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The map label for this gene is hisG

Identifier: 220915512

GI number: 220915512

Start: 442604

End: 443269

Strand: Reverse

Name: hisG

Synonym: A2cp1_0393

Alternate gene names: 220915512

Gene position: 443269-442604 (Counterclockwise)

Preceding gene: 220915513

Following gene: 220915511

Centisome position: 8.81

GC content: 73.57

Gene sequence:

>666_bases
ATGCCGGGTACGAGCGAGCTCATCACGGTGGCGGTGCCGAAGGGGCGCCTCCTGCAGGAGTCCTCGGCGCTGTTCGAGCG
GGCGCTCGGCGTGTCGCCGCGCAAGCTGCTGGAGGGCACGCGCAAGCTGGCCGCCGACGCCCCCGAGGCCGGCCTGCGCT
TCATCTCGATCCGCGCCGGCGACGTGGCGAGCTACGTGGAGCACGGCGCCGCCGAGGTCGGCATCGTCGGGCTCGACGTG
CTGCGCGAGGAACCGCGCGATCTGTACGAGCCGCTCGACCTGGGGATCGGCCGCTGCACCGTGATCGTGGCCCGCCCGAA
GGGCGCCCGGCCGCTGCCGCGCGGGGTCGCGCCGCGGGTGGCGACGAAGTACCTGTCGCTCGCGGCCCGGCACTTCGCCG
CCAAGGGGGTGCCGGCGGAGATCATCCCGCTGCACGGCTCCATCGAGGTGGCGCCCTCGCTCGGGCTCGCCGACACCATC
GTGGACATCACCGAGACCGGGGAGACGCTGCGCGCCAACGGCCTGGTCATCGAGGAGAAGGTCCTCGAGGTCTCGGCGCG
CCTCGTCGTGAACCGGGTGGCCCTGAAGCTCCACCCGGAGCGGCTGCGTCGTCTGATCGAGGCATTGCGCGCCGCCGTGG
CCGAAGCCGGCGCCGAAGCCCGTTGA

Upstream 100 bases:

>100_bases
CGACCGAGGTGCTGCGCGTGTACCATCTCGACCGCGGCTACGAGCGGATCGAGGAGAAGCTGGCGCCCCTCGGGGCGCGC
ATCCGGAGGGTGAGAGGCTG

Downstream 100 bases:

>100_bases
AACGTGGCACGGCTTCTGCCTAGTATGACCAGGACTCGGCAAGAGCCCGTCCTCGCTTGAAATCCCGATCCCAACCCGTC
GTGTCACCGGTCCGAGGAGG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MPGTSELITVAVPKGRLLQESSALFERALGVSPRKLLEGTRKLAADAPEAGLRFISIRAGDVASYVEHGAAEVGIVGLDV
LREEPRDLYEPLDLGIGRCTVIVARPKGARPLPRGVAPRVATKYLSLAARHFAAKGVPAEIIPLHGSIEVAPSLGLADTI
VDITETGETLRANGLVIEEKVLEVSARLVVNRVALKLHPERLRRLIEALRAAVAEAGAEAR

Sequences:

>Translated_221_residues
MPGTSELITVAVPKGRLLQESSALFERALGVSPRKLLEGTRKLAADAPEAGLRFISIRAGDVASYVEHGAAEVGIVGLDV
LREEPRDLYEPLDLGIGRCTVIVARPKGARPLPRGVAPRVATKYLSLAARHFAAKGVPAEIIPLHGSIEVAPSLGLADTI
VDITETGETLRANGLVIEEKVLEVSARLVVNRVALKLHPERLRRLIEALRAAVAEAGAEAR
>Mature_220_residues
PGTSELITVAVPKGRLLQESSALFERALGVSPRKLLEGTRKLAADAPEAGLRFISIRAGDVASYVEHGAAEVGIVGLDVL
REEPRDLYEPLDLGIGRCTVIVARPKGARPLPRGVAPRVATKYLSLAARHFAAKGVPAEIIPLHGSIEVAPSLGLADTIV
DITETGETLRANGLVIEEKVLEVSARLVVNRVALKLHPERLRRLIEALRAAVAEAGAEAR

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=188, Percent_Identity=33.5106382978723, Blast_Score=77, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320896, Length=212, Percent_Identity=30.188679245283, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_ANAD2 (B8JAT9)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002490816.1
- ProteinModelPortal:   B8JAT9
- SMR:   B8JAT9
- GeneID:   7299112
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_0393
- HOGENOM:   HBG391868
- ProtClustDB:   PRK01686
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23500; Mature: 23368

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGTSELITVAVPKGRLLQESSALFERALGVSPRKLLEGTRKLAADAPEAGLRFISIRAG
CCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEECC
DVASYVEHGAAEVGIVGLDVLREEPRDLYEPLDLGIGRCTVIVARPKGARPLPRGVAPRV
HHHHHHHCCCHHEEHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHH
ATKYLSLAARHFAAKGVPAEIIPLHGSIEVAPSLGLADTIVDITETGETLRANGLVIEEK
HHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCCCHHHHHHHHHHCCCEEECCCEEEHHH
VLEVSARLVVNRVALKLHPERLRRLIEALRAAVAEAGAEAR
HHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PGTSELITVAVPKGRLLQESSALFERALGVSPRKLLEGTRKLAADAPEAGLRFISIRAG
CCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEECC
DVASYVEHGAAEVGIVGLDVLREEPRDLYEPLDLGIGRCTVIVARPKGARPLPRGVAPRV
HHHHHHHCCCHHEEHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHH
ATKYLSLAARHFAAKGVPAEIIPLHGSIEVAPSLGLADTIVDITETGETLRANGLVIEEK
HHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCCCHHHHHHHHHHCCCEEECCCEEEHHH
VLEVSARLVVNRVALKLHPERLRRLIEALRAAVAEAGAEAR
HHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA