.6262626262626, Blast_Score=285, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 42493; Mature: 42493

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLILRRVDRQNEEMILNFGPQHPSTHGVINFLVETDGEVLKRATPDVGYLHRSIEKIG
CCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHHHH
EMVGYPGFMPYTDRVDYVAAMFANEGYAIAVERLLKIEVPQRAQWLRAISCELCRIASHL
HHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VSVGTMVMDIGAFTPMLHGIRERETINDLLEALCGARLTYNYHRIGGVAFDLPEGWRDKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHCCEEEECCCCHHHHH
LHFLDHFDKFLAEFDRLISFNEIYVKRLANVAVIPGPMAINYGLVGPNLRGSGVDWDVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCHHHC
DLPYGAYPNFKFDVPVGKGFYGTSGDSFDRYYVRCLEMAESSKIVRQALDSLPEGEITAK
CCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VPRNIKPEAGEAIGRVESARGELAYYVISDGTNKAYRVRARTGSFTAMCIIEDISRGLMV
CCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEEEHHHHHHHCHHHH
ADLVALISSLDVVAPEIDR
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEKLILRRVDRQNEEMILNFGPQHPSTHGVINFLVETDGEVLKRATPDVGYLHRSIEKIG
CCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHHHH
EMVGYPGFMPYTDRVDYVAAMFANEGYAIAVERLLKIEVPQRAQWLRAISCELCRIASHL
HHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VSVGTMVMDIGAFTPMLHGIRERETINDLLEALCGARLTYNYHRIGGVAFDLPEGWRDKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHCCEEEECCCCHHHHH
LHFLDHFDKFLAEFDRLISFNEIYVKRLANVAVIPGPMAINYGLVGPNLRGSGVDWDVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCHHHC
DLPYGAYPNFKFDVPVGKGFYGTSGDSFDRYYVRCLEMAESSKIVRQALDSLPEGEITAK
CCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VPRNIKPEAGEAIGRVESARGELAYYVISDGTNKAYRVRARTGSFTAMCIIEDISRGLMV
CCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEEEHHHHHHHCHHHH
ADLVALISSLDVVAPEIDR
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA