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The map label for this gene is moaA [H]

Identifier: 220915987

GI number: 220915987

Start: 985801

End: 986814

Strand: Reverse

Name: moaA [H]

Synonym: A2cp1_0873

Alternate gene names: 220915987

Gene position: 986814-985801 (Counterclockwise)

Preceding gene: 220915988

Following gene: 220915986

Centisome position: 19.62

GC content: 76.73

Gene sequence:

>1014_bases
ATGGAGCAGCTCCGTGAACCCACGCCCGCCGCGCCGCGCAAGGGGCCGGCCCTGGCCGACGCCCAGGGGCGCCTCATCCG
CTACCTGCGCGTGTCGCTCACCGACCGCTGCAACTTCCGGTGCACCTACTGCTCCCCGGCCGAGCACGAGGCCCCCGACG
CGCTCCTGCAGCGCCCCGAGATCGCGCGGCTGGTGCGCGTCTTCGCCGGGCTGGGCGTCCGGCGCGTGCGGCTCACCGGC
GGCGAGCCCACGCTCCGCAAGGATCTGGTGGAGATCGTCGCCGACGCCGCCGCCACCCCGGGCATCGAGGAGGTCGCGCT
GACCACGAACGGCCACCGCCTCGACGAGCTGGTGGCGCCGCTCCGCGCCGCCGGGCTGGGCGCGGTGAACGTCTCGCTCG
ACACGCTGGTGCCGGAGCGGCTGGGCGGCGTGTCCGGGAAGGGCGCGCGCCTGGACCGGATCCTGGCCGGCATCGACGCG
GCGGCGGGCCGCTTCCGGTCGCTGAAGCTCAACACGGTGGTGATGCGCGGCGTGAACGAGGACGAGCTGGGCGCGCTGGT
GCGGTACGCCTGGGACCGCGGCGCGCTCCCGCGCTTCATCGAGCAGATGCCGTTCGGCGGGGGCGTGCCGGTGCCGCTCG
CGGAGGTCCGCGCCGGGCTCGAGGCGCAGGGCTTCGCGCTCGAGCCGGACGGCTGGAAGGGCTGGGGGCCGGCCCGGCAC
ATGCGCGCGCGCGACGCGGCCGGGCGCACCGGCCTCGTCGGCTTCATCGGCGCCATGACCGAGAACTTCTGCGAGGACTG
CAACCGCGCGCGGGTGGCGGCGGACGGCGGGTTCCAGGCGTGCCTGGGGGGCCAGGACCGGGTGAACCTGCGCGACCTGA
TGCGCGGCGGCGCGCAGGACGAGGGGCTGGCGGAGGCGGTGCGCGGCGCGCTCTGGCGCAAGGCGCCCCGCCACCACATG
GAGGACGCGGGGTCCGGGCTGGTGCTCCTGCCCATGCGCGGCCTCGGCGGGTGA

Upstream 100 bases:

>100_bases
GCCGGGCGCGGGGCGGCGGAGCTGGCTAGGAAGGAAGGGGCCCGCCCTCGCATGCCGTCCCCTCCCGGCATCGATCCCAC
GGGCAAGGAGACCGCCGAGC

Downstream 100 bases:

>100_bases
TCGGGGCCGGCGGCGCAGGACGTGCCGCCGGTGAGGGGAAGGGGGAGGGACATGACGTCGAACCGCTGGTTCATCGCGGT
GGCCGGCACCATCACCATGG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MEQLREPTPAAPRKGPALADAQGRLIRYLRVSLTDRCNFRCTYCSPAEHEAPDALLQRPEIARLVRVFAGLGVRRVRLTG
GEPTLRKDLVEIVADAAATPGIEEVALTTNGHRLDELVAPLRAAGLGAVNVSLDTLVPERLGGVSGKGARLDRILAGIDA
AAGRFRSLKLNTVVMRGVNEDELGALVRYAWDRGALPRFIEQMPFGGGVPVPLAEVRAGLEAQGFALEPDGWKGWGPARH
MRARDAAGRTGLVGFIGAMTENFCEDCNRARVAADGGFQACLGGQDRVNLRDLMRGGAQDEGLAEAVRGALWRKAPRHHM
EDAGSGLVLLPMRGLGG

Sequences:

>Translated_337_residues
MEQLREPTPAAPRKGPALADAQGRLIRYLRVSLTDRCNFRCTYCSPAEHEAPDALLQRPEIARLVRVFAGLGVRRVRLTG
GEPTLRKDLVEIVADAAATPGIEEVALTTNGHRLDELVAPLRAAGLGAVNVSLDTLVPERLGGVSGKGARLDRILAGIDA
AAGRFRSLKLNTVVMRGVNEDELGALVRYAWDRGALPRFIEQMPFGGGVPVPLAEVRAGLEAQGFALEPDGWKGWGPARH
MRARDAAGRTGLVGFIGAMTENFCEDCNRARVAADGGFQACLGGQDRVNLRDLMRGGAQDEGLAEAVRGALWRKAPRHHM
EDAGSGLVLLPMRGLGG
>Mature_337_residues
MEQLREPTPAAPRKGPALADAQGRLIRYLRVSLTDRCNFRCTYCSPAEHEAPDALLQRPEIARLVRVFAGLGVRRVRLTG
GEPTLRKDLVEIVADAAATPGIEEVALTTNGHRLDELVAPLRAAGLGAVNVSLDTLVPERLGGVSGKGARLDRILAGIDA
AAGRFRSLKLNTVVMRGVNEDELGALVRYAWDRGALPRFIEQMPFGGGVPVPLAEVRAGLEAQGFALEPDGWKGWGPARH
MRARDAAGRTGLVGFIGAMTENFCEDCNRARVAADGGFQACLGGQDRVNLRDLMRGGAQDEGLAEAVRGALWRKAPRHHM
EDAGSGLVLLPMRGLGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=332, Percent_Identity=38.855421686747, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI22027536, Length=332, Percent_Identity=38.855421686747, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI1786999, Length=327, Percent_Identity=38.2262996941896, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI32566329, Length=345, Percent_Identity=38.2608695652174, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI32566331, Length=326, Percent_Identity=38.3435582822086, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17561210, Length=317, Percent_Identity=40.0630914826498, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI28574490, Length=322, Percent_Identity=41.304347826087, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI28574488, Length=322, Percent_Identity=41.304347826087, Blast_Score=222, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36028; Mature: 36028

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLREPTPAAPRKGPALADAQGRLIRYLRVSLTDRCNFRCTYCSPAEHEAPDALLQRPE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHCCHH
IARLVRVFAGLGVRRVRLTGGEPTLRKDLVEIVADAAATPGIEEVALTTNGHRLDELVAP
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
LRAAGLGAVNVSLDTLVPERLGGVSGKGARLDRILAGIDAAAGRFRSLKLNTVVMRGVNE
HHHHCCCEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHEEEEHHHEECCCCH
DELGALVRYAWDRGALPRFIEQMPFGGGVPVPLAEVRAGLEAQGFALEPDGWKGWGPARH
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCEEECCCCCCCCCHHHH
MRARDAAGRTGLVGFIGAMTENFCEDCNRARVAADGGFQACLGGQDRVNLRDLMRGGAQD
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCEEECCCCCHHHCCCCCCCCHHHHHCCCCCC
EGLAEAVRGALWRKAPRHHMEDAGSGLVLLPMRGLGG
CHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCCCC
>Mature Secondary Structure
MEQLREPTPAAPRKGPALADAQGRLIRYLRVSLTDRCNFRCTYCSPAEHEAPDALLQRPE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHCCHH
IARLVRVFAGLGVRRVRLTGGEPTLRKDLVEIVADAAATPGIEEVALTTNGHRLDELVAP
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
LRAAGLGAVNVSLDTLVPERLGGVSGKGARLDRILAGIDAAAGRFRSLKLNTVVMRGVNE
HHHHCCCEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHEEEEHHHEECCCCH
DELGALVRYAWDRGALPRFIEQMPFGGGVPVPLAEVRAGLEAQGFALEPDGWKGWGPARH
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCEEECCCCCCCCCHHHH
MRARDAAGRTGLVGFIGAMTENFCEDCNRARVAADGGFQACLGGQDRVNLRDLMRGGAQD
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCEEECCCCCHHHCCCCCCCCHHHHHCCCCCC
EGLAEAVRGALWRKAPRHHMEDAGSGLVLLPMRGLGG
CHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA